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Microtubules and microtubule-associated proteins

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Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

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Enlightening the Postsynaptic Density

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Glycogen synthase kinase-3: functions in oncogenesis and development

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MAP2 is localized to the dendrites of hippocampal neurons which develop in culture

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Molecular characterization of microtubule-associated proteins tau and map2

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Discussion

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Protein Kinase A Anchoring

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Molecular Glue: Kinase Anchoring and Scaffold Proteins

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A Spatial Gradient of Tau Protein Phosphorylation in Nascent Axons

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Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.

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Positive feedback interactions between microtubule and actin dynamics during cell motility

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Role of MAP kinase in neurons

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Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins

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Cellular phosphorylation of tau by GSK-3β influences tau binding to microtubules and microtubule organisation

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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription

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Heterogeneity of microtubule-associated protein 2 during rat brain development.

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Cellular substrates of p34cdc2 and its companion cyclin-dependent kinases

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Insulin Transiently Increases Tau Phosphorylation

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Increased Phosphorylation of Ca2+/Calmodulin-dependent Protein Kinase II and Its Endogenous Substrates in the Induction of Long Term Potentiation

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Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2

1990 • 220 citations

mRNA and cytoskeletal filaments

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Modulatory Role of Drebrin on the Cytoskeleton within Dendritic Spines in the Rat Cerebral Cortex

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Phosphorylation of microtubule-associated proteins by a Ca2+/calmodulin-dependent protein kinase.

1984 • 213 citations

Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation

1991 • 207 citations

Mechanisms of Calpain Proteolysis Following Traumatic Brain Injury: Implications for Pathology and Therapy: A Review and Update

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Synaptogenesis in hippocampal cultures: evidence indicating that axons and dendrites become competent to form synapses at different stages of neuronal development

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Concepts and principles of glycobiology

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Organelle motility and metabolism in axons vs dendrites of cultured hippocampal neurons

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PKA isoforms, neural pathways, and behaviour: making the connection

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Differential subcellular localization of particular mRNAs in hippocampal neurons in culture

1990 • 201 citations

Immunocytochemical localization of actin and microtubule-associated protein MAP2 in dendritic spines.

1983 • 201 citations

Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells.

1991 • 200 citations

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

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Demonstration of local protein synthesis within dendrites using a new cell culture system that permits the isolation of living axons and dendrites from their cell bodies.

1992 • 197 citations

Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2.

1990 • 196 citations

Evidence for the Participation of the Neuron-Specific CDK5 Activator P35 during Laminin-Enhanced Axonal Growth

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Association of microtubule-associated protein 2 (MAP 2) with microtubules and intermediate filaments in cultured brain cells.

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1992 • 192 citations

Microtubules and Neuronal Polarity

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1992 • 190 citations

Phosphorylation of Microtubule-associated Proteins MAP2 and MAP4 by the Protein Kinase p110mark

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Is the Ras-MAPK signalling pathway necessary for long-term memory formation?

1999 • 186 citations

Signal transduction molecules at the glutamatergic postsynaptic membrane1Published on the World Wide Web on 24 October 1997.1

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1985 • 183 citations

NMDA receptor activation during status epilepticus is required for the development of epilepsy

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MAP2 is a component of crossbridges between microtubules and neurofilaments in the neuronal cytoskeleton: quick-freeze, deep-etch immunoelectron microscopy and reconstitution studies

1988 • 182 citations

Degradation of Microtubule‐Associated Protein 2 and Brain Spectrin by Calpain: A Comparative Study

1991 • 180 citations

Ca²⁺– and Calmodulin‐Dependent Phosphorylation of Microtubule‐Associated Protein 2 and t Factor, and Inhibition of Microtubule Assembly

1983 • 180 citations

Neuronal cdc2-like kinase

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Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy

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Purification and properties of extracellular regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase

1991 • 175 citations

Dephosphorylation of Microtubule‐Associated Protein 2, τ Factor, and Tubulin by Calcineurin

1985 • 173 citations

The adult rat olfactory system expresses microtubule-associated proteins found in the developing brain

1989 • 172 citations

Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain.

1992 • 171 citations

An emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance

1998 • 170 citations

Functional design in the actin cytoskeleton

1999 • 170 citations

Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.

1996 • 167 citations

Molecular Structure and Function of Microtubule-Associated Proteins

1991 • 166 citations

Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro: Real-time observations using video microscopy

1992 • 166 citations

Domains of Neuronal Microtubule-associated Proteins and Flexural Rigidity of Microtubules

1997 • 166 citations

In situ localization of microtubule-associated protein mRNA in the developing and adult rat brain

1989 • 165 citations

Microtubule assembly using the microtubule‐associated protein MAP‐2 prepared in defined states of phosphorylation with protein kinase and phosphatase

1983 • 163 citations

Cytoskeletal Plasticity in Cells Expressing Neuronal Microtubule-Associated Proteins

1996 • 162 citations

Role of Phosphorylation in Determining the Backbone Dynamics of the Serine/Threonine-Proline Motif and Pin1 Substrate Recognition

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Regulation of microtubule dynamics by microtubule-associated protein expression and phosphorylation during neuronal development.

