Regulation of microtubule-associated proteins

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Dynamic instability of microtubule growth

1984 • 3,187 citations

A protein factor essential for microtubule assembly.

1975 • 2,863 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Structure of the αβ tubulin dimer by electron crystallography

1998 • 2,006 citations

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

2000 • 1,878 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating Neurons

1999 • 1,297 citations

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

2000 • 1,253 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

High-Resolution Model of the Microtubule

1999 • 1,138 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.

1988 • 985 citations

Doublecortin Is a Developmentally Regulated, Microtubule-Associated Protein Expressed in Migrating and Differentiating Neurons

1999 • 974 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

1992 • 936 citations

Cytoskeletal dynamics and nerve growth

1988 • 855 citations

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

1997 • 836 citations

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

1977 • 834 citations

Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

1997 • 762 citations

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

1993 • 759 citations

Altered microtubule organization in small-calibre axons of mice lacking tau protein

1994 • 742 citations

Tau protein function in living cells.

1986 • 727 citations

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

1992 • 709 citations

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1993 • 702 citations

Kin I Kinesins Are Microtubule-Destabilizing Enzymes

1999 • 697 citations

Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules

1996 • 651 citations

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

1990 • 638 citations

Domains of tau Protein and Interactions with Microtubules

1994 • 630 citations

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain.

1995 • 601 citations

Multiple Forms of Tubulin: Different Gene Products and Covalent Modifications

1997 • 597 citations

Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 Activity

2001 • 592 citations

Developmentally regulated expression of specific tau sequences

1989 • 589 citations

Structure and novel exons of the human .tau. gene

1992 • 587 citations

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

1992 • 569 citations

In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain

1990 • 566 citations

A Complex of NuMA and Cytoplasmic Dynein Is Essential for Mitotic Spindle Assembly

1996 • 565 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Visualization of the dynamic instability of individual microtubules by dark-field microscopy

1986 • 547 citations

Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites

1988 • 546 citations

Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study.

1991 • 544 citations

Tau protein binds to microtubules through a flexible array of distributed weak sites.

1991 • 540 citations

XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly

1996 • 539 citations

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

1986 • 535 citations

Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles : Implications for the role of microtubule dynamics in mitosis

1992 • 521 citations

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

1999 • 506 citations

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors.

1985 • 506 citations

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1996 • 494 citations

Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function

2000 • 494 citations

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

1999 • 492 citations

Identification of katanin, an ATPase that severs and disassembles stable microtubules

1993 • 490 citations

Tubulin dynamics in cultured mammalian cells.

1984 • 489 citations

Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains

1989 • 478 citations

The microtubule binding domain of tau protein

1989 • 472 citations

Actomyosin-based Retrograde Flow of Microtubules in the Lamella of Migrating Epithelial Cells Influences Microtubule Dynamic Instability and Turnover and Is Associated with Microtubule Breakage and Treadmilling

1997 • 470 citations

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a

1999 • 453 citations

APC binds to the novel protein EB1.

1995 • 450 citations

Drosophila Futsch/22C10 Is a MAP1B-like Protein Required for Dendritic and Axonal Development

2000 • 447 citations

The adenomatous polyposis coli (APC) tumor suppressor

1997 • 446 citations

Tau interacts with src-family non-receptor tyrosine kinases

1998 • 441 citations

A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function

2000 • 432 citations

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

1996 • 430 citations

Structure of growing microtubule ends: two-dimensional sheets close into tubes at variable rates.

1995 • 429 citations

CENP-E is a putative kinetochore motor that accumulates just before mitosis

1992 • 424 citations

Light and electron microscopic studies of the distribution of microtubule‐associated protein 2 in rat brain: A difference between dendritic and axonal cytoskeletons

1984 • 424 citations

Microtubule organization and dynamics dependent on microtubule-associated proteins

1994 • 411 citations

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

1994 • 406 citations

The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

2000 • 401 citations

Stimulation of Microtubule Aster Formation and Spindle Assembly by the Small GTPase Ran

1999 • 393 citations

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau

1994 • 391 citations

Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A

1996 • 389 citations

CLIP-170 Highlights Growing Microtubule Ends In Vivo

1999 • 389 citations

Defects in Axonal Elongation and Neuronal Migration in Mice with Disrupted tau and map1b Genes

2000 • 388 citations

Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae.

1995 • 384 citations

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.

1991 • 384 citations

Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.

1995 • 379 citations

Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.

1992 • 376 citations

Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly

2001 • 374 citations

Guidebook to the cytoskeletal and motor proteins

1994 • 374 citations

CLIP-170 links endocytic vesicles to microtubules

1992 • 367 citations

Real-time observations of microtubule dynamic instability in living cells.

1988 • 364 citations

Microtubule dynamics in vitro are regulated by the tubulin isotype composition.

1994 • 364 citations

Tpx2, a Novel Xenopus Map Involved in Spindle Pole Organization

2000 • 363 citations

Microtubule-associated Protein/Microtubule Affinity-regulating Kinase (p110mark)

1995 • 361 citations

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

1989 • 354 citations

The Ran GTPase regulates mitotic spindle assembly

1999 • 349 citations

The Molecular and Genetic Basis of Neurological Disease

1993 • 345 citations

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

1998 • 340 citations

A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end.

