Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis
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THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES
1989 • 2,518 citations
Cyclin is degraded by the ubiquitin pathway
1991 • 2,355 citations
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
1989 • 1,114 citations
Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.
1988 • 985 citations
Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts
1996 • 978 citations
Chapter 30 Cell Cycle Extracts
1991 • 953 citations
[39] Preparation of modified tubulins
1991 • 724 citations
Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules
1996 • 651 citations
Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor
1993 • 569 citations
XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly
1996 • 539 citations
The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases
1989 • 486 citations
Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.
1993 • 483 citations
Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs
1990 • 446 citations
Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts
1990 • 444 citations
Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs
1993 • 437 citations
Protein Serine/Threonine Phosphatases—New Avenues for Cell Regulation
1994 • 424 citations
Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts.
1992 • 419 citations
A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts
1994 • 402 citations
The Protein Phosphatases Involved in Cellular Regulation. 6. Measurement of Type-1 and Type-2 Protein Phosphatases in Extracts of Mammalian Tissues; an Assessment of Their Physiological Roles
1983 • 362 citations
The protein phosphatases involved in cellular regulation. Identification of the inhibitor-2 phosphatases in rabbit skeletal muscle
1984 • 330 citations
The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1
1989 • 326 citations
A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.
1995 • 305 citations
The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.
1993 • 297 citations
Morphogenetic Properties of Microtubules and Mitotic Spindle Assembly
1996 • 292 citations
One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis
1990 • 291 citations
Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics.
1996 • 275 citations
Stathmin: a relay phosphoprotein for multiple signal transduction?
1991 • 273 citations
p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A1 Implications for Alzheimer's disease
1992 • 273 citations
A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.
1994 • 261 citations
Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases.
1994 • 256 citations
Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.
1990 • 244 citations
Mitotic spindle assembly by two different pathways in vitro.
1991 • 235 citations
Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase
1992 • 235 citations
PPX, a novel protein serine/threonine phosphatase localized to centrosomes.
1993 • 221 citations
Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis.
1988 • 210 citations
Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase
1997 • 206 citations
Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit.
1992 • 198 citations
Microtubule dynamics at the G2/M transition: abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis.
1996 • 197 citations
Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control
1989 • 188 citations
Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.
1993 • 186 citations
Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish.
1989 • 141 citations
The Microtubule-destabilizing Activity of Metablastin (p19) Is Controlled by Phosphorylation
1997 • 140 citations
Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.
1993 • 135 citations
Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.
1992 • 134 citations
Mitotic chromatin regulates phosphorylation of Stathmin/Op18
1997 • 131 citations
A post-ribosomal supernatant from activated Xenopus eggs that displays post-translationally regulated oscillation of its cdc2+ mitotic kinase activity.
1989 • 126 citations
[39] Protein phosphatase-2C from rabbit skeletal muscle and liver: An Mg2+-dependent enzyme
1988 • 124 citations
Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation.
1994 • 119 citations
The spindle-assembly checkpoint: aiming for a perfect mitosis, every time
1996 • 119 citations
Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue.
1992 • 118 citations
G2/M Transition Requires Multisite Phosphorylation of Oncoprotein 18 by Two Distinct Protein Kinase Systems
1995 • 112 citations
Cell‐cycle‐regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38
1994 • 106 citations
Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases.
1993 • 106 citations
Inhibition of cdc2 activation by INH/PP2A.
1994 • 103 citations
The impact of chromosomes and centrosomes on spindle assembly as observed in living cells.
1995 • 99 citations
The Glc7 Type 1 Protein Phosphatase of Saccharomyces cerevisiae Is Required for Cell Cycle Progression in G2/M
1994 • 98 citations
Mutations in the Saccharomyces cerevisiae Type 2A Protein Phosphatase Catalytic Subunit Reveal Roles in Cell Wall Integrity, Actin Cytoskeleton Organization and Mitosis
1997 • 96 citations
The role of Saccharomyces cerevisiae type 2A phosphatase in the actin cytoskeleton and in entry into mitosis.
1995 • 96 citations
Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos
1996 • 92 citations
Identification, purification, and characterization of a novel serine/threonine protein phosphatase from bovine brain.
1991 • 90 citations
Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+.
1996 • 89 citations
The proteolysis-dependent metaphase to anaphase transition: calcium/calmodulin-dependent protein kinase II mediates onset of anaphase in extracts prepared from unfertilized Xenopus eggs.
1994 • 88 citations
Influence of M-phase chromatin on the anisotropy of microtubule asters.
1996 • 85 citations
The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis
1996 • 74 citations
Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phase.
1991 • 71 citations
An okadaic acid-sensitive phosphatase negatively controls the cyclin degradation pathway in amphibian eggs.
1991 • 65 citations
Regulation of yeast chromosome segregation by Ipl1 protein kinase and type 1 protein phosphatase.
1994 • 63 citations
Studies on the ejection properties of asters: astral microtubule turnover influences the oscillatory behavior and positioning of mono-oriented chromosomes
1991 • 61 citations
The total length of spindle microtubules depends on the number of chromosomes present.
1985 • 60 citations
Mitotic spindle morphogenesis in animal cells.
1991 • 57 citations
Microtubule assembly in clarifiedXenopus egg extracts
1997 • 53 citations
Dissection of fission yeast microtubule associating protein p93Dis1: regions implicated in regulated localization and microtubule interaction
1996 • 48 citations
Abnormal anaphase resolution (aar): a locus required for progression through mitosis in Drosophila
1993 • 43 citations
Okadaic acid inhibits a protein phosphatase activity involved in formation of the mitotic spindle of GH4 rat pituitary cells
1992 • 39 citations
The role of protein phosphatase type-2A in the cell cycle: initiation of the G2/M transition
1995 • 38 citations
A regulatedMET3‐GLC7gene fusion provides evidence of a mitotic role forSaccharomyces cerevisiaeprotein phosphatase 1
1995 • 37 citations
Protein Serine/Threonine Phosphatases: New Avenues for Cell Regulation
1994 • 34 citations
Okadaic Acid Induces Spindle Lengthening and Disrupts the Interaction of Microtubules with the Kinetochores in Metaphase II-Arrested Mouse Oocytes
1993 • 28 citations
Drosophila ppy, a novel male specific protein serine/threonine phosphatase localised in somatic cells of the testis
1995 • 27 citations
Radioisotopes in Medicine
1954 • 16 citations
Mammalian Phosphoprotein Phosphatase
1962 • 8 citations
Mitotic spindles and microtubule dynamics inXenopusegg extracts
1996 • 2 citations
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