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The α- and β-tubulin folding pathways

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Modification of microtubule steady-state dynamics by phosphorylation of the microtubule-associated proteins.

1981 • 160 citations

Calcineurin: Not Just a Simple Protein Phosphatase

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p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites

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Neurobiology of schizophrenia

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Different forms of microtubule-associated protein 2 are encoded by separate mRNA transcripts.

1988 • 157 citations

Schizophrenia as a developmental disorder of the cerebral cortex

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GSK3: a SHAGGY frog story

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Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau

1989 • 148 citations

Extensive cAMP-dependent and cAMP-independent phosphorylation of microtubule-associated protein 2.

1983 • 146 citations

ERKs, extracellular signal-regulated MAP-2 kinases

1991 • 145 citations

Ontogeny of microtubule-associated protein 2 in rat cerebellum: Differential expression of the doublet polypeptides

1984 • 144 citations

Protein Phosphatase 1 Is Targeted to Microtubules by the Microtubule-associated Protein Tau

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The Development of Cell Processes Induced by tau Protein Requires Phosphorylation of Serine 262 and 356 in the Repeat Domain and Is Inhibited by Phosphorylation in the Proline-rich Domains

1999 • 143 citations

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

1998 • 143 citations

The pool of map kinase associated with microtubules is small but constitutively active.

1996 • 142 citations

Protein phosphatase 2A: Who shall regulate the regulator?

1999 • 142 citations

Microtubule-Associated Protein 2 Levels Decrease in Hippocampus Following Traumatic Brain Injury

1992 • 140 citations

Plasticity in Brain Development

1988 • 139 citations

Sorting mechanisms of Tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding

1995 • 138 citations

Rapid Calpain I Activation and Cytoskeletal Protein Degradation Following Traumatic Spinal Cord Injury: Attenuation with Riluzole Pretreatment

1997 • 137 citations

The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin binding

1990 • 137 citations

Postsynaptic Mechanisms for Bidirectional Control of MAP2 Phosphorylation by Glutamate Receptors

1996 • 136 citations

Microtubule-associated proteins and neuronal morphogenesis

1991 • 136 citations

Reversible loss of dendritic spines and altered excitability after chronic epilepsy in hippocampal slice cultures.

1993 • 135 citations

Ca2+–calmodulin and protein kinase Cs: a hypothetical synthesis of their conflicting convergences on shared substrate domains

1999 • 134 citations

Axin prevents Wnt-3a-induced accumulation of β-catenin

1999 • 134 citations

Ontogenetic changes in the cyclic adenosine 3',5'-monophosphate- stimulatable phosphorylation of cat visual cortex proteins, particularly of microtubule-associated protein 2 (MAP 2): effects of normal and dark rearing and of the exposure to light

1985 • 132 citations

Distinct spatial localization of specific mRNAs in cultured sympathetic neurons

1990 • 132 citations

A Kinase to Remember: Dual Roles for MAP Kinase in Long-Term Memory

1997 • 132 citations

Cytoskeletal dynamics in dendritic spines: direct modulation by glutamate receptors?

1999 • 131 citations

Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons

1994 • 131 citations

Discussion

1996 • 131 citations

Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons

1997 • 131 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase

1993 • 130 citations

Stiff microtubules and neuronal morphology

1994 • 130 citations

The RII subunit of camp-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C

1989 • 130 citations

Localization and Developmental Changes of τ Protein Kinase I/Glycogen Synthase Kinase‐3β in Rat Brain

1994 • 130 citations

Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules

1988 • 130 citations

Identification of a Microtubule-associated Motor Protein Essential for Dendritic Differentiation

1997 • 129 citations

Mitogen‐activated‐protein‐kinase‐catalyzed phosphorylation of microtubule‐associated proteins, microtubule‐associated protein 2 and microtubule‐associated protein 4, induces an alteration in their function

1992 • 128 citations

Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2

1989 • 128 citations

Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects

1996 • 124 citations

Diverse Distribution and Function of Fibrous Microtubule-Associated Proteins in the Nervous System

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Initial phase of dendrite growth: evidence for the involvement of high molecular weight microtubule-associated proteins (HMWP) before the appearance of tubulin.

1982 • 124 citations

The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines.

1995 • 124 citations

Okadaic Acid Induces Early Changes in Microtubule‐Associated Protein 2 and γ Phosphorylation Prior to Neurodegeneration in Cultured Cortical Neurons

1993 • 121 citations

Dephosphorylation of Microtubule Proteins by Brain Protein Phosphatases 1 and 2A, and Its Effect on Microtubule Assembly

1988 • 119 citations

Actin depolymerisation induces process formation on MAP2-transfected non-neuronal cells

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Dendritic changes in Alzheimer's disease and factors that may underlie these changes

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The regulation of phosphorylation of τ in SY5Y neuroblastoma cells: the role of protein phosphatases

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CaM KINASE II IN LONG-TERM POTENTIATION

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Microtubules and axonal growth

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The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2: tubulin interaction

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Molecular structure of microtubule-associated protein 2b and 2c from rat brain.

