Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro: Real-time observations using video microscopy

Dynamic instability of microtubule growth

1984 • 3,187 citations

Intracellular transport in neurons.

1980 • 1,011 citations

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.

1988 • 985 citations

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

1977 • 878 citations

Microtubule assembly nucleated by isolated centrosomes

1984 • 775 citations

Tau protein function in living cells.

1986 • 727 citations

Microtubule-Associated Proteins

1986 • 559 citations

Visualization of the dynamic instability of individual microtubules by dark-field microscopy

1986 • 547 citations

Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study.

1991 • 544 citations

Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro.

1975 • 535 citations

The periodic association of MAP2 with brain microtubules in vitro.

1979 • 510 citations

Tubulin dynamics in cultured mammalian cells.

1984 • 489 citations

Microtubule-Associated Protein MAP2 Shares a Microtubule Binding Motif with Tau Protein

1988 • 476 citations

Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts

1990 • 444 citations

Microtubule-associated proteins and the stimulation of tubulin assembly in vitro

1976 • 434 citations

Real-time observations of microtubule dynamic instability in living cells.

1988 • 364 citations

Tau proteins: the molecular structure and mode of binding on microtubules.

1988 • 363 citations

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

1989 • 354 citations

Microtubule behavior in the growth cones of living neurons during axon elongation.

1991 • 343 citations

Microtubule dynamics in interphase cells.

1986 • 331 citations

Direct observation of microtubule dynamics in living cells

1988 • 318 citations

Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau

1989 • 281 citations

Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly.

1980 • 279 citations

Assembly of microtubules at the tip of growing axons

1986 • 277 citations

Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues

1978 • 253 citations

Role of tubulin-associated proteins in microtubule nucleation and elongation

1977 • 225 citations

Common and distinct tubulin binding sites for microtubule-associated proteins.

1986 • 216 citations

COLCHICINE INHIBITION OF NERVE FIBER FORMATION IN VITRO

1972 • 210 citations

Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells.

1991 • 200 citations

MOTOR PROTEINS OF CYTOPLASMIC MICROTUBULES

1990 • 196 citations

New features of microtubule behaviour observed in vivo

1988 • 191 citations

A Miniature Flow Cell Designed for Rapid Exchange of Media Under High-power Microscope Objectives

1984 • 189 citations

Identity and polymerization-stimulatory activity of the nontubulin proteins associated with microtubules

1977 • 184 citations

Microtubule assembly using the microtubule‐associated protein MAP‐2 prepared in defined states of phosphorylation with protein kinase and phosphatase

1983 • 163 citations

Dynamic instability of microtubules

1987 • 162 citations

Modification of microtubule steady-state dynamics by phosphorylation of the microtubule-associated proteins.

1981 • 160 citations

Dilution of individual microtubules observed in real time in vitro: evidence that cap size is small and independent of elongation rate.

1991 • 153 citations

Asymmetric behavior of severed microtubule ends after ultraviolet-microbeam irradiation of individual microtubules in vitro.

1989 • 144 citations

Polymerization of tubulin in vivo: direct evidence for assembly onto microtubule ends and from centrosomes.

1985 • 142 citations

Electron microscopy of map 2 (microtubule-associated protein 2)

1982 • 135 citations

Decoration and stabilization of intact, smooth-walled microtubules with microtubule-associated proteins

1979 • 130 citations

Microtubule dynamics in nerve cells: analysis using microinjection of biotinylated tubulin into PC12 cells.

1988 • 125 citations

Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue.

1992 • 118 citations

GTP hydrolysis during microtubule assembly

1987 • 117 citations

Head-to-tail polymerization of microtubules in vitro

1981 • 115 citations

Low molecular weight microtubule-associated proteins are light chains of microtubule-associated protein 1 (MAP 1).

1983 • 112 citations

The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2: tubulin interaction

1984 • 112 citations

Analysis of the treadmilling model during metaphase of mitosis using fluorescence redistribution after photobleaching.

1986 • 106 citations

Dynamics of microtubules visualized by darkfield microscopy: Treadmilling and dynamic instability

1988 • 101 citations

Phase dynamics at microtubule ends: the coexistence of microtubule length changes and treadmilling

1987 • 99 citations

Effects of brain microtubule‐associated proteins on microtubule dynamics and the nucleating activity of centrosomes

1990 • 96 citations

The structure of microtubule ends during the elongation and shortening phases of dynamic instability examined by negative-stain electron microscopy

1990 • 94 citations

Chapter 23 Preparation and Purification of Dynein

1982 • 82 citations

Generation of microtubule stability subclasses by microtubule-associated proteins: implications for the microtubule "dynamic instability" model.

1985 • 81 citations

Effects of magnesium on the dynamic instability of individual microtubules

1990 • 81 citations

Role of GTP hydrolysis in microtubule polymerization: evidence for a coupled hydrolysis mechanism

1990 • 81 citations

Dynamics of the microtubule oscillator: role of nucleotides and tubulin-MAP interactions.

1988 • 78 citations

Microtubule dynamics

1992 • 75 citations

Buffer conditions and non‐tubulin factors critically affect the microtubule dynamic instability of sea urchin egg tubulin

1992 • 56 citations

Cell cycle-dependent changes in the dynamics of MAP 2 and MAP 4 in cultured cells.

1989 • 52 citations

A comparative study of the in vitro polymerization of tubulin in the presence of the microtubule-associated proteins MAP2 and tau.

1981 • 51 citations

Oscillations in microtubule polymerization: the rate of GTP regeneration on tubulin controls the period.

1988 • 50 citations

Dynamic interactions of fluorescently labeled microtubule-associated proteins in living cells.

1984 • 49 citations

Polarized microtubule gliding and particle saltations produced by soluble factors from sea urchin eggs and embryos

1986 • 42 citations

Chapter 6 Techniques for Observing Living Gametes and Embryos

1986 • 38 citations

Video-enhanced differential interference contrast light microscopy.

1989 • 35 citations

Dynamic instability of native microtubules from squid axons is rare and independent of gliding and vesicle transport

1988 • 19 citations