1987 • 338 citations

MAPs, MARKs and microtubule dynamics

1998 • 337 citations

Katanin, a Microtubule-Severing Protein, Is a Novel AAA ATPase that Targets to the Centrosome Using a WD40-Containing Subunit

1998 • 332 citations

The Microtubule-associated Protein Tau Is Extensively Modified with O-linked N-acetylglucosamine

1996 • 331 citations

Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts

1999 • 327 citations

CENP-E Function at Kinetochores Is Essential for Chromosome Alignment

1997 • 326 citations

Formation of Spindle Poles by Dynein/Dynactin-Dependent Transport of Numa

2000 • 323 citations

Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau

1992 • 322 citations

Farnesyl Transferase Inhibitors Block the Farnesylation of CENP-E and CENP-F and Alter the Association of CENP-E with the Microtubules

2000 • 321 citations

Microtubule Interactions with the Cell Cortex Causing Nuclear Movements in Saccharomyces cerevisiae

2000 • 321 citations

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains.

1989 • 321 citations

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

1994 • 319 citations

Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments.

1983 • 319 citations

Role of Importin-β in Coupling Ran to Downstream Targets in Microtubule Assembly

2001 • 318 citations

Direct observation of microtubule dynamics in living cells

1988 • 318 citations

Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules.

1995 • 317 citations

The APC Protein and E-cadherin Form Similar but Independent Complexes with α-Catenin, β-Catenin, and Plakoglobin

1995 • 315 citations

Neuronal cytoskeletal changes are an early consequence of repetitive head injury

1999 • 315 citations

Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments

1993 • 312 citations

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

1989 • 306 citations

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

1995 • 305 citations

Self-Organization of Microtubule Asters Induced in Xenopus Egg Extracts by GTP-Bound Ran

1999 • 305 citations

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.

1996 • 301 citations

Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit

1997 • 298 citations

The Endogenous and Cell Cycle-dependent Phosphorylation of tau Protein in Living Cells: Implications for Alzheimer’s Disease

1998 • 296 citations

Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases

1997 • 294 citations

5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10

1999 • 294 citations

The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau.

1989 • 294 citations

Rac/Cdc42 and p65PAK Regulate the Microtubule-destabilizing Protein Stathmin through Phosphorylation at Serine 16

2001 • 293 citations

Morphogenetic Properties of Microtubules and Mitotic Spindle Assembly

1996 • 292 citations

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

1993 • 289 citations

Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation

1998 • 288 citations

Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells

2000 • 284 citations

Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau

1989 • 281 citations

Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.

1995 • 279 citations

Microtubule treadmills—possible molecular machinery

1981 • 279 citations

Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B

1994 • 278 citations

Overexpression of tau in a nonneuronal cell induces long cellular processes.

1991 • 278 citations

Glycogen synthase kinase 3β phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones

1999 • 276 citations

Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics.

1996 • 275 citations

Stathmin: a relay phosphoprotein for multiple signal transduction?

1991 • 273 citations

Positioning of the Mitotic Spindle by a Cortical-Microtubule Capture Mechanism

2000 • 271 citations

Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.

1994 • 271 citations

Widespread cytoskeletal pathology characterizes corticobasal degeneration.

1995 • 271 citations

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly.

1997 • 270 citations

Eb1 Proteins Regulate Microtubule Dynamics, Cell Polarity, and Chromosome Stability

2000 • 265 citations

Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

1987 • 264 citations

Doublecortin, a Stabilizer of Microtubules

1999 • 263 citations

Neuropathologic Overlap of Progressive Supranuclear Palsy, Pickʼs Disease and Corticobasal Degeneration

1996 • 260 citations

Tau Is Enriched on Dynamic Microtubules in the Distal Region of Growing Axons

1996 • 259 citations

A Spatial Gradient of Tau Protein Phosphorylation in Nascent Axons

1996 • 258 citations

The 4 Å X-Ray Structure of a Tubulin:Stathmin-like Domain Complex

2000 • 255 citations

Suppression of MAP2 in cultured cerebeller macroneurons inhibits minor neurite formation

1992 • 255 citations

Differential expression of distinct microtubule-associated proteins during brain development.

1985 • 255 citations

Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system.

1992 • 249 citations

Structural polarity and directional growth of microtubules of Chlamydomonas flagella

1974 • 249 citations

Yeast Bim1p Promotes the G1-specific Dynamics of Microtubules

1999 • 248 citations

NuMA is required for the organization of microtubules into aster-like mitotic arrays.

1995 • 242 citations

MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS

1989 • 241 citations

Stathmin: A Tubulin-Sequestering Protein Which Forms a Ternary T₂S Complex with Two Tubulin Molecules

1997 • 238 citations

Widespread distribution of the major polypeptide component of MAP 1 (microtubule-associated protein 1) in the nervous system.

1984 • 238 citations

Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: Distribution in a human/hamster hybrid cell

1980 • 236 citations

A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubule

1993 • 235 citations

CENP-E as an Essential Component of the Mitotic Checkpoint In Vitro

2000 • 235 citations

Structure and phosphorylation of microtubule-associated protein 2 (MAP 2).

1980 • 235 citations

In vivo phosphorylation sites in fetal and adult rat tau.

1993 • 233 citations

The polarity and dynamics of microtubule assembly in the budding yeast Saccharomyces cerevisiae

1999 • 233 citations

NuMA: an unusually long coiled-coil related protein in the mammalian nucleus.

1992 • 231 citations

Microtubule Disassembly by ATP-Dependent Oligomerization of the AAA Enzyme Katanin

1999 • 228 citations

Role of tubulin-associated proteins in microtubule nucleation and elongation

1977 • 225 citations

EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle

1998 • 224 citations

Wild-type p53 negatively regulates the expression of a microtubule-associated protein.

1996 • 223 citations

Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2

1990 • 220 citations

The Stathmin/Tubulin Interaction in Vitro

1997 • 218 citations

Common and distinct tubulin binding sites for microtubule-associated proteins.