1990 • 111 citations

Disruption of MAP-2 Immunostaining in Rat Hippocampus After Traumatic Brain Injury

1998 • 111 citations

Steric inhibition of cytoplasmic dynein and kinesin motility by MAP2

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Brain protein serine/threonine phosphatases

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Competition between motor molecules (kinesin and cytoplasmic dynein) and fibrous microtubule-associated proteins in binding to microtubules.

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Protein kinases and phosphorylation in neurologic disorders and cell death.

1991 • 108 citations

Microtubule-associated proteins characteristic of embryonic brain are found in the adult mammalian retina

1988 • 107 citations

High-Mr microtubule-associated proteins: properties and functions

1989 • 107 citations

Calcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity.

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A structural basis for memory storage in mammals

1998 • 104 citations

Phosphorylation of microtubule-associated protein 2 by calmodulin-dependent protein kinase (Kinase II) which occurs only in the brain tissues

1982 • 103 citations

Reorganisation of the microtubular cytoskeleton by embryonic microtubule-associated protein 2 (MAP2c)

1992 • 103 citations

cAMP-dependent phosphorylation of soluble and crude microtubule fractions of rat cerebral cortex after prolonged desmethylimipramine treatment

1989 • 102 citations

The Microtubule-Associated Protein Tau Cross-Links to Two Distinct Sites on Each α and β Tubulin Monomer via Separate Domains

1998 • 102 citations

The ‘jaws’ model of tau-microtubule interaction examined in CHO cells

1997 • 101 citations

A Turning Point in Schizophrenia Genetics

1997 • 101 citations

Microtubule stabilization by assembly‐promoting microtubule‐associated proteins: A repeat performance

1992 • 101 citations

Modulation of microtubule dynamic instability in vivo by brain microtubule associated proteins

1995 • 99 citations

Development of subcellular mRNA compartmentation in hippocampal neurons in culture

1994 • 98 citations

Temporal response and effects of excitatory amino acid antagonism on microtubule-associated protein 2 immunoreactivity following experimental brain injury in rats

1995 • 98 citations

Effect of Glutamate on Dendritic Growth in Embryonic Rat Motoneurons

1998 • 97 citations

Microtubule-associated proteins bind specifically to the 70-kDa neurofilament protein.

1985 • 97 citations

Physicochemical characterization of the heat-stable microtubule-associated protein MAP2

1986 • 96 citations

Okadaic acid activates microtubule‐associated protein kinase in quiescent fibroblastic cells

1990 • 96 citations

A bimodal model of the mechanism of action of lithium

1999 • 95 citations

Calcium/phospholipid-dependent kinase recognizes sites in microtubule-associated protein 2 which are phosphorylated in living brain and are not accessible to other kinases.

1986 • 95 citations

The cytoskeleton in nerve growth cone motility and axonal pathfinding.

1996 • 95 citations

Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons

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Microtubule-associated protein 2 alters the dynamic properties of microtubule assembly and disassembly

1993 • 91 citations

Microtubule-associated Protein 2c Reorganizes Both Microtubules and Microfilaments into Distinct Cytological Structures in an Actin-binding Protein-280–deficient Melanoma Cell Line

1997 • 90 citations

Targeting of mRNAs to subsynaptic microdomains in dendrites

1995 • 90 citations

Emergence of Activity-Dependent, Bidirectional Control of Microtubule-Associated Protein MAP2 Phosphorylation during Postnatal Development

1996 • 89 citations

Heterogeneity in the Phosphorylation of Micro tubule‐Associated Protein MAP 1B During Rat Brair Development

1993 • 89 citations

Microtubule-associated protein 2 within axons of spinal motor neurons: associations with microtubules and neurofilaments in normal and beta,beta'-iminodipropionitrile-treated axons.

1985 • 89 citations

Immature and mature variants of MAP2 and tau proteins and neuronal plasticity

1988 • 88 citations

Making sense of the multiple MAP-2 transcripts and their role in the neuron

1998 • 88 citations

Numerous phosphates of microtubule-associated protein 2 in living rat brain.

1987 • 87 citations

Mechanisms of neuronal polarity

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An isoform of microtubule-associated protein 2 (MAP2) containing four repeats of the tubulin-binding motif

1993 • 87 citations

Association of p34cdc2/cyclin B complex with microtubules in starfish oocytes

1993 • 87 citations

Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells

1998 • 85 citations

Actin Matrix of Dendritic Spines, Synaptic Plasticity, and Long-Term Potentiation

1992 • 85 citations

Calcium-stimulated Phosphorylation of MAP-2 in Pancreatic ॆTC3-cells Is Mediated by Ca2+/Calmodulin-dependent Kinase II

1997 • 85 citations

Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions.

