Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

1996 • 974 citations

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.

1990 • 849 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

1992 • 709 citations

Domains of tau Protein and Interactions with Microtubules

1994 • 630 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau

1994 • 561 citations

Proline-directed and Non-proline-directed Phosphorylation of PHF-tau

1995 • 549 citations

Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

1992 • 507 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

1994 • 461 citations

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

1993 • 439 citations

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

1992 • 415 citations

Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A

1996 • 389 citations

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1997 • 363 citations

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1994 • 349 citations

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1995 • 345 citations

The Molecular and Genetic Basis of Neurological Disease

1993 • 345 citations

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

1993 • 289 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly.

1997 • 270 citations

A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubule

1993 • 235 citations

In vivo phosphorylation sites in fetal and adult rat tau.

1993 • 233 citations

Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1992 • 217 citations

Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein

1997 • 213 citations

Microtubule bundling by tau proteins in vivo: analysis of functional domains.

1992 • 186 citations

Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase

1995 • 161 citations

SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases

1996 • 159 citations

Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein

1996 • 156 citations

AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease

1996 • 150 citations

Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.

1996 • 134 citations

Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1993 • 104 citations

Phosphorylation of tau protein by purified p34cdc28 and a related protein kinase from neurofilaments.

1992 • 66 citations

ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation

1995 • 56 citations

Stress activated protein kinases, a novel family of mitogen-activated protein kinases, are heterogeneously expressed in the adult rat brain and differentially distributed from extracellular-signal-regulated protein kinases

1995 • 47 citations