Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

SUMO-1 Modification of IκBα Inhibits NF-κB Activation

1998 • 1,002 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

A new protease required for cell-cycle progression in yeast

1999 • 718 citations

Signaling to p53

1998 • 636 citations

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

1996 • 508 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

SUMO-1 Modification and Its Role in Targeting the Ran GTPase-activating Protein, RanGAP1, to the Nuclear Pore Complex

1998 • 455 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

1994 • 394 citations

Identification of the Enzyme Required for Activation of the Small Ubiquitin-like Protein SUMO-1

1999 • 353 citations

PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.

1996 • 347 citations

Mutations in Human ARF Exon 2 Disrupt Its Nucleolar Localization and Impair Its Ability to Block Nuclear Export of MDM2 and p53

1999 • 343 citations

Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins

1999 • 330 citations

Evidence for Covalent Modification of the Nuclear Dot–associated Proteins PML and Sp100 by PIC1/SUMO-1

1997 • 329 citations

Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body Disruption

1999 • 303 citations

Allosteric activation of latent p53 tetramers

1994 • 302 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

Molecular Characterization of the SUMO-1 Modification of RanGAP1 and Its Role in Nuclear Envelope Association

1998 • 290 citations

In VitroSUMO-1 Modification Requires Two Enzymatic Steps, E1 and E2

1999 • 224 citations

The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme

1998 • 210 citations

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

1996 • 203 citations

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

1998 • 194 citations

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

1999 • 193 citations

Modification of Ran GTPase-activating Protein by the Small Ubiquitin-related Modifier SUMO-1 Requires Ubc9, an E2-type Ubiquitin-conjugating Enzyme Homologue

1998 • 155 citations

SUMO-1: wrestling with a new ubiquitin-related modifier

1997 • 143 citations

Associations of UBE2I with RAD52, UBL1, p53, and RAD51 Proteins in a Yeast Two-Hybrid System

1996 • 135 citations

An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODs

1999 • 133 citations

Protein regulation: Tag wrestling with relatives of ubiquitin

1998 • 36 citations