1986 • 216 citations

Interaction of Tau with the Neural Membrane Cortex Is Regulated by Phosphorylation at Sites That Are Modified in Paired Helical Filaments

2000 • 216 citations

Mal3, the Fission Yeast Homologue of the Human APC-interacting Protein EB-1 Is Required for Microtubule Integrity and the Maintenance of Cell Form

1997 • 215 citations

Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis.

1992 • 215 citations

Expression of tau protein in non-neuronal cells: microtubule binding and stabilization

1992 • 215 citations

Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends

1999 • 215 citations

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

1998 • 215 citations

Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op18

2000 • 211 citations

Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments

1992 • 211 citations

XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover.

1994 • 209 citations

Guidebook to the Cytoskeletal and Motor Proteins

1999 • 209 citations

NuMA is required for the proper completion of mitosis.

1993 • 207 citations

Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation

1991 • 207 citations

Localization of Postsynaptic Density-93 to Dendritic Microtubules and Interaction with Microtubule-Associated Protein 1A

1998 • 204 citations

Molecular Linkage Underlying Microtubule Orientation Toward Cortical Sites in Yeast

2000 • 204 citations

Severing of stable microtubules by a mitotically activated protein in xenopus egg extracts

1991 • 196 citations

Localization of the Kinesin-like Protein Xklp2 to Spindle Poles Requires a Leucine Zipper, a Microtubule-associated Protein, and Dynein

1998 • 196 citations

Analysis of MAP 4 function in living cells using green fluorescent protein (GFP) chimeras.

1995 • 195 citations

Map1b Is Required for Axon Guidance and Is Involved in the Development of the Central and Peripheral Nervous System

2000 • 194 citations

New features of microtubule behaviour observed in vivo

1988 • 191 citations

Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein

1995 • 191 citations

Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis

1997 • 191 citations

Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation.

1989 • 191 citations

Control of Microtubule Dynamics by Oncoprotein 18: Dissection of the Regulatory Role of Multisite Phosphorylation during Mitosis

1997 • 189 citations

Phosphorylation of Microtubule-associated Proteins MAP2 and MAP4 by the Protein Kinase p110mark

1996 • 188 citations

Differential Subcellular Localization of Protein Phosphatase-1 α, γ1, and δ Isoforms during Both Interphase and Mitosis in Mammalian Cells

1998 • 187 citations

Microtubule bundling by tau proteins in vivo: analysis of functional domains.

1992 • 186 citations

Microtubule-associated protein 1B: Molecular structure, localization, and phosphorylation-dependent expression in developing neurons

1989 • 185 citations

Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10

1997 • 184 citations

The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules

1998 • 180 citations

Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability

1994 • 179 citations

BIM1Encodes a Microtubule-binding Protein in Yeast

1997 • 179 citations

The TOGp protein is a new human microtubule-associated protein homologous to the Xenopus XMAP215

1998 • 178 citations

Dissociation of the Tubulin-sequestering and Microtubule Catastrophe-promoting Activities of Oncoprotein 18/Stathmin

1999 • 177 citations

Subcellular localization of tau mRNA in differentiating neuronal cell culture: Implications for neuronal polarity

1993 • 175 citations

Identification of acis-Acting Dendritic Targeting Element in MAP2 mRNAs

1999 • 174 citations

ZYG-9, A Caenorhabditis elegans Protein Required for Microtubule Organization and Function, Is a Component of Meiotic and Mitotic Spindle Poles

1998 • 173 citations

Two Separate 18-Amino Acid Domains of Tau Promote the Polymerization of Tubulin

1989 • 167 citations

Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.

1996 • 167 citations

Domains of Neuronal Microtubule-associated Proteins and Flexural Rigidity of Microtubules

1997 • 166 citations

Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro: Real-time observations using video microscopy

1992 • 166 citations

Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes.

1984 • 164 citations

Stu2p: A Microtubule-Binding Protein that Is an Essential Component of the Yeast Spindle Pole Body

1997 • 164 citations

Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.

1993 • 162 citations

Regulation of microtubule dynamics by microtubule-associated protein expression and phosphorylation during neuronal development.

1994 • 162 citations

mini spindles

1999 • 161 citations

Modification of microtubule steady-state dynamics by phosphorylation of the microtubule-associated proteins.

1981 • 160 citations

Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells.

1988 • 160 citations

Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

2000 • 160 citations

Microtubule Treadmilling in Vivo

1997 • 159 citations

A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein

1998 • 158 citations

Different forms of microtubule-associated protein 2 are encoded by separate mRNA transcripts.

1988 • 157 citations

The minimum GTP cap required to stabilize microtubules

1994 • 154 citations

The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells

1998 • 154 citations

A casein kinase II-related activity is involved in phosphorylation of microtubule-associated protein MAP-1B during neuroblastoma cell differentiation.

1988 • 153 citations

Microtubule-associated protein 1b (MAP1b) is concentrated in the distal region of growing axons

1994 • 152 citations

Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells

1999 • 151 citations

p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites.

1995 • 151 citations

Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein.

1994 • 151 citations

Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis.

1994 • 151 citations

Neuronal abnormalities in microtubule-associated protein 1B mutant mice.

1996 • 150 citations

Novel Features of the Light Chain of Microtubule-associated Protein MAP1B: Microtubule Stabilization, Self Interaction, Actin Filament Binding, and Regulation by the Heavy Chain

1998 • 150 citations

Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration.

1997 • 149 citations

Taxol-induced flexibility of microtubules and its reversal by MAP-2 and Tau.

