Mechanisms of switching on p53: a role for covalent modification?

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

The p53 pathway

1999 • 1,322 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1998 • 912 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

The p53 Network

1998 • 731 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1998 • 533 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

1996 • 508 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Phosphorylation of p53 Serine 15 Increases Interaction with CBP

1998 • 427 citations

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

1990 • 415 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK

1995 • 344 citations

JNK targets p53 ubiquitination and degradation in nonstressed cells

1998 • 339 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1998 • 313 citations

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1999 • 296 citations

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

1992 • 289 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

1990 • 277 citations

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

1995 • 271 citations

p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1

1995 • 256 citations

Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Suppressor Protein p53

1997 • 249 citations

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

1997 • 243 citations

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

1998 • 228 citations

Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiation

1998 • 210 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

Genomic instability and apoptosis are frequent in p53 deficient young mice

1997 • 197 citations

Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

1997 • 186 citations

Multisite Phosphorylation and the Integration of Stress Signals at p53

1998 • 185 citations

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1999 • 182 citations

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

1996 • 173 citations

p53 Is Phosphorylated by CDK7-Cyclin H in a p36^MAT1-Dependent Manner

1997 • 173 citations

p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

1997 • 167 citations

Ultraviolet radiation, but not γ radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

1998 • 161 citations

Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases.

1994 • 154 citations

The CDK₇-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its Sequence-Specific DNA Binding Activity In Vitro

1997 • 152 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes.

1993 • 152 citations

Human Cells Contain a DNA-Activated Protein Kinase that Phosphorylates Simian Virus 40 T Antigen, Mouse p53, and the Human Ku Autoantigen

1990 • 144 citations

Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells

1998 • 134 citations

JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases

1997 • 122 citations

Conformation-dependent phosphorylation of p53

1997 • 120 citations

Reciprocal Interference between the Sequence-Specific Core and Nonspecific C-Terminal DNA Binding Domains of p53: Implications for Regulation

1997 • 119 citations

Magnetization curve of a square-lattice Heisenberg antiferromagnet

1998 • 108 citations

Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein Kinases

1994 • 106 citations

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

1998 • 106 citations

Mutation of Phosphoserine 389 Affects p53 Function in Vivo

1996 • 103 citations

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p53 induction

1996 • 94 citations

DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.

1997 • 85 citations

Stabilization and activation of p53 are regulated independently by different phosphorylation events

1998 • 81 citations

The protein kinase C activator, phorbol ester, cooperates with the wild-type p53 species of Ras-transformed embryo fibroblasts growth arrest.

1994 • 48 citations

Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential

1997 • 46 citations

Protein kinases and the response to DNA damage

1994 • 36 citations

Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells

1999 • 21 citations

Untitled

1998 • 14 citations

Segmentační tendence a procesy na trhu práce v České republice

1997 • 2 citations