P53 Inhibits α6β4 Integrin Survival Signaling by Promoting the Caspase 3–Dependent Cleavage of Akt/PKB

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1999 • 787 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

1995 • 736 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

1995 • 627 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Regulation of G₁progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1999 • 572 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

1998 • 496 citations

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

1996 • 496 citations

Caspase-dependent Cleavage of Signaling Proteins during Apoptosis

1998 • 420 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

Interleukin 3-dependent survival by the Akt protein kinase

1997 • 374 citations

The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

1998 • 360 citations

Desmosomes and hemidesmosomes: structure and function of molecular components

1996 • 350 citations

The coupling of α₆β₄integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation

1997 • 328 citations

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

1989 • 314 citations

Association of the VLA a Subunit with a Novel Protein

1989 • 285 citations

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.

1999 • 275 citations

Transgenic mice with p53-responsive lacZ: p53activity varies dramatically during normal development and determines radiation and drug sensitivity invivo

1997 • 270 citations

Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression

1997 • 259 citations

Epidermal Growth Factor Protects Epithelial Cells against Fas-induced Apoptosis

1999 • 257 citations

The Activation of p38 and Apoptosis by the Inhibition of Erk Is Antagonized by the Phosphoinositide 3-Kinase/Akt Pathway

1998 • 252 citations

Linking Integrin α6β4-based Cell Adhesion to the Intermediate Filament Cytoskeleton: Direct Interaction between the β4 Subunit and Plectin at Multiple Molecular Sites

1998 • 238 citations

Hemidesmosomes: roles in adhesion, signaling and human diseases

1996 • 213 citations

Cellular growth and survival are mediated by β1 integrins in normal human breast epithelium but not in breast carcinoma

1995 • 203 citations

Extracellular Matrix Regulates Apoptosis in Mammary Epithelium through a Control on Insulin Signaling

1999 • 197 citations

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin β4 cytoplasmic domain

1998 • 197 citations

Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line

1998 • 192 citations

p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin.

1995 • 167 citations

Analysis of the tumor-associated antigen TSP-180

1989 • 166 citations

Cleavage of DFF-45/ICAD by Multiple Caspases Is Essential for Its Function during Apoptosis

1998 • 163 citations

EGF-R dependent regulation of keratinocyte survival

1997 • 162 citations

Release of cAMP Gating by the α6β4 Integrin Stimulates Lamellae Formation and the Chemotactic Migration of Invasive Carcinoma Cells

1998 • 156 citations

Systemic Gene Therapy with p53 Reduces Growth and Metastases of a Malignant Human Breast Cancer in Nude Mice

1995 • 145 citations

Phosphoinositide 3-OH Kinase (PI3K) and PKB/Akt Delay the Onset of p53-mediated, Transcriptionally Dependent Apoptosis

1999 • 141 citations

Activation of the p21 Pathway of Growth Arrest and Apoptosis by the β4 Integrin Cytoplasmic Domain

1995 • 136 citations

A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells.

1996 • 135 citations

p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32beta.

1997 • 130 citations

A temperature-sensitive mutant of human p53.

1994 • 128 citations

Cell Anchorage Regulates Apoptosis through the Retinoblastoma Tumor Suppressor/E2F Pathway

1997 • 108 citations

Oncogene-dependent Regulation of Caspase Activation by p53 Protein in a Cell-free System

1998 • 91 citations

The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice.

1997 • 90 citations

Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells.

1995 • 87 citations

Monoclonal antibody to human carcinoma-associated protein complex: quantitation in normal and tumor tissue.

1988 • 85 citations

p53 is involved in but not required for ionizing radiation-induced caspase-3 activation and apoptosis in human lymphoblast cell lines.

1998 • 85 citations

Activation of p53 Function in Carcinoma Cells by the α6β4 Integrin

1999 • 74 citations

Integrin α 6β 4 mediates dynamic interactions with laminin

1994 • 61 citations

Integrin β4 Is Involved in Apoptotic Signal Transduction in Endothelial Cells

1997 • 47 citations

Cellular adhesion regulates p53 protein levels in primary human keratinocytes.

1997 • 45 citations

Activation of p21WAF1/Cip1 expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis.

1995 • 40 citations

Downstream events in mammary gland morphogenesis mediated by reexpression of the alpha2beta1 integrin: the role of the alpha6 and beta4 integrin subunits.

1998 • 32 citations

Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells.

1995 • 31 citations

Enhanced p53 activity and accumulation in response to DNA damage upon DNA transfection.

1995 • 30 citations

Beta 4 integrin transfection of UM-UC-2 (human bladder carcinoma) cells: stable expression of a spontaneous cytoplasmic truncation mutant with rapid loss of clones expressing intact beta 4.

1997 • 26 citations