Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

1992 • 936 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

1984 • 852 citations

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

1977 • 834 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

1992 • 709 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Tau protein binds to microtubules through a flexible array of distributed weak sites.

1991 • 540 citations

Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

1992 • 507 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains

1989 • 478 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.

1992 • 463 citations

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

1992 • 415 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains.

1989 • 321 citations

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1990 • 298 citations

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression.

1992 • 275 citations

Alzheimer's disease: a cell biological perspective

1992 • 274 citations

Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

1987 • 264 citations

Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins

1980 • 245 citations

Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments

1992 • 211 citations

The Alzheimer‐like phosphorylation of tau protein reduces microtubule binding and involves Ser‐Pro and Thr‐Pro motifs

1992 • 210 citations

Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells.

1991 • 200 citations

Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation.

1989 • 191 citations

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

1992 • 190 citations

Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles.

1987 • 181 citations

Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain.

1992 • 171 citations

Two Separate 18-Amino Acid Domains of Tau Promote the Polymerization of Tubulin

1989 • 167 citations

Microtubule assembly using the microtubule‐associated protein MAP‐2 prepared in defined states of phosphorylation with protein kinase and phosphatase

1983 • 163 citations

Proline-directed phosphorylation of human Tau protein.

1992 • 162 citations

Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease.

1991 • 143 citations

Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios

1991 • 134 citations

The disordered neuronal cytoskeleton in Alzheimer's disease

1992 • 124 citations

A Common Amino Acid Sequence in 190-kDa Microtubule-associated Protein and Tau for the Promotion of Microtubule Assembly

1989 • 121 citations

Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease

1991 • 116 citations

Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).

1992 • 113 citations

The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2: tubulin interaction

1984 • 112 citations

A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities

1991 • 110 citations

A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope

1991 • 109 citations

Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels

1986 • 87 citations

Non-motor microtubule-associated proteins

1993 • 76 citations

In vivo activation of a microtubule‐associated protein kinase during meiotic maturation of the Xenopus oocyte

1990 • 69 citations

A protein kinase associated with paired helical filaments in Alzheimer disease.

1992 • 65 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (?)

1987 • 63 citations

Resolution and purification of a neurofilament-specific kinase.

1989 • 45 citations

Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles

1987 • 30 citations