Making sense of the multiple MAP-2 transcripts and their role in the neuron

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

1977 • 878 citations

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture.

1987 • 833 citations

Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite.

1988 • 716 citations

Microtubule-Associated Proteins: Their Potential Role in Determining Neuronal Morphology

1988 • 599 citations

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

1992 • 569 citations

Microtubule-Associated Proteins

1986 • 559 citations

Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein.

1975 • 551 citations

Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites

1988 • 546 citations

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

1986 • 535 citations

Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro.

1975 • 535 citations

The periodic association of MAP2 with brain microtubules in vitro.

1979 • 510 citations

Microtubule-Associated Protein MAP2 Shares a Microtubule Binding Motif with Tau Protein

1988 • 476 citations

Translocation of RNA Granules in Living Neurons

1996 • 426 citations

Light and electron microscopic studies of the distribution of microtubule‐associated protein 2 in rat brain: A difference between dendritic and axonal cytoskeletons

1984 • 424 citations

Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence

1984 • 378 citations

High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain.

1981 • 363 citations

Individual microtubules in the axon consist of domains that differ in both composition and stability.

1990 • 356 citations

The growth of dendrites in the mammalian brain

1969 • 356 citations

The roles of microtubule-associated proteins in brain morphogenesis: a review

1990 • 352 citations

Microtubule Assembly in vitro. Purification of Assembly-Promoting Factors

1977 • 338 citations

The role of microtubule‐associated protein 2 (MAP‐2) in neuronal growth, plasticity, and degeneration

1992 • 333 citations

Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau

1992 • 322 citations

Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C.

1989 • 318 citations

MAP2 is localized to the dendrites of hippocampal neurons which develop in culture

1984 • 313 citations

Postpolymerization detyrosination of alpha-tubulin: a mechanism for subcellular differentiation of microtubules.

1987 • 297 citations

Dynamic and stable populations of microtubules in cells.

1987 • 273 citations

Stabilization and post‐translational modification of microtubules during cellular morphogenesis

1991 • 269 citations

Molecular Characterization of the Dendritic Growth Cone: Regulated mRNA Transport and Local Protein Synthesis

1996 • 265 citations

Suppression of MAP2 in cultured cerebeller macroneurons inhibits minor neurite formation

1992 • 255 citations

Differential expression of distinct microtubule-associated proteins during brain development.

1985 • 255 citations

A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2)

1981 • 243 citations

Heterogeneity of microtubule-associated protein 2 during rat brain development.

1984 • 236 citations

Structure and phosphorylation of microtubule-associated protein 2 (MAP 2).

1980 • 235 citations

Presynaptic Serotonergic Dysfunction in Patients with Alzheimer's Disease

1987 • 213 citations

Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation

1991 • 207 citations

Differential subcellular localization of particular mRNAs in hippocampal neurons in culture

1990 • 201 citations

MAP2 expression and neuritic outgrowth and branching are coregulated through region-specific neuro-astroglial interactions

1987 • 201 citations

Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells.

1991 • 200 citations

The adult rat olfactory system expresses microtubule-associated proteins found in the developing brain

1989 • 172 citations

Posttranslational modifications of alpha-tubulin: acetylated and detyrosinated forms in axons of rat cerebellum.

1987 • 167 citations

Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.

1996 • 167 citations

In situ localization of microtubule-associated protein mRNA in the developing and adult rat brain

1989 • 165 citations

Cytoskeletal Plasticity in Cells Expressing Neuronal Microtubule-Associated Proteins

1996 • 162 citations

Different forms of microtubule-associated protein 2 are encoded by separate mRNA transcripts.

1988 • 157 citations

A dynein‐like protein associated with neurotubules

1974 • 154 citations

Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau

1989 • 148 citations

Extensive cAMP-dependent and cAMP-independent phosphorylation of microtubule-associated protein 2.

1983 • 146 citations

Ontogeny of microtubule-associated protein 2 in rat cerebellum: Differential expression of the doublet polypeptides

1984 • 144 citations

Sorting mechanisms of Tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding

1995 • 138 citations

Postsynaptic Mechanisms for Bidirectional Control of MAP2 Phosphorylation by Glutamate Receptors

1996 • 136 citations

Electron microscopy of map 2 (microtubule-associated protein 2)

1982 • 135 citations

Distinct spatial localization of specific mRNAs in cultured sympathetic neurons

1990 • 132 citations

The RII subunit of camp-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C

1989 • 130 citations

Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2

1989 • 128 citations

Mitogen‐activated‐protein‐kinase‐catalyzed phosphorylation of microtubule‐associated proteins, microtubule‐associated protein 2 and microtubule‐associated protein 4, induces an alteration in their function

1992 • 128 citations

Embryonic MAP2 lacks the cross-linking sidearm sequences and dendritic targeting signal of adult MAP2

1989 • 118 citations

The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2: tubulin interaction

1984 • 112 citations

Molecular structure of microtubule-associated protein 2b and 2c from rat brain.