1993 • 149 citations

Identification with cellular microtubules of one of the co-assembling microtubule-associated proteins

1979 • 148 citations

Mitotic Regulation of Microtubule Cross-Linking Activity of CENP-E Kinetochore Protein

1994 • 148 citations

Patient Mutations in Doublecortin Define a Repeated Tubulin-binding Domain

2000 • 148 citations

Evidence that a single monolayer tubulin-GTP cap is both necessary and sufficient to stabilize microtubules.

1996 • 148 citations

Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization.

1991 • 146 citations

The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain

1999 • 146 citations

Extensive cAMP-dependent and cAMP-independent phosphorylation of microtubule-associated protein 2.

1983 • 146 citations

Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin

2000 • 146 citations

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

1999 • 145 citations

Protein Phosphatase 1 Is Targeted to Microtubules by the Microtubule-associated Protein Tau

1998 • 144 citations

The Development of Cell Processes Induced by tau Protein Requires Phosphorylation of Serine 262 and 356 in the Repeat Domain and Is Inhibited by Phosphorylation in the Proline-rich Domains

1999 • 143 citations

A new class of microtubule-associated proteins in plants

2000 • 143 citations

The pool of map kinase associated with microtubules is small but constitutively active.

1996 • 142 citations

Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium.

1996 • 142 citations

Regulation of Microtubule Dynamics by Extracellular Signals: cAMP-dependent Protein Kinase Switches Off the Activity of Oncoprotein 18 in Intact Cells

1998 • 141 citations

Microtubule-Associated Protein 2 Levels Decrease in Hippocampus Following Traumatic Brain Injury

1992 • 140 citations

The Microtubule-destabilizing Activity of Metablastin (p19) Is Controlled by Phosphorylation

1997 • 140 citations

The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases.

1994 • 138 citations

Sorting mechanisms of Tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding

1995 • 138 citations

Rapid Calpain I Activation and Cytoskeletal Protein Degradation Following Traumatic Spinal Cord Injury: Attenuation with Riluzole Pretreatment

1997 • 137 citations

Postsynaptic Mechanisms for Bidirectional Control of MAP2 Phosphorylation by Glutamate Receptors

1996 • 136 citations

The protein MAP-1B links GABAC receptors to the cytoskeleton at retinal synapses

1999 • 135 citations

Both adult and juvenile tau microtubule-associated proteins are axon specific in the developing and adult rat cerebellum

1988 • 135 citations

Polyglycylation of Tubulin Is Essential and Affects Cell Motility and Division in Tetrahymena thermophila

2000 • 134 citations

Regulation of Microtubule Dynamics by Ca²⁺/Calmodulin-Dependent Kinase IV/Gr-Dependent Phosphorylation of Oncoprotein 18

1997 • 132 citations

E-MAP-115 (ensconsin) associates dynamically with microtubules in vivo and is not a physiological modulator of microtubule dynamics

1999 • 132 citations

Mitotic chromatin regulates phosphorylation of Stathmin/Op18

1997 • 131 citations

Molecular Cloning of Microtubule‐Associated Protein 1 (MAP1A) and Microtubule‐Associated Protein 5 (MAP1B): Identification of Distinct Genes and Their Differential Expression in Developing Brain

1990 • 131 citations

Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons

1997 • 131 citations

Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules

1988 • 130 citations

Distribution of cortical neurofibrillary tangles in progressive supranuclear palsy: A quantitative analysis of six cases

1992 • 130 citations

A Class VI Unconventional Myosin Is Associated with a Homologue of a Microtubule-binding Protein, Cytoplasmic Linker Protein–170, in Neurons and at the Posterior Pole of Drosophila Embryos

1998 • 130 citations

Determinants of 4-Repeat Tau Expression

2000 • 129 citations

Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase

1993 • 128 citations

Mitogen‐activated‐protein‐kinase‐catalyzed phosphorylation of microtubule‐associated proteins, microtubule‐associated protein 2 and microtubule‐associated protein 4, induces an alteration in their function

1992 • 128 citations

A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences.

1991 • 127 citations

The Saccharomyces cerevisiae Kinesin-related Motor Kar3p Acts at Preanaphase Spindle Poles to Limit the Number and Length of Cytoplasmic Microtubules

1997 • 127 citations

MAP1B expression and microtubule stability in growing and regenerating axons

2000 • 127 citations

Orbit, a Novel Microtubule-Associated Protein Essential for Mitosis inDrosophila melanogaster

2000 • 127 citations

Dynamics of β-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis

1997 • 127 citations

MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth

1996 • 126 citations

EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue

2000 • 125 citations

Dynamic Localization of CLIP-170 to Microtubule Plus Ends Is Coupled to Microtubule Assembly

1999 • 124 citations

Phosphorylation-dependent Localization of Microtubule-associated Protein MAP2c to the Actin Cytoskeleton

2000 • 123 citations

Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction

1999 • 122 citations

Molecular cloning of a ubiquitously distributed microtubule-associated protein with Mr 190,000.

1990 • 122 citations

Regulation and function of the interaction between the APC tumour suppressor protein and EB1

2000 • 121 citations

Delayed Development of Nervous System in Mice Homozygous for Disrupted Microtubule-associated Protein 1B (MAP1B) Gene

1997 • 120 citations

β-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways

1994 • 118 citations

Embryonic MAP2 lacks the cross-linking sidearm sequences and dendritic targeting signal of adult MAP2

1989 • 118 citations

Katanin Is Responsible for the M-Phase Microtubule-severing Activity inXenopusEggs

1998 • 115 citations

Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein

2000 • 115 citations

Functional analysis of CLIP-115 and its binding to microtubules

2000 • 114 citations

Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice

1999 • 114 citations

The Stathmin Family

1997 • 113 citations

Microtubule-associated proteins 1A and LC2. Two proteins encoded in one messenger RNA.

