Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

A protein factor essential for microtubule assembly.

1975 • 2,863 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

1977 • 878 citations

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

1977 • 834 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain

1988 • 671 citations

Developmentally regulated expression of specific tau sequences

1989 • 589 citations

Structural characterization of the core of the paired helical filament of Alzheimer disease.

1988 • 566 citations

Visualization of the dynamic instability of individual microtubules by dark-field microscopy

1986 • 547 citations

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

1986 • 535 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains

1989 • 478 citations

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains.

1989 • 321 citations

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

1986 • 310 citations

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

1989 • 306 citations

The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.

1987 • 278 citations

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

1987 • 222 citations

Dendritic sprouting in Alzheimer's presenile dementia

1978 • 174 citations

Two Separate 18-Amino Acid Domains of Tau Promote the Polymerization of Tubulin

1989 • 167 citations

Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes.

1984 • 164 citations

Mise en évidence immunologique de la protéine tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d'Alzheimer

1985 • 163 citations

Microtubule-associated protein tau (? ) is a major antigenic component of paired helical filaments in Alzheimer disease

1987 • 99 citations

Immunological characterization of microtubule‐associated proteins specific for the immature brain

1985 • 81 citations

A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments

1989 • 50 citations