In vivo phosphorylation sites in fetal and adult rat tau.

High resolution two-dimensional electrophoresis of basic as well as acidic proteins

1977 • 3,556 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

A protein factor essential for microtubule assembly.

1975 • 2,863 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

Developmentally regulated expression of specific tau sequences

1989 • 589 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

1986 • 504 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

1992 • 415 citations

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

1993 • 397 citations

Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.

1987 • 357 citations

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

1989 • 354 citations

The car☐yl third of tau is tightly bound to paired helical filaments

1988 • 342 citations

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1990 • 298 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments.

1992 • 246 citations

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.

1992 • 230 citations

τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

1993 • 228 citations

Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1992 • 217 citations

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

1993 • 198 citations

Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain.

1992 • 171 citations

Proline-directed phosphorylation of human Tau protein.

1992 • 162 citations

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau.

1992 • 157 citations

Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments

1992 • 146 citations

A common denominator linking glycogen metabolism, nuclear oncogenes and development

1991 • 138 citations

Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties

1990 • 115 citations

Microheterogeneity of Micro tubule‐Associated τ Proteins Is Due to Differences in Phosphorylation

1986 • 106 citations

Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease

1990 • 106 citations

Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1993 • 104 citations

[14] Determination and location of phosphoserine in proteins and peptides by conversion to S-ethylcysteine

1991 • 102 citations

τ Protein Kinase II Is Involved in the Regulation of the Normal Phosphorylation State of τ Protein

1993 • 85 citations

A Novel Tubulin-Dependent Protein Kinase Forming a Paired Helical Filament Epitope on Tau

1988 • 80 citations

Protein kinase C phosphorylates tau and induces its functional alterations

1987 • 78 citations

Phosphorylation of tau protein by purified p34cdc28 and a related protein kinase from neurofilaments.

1992 • 66 citations

Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads.

1992 • 40 citations

Characterization of Antisera to Paired Helical Filaments and Tau

1990 • 33 citations

Surprise Fees Leave U.S. Research Reactors Gasping

1993 • 1 citations