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Microtubule-Microfilament Synergy in the Cytoskeleton

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Purified protein kinase C phosphorylates microtubule-associated protein 2.

1986 • 82 citations

Immunological characterization of microtubule‐associated proteins specific for the immature brain

1985 • 81 citations

Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms.

1995 • 79 citations

Phosphorylation States of Microtubule-Associated Protein 2 (MAP2) Determine the Regulatory Role of MAP2 in Microtubule Dynamics

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Protein‐kinase‐C‐catalyzed phosphorylation of the microtubule‐binding domain of microtubule‐associated protein 2 inhibits its ability to induce tubulin polymerization

1988 • 78 citations

Cytoplasmic Mechanisms of Axonal and Dendritic Growth in Neurons

1996 • 77 citations

Synaptic plasticity: Going through phases with LTP

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Non-motor microtubule-associated proteins

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Phosphorylation of Microtubule‐Associated Protein 2 at Distinct Sites by Calmodulin‐Dependent and Cyclic‐AMP‐Dependent Kinases

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Age-related alteration of PKC, a key enzyme in memory processes

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Interaction of Cytoskeletal Proteins with Membrane Lipids

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Correlation between reactive sprouting and microtubule protein expression in epileptic hippocampus

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Reorganization of the Cytoskeleton in Rat Neurons Following Stimulation With Excitatory Amino Acids In Vitro

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Calcium calmodulin-dependent microtubule-associated protein 2 kinase: broad substrate specificity and multifunctional potential in diverse tissues

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Structures of kinesin and kinesin–microtubule interactions

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Modulation of neurite branching by protein phosphorylation in cultured rat hippocampal neurons

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Ammonium Injection Induces an N‐Methyl‐<scp>d</scp>‐Aspartate Receptor‐Mediated Proteolysis of the Microtubule‐Associated Protein MAP‐2

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Phosphorylation of Microtubule Proteins in Rat Brain at Different Developmental Stages: Comparison with That Found in Neuronal Cultures

1990 • 72 citations

Hippocampal microtubule-associated protein-2 alterations with contextual memory1Published on the World Wide Web on 28 January 1999.1

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Morphological alterations in dendritic spines of rat hippocampal neurons exposed to N-methyl-d-aspartate

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Protein components of a rat brain synaptic junctional protein preparation

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Calpain-mediated proteolysis of microtubule associated proteins MAP1B and MAP2 in developing brain

1991 • 65 citations

MAP-1 and MAP-2 binding sites at the C-terminus of .beta.-tubulin. Studies with synthetic tubulin peptides

1991 • 65 citations

Inhibitors of protein phosphatase-1 and -2A; two of the major serine/threonine protein phosphatases involved in cellular regulation

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Okadaic acid stimulates the activity of microtubule associated protein kinasein PC-12 pheochromocytoma cells

1990 • 64 citations

MAP2: a sensitive cross-linker and adjustable spacer in dendritic architecture

1991 • 63 citations

The role of protein phosphatases in synaptic transmission, plasticity and neuronal development

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Sequence analysis of MAP2 function in living cells

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Regulation of neuronal plasticity in the central nervous system by phosphorylation and dephosphorylation

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Changes of MAP2 phosphorylation during brain development.

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The interrelationship between selective tau phosphorylation and microtubule association

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High Molecular Weight Microtubule-associated Proteins Contain O-Linked N-Acetylglucosamine

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The neuronal cytoskeleton and its role in axonal and dendritic plasticity

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Widespread occurrence of polypeptides related to neurotubule-associated proteins (MAP-1 and MAP-2) in non-neuronal cells and tissues.

1984 • 61 citations

Stimulation of tubulin polymerization by MAP-2. Control by protein kinase C-mediated phosphorylation at specific sites in the microtubule-binding region.

1994 • 59 citations

Dynamics of microtubules bundled by microtubule associated protein 2C (MAP2C).

1993 • 59 citations

Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons.

1989 • 59 citations

Isolation and chromosomal mapping of human glycogen synthase kinase-3 α and -3β encoding genes

1998 • 59 citations

Long-term potentiation and spatial training are both associated with the generation of new excitatory synapses1Published on the World Wide Web on 4 November 1997.1

1998 • 59 citations

Antisense MAP‐2 oligonucleotides induce changes in microtubule assembly and neuritic elongation in pre‐existing neurites of rat cortical neurons

1994 • 59 citations

Localization of differentially phosphorylated isoforms of microtubule-associated protein 1B in cultured rat hippocampal neurons

1994 • 59 citations

Microtubule-Associated Proteins and the Flexibility of Microtubules

1995 • 58 citations

Dynamic Interaction Between Soluble Tubulin and C‐Terminal Domains of N‐Methyl‐D‐Aspartate Receptor Subu

1999 • 57 citations

Microtubule‐associated proteins in developing oligodendrocytes: Transient expression of a MAP2c isoform in oligodendrocyte precursors

1995 • 57 citations

Microtubule-associated proteins

1990 • 57 citations

The regulation and function of protein phosphatases in the brain

1991 • 56 citations

Microtubule-Stabilizing Activity of Microtubule-Associated Proteins (MAPs) Is Due to Increase in Frequency of Rescue in Dynamic Instability: Shortening Length Decreases with Binding of MAPs onto Microtubules.

