Transcriptional activation by p53 correlates with suppression of growth but not transformation

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Gain of function mutations in p53

1993 • 876 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Braking the cycle

1993 • 378 citations

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

1992 • 344 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.

1990 • 323 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours

1992 • 313 citations

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.

1992 • 278 citations

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

1994 • 275 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

The mdm-2 gene is induced in response to UV light in a p53-dependent manner.

1993 • 250 citations

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

1993 • 246 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

A point mutational analysis of human papillomavirus type 16 E7 protein

1989 • 241 citations

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1993 • 239 citations

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

1994 • 234 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1993 • 193 citations

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.

1992 • 193 citations

Inhibition of viral and cellular promoters by human wild-type p53

1992 • 178 citations

Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.

1992 • 146 citations

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.

1993 • 131 citations

A temperature-sensitive mutant of human p53.

1994 • 128 citations

Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.

1993 • 124 citations

Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells.

1991 • 117 citations

Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences.

1993 • 110 citations

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

1993 • 108 citations

Analysis of p53 mutants for transcriptional activity.

1991 • 106 citations

Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53

1992 • 105 citations

Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.

1992 • 96 citations

Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas.

1989 • 88 citations

Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation.

1994 • 84 citations

Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity.

1993 • 73 citations

Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.

1994 • 70 citations

Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.

1993 • 70 citations

Novel DNA binding of p53 mutants and their role in transcriptional activation.

1993 • 65 citations

Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor-suppressor gene isolated from nasopharyngeal carcinoma.

1993 • 54 citations

Overlapping domains on the p53 protein regulate its transcriptional activation and repression functions.

1994 • 45 citations

Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein.

1993 • 37 citations

Analysis of p53 transactivation through high-affinity binding sites.

1993 • 37 citations

Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression

1991 • 35 citations

Distinct regions of p53 have a differential role in transcriptional activation and repression functions.

1994 • 28 citations

Synergism between pairs of immortalizing genes in transformation assays of rat embryo fibroblasts.

1990 • 11 citations