1992 • 113 citations

G2/M Transition Requires Multisite Phosphorylation of Oncoprotein 18 by Two Distinct Protein Kinase Systems

1995 • 112 citations

Regulation of a major microtubule-associated protein by MPF and MAP kinase.

1992 • 112 citations

The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2: tubulin interaction

1984 • 112 citations

Steric inhibition of cytoplasmic dynein and kinesin motility by MAP2

1993 • 111 citations

A 210 kDa nuclear matrix protein is a functional part of the mitotic spindle; a microinjection study using SPN monoclonal antibodies.

1991 • 111 citations

Molecular structure of microtubule-associated protein 2b and 2c from rat brain.

1990 • 111 citations

Neurodegenerative Tauopathies

1999 • 110 citations

How motor proteins influence microtubule polymerization dynamics

2000 • 109 citations

Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis

1997 • 108 citations

Structural Transitions at Microtubule Ends Correlate with Their Dynamic Properties in Xenopus Egg Extracts

2000 • 108 citations

Tau dephosphorylation at tau-1 site correlates with its association to cell membrane.

2000 • 108 citations

The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression

2000 • 107 citations

Cell‐cycle‐regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38

1994 • 106 citations

The phenotype of a “Cdc2 kinase target site-deficient” mutant of oncoprotein 18 reveals a role of this protein in cell cycle control.

1994 • 105 citations

Phosphorylation of tubulin and microtubule-associated proteins by the purified insulin receptor kinase.

1985 • 104 citations

Widespread distribution of a 210,000 mol wt microtubule-associated protein in cells and tissues of primates.

1980 • 104 citations

Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells.

1993 • 104 citations

Mutation of the predicted p34cdc2 phosphorylation sites in numa impair the assembly of the mitotic spindle and block mitosis

1995 • 103 citations

The Interaction of TOGp with Microtubules and Tubulin

2000 • 102 citations

The ‘jaws’ model of tau-microtubule interaction examined in CHO cells

1997 • 101 citations

MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain

1991 • 101 citations

Localization of NuMA protein isoforms in the nuclear matrix of mammalian cells

1994 • 101 citations

Cloning, expression, and properties of the microtubule-stabilizing protein STOP.

1996 • 101 citations

Microtubule stabilization by assembly‐promoting microtubule‐associated proteins: A repeat performance

1992 • 101 citations

Dynamics of microtubules visualized by darkfield microscopy: Treadmilling and dynamic instability

1988 • 101 citations

Binding of pp170 to microtubules is regulated by phosphorylation.

1991 • 101 citations

Dictyostelium DdCP224 is a microtubule-associated protein and a permanent centrosomal resident involved in centrosome duplication

2000 • 100 citations

Functional analyses of the domain structure of microtubule-associated protein-4 (MAP-U)

1991 • 100 citations

Centrophilin: a novel mitotic spindle protein involved in microtubule nucleation.

1991 • 100 citations

Op18/stathmin caps a kinked protofilament-like tubulin tetramer

2000 • 99 citations

Modulation of microtubule dynamic instability in vivo by brain microtubule associated proteins

1995 • 99 citations

The microtubule-binding fragment of microtubule-associated protein-2: location of the protease-accessible site and identification of an assembly-promoting peptide.

1989 • 98 citations

Phosphorylation regulates the microtubule‐destabilizing activity of stathmin and its interaction with tubulin

1997 • 97 citations

Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle

1998 • 96 citations

Effects of brain microtubule‐associated proteins on microtubule dynamics and the nucleating activity of centrosomes

1990 • 96 citations

Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin.

1998 • 94 citations

The structure of microtubule ends during the elongation and shortening phases of dynamic instability examined by negative-stain electron microscopy

1990 • 94 citations

Overexpression of full- or partial-length MAP4 stabilizes microtubules and alters cell growth

1997 • 94 citations

Expression of a Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling.

1993 • 93 citations

Binding of microtubule-associated protein 2 and tau to the intermediate filament reassembled from neurofilament 70-kDa subunit protein. Its regulation by calmodulin.

1986 • 91 citations

Functional Elements within the Dynein Microtubule-binding Domain

2000 • 91 citations

Microtubule-associated protein 2 alters the dynamic properties of microtubule assembly and disassembly

1993 • 91 citations

Microtubule-associated Protein 2c Reorganizes Both Microtubules and Microfilaments into Distinct Cytological Structures in an Actin-binding Protein-280–deficient Melanoma Cell Line

1997 • 90 citations

MAP 4: a microtubule-associated protein specific for a subset of tissue microtubules.

1984 • 90 citations

Cellular Samurai: katanin and the severing of microtubules

2000 • 90 citations

Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons

1999 • 90 citations

Association of Tau Protein with Microtubules in Living Cells

1986 • 90 citations

Characterization of the cDNA and Pattern of Expression of a New Gene Over‐Expressed in Human Hepatomas and Colonic Tumors

1995 • 89 citations

Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor.

1994 • 89 citations

The distribution and phosphorylation of the microtubule-associated protein MAP 1B in growth cones

1991 • 88 citations

Making sense of the multiple MAP-2 transcripts and their role in the neuron

1998 • 88 citations

Complex Regulation of Tau Exon 10, Whose Missplicing Causes Frontotemporal Dementia

2000 • 88 citations

Microtubule elongation and guanosine 5'-triphosphate hydrolysis. Role of guanine nucleotides in microtubule dynamics

1987 • 88 citations

MAP4 Is the in Vivo Substrate for CDC2 Kinase in HeLa Cells: Identification of an M-Phase Specific and a Cell Cycle-Independent Phosphorylation Site in MAP4

1997 • 88 citations

Effect on microtubule dynamics of XMAP230, a microtubule-associated protein present in Xenopus laevis eggs and dividing cells [published erratum appears in J Cell Biol 1995 Mar;128(5):following 988]

1994 • 87 citations

Microtubule-associated proteins from cultured HeLa cells. Analysis of molecular properties and effects on microtubule polymerization.

