Growth factor modulation of p53-mediated growth arrest versus apoptosis.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1993 • 526 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

1994 • 415 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo.

1994 • 333 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 305 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

MAMMALIAN GENES INDUCED BY RADIATION; Activation of Genes Associated with Growth Control

1992 • 284 citations

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

1994 • 275 citations

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.

1991 • 268 citations

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.

1994 • 255 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

The p53-dependent gamma-ray response of GADD45.

1994 • 225 citations

Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents.

1992 • 224 citations

Participation of cyclin A in Myc-induced apoptosis.

1994 • 207 citations

Effect of Antisense c- raf -1 on Tumorigenicity and Radiation Sensitivity of a Human Squamous Carcinoma

1989 • 189 citations

Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells.

1985 • 171 citations

Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).

1994 • 151 citations

Oncogenes in Radioresistant, Noncancerous Skin Fibroblasts from a Cancer-Prone Family

1987 • 111 citations

v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells.

1994 • 111 citations

Tyrosine kinase(s) regulate apoptosis and bcl-2 expression in a growth factor-dependent cell line.

1993 • 98 citations

Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1.

1994 • 91 citations

Apoptosis in Burkitt lymphoma cells is driven by c-myc.

1993 • 77 citations

Radioprotection with cytokines--learning from nature to cope with radiation damage.

1991 • 54 citations

The effect of stem cell factor on irradiated human bone marrow.

1993 • 6 citations

Effects of Recombinant Interleukin‐3 and Recombinant Interleukin‐6 on Radiation Survival of Normal Human Bone Marrow Progenitor Cells

1993 • 4 citations