Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization

1999 • 2,159 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α

1998 • 759 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

The oncogenic activation of β-catenin

1999 • 655 citations

Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover

2000 • 472 citations

Regulation of protein transport to the nucleus: central role of phosphorylation

1996 • 429 citations

Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A

1999 • 423 citations

The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen.

1991 • 351 citations

The APC tumour suppressor has a nuclear export function

2000 • 348 citations

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

1994 • 319 citations

Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

1998 • 302 citations

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

1998 • 258 citations

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

1999 • 237 citations

p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins.

1991 • 203 citations

Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase

1995 • 161 citations

Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

2000 • 160 citations

Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium.

1996 • 142 citations

The localization of porcine reproductive and respiratory syndrome virus nucleocapsid protein to the nucleolus of infected cells and identification of a potential nucleolar localization signal sequence

1999 • 128 citations

Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein

1997 • 124 citations

Cyclin-dependent Kinase Site-regulated Signal-dependent Nuclear Localization of the SWI5 Yeast Transcription Factor in Mammalian Cells

1995 • 100 citations

Negative charge at the casein kinase II site flanking the nuclear localization signal of the SV40 large T-antigen is mechanistically important for enhanced nuclear import.

1994 • 94 citations

Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin.

1995 • 86 citations

Phosphorylation of the Tumor Suppressor Adenomatous Polyposis Coli (APC) by the Cyclin-dependent Kinase p34

1997 • 66 citations

Membrane-anchored Plakoglobins Have Multiple Mechanisms of Action in Wnt Signaling

1999 • 54 citations

The APC protein binds to A/T rich DNA sequences

1999 • 47 citations

Suppression of the malignant phenotype of human prostate cancer cell line PPC-1 by introduction of normal fragments of human chromosome 10.

1996 • 35 citations

Pattern Formation on Cardiac Troponin I by Consecutive Phosphorylation and Dephosphorylation

1995 • 29 citations

Pattern Formation on Cardiac Troponin I by Consecutive Phosphorylation and Dephosphorylation

1995 • 21 citations

Phosphorylation of the Adenomatous Polyposis Coli Protein and Its Possible Regulatory Effects in Cells

1995 • 13 citations

Site-Directed Mutagenesis Using a PCR-Based Staggered Re-annealing Method Without Restriction Enzymes

1997 • 11 citations

Family of Plasmid Vectors for the Expression of β- galactosidase Fusion Proteins in Eukaryotic Cells

1997 • 10 citations