1980 • 87 citations

Numerous phosphates of microtubule-associated protein 2 in living rat brain.

1987 • 87 citations

Regulating Cell Proliferation—As Easy as APC

1996 • 86 citations

Calcium and calmodulin-dependent phosphorylation of a 62 kd protein induces microtubule depolymerization in sea urchin mitotic apparatuses

1988 • 86 citations

Normal Development of Mice Lacking Metablastin (P19), a Phosphoprotein Implicated in Cell Cycle Regulation

1996 • 85 citations

Overexpression of MAP4 inhibits organelle motility and trafficking in vivo

1997 • 85 citations

A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule‐associated protein tau

1998 • 84 citations

Regulated Association of Microtubule-associated Protein 2 (MAP2) with Src and Grb2: Evidence for MAP2 as a Scaffolding Protein

2000 • 84 citations

cis‐Acting signals and trans‐acting proteins are involved in tau mRNA targeting into neurites of differentiating neuronal cells

1995 • 83 citations

Phosphorylation of Tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer's disease and Down's syndrome

1990 • 83 citations

EB/RP gene family encodes tubulin binding proteins

1999 • 82 citations

CENP-meta, an Essential Kinetochore Kinesin Required for the Maintenance of Metaphase Chromosome Alignment in Drosophila

2000 • 81 citations

NuMA is a component of an insoluble matrix at mitotic spindle poles

1999 • 81 citations

Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain

2000 • 80 citations

Phosphorylation by CDK1 regulates XMAP215 function in vitro

1999 • 80 citations

Redistribution of the nuclear mitotic apparatus protein (NuMA) during mitosis and nuclear assembly

1986 • 79 citations

Identification of a minus end-specific microtubule-associated protein located at the mitotic poles in cultured mammalian cells.

1991 • 79 citations

Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms.

1995 • 79 citations

Decreasing oncoprotein 18/stathmin levels reduces microtubule catastrophes and increases microtubule polymer in vivo

1999 • 79 citations

Phosphorylation States of Microtubule-Associated Protein 2 (MAP2) Determine the Regulatory Role of MAP2 in Microtubule Dynamics

1997 • 78 citations

Tau protein and Alzheimer's disease

1990 • 78 citations

Differential Expression of Alternatively Spliced Forms of MAP4: A Repertoire of Structurally Different Microtubule-Binding Domains

1995 • 77 citations

Rapid treadmilling of brain microtubules free of microtubule-associated proteins in vitro and its suppression by tau

1999 • 75 citations

Stable expression of heterologous microtubule-associated proteins (MAPs) in Chinese hamster ovary cells: evidence for differing roles of MAPs in microtubule organization.

1994 • 75 citations

Induction of a Regular Nuclear Lattice by Overexpression of NuMA

1998 • 73 citations

Temperature and ph govern the self-assembly of microtubules from unfertilized sea-urchin egg extracts

1987 • 73 citations

Focusing-in on microtubules

2000 • 72 citations

Multiple signal transduction pathways induce phosphorylation of serines 16, 25, and 38 of oncoprotein 18 in T lymphocytes.

1993 • 71 citations

Removal of MAP4 from microtubules in vivo produces no observable phenotype at the cellular level.

1996 • 71 citations

E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis

2000 • 70 citations

The Catastrophe-promoting Activity of Ectopic Op18/Stathmin Is Required for Disruption of Mitotic Spindles But Not Interphase Microtubules

2001 • 69 citations

Microtubule associated protein MAP1A is an actin‐binding and crosslinking protein

1994 • 69 citations

GABA_C Receptors Are Localized with Microtubule-Associated Protein 1B in Mammalian Cone Photoreceptors

2000 • 69 citations

Dephosphorylated but not phosphorylated microtubule associated protein MAP1B binds to microfilaments

1996 • 68 citations

Microtubule dynamics: If you need a shrink try stathmin/Op18

1998 • 67 citations

EMAP, an echinoderm microtubule-associated protein found in microtubule-ribosome complexes

1993 • 67 citations

Antisense RNA inhibition of phosphoprotein p18 expression abrogates the transformed phenotype of leukemic cells.

1996 • 67 citations

Mapmodulin, Cytoplasmic Dynein, and Microtubules Enhance the Transport of Mannose 6-Phosphate Receptors from Endosomes to theTrans-Golgi Network

1999 • 67 citations

Serine 16 of Oncoprotein 18 is a Major Cytosolic Target for the Ca²⁺/Calmodulin‐Dependent Kinase‐Gr

1994 • 66 citations

Phosphorylation of the Tumor Suppressor Adenomatous Polyposis Coli (APC) by the Cyclin-dependent Kinase p34

1997 • 66 citations

Stathmin gene family: phylogenetic conservation and developmental regulation in Xenopus

1993 • 65 citations

Phosphorylation regulates the assembly of NuMA in a mammalian mitotic extract

1997 • 65 citations

Op18/Stathmin Mediates Multiple Region-Specific Tubulin and Microtubule-Regulating Activities

1999 • 64 citations

XMAP310: A Xenopus Rescue-promoting Factor Localized to the Mitotic Spindle

1997 • 63 citations

CENP-E is an essential kinetochore motor in maturing oocytes and is masked during Mos-dependent, cell cycle arrest at metaphase II

1997 • 62 citations

High Molecular Weight Microtubule-associated Proteins Contain O-Linked N-Acetylglucosamine

1996 • 62 citations

Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation.