1994 • 56 citations

Microtubule-associated proteins, phosphorylation gradients, and the establishment of neuronal polarity.

1996 • 56 citations

Differences in the regulation of microtubule dynamics by microtubule-associated proteins MAP1B and MAP2

1996 • 55 citations

Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells

1997 • 55 citations

Phosphorylation of microtubule-associated proteins MAP2a,b and MAP2c at Ser136 by proline-directed kinases in vivo and in vitro.

1994 • 55 citations

Mapmodulin: A possible modulator of the interaction of microtubule-associated proteins with microtubules

1997 • 55 citations

Microtubule-associated protein 2 (MAP-2): a sensitive marker of seizure-related brain damage

1995 • 55 citations

Neuronal polarity: Giving neurons heads and tails

1995 • 54 citations

The regional distribution of extracellularly regulated kinase-1 and -2 messenger RNA in the adult rat central nervous system

1993 • 54 citations

Region‐Specific Targets of p42/p44^MAPK Signaling in Rat Brain

1998 • 54 citations

Recent advances on cyclins, CDKs and CDK inhibitors

1997 • 54 citations

Ca2+ and synaptic plasticity

1998 • 54 citations

Phosphorylation and Dephosphorylation in the Proline‐Rich C‐Terminal Domain of Microtubule‐Associated Protein 2

1996 • 54 citations

Mechanisms of trafficking in axons and dendrites: implications for development and neurodegeneration

1998 • 54 citations

A novel tau‐tubulin kinase from bovine brain

1995 • 53 citations

Ultrastructural Localization of Dendritic Messenger RNA in Adult Rat Hippocampus

1996 • 53 citations

Protein kinases involved in the expression of long-term potentiation

1994 • 53 citations

The role of calcium in activity-dependent neuronal gene regulation

1998 • 53 citations

Multisite phosphorylation of microtubule-associated protein 2 (MAP-2) in rat brain: Peptide mapping distinguishes between cyclic AMP-, calcium/calmodulin-, and calcium/phospholipid-regulated phosphorylation mechanisms

1989 • 52 citations

Calpain‐mediated proteolysis of microtubule‐associated protein 2 (MAP‐2) is inhibited by phosphorylation by cAMP‐dependent protein kinase, but not by Ca²⁺/calmodulin‐dependent protein kinase II

1993 • 52 citations

Process formation in Sf9 cells induced by the expression of a microtubule-associated protein 2C-like construct.

1993 • 52 citations

The Role of GSK3β in Regulating Neuronal Differentiation inXenopus laevis

1998 • 51 citations

MAP2a, an Alternatively Spliced Variant of Microtubule‐Associated Protein 2

1996 • 51 citations

Cytoskeletal involvement in neuronal learning: a review

1994 • 51 citations

Alterations in hippocampal non-phosphorylated MAP2 protein expression in schizophrenia

1997 • 50 citations

Isolation and chromosomal mapping of human glycogen synthase kinase-3 α and -3β encoding genes

1998 • 50 citations

Specificity in signaling pathways: assembly into multimolecular signaling complexes

1998 • 49 citations

Domain structure and antiparallel dimers of microtubule-associated protein 2 (MAP2)

1992 • 48 citations

Quantitation and characterization of the microtubule associated MAP2 in porcine tissues and its isolation from porcine (PK15) and human (HeLa) cell lines

1982 • 48 citations

Expression of Various Microtubule‐Associated Protein 2 Forms in the Developing Mouse Brain and in Cultured Neurons and Astrocytes

1991 • 47 citations

Regulation of a site-specific phosphorylation of the microtubule-associated protein 2 during the development of cultured neurons

1998 • 47 citations

Glycogen synthase kinase 3 phosphorylates recombinant human tau protein at serine‐262 in the presence of heparin (or tubulin)

1995 • 47 citations

Experience-Dependent Modifications in MAP2 Phosphorylation in Rat Olfactory Bulb

1997 • 47 citations

Nonuniform Microtubular Polarity Established by CHO1/MKLP1 Motor Protein Is Necessary for Process Formation of Podocytes

1998 • 46 citations

MAP2 phosphorylation parallels dendrite arborization in hippocampal neurones in culture

1993 • 46 citations

Neuronal damage and MAP2 changes induced by the glutamate transport inhibitor dihydrokainate and by kainate in rat hippocampus in vivo

1997 • 46 citations

Protein phosphatases: structures and implications.

