The Insulin-Like Growth Factor I Receptor as a Physiologically Relevant Target of p53 in Apoptosis Caused by Interleukin-3 Withdrawal

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 • 559 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

1995 • 385 citations

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

1992 • 381 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

1996 • 365 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis.

1995 • 286 citations

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor.

1994 • 282 citations

Identification of Domains of the Insulin-Like Growth Factor I Receptor That Are Required for Protection from Apoptosis

1997 • 258 citations

Oncogenes and the strategy of growth factors

1994 • 232 citations

Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells.

1992 • 225 citations

Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase

1996 • 217 citations

A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis.

1996 • 181 citations

Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors.

1995 • 172 citations

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation

1993 • 170 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker

1988 • 146 citations

Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.

1996 • 144 citations

The IGF-I Receptor in Mitogenesis and Transformation of Mouse Embryo Cells: Role of Receptor Number

1997 • 133 citations

Suppression of Interleukin-1β-converting Enzyme-mediated Cell Death by Insulin-like Growth Factor

1996 • 121 citations

Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism

1991 • 112 citations

Inhibition of Cellular Proliferation by the Wilms’ Tumor Suppressor WT1 Is Associated with Suppression of Insulin-Like Growth Factor I Receptor Gene Expression

1995 • 110 citations

Amino acid sequence of a variant pro-form of insulin-like growth factor II.

1985 • 106 citations

Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor.

1996 • 104 citations

Platelet-Derived Growth Factor Increases the Activity of the Promoter of the Insulin-like Growth Factor-1 (IGF-1) Receptor Gene

1994 • 103 citations

Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.

1996 • 99 citations

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.

1992 • 98 citations

Wild-type human p53 activates the human epidermal growth factor receptor promoter.

1994 • 97 citations

The Drosophila Insulin Receptor Activates Multiple Signaling Pathways but Requires Insulin Receptor Substrate Proteins for DNA Synthesis

1996 • 88 citations

Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene

1990 • 84 citations

Dissociation of Mitogenesis and Transforming Activity by C-Terminal Truncation of the Insulin-like Growth Factor-I Receptor

1995 • 75 citations

Wild-type p53 modulates apoptosis of normal, IL-3 deprived, hematopoietic cells.

1995 • 55 citations

Enhancement or Inhibition of Insulin Signaling by Insulin Receptor Substrate 1 Is Cell Context Dependent

1994 • 48 citations

IGF-1 Receptor Levels and the Proliferation of Young and Senescent Human Fibroblasts

1993 • 38 citations

Alpha 2a-interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: correlation with down-regulation of the insulin-like growth factor type I receptor.

1996 • 31 citations

Wild-Type p53 Induces Diverse Effects in 32D Cells Expressing Different Oncogenes

1996 • 29 citations

Induction of c-myc mediated apoptosis in SV40-transformed rat fibroblasts.

1996 • 22 citations

The IGF-I Receptor Protects Tumor Cells from Apoptosis Induced by High Concentrations of Serum

1996 • 21 citations

Deleted Work

1955 • 0 citations