1990 • 111 citations

Tubulin requires an accessory protein for self assembly into microtubules

1975 • 110 citations

Dendrites of mitral cell neurons contain microtubules of opposite polarity

1988 • 108 citations

Microtubule-associated proteins characteristic of embryonic brain are found in the adult mammalian retina

1988 • 107 citations

A 70‐Kilodalton Microtubule‐Associated Protein (MAP2c), Related to MAP2

1988 • 104 citations

The sequential appearance of low- and high-molecular-weight forms of MAP2 in the developing cerebellum

1988 • 96 citations

Calcium/phospholipid-dependent kinase recognizes sites in microtubule-associated protein 2 which are phosphorylated in living brain and are not accessible to other kinases.

1986 • 95 citations

Microtubule-associated Protein 2c Reorganizes Both Microtubules and Microfilaments into Distinct Cytological Structures in an Actin-binding Protein-280–deficient Melanoma Cell Line

1997 • 90 citations

Emergence of Activity-Dependent, Bidirectional Control of Microtubule-Associated Protein MAP2 Phosphorylation during Postnatal Development

1996 • 89 citations

Protein phosphatase inhibitors induce the selective breakdown of stable microtubules in fibroblasts and epithelial cells.

1993 • 88 citations

Numerous phosphates of microtubule-associated protein 2 in living rat brain.

1987 • 87 citations

An isoform of microtubule-associated protein 2 (MAP2) containing four repeats of the tubulin-binding motif

1993 • 87 citations

Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms.

1995 • 79 citations

Dynamics of the microtubule oscillator: role of nucleotides and tubulin-MAP interactions.

1988 • 78 citations

MAP2: a sensitive cross-linker and adjustable spacer in dendritic architecture

1991 • 63 citations

Antisense MAP‐2 oligonucleotides induce changes in microtubule assembly and neuritic elongation in pre‐existing neurites of rat cortical neurons

1994 • 59 citations

Stimulation of tubulin polymerization by MAP-2. Control by protein kinase C-mediated phosphorylation at specific sites in the microtubule-binding region.

1994 • 59 citations

Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons.

1989 • 59 citations

MAP2a, an Alternatively Spliced Variant of Microtubule‐Associated Protein 2

1996 • 51 citations

Partial Sequence of MAP2 in the Region of a Shared Epitope with Alzheimer Neuronbrillary Tangles

1988 • 50 citations

Regulation of microtubule associated protein 2 (MAP2) expression by nerve growth factor in PC12 cells

1991 • 49 citations

Ganglioside-enhanced neurite growth: evidence for a selective induction of high-molecular-weight MAP-2

1990 • 49 citations

Microtubule-associated protein 2 (MAP2) is present in astrocytes of the optic nerve but absent from astrocytes of the optic tract

1986 • 48 citations

Localization of the Phosphorylation Sites for Different Kinases in the Microtubule‐Associated Protein MAP₂

1987 • 38 citations

Transgenic Expression of Embryonic MAP2 in Adult Mouse Brain: Implications for Neuronal Polarization

1996 • 36 citations

Inhibition of protein synthesis alters the subcellular distribution of mRNA in neurons but does not prevent dendritic transport of RNA.

1993 • 34 citations

Molecular and functional characteristics of MAP-2a: Ability of MAP-2a versus MAP-2b to induce stable microtubules in COS cells

1998 • 34 citations

Microtubule-associated protein-2 in the rat testis: a novel site of expression

1996 • 33 citations

Human Microtubule‐Associated Protein‐2c Localizes to Dendrites and Axons in Fetal Spinal Motor Neurons

1995 • 30 citations

Structure, regional and developmental expression of rat MAP2d, a MAP2 splice variant encoding four microtubule-binding domains

1994 • 30 citations

MAP2d promotes bundling and stabilization of both microtubules and microfilaments

1996 • 29 citations

Immunofluorescence distribution of α tubulin, β tubulin and microtubule-associated protein 2 during in vitro maturation of cerebellar granule cell neurones

1984 • 29 citations

Sequence of a human MAP‐2 region sharing epitopes with Alzheimer neurofibrillary tangles

1989 • 28 citations

Nucleotide and amino acid sequences of embryonic rat MAP2c

1990 • 27 citations

Molecular characterization of dendritically localized transcripts encoding MAP2

1996 • 25 citations

Four repeat MAP2 isoforms in human and rat brain

1994 • 15 citations

Expression of Microtubule‐Associated Protein‐2a and Other Novel Microtubule‐Associated Protein‐2 Transcripts in Human Fetal Spinal Cord

1997 • 15 citations

Expression of low molecular weight isoforms of microtubule-associated protein 2. Phosphorylation and induction of microtubule assembly in vitro

1994 • 14 citations

Distribution and Subcellular Localization of High‐Molecular‐Weight Microtubule‐Associated Protein‐2 Expressing Exon 8 in Brain and Spinal Cord

1997 • 14 citations

Two novel HMW MAP2 variants with four microtubule‐binding repeats and different projection domains

1994 • 13 citations

Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2)

1993 • 12 citations

Four repeat high-mol-wt MAP2 forms in rat dorsal root ganglia

1996 • 12 citations

Three Unique 5′ Untranslated Regions Are Spliced to Common Coding Exons of High‐ and Low‐Molecular‐Weight Microtubule‐Associated Protein‐2

1995 • 9 citations

New forms of HMW MAP2 are preferentially expressed in the spinal cord

1996 • 9 citations

Deleted Work

1955 • 0 citations