1997 • 45 citations

Developmental regulation of MAP2 variants during neuronal differentiation in vitro

1995 • 44 citations

Early forms of microtubule-associated protein are strongly expressed in cortical dysplasia

1998 • 43 citations

Juvenile and mature MAP2 isoforms induce distinct patterns of process outgrowth.

1996 • 43 citations

Microtubule‐associated protein function: Lessons from expression in spodoptera frugiperda cells

1994 • 43 citations

Expression of a minus-end-directed motor protein induces Sf9 cells to form axon-like processes with uniform microtubule polarity orientation

1997 • 42 citations

N-methyl-d-aspartate stimulates the dephosphorylation of the microtubule-associated protein 2 and potentiates excitatory synaptic pathways in the rat hippocampus

1993 • 42 citations

Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions

1997 • 42 citations

Pieces of the Schizophrenia Puzzle Fall into Place

1996 • 42 citations

Interactions of Microtubule-Associated Protein MAP2 with Unpolymerized and Polymerized Tubulin and Actin Using a 96-Well Microtiter Plate Solid-Phase Immunoassay

1994 • 42 citations

Expression of the mitotic motor protein CHO1/MKLP1 in postmitotic neurons

1998 • 41 citations

Microtubule protein ADP-ribosylation in vitro leads to assembly inhibition and rapid depolymerization

1992 • 41 citations

Regulation of the interaction of actin filaments with microtubule-associated protein 2 by calmodulin-dependent protein kinase II

1988 • 40 citations

Kinase and phosphatase inhibitors cause rapid alterations in microtubule dynamic instability in living cells

1997 • 40 citations

NMDA and Nitric Oxide Increase Microtubule‐Associated Protein 2 Gene Expression in Hippocampal Granule Cells

1994 • 40 citations

The Difference in the Binding of Phosphatidylinositol Distinguishes MAP2 from MAP2C and Tau

1994 • 40 citations

mRNA distribution within dendrites: Relationship to afferent innervation

1995 • 39 citations

Mitogen-Activated Protein Kinase and Cytoskeleton in Mitogenic Signal Transduction

1992 • 39 citations

The Protein Phosphatase Inhibitor Okadaic Acid Induces Heat Shock Protein Expression and Neurodegeneration in Rat Hippocampusin Vivo

1998 • 39 citations

Pavlovian conditioning alters cortical microtubule-associated protein-2

1994 • 39 citations

A Microtubule-associated Protein (MAP2) Kinase Restores Microtubule Motility in Embryonic Brain

1995 • 39 citations

Long-term alcohol self-administration and alcohol withdrawal differentially modulate microtubule-associated protein 2 (MAP2) gene expression in the rat brain

1998 • 39 citations

The mechanism of equilibrium binding of microtubule-associated protein 2 to microtubules. Binding is a multi-phasic process and exhibits positive cooperativity

1993 • 39 citations

An Increase in Phosphorylation of Microtubule‐associated Protein 2 Accompanies Dendrite Extension During the Differentiation of Cultured Hippocampal Neurones

1995 • 38 citations

Microtubule Function in Morphological Differentiation: Growth Zones and Growth Cones

1997 • 38 citations

Localization of the Phosphorylation Sites for Different Kinases in the Microtubule‐Associated Protein MAP₂

1987 • 38 citations

The low molecular weight form of microtubule-associated protein 2 is transported into both axons and dendrites

1993 • 37 citations

Changes in mRNA abundance of microtubule-associated proteins in the rat brain following electroconvulsive shock

1998 • 37 citations

Effect of MAP2, MAP2c, and tau on kinesin-dependent microtubule motility

1991 • 37 citations

Stabilization and bundling of subtilisin-treated microtubules induced by microtubule associated proteins

1995 • 36 citations

Transgenic Expression of Embryonic MAP2 in Adult Mouse Brain: Implications for Neuronal Polarization

1996 • 36 citations

Microtubule destabilization by cdc2/H1 histone kinase: Phosphorylation of a “Pro-rich region” in the microtubule-binding domain of MAP-4

1991 • 36 citations

Pixel-based image analysis of HSP70, GADD45 and MAP2 mRNA expression after focal cerebral ischemia: hemodynamic and histological correlates

1998 • 35 citations

Neuronal polarity: targeting of microtubule components into axons and dendrites

1991 • 35 citations

Upregulation of nuclear GM1 accompanies axon-like, but not dendrite-like, outgrowth in NG108-15 cells

1999 • 34 citations

Molecular and functional characteristics of MAP-2a: Ability of MAP-2a versus MAP-2b to induce stable microtubules in COS cells

1998 • 34 citations

Hyperammonemia decreases protein‐kinase‐C‐dependent phosphorylation of microtubule‐associated protein 2 and increases its binding to tubulin

1993 • 34 citations

Glutamate modulation of dendrite outgrowth: Alterations in the distribution of dendritic microtubules

1998 • 34 citations

Mutual protection of microtubule-associated protein 2 (MAP2) and cyclic AMP-dependent protein kinase II against ?-calpain

1996 • 34 citations

Effect of excitatory amino acids on microtubule-associated proteins in cultured cortical and spinal neurones

1990 • 33 citations

Microtubule-associated protein-2 in the rat testis: a novel site of expression

1996 • 33 citations

Calpain and calpastatin in porcine retina. Identification and action on microtubule-associated proteins

1984 • 33 citations

The juvenile microtubule-associated protein MAP2c is a rod-like molecule that forms antiparallel dimers.

