The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

Protein modules and signalling networks

1995 • 2,447 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

cdc25+ functions as an inducer in the mitotic control of fission yeast

1986 • 973 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

Chapter 30 Cell Cycle Extracts

1991 • 953 citations

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1995 • 940 citations

Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

1995 • 918 citations

A human peptidyl–prolyl isomerase essential for regulation of mitosis

1996 • 891 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

1997 • 762 citations

Mitosis in transition

1994 • 745 citations

Mammalian Cell Fusion : Induction of Premature Chromosome Condensation in Interphase Nuclei

1970 • 699 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Structural and Functional Analysis of the Mitotic Rotamase Pin1 Suggests Substrate Recognition Is Phosphorylation Dependent

1997 • 681 citations

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

1995 • 658 citations

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1990 • 642 citations

Monoclonal antibodies to mitotic cells.

1983 • 609 citations

Ordering S phase and M phase in the cell cycle

1994 • 596 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

1995 • 471 citations

Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle.

1983 • 452 citations

Cdc2 regulatory factors

1994 • 414 citations

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.

1997 • 344 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

Cell cycle extracts.

1991 • 304 citations

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.

1992 • 294 citations

Human Myt1 Is a Cell Cycle-regulated Kinase That Inhibits Cdc2 but Not Cdk2 Activity

1997 • 294 citations

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.

1993 • 291 citations

Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.

1994 • 257 citations

Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

1998 • 253 citations

Phosphoproteins are components of mitotic microtubule organizing centers.

1984 • 246 citations

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.

1995 • 237 citations

Systematic identification of mitotic phosphoproteins

1997 • 225 citations

Regulation of Human Histone Gene Expression: Kinetics of Accumulation and Changes in the Rate of Synthesis and in the Half-Lives of Individual Histone mRNAs During the HeLa Cell Cycle

1983 • 218 citations

Identification of novel M phase phosphoproteins by expression cloning.

1996 • 185 citations

Negative regulation of the weel protein kinase by direct action of the nim1/cdr1 mitotic inducer

1993 • 184 citations

Evidence for a NIMA-like mitotic pathway in vertebrate cells

1995 • 174 citations

Polo-like Kinase Is a Cell Cycle-regulated Kinase Activated during Mitosis

1995 • 165 citations

Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.

1994 • 164 citations

Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2

1991 • 163 citations

DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein antibody MPM-2.

1993 • 162 citations

Sequence and mutational analysis of ESS1, a gene essential for growth in Saccharomyces cerevisiae

1989 • 161 citations

The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.

1995 • 148 citations

Proteins of the mammalian mitotic spindle: phosphorylation/dephosphorylation of MAP-4 during mitosis

1991 • 121 citations

Distribution of cytoskeletal proteins sharing a conserved phosphorylated epitope.

1986 • 118 citations

The Drosophila melanogaster dodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1 cell division gene of Saccharomyces cerevisiae.

1996 • 110 citations

Cell cycle control of higher-order chromatin assembly around naked DNA in vitro.

1991 • 103 citations

Inhibition of cdc2 activation by INH/PP2A.

1994 • 103 citations

cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor.

1994 • 100 citations

Protein folding: Prolyl isomerases join the fold

1995 • 95 citations

Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216.

1994 • 95 citations

At least two kinases phosphorylate the MPM-2 epitope during Xenopus oocyte maturation.

1993 • 79 citations

Mitosis-specific monoclonal antibody MPM-2 inhibits Xenopus oocyte maturation and depletes maturation-promoting activity.

1989 • 77 citations

Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans.

1993 • 72 citations

Protein phosphorylation and dynamics of cytoskeletal structures associated with basal bodies in Paramecium

1987 • 57 citations

PEPTIDYL-PROLYL CIS/TRANS ISOMERASES

1999 • 49 citations

MPM-2 antibody-reactive phosphorylations can be created in detergentextracted cells by kinetochore-bound and soluble kinases

1997 • 35 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

1992 • 31 citations

The MPM-2 antibody inhibits mitogen-activated protein kinase activity by binding to an epitope containing phosphothreonine-183.

1994 • 24 citations

Conditional absence of mitosis-specific antigens in a temperature-sensitive embryonic-arrest mutant of Caenorhabditis elegans

1987 • 22 citations

Mitosis-specific monoclonal antibodies block cleavage in amphibian embryos.

1989 • 18 citations

Distribution of phosphorylated spindle‐associated proteins in the diatom Stephanopyxis turris

1989 • 17 citations