Identification of a cryptic nucleolar-localization signal in MDM2

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Nucleolar Arf sequesters Mdm2 and activates p53

1999 • 937 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

P19 ^ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1999 • 543 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

Mutations in Human ARF Exon 2 Disrupt Its Nucleolar Localization and Impair Its Ability to Block Nuclear Export of MDM2 and p53

1999 • 343 citations

Mechanisms of p53-mediated apoptosis

1999 • 303 citations

Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

1995 • 215 citations

Keeping an old friend under control: regulation of p53 stability

1998 • 122 citations

Analysis of the degradation function of Mdm2.

1999 • 104 citations