1992 • 33 citations

Differential localization of the high- and low-molecular weight variants of MAP2 in the developing retina

1988 • 32 citations

Organization of Pyramidal Cell Apical Dendrites and Composition of Dendritic Clusters in the Mouse: Emphasis on Primary Motor Cortex

1997 • 32 citations

Microtubulebundling studies revisited: is there a role for MAPs?

1992 • 32 citations

Functional analysis of the MAP2 repeat domain

1996 • 31 citations

Immunohistochemical localization of protein phosphatase isoforms in the rat cerebellum

1995 • 31 citations

Phosphorylation of microtubule-associated protein-2 in GH3 cells. Regulation by cAMP and by calcium.

1991 • 31 citations

Modulation of microtubule assembly and stability by phosphatidylinositol action on microtubule-associated protein-2.

1987 • 31 citations

Ethanol induces MAP2 changes in organotypic hippocampal slice cultures

1998 • 31 citations

A new model for microtubule‐associated protein (MAP)‐induced microtubule assembly

1999 • 31 citations

cdc2 kinase-induced destabilization of map2-coated microtubules in Xenopus egg extracts

1992 • 31 citations

Differential phosphorylation of some proteins of the neuronal cytoskeleton during brain development

1992 • 31 citations

Serine/threonine kinases in the nervous system

1991 • 30 citations

Structure, regional and developmental expression of rat MAP2d, a MAP2 splice variant encoding four microtubule-binding domains

1994 • 30 citations

Calcineurin in the adult rat hippocampus: different distribution in CA1 and CA3 subfields

1997 • 30 citations

Human Microtubule‐Associated Protein‐2c Localizes to Dendrites and Axons in Fetal Spinal Motor Neurons

1995 • 30 citations

Cytoskeletal mechanisms of axon outgrowth and pathfinding

1998 • 30 citations

MAP2d promotes bundling and stabilization of both microtubules and microfilaments

1996 • 29 citations

Variations in in vivo phosphorylation at the proline-rich domain of the microtubule-associated protein 2 (MAP2) during rat brain development

1995 • 29 citations

Neuronal Cell Death and Repair

1993 • 28 citations

Time course of protein changes following in vitro ischemia in the rat hippocampal slice

1995 • 27 citations

Bundling of microtubules in transfected cells does not involve an autonomous dimerization site on the MAP2 molecule.

1994 • 27 citations

Localization of Specific Epitopes on Human Microtubule‐Associated Protein 2

1994 • 27 citations

Effects of long-term treatment with desipramine on microtubule proteins in rat cerebral cortex

1997 • 27 citations

Specific Binding of Acidic Phospholipids to Microtubule-associated Protein MAP1B Regulates Its Interaction with Tubulin

1997 • 27 citations

The Ganglioside GM1 Enhances Microtubule Networks and Changes the Morphology of Neuro-2a Cellsin Vitroby Altering the Distribution of MAP2

1996 • 26 citations

Regulation of microtubule-associated protein 2 (MAP2) mRNA expression during rat brain development

1989 • 26 citations

Phosphorylation of microtubule-associated protein 2 by map kinase primarily involves the projection domain

1989 • 26 citations

Molecular characterization of dendritically localized transcripts encoding MAP2

1996 • 25 citations

Microtubule‐associated protein autophosphorylation alters in vitro microtubule dynamic instability

1992 • 25 citations

NMDA-glutamate receptors regulate phosphorylation of dendritic cytoskeletal proteins in the hippocampus

1997 • 25 citations

Stimulation of microtubule dynamic turnover in living cells treated with okadaic acid

1996 • 25 citations

Role of the cytoskeleton in growth cone motility and axonal elongation

1996 • 24 citations

Reexpression of Developmentally Regulated MAP2c mRNA after Ischemia: Colocalization with hsp72 mRNA in Vulnerable Neurons

1995 • 24 citations

On the identity of the major postsynaptic density protein.

