Farnesyl Transferase Inhibitors Block the Farnesylation of CENP-E and CENP-F and Alter the Association of CENP-E with the Microtubules

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

1997 • 848 citations

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores.

1995 • 701 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

How Cells Get the Right Chromosomes

1997 • 625 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

1992 • 542 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle.

1994 • 511 citations

CENP-E Is a Plus End–Directed Kinetochore Motor Required for Metaphase Chromosome Alignment

1997 • 428 citations

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

1995 • 393 citations

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.

1991 • 384 citations

Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.

1995 • 379 citations

Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC

1999 • 379 citations

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.

1995 • 367 citations

Direct Demonstration of Geranylgeranylation and Farnesylation of Ki-Ras in Vivo

1997 • 361 citations

CENP-E Function at Kinetochores Is Essential for Chromosome Alignment

1997 • 326 citations

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.

1998 • 314 citations

Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro

1995 • 285 citations

Characterization of the Kinetochore Binding Domain of CENP-E Reveals Interactions with the Kinetochore Proteins CENP-F and hBUBR1

1998 • 280 citations

Phase I and Pharmacokinetic Study of Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer

2000 • 275 citations

A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.

2000 • 247 citations

Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956.

1995 • 241 citations

The Microtubule-dependent Motor Centromere–associated Protein E (CENP-E) Is an Integral Component of Kinetochore Corona Fibers That Link Centromeres to Spindle Microtubules

1997 • 231 citations

Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro.

1995 • 222 citations

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.

1993 • 222 citations

CENP‐F is a ca 400 kDa kinetochore protein that exhibits a cell‐cycle dependent localization

1993 • 220 citations

Microinjection of Antibody to Mad2 Protein into Mammalian Cells in Mitosis Induces Premature Anaphase

1998 • 215 citations

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

1998 • 215 citations

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

1998 • 212 citations

Protein prenylation: more than just glue?

1992 • 208 citations

Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I

1997 • 203 citations

Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase

1997 • 176 citations

Novel Tricyclic Inhibitors of Farnesyl Protein Transferase

1995 • 157 citations

Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements.

1992 • 157 citations

Mitotic Regulation of Microtubule Cross-Linking Activity of CENP-E Kinetochore Protein

1994 • 148 citations

GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.

1997 • 139 citations

Characterization of a Novel 350-Kilodalton Nuclear Phosphoprotein That Is Specifically Involved in Mitotic-Phase Progression

1995 • 138 citations

Entry into Mitosis in Vertebrate Somatic Cells Is Guarded by a Chromosome Damage Checkpoint That Reverses the Cell Cycle When Triggered during Early but Not Late Prophase

1998 • 132 citations

Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity.

1991 • 126 citations

Prenylation-dependent Association of Ki-Ras with Microtubules

1997 • 117 citations

The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.

1994 • 113 citations

Farnesyl Protein Transferase Inhibitors and Other Therapies Targeting the Ras Signal Transduction Pathway

1999 • 105 citations

The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A

1996 • 94 citations

The structure of the kinetochore in meiosis and mitosis in eggs

1965 • 75 citations

Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor.

1995 • 63 citations

Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

1997 • 50 citations

Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited

2000 • 44 citations

Cell Division Gatekeepers Identified

1998 • 33 citations

Structural Requirements and Dynamics of Mitosin-Kinetochore Interaction in M Phase

1999 • 30 citations

Carboxyl terminus of mitosin is sufficient to confer spindle pole localization

1997 • 27 citations

Microtubule associated proteins in microtubule preparations made with and without glycerol

1984 • 16 citations

Clinical trials referral resource. Clinical trials with the farnesyl transferase inhibitor R115777.

1999 • 11 citations