Actomyosin-based Retrograde Flow of Microtubules in the Lamella of Migrating Epithelial Cells Influences Microtubule Dynamic Instability and Turnover and Is Associated with Microtubule Breakage and Treadmilling

Dynamic instability of microtubule growth

1984 • 3,187 citations

Effects of cytochalasin and phalloidin on actin.

1987 • 1,989 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

Beyond self-assembly: From microtubules to morphogenesis

1986 • 1,334 citations

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.

1988 • 985 citations

Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone.

1988 • 851 citations

Actin microfilament dynamics in locomoting cells

1991 • 789 citations

Microtubule assembly nucleated by isolated centrosomes

1984 • 775 citations

[39] Preparation of modified tubulins

1991 • 724 citations

Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules

1996 • 651 citations

Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling.

1985 • 637 citations

Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence.

1989 • 603 citations

XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly

1996 • 539 citations

Microtubule nucleation by γ-tubulin-containing rings in the centrosome

1995 • 530 citations

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1996 • 494 citations

Identification of katanin, an ATPase that severs and disassembles stable microtubules

1993 • 490 citations

Tubulin dynamics in cultured mammalian cells.

1984 • 489 citations

Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells.

1990 • 488 citations

Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

1997 • 451 citations

Myosin Drives Retrograde F-Actin Flow in Neuronal Growth Cones

1996 • 403 citations

Growth cone advance is inversely proportional to retrograde F-actin flow

1995 • 371 citations

Real-time observations of microtubule dynamic instability in living cells.

1988 • 364 citations

The role of microtubule dynamics in growth cone motility and axonal growth.

1995 • 362 citations

Unconventional Myosins

1995 • 362 citations

Evidence for actin filament-microtubule interaction mediated by microtubule-associated proteins

1978 • 346 citations

Microtubule behavior in the growth cones of living neurons during axon elongation.

1991 • 343 citations

Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments.

1983 • 319 citations

Direct observation of microtubule dynamics in living cells

1988 • 318 citations

Cytoplasmic microtubules in normal and transformed cells in culture: analysis by tubulin antibody immunofluorescence.

1975 • 307 citations

Myosin is involved in postmitotic cell spreading.

1995 • 306 citations

Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity.

1992 • 305 citations

Effect of colcemid on the locomotory behaviour of fibroblasts

1970 • 296 citations

Control of actin polymerization in live and permeabilized fibroblasts.

1991 • 289 citations

Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis.

1981 • 263 citations

Cytoplasmic microtubules and their functions

1974 • 254 citations

Microtubule release from the centrosome

1997 • 252 citations

Microtubule Severing by Elongation Factor 1α

1994 • 252 citations

The interaction of actin filaments with microtubules and microtubule-associated proteins.

1982 • 246 citations

Persistent, directional motility of cells and cytoplasmic fragments in the absence of microtubules

1984 • 244 citations

Actin filament organization in the fish keratocyte lamellipodium.

1995 • 236 citations

Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: Implications for the role of dynamic microtubules in cell locomotion

1995 • 218 citations

The actin cytoskeleton

1988 • 218 citations

Effect of 2,3-butanedione monoxime on myosin and myofibrillar ATPases. An example of an uncompetitive inhibitor

1992 • 206 citations

Control of microtubule nucleation and stability in Madin-Darby canine kidney cells: the occurrence of noncentrosomal, stable detyrosinated microtubules.

1987 • 199 citations

Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific.

1993 • 197 citations

Contractile systems in non-muscle tissues

1977 • 193 citations

Polarity and nucleation of microtubules in polarized epithelial cells

1995 • 192 citations

New features of microtubule behaviour observed in vivo

1988 • 191 citations

The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work.

1996 • 188 citations

Cytoskeletal reorganization underlying growth cone motility

1994 • 169 citations

Microtubule Treadmilling in Vivo

1997 • 159 citations

Tubulin assembly sites and the organization of cytoplasmic microtubules in cultured mammalian cells.

1981 • 154 citations

Microtubule assembly in cytoplasmic extracts of Xenopus oocytes and eggs.

1987 • 153 citations

Comparison of actin and cell surface dynamics in motile fibroblasts.

1992 • 146 citations

Actin dynamics in growth cones

1991 • 145 citations

Asymmetric behavior of severed microtubule ends after ultraviolet-microbeam irradiation of individual microtubules in vitro.

1989 • 144 citations

Polymerization of tubulin in vivo: direct evidence for assembly onto microtubule ends and from centrosomes.

1985 • 142 citations

Fluorescent microtubules break up under illumination.

1988 • 139 citations

Cell locomotion: New research tests old ldeas on membrane and cytoskeletal flow

1991 • 133 citations

Polarity of some motility-related microtubules.

1981 • 132 citations

Microtubule nucleation and release from the neuronal centrosome

1993 • 128 citations

Distribution of tubulin-containing structures in the egg of the sea urchin Strongylocentrotus purpuratus from fertilization through first cleavage.

1980 • 125 citations

Microtubule dynamics in vivo: a test of mechanisms of turnover.

1987 • 120 citations

Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue.

1992 • 118 citations

Self-centring activity of cytoplasm

1997 • 113 citations

Pathways of spindle assembly

1997 • 110 citations

Microtubule structure and dynamics

1997 • 108 citations

A Metastable Intermediate State of Microtubule Dynamic Instability That Differs Significantly between Plus and Minus Ends

1997 • 107 citations

Dynamics of organelles in the mitotic spindles of living cells: Membrane and microtubule interactions

1993 • 105 citations

Microtubule dynamics: Treadmilling comes around again

1997 • 103 citations

Microtubules are stabilized in confluent epithelial cells but not in fibroblasts.

1990 • 103 citations

How the transition frequencies of microtubule dynamic instability (nucleation, catastrophe, and rescue) regulate microtubule dynamics in interphase and mitosis: analysis using a Monte Carlo computer simulation.

1993 • 95 citations

How Tubulin Subunits Are Lost from the Shortening Ends of Microtubules

1997 • 92 citations

Incorporation and turnover of biotin-labeled actin microinjected into fibroblastic cells: an immunoelectron microscopic study.

1989 • 91 citations

Newt Lung Epithelial Cells: Cultivation, Use, and Advantages for Biomedical Research

1990 • 88 citations

Interactions among endoplasmic reticulum, microtubules, and retrograde movements of the cell surface

1994 • 82 citations

Microtubule dynamics in fish melanophores.

1994 • 76 citations

Imaging green fluorescent protein fusion proteins in Saccharomyces cerevisiae