1995 • 60 citations

Ability to organize microtubules in taxol-treated mitotic PtK2 cells goes with the SPN antigen and not with the centrosome

1992 • 59 citations

Antisense MAP‐2 oligonucleotides induce changes in microtubule assembly and neuritic elongation in pre‐existing neurites of rat cortical neurons

1994 • 59 citations

Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons.

1989 • 59 citations

Nonneuronal isoforms of STOP protein are responsible for microtubule cold stability in mammalian fibroblasts

1998 • 59 citations

Recombinant Microtubule-Associated Protein 2c Reduces the Dynamic Instability of Individual Microtubules

1996 • 58 citations

Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various numa isoforms

1994 • 58 citations

Nuclear proteins of the bovine esophageal epithelium: II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1

1993 • 58 citations

Tyrosine phosphorylation by the epidermal growth factor receptor kinase induces functional alterations in microtubule-associated protein 2.

1987 • 57 citations

Microtubule-Stabilizing Activity of Microtubule-Associated Proteins (MAPs) Is Due to Increase in Frequency of Rescue in Dynamic Instability: Shortening Length Decreases with Binding of MAPs onto Microtubules.

1994 • 56 citations

Identification of two distinct microtubule binding domains on recombinant rat MAP 1B.

1992 • 56 citations

Differences in the regulation of microtubule dynamics by microtubule-associated proteins MAP1B and MAP2

1996 • 55 citations

It’s a kar9ochore to capture microtubules

2000 • 55 citations

Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells

1999 • 55 citations

A muscle-specific variant of microtubule-associated protein 4 (MAP4) is required in myogenesis

1996 • 55 citations

Mapmodulin: A possible modulator of the interaction of microtubule-associated proteins with microtubules

1997 • 55 citations

Expression and distribution of phosphorylated MAP1B in growing axons of cultured hippocampal neurons

1995 • 54 citations

Microtubule assembly in clarifiedXenopus egg extracts

1997 • 53 citations

Process formation in Sf9 cells induced by the expression of a microtubule-associated protein 2C-like construct.

1993 • 52 citations

MAP2a, an Alternatively Spliced Variant of Microtubule‐Associated Protein 2

1996 • 51 citations

Purification of a WD Repeat Protein, EMAP, That Promotes Microtubule Dynamics through an Inhibition of Rescue

1998 • 51 citations

Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells

1998 • 50 citations

Serine 16 of Stathmin as a Cytosolic Target for Ca2+/Calmodulin-Dependent Kinase II After CD2 Triggering of Human T Lymphocytes

1998 • 49 citations

Dissection of fission yeast microtubule associating protein p93^Dis1: regions implicated in regulated localization and microtubule interaction

1996 • 48 citations

Microinjection of antibodies to a 62 kd mitotic apparatus protein arrests mitosis in dividing sea urchin embryos

1989 • 47 citations

HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings

2000 • 46 citations

Isolation of a Novel Human Homologue of the Gene Coding for Echinoderm Microtubule-Associated Protein (EMAP) from the Usher Syndrome Type 1a Locus at 14q32

1997 • 45 citations

Identification of high molecular weight microtubule-associated proteins in anterior pituitary tissue and cells using taxol-dependent purification combined with microtubule-associated protein specific antibodies

1985 • 44 citations

The Xenopus XMAP215 and Its Human Homologue TOG Proteins Interact with Cyclin B1 to Target p34cdc2 to Microtubules during Mitosis

2000 • 44 citations

Juvenile and mature MAP2 isoforms induce distinct patterns of process outgrowth.

1996 • 43 citations

Tau protein and the establishment of an axonal morphology

1991 • 43 citations

Mutations at Phosphorylation Sites ofXenopusMicrotubule-associated Protein 4 Affect Its Microtubule-binding Ability and Chromosome Movement during Mitosis

1999 • 42 citations

An Analysis of an Axonal Gradient of Phosphorylated MAP 1B in Cultured Rat Sensory Neurons

1996 • 42 citations

Specific association of STOP protein with microtubules in vitro and with stable microtubules in mitotic spindles of cultured cells.

1990 • 42 citations

Site-specific phosphorylation by protein kinase C inhibits assembly-promoting activity of microtubule-associated protein 4

1991 • 42 citations

The Mouse and Rat MAP1B Genes: Genomic Organization and Alternative Transcription

1998 • 41 citations

Ser787 in the Proline-Rich Region of Human MAP4 is a Critical Phosphorylation Site that Reduces its Activity to Promote Tubulin Polymerization.

2000 • 41 citations

Mutations of Oncoprotein 18/Stathmin Identify Tubulin-Directed Regulatory Activities Distinct from Tubulin Association

1999 • 40 citations

The adenomatous polyposis coli protein

1999 • 40 citations

The Difference in the Binding of Phosphatidylinositol Distinguishes MAP2 from MAP2C and Tau

1994 • 40 citations

DMAP‐85: A τ‐Like Protein from Drosophila melanogaster Larvae

1995 • 39 citations

Identification of a Tau Promoter Region Mediating Tissue-specific-regulated Expression in PC12 Cells

1996 • 39 citations

Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic map located at the spindle pole and characterized as a homologous protein to NuMA

1993 • 38 citations

Changes in mRNA abundance of microtubule-associated proteins in the rat brain following electroconvulsive shock

1998 • 37 citations

Expression of Microtubule‐Associated Proteins During the Early Stages of Neurite Extension by Brain Neurons Cultured in a Defined Medium

1986 • 36 citations

Analysis of phosphoprotein p19 by liquid chromatography/mass spectrometry. Identification of two proline-directed serine phosphorylation sites and a blocked amino terminus.

1992 • 35 citations

Differential regulation of microtubule-associated protein 1B (MAP1B) in rat CNS and PNS during development

1997 • 35 citations

Non-cooperative Binding of the MAP-2 Microtubule-binding Region to Microtubules

1995 • 35 citations

Phosphorylation of numa occurs during nuclear breakdown and not mitotic spindle assembly

1995 • 34 citations

NuMA: A Bipartite Nuclear Location Signal and Other Functional Properties of the Tail Domain

1996 • 34 citations

Molecular and functional characteristics of MAP-2a: Ability of MAP-2a versus MAP-2b to induce stable microtubules in COS cells

1998 • 34 citations

Purified native microtubule associated protein MAP1A: Kinetics of microtubule assembly and MAP1A/tubulin stoichiometry

1994 • 33 citations

PKA Phosphorylations on Tau: Developmental Studies in the Mouse

2000 • 33 citations

Human Microtubule-Associated Protein 1a (MAP1A) Gene: Genomic Organization, cDNA Sequence, and Developmental- and Tissue-Specific Expression

1996 • 33 citations

ch-TOGp Is Required for Microtubule Aster Formation in a Mammalian Mitotic Extract

2000 • 32 citations

Two Alternative Promoters Direct Neuron-Specific Expression of the Rat Microtubule-Associated Protein 1B Gene

1996 • 32 citations

Functional analysis of the MAP2 repeat domain

1996 • 31 citations

A new model for microtubule‐associated protein (MAP)‐induced microtubule assembly

1999 • 31 citations

Characterization of the Microtubule-binding Domain of Microtubule-associated Protein 1A and Its Effects on Microtubule Dynamics

1998 • 30 citations

Cell cycle-dependent phosphorylation of the 77 kDa echinoderm microtubule-associated protein (EMAP) in vivo and association with the p34cdc2 kinase

1996 • 28 citations

Specific Binding of Acidic Phospholipids to Microtubule-associated Protein MAP1B Regulates Its Interaction with Tubulin

1997 • 27 citations

Dlx-2 homeobox gene controls neuronal differentiation in primary cultures of developing basal ganglia

1997 • 26 citations

Conservation of the WD-repeat, microtubule-binding protein, EMAP, in sea urchins, humans, and the nematode C. elegans

2000 • 26 citations

The cellular distribution of the adenomatous polyposis coli tumour suppressor protein in neuroblastoma cells is regulated by microtubule dynamics

1997 • 25 citations

Regulation of the expression and phosphorylation of microtubule-associated protein 1B during regeneration of adult dorsal root ganglion neurons

2000 • 24 citations

Teaching tumour suppressors new tricks

2000 • 24 citations

A General RNA-Binding Protein Complex That Includes the Cytoskeleton-associated Protein MAP 1A

1998 • 23 citations

Microinjection of intact MAP-4 and fragments induces changes of the cytoskeleton in PtK2 cells

1996 • 23 citations

Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2)

1999 • 23 citations

A Novel Microtubule‐Associated Protein‐2 Expressed in Oligodendrocytes in Multiple Sclerosis Lesions

1999 • 22 citations

High and Low Molecular Weight r Proteins Are Differentially Expressed from a Single Gene

1993 • 22 citations

XMAP230 is required for normal spindle assembly in vivo and in vitro

1999 • 21 citations

Regulation of microtubule‐associated protein 1B (MAP1B) subunit composition

2000 • 20 citations

High concentrations of STOP protein induce a microtubule super-stable state

1987 • 20 citations

Identification of MINUS, a small polypeptide that functions as a microtubule nucleation suppressor

1999 • 20 citations

Regulation of microtubule-associated protein 1B (MAP1B) subunit composition

2000 • 19 citations

Modulation of microtubule shape in vitro by high molecular weight microtubule associated proteins MAP1A, MAP1B, and MAP2

1996 • 19 citations

Microtubule‐binding property of microtubule‐associated protein 2 differs from that of microtubule‐associated protein 4 and tau

1999 • 17 citations

Tau promoter activity in neuronally differentiated P19 cells

2000 • 16 citations

Does NuMA Have a Scaffold Function in the Interphase Nucleus?

1999 • 14 citations

Distinct mode of microtubule‐associated protein 2 expression in the neuroblastoma/glioma cell line 108CC15/NG108‐15

1993 • 14 citations

A 62-kD protein required for mitotic progression is associated with the mitotic apparatus during M-phase and with the nucleus during interphase.

1992 • 13 citations

Multiple isoforms of the high molecular weight microtubule associated protein XMAP215 are expressed during development inXenopus

2000 • 13 citations

Mouse microtubule-associated protein 4 (MAP4) transcript diversity generated by alternative polyadenylation

1992 • 12 citations

Plant microtubules meet their MAPs and mimics

2000 • 10 citations

Microtubule binding of the Drosophila DMAP‐85 protein is regulated by phosphorylation in vitro

2000 • 9 citations

Accumulation of microtubule-associated protein 1A (MAP1A) in differentiating P19 embryonal carcinoma cells

1995 • 8 citations

Structural Analysis of the Proximal Region of the Microtubule‐Associated Protein 1B Promoter

1997 • 8 citations

Microtubule-associated protein 1A is the fibroblast HMW MAP undergoing mitogen-stimulated serine phosphorylation

1990 • 7 citations

A 62‐kDA mitotic apparatus protein required for mitotic progression is sequestered to the interphase nucleus by associating with the chromosomes during anaphase

1995 • 6 citations

Characterization of a microtubule assembly inhibitor fromXenopus oocytes

2000 • 3 citations