1992 • 24 citations

Okadaic Acid Induces Hyperphosphorylation of τ Independently of Mitogen‐Activated Protein Kinase Activation

1997 • 22 citations

Postnatal changes in serine/threonine protein phosphatases and their association with the microtubules

1995 • 21 citations

Differential expression of microtubule-associated protein 1B phosphorylated isoforms in the adult rat nervous system

1997 • 21 citations

Reduction in Microtubule Dynamics In Vitro by Brain Microtubule-Associated Proteins and by a Microtubule-Associated Protein-2 Second Repeated Sequence Analogue

1993 • 21 citations

Association of p34cdc2 kinase and MAP kinase with microtubules during the meiotic maturation of Xenopus oocytes.

1994 • 21 citations

Microtubule-associated protein-2 in the hypothalamo-neurohypophysial system: low-molecular-weight microtubule-associated protein-2 in pituitary astrocytes

1999 • 21 citations

Tau-mediated process outgrowth is differentially altered by the expression of MAP2b and MAP2c in Sf9 cells

1999 • 20 citations

Probing modifications of the neuronal cytoskeleton

1993 • 20 citations

Disruption by Lithium of Phosphoinositide Signalling in Cerebellar Granule Cells in Primary Culture

1998 • 20 citations

High External Potassium Induces an Increase in the Phosphorylation of the Cytoskeletal Protein MAP2 in Rat Hippocampal Slices

1993 • 19 citations

Correspondence

1997 • 18 citations

Differential interactions of MAP2, tau and MAP5 during axogenesis in culture

1998 • 18 citations

Ganglioside GM1 alters neuronal morphology by modulating the association of MAP2 with microtubules and actin filaments

1998 • 18 citations

MAP2d mRNA is expressed in identified neuronal populations in the developing and adult rat brain and its subcellular distribution differs from that of MAP2b in hippocampal neurones

1998 • 18 citations

Polarity orientation and assembly process of microtubule bundles in nocodazole-treated, MAP2c-transfected COS cells.

1995 • 17 citations

Effects of hyperammonemia on brain protein kinase C substrates

1996 • 17 citations

Phosphatidylinositol inhibits microtubule assembly by binding to microtubule-associated protein 2 at a single, specific, high-affinity site

1992 • 17 citations

MAP2‐mediated binding of chromaffin granules to microtubules

1991 • 16 citations

A brain phosphatase with specificity for microtubule-associated protein-2.

1986 • 16 citations

Downregulation of glycogen synthase kinase-3β (GSK-3β) protein expression during neuroblastoma IMR-32 cell differentiation

1999 • 16 citations

Dark-rearing changes dendritic microtubule-associated protein 2 (MAP2) but not subplate neurons in cat visual cortex

1995 • 15 citations

The characterization of phospholipids associated with microtubules, purified tubulin and microtubule associated proteins in vitro

1988 • 15 citations

Four repeat MAP2 isoforms in human and rat brain

1994 • 15 citations

Expression of Microtubule‐Associated Protein‐2a and Other Novel Microtubule‐Associated Protein‐2 Transcripts in Human Fetal Spinal Cord

1997 • 15 citations

Expression of low molecular weight isoforms of microtubule-associated protein 2. Phosphorylation and induction of microtubule assembly in vitro

1994 • 14 citations

Distribution and Subcellular Localization of High‐Molecular‐Weight Microtubule‐Associated Protein‐2 Expressing Exon 8 in Brain and Spinal Cord

1997 • 14 citations

Chromatographic Resolution and Characterization of a Nerve Growth Factor‐Dependent Kinase That Phosphorylates Microtubule‐Associated Proteins 1 and 2 in PC12 Cells

1992 • 10 citations

Rapid dephosphorylation of microtubule‐associated protein 2 in the rat brain hippocampus after pentylenetetrazole‐induced seizures

1993 • 10 citations

The effects of quisqualate and nocodazole on the organization of MAP2 and neurofilaments in spinal cord neurons in vitro

1991 • 9 citations

The phosphatidylinositol-binding site of microtubule-associated protein MAP2

1995 • 9 citations

τ and Microtubule‐Associated Protein 2c Transfection and Neurite Outgrowth in ND 7/23 Cells

1995 • 9 citations

New forms of HMW MAP2 are preferentially expressed in the spinal cord

1996 • 9 citations

Estramustine phosphate but not estramustine inhibits the interaction of microtubule associated protein 2 (MAP2) with actin filaments

1997 • 8 citations

Neuronal cytoskeleton and growth

1992 • 8 citations

A novel 24‐kDa microtubule‐associated protein purified from sea urchin eggs

1992 • 6 citations

Tau protein kinases

1992 • 6 citations

Phosphorylation of MAP‐2 at Distinct Sites by Calmodulin‐ and Cyclic AMP‐Dependent Kinases

1986 • 6 citations

Cellular expression of MAP 2 kinase in rat brain

1996 • 5 citations

Cytochemical polarity in lateral geniculate interneurons

1994 • 4 citations

The susceptibility of MAP-2 to proteolytic degradation increases when bound to tubulin

1992 • 4 citations

The microtubule cytoskeleton in neuronal development and degeneration

1993 • 3 citations

Factors regulating organelles transport along microtubules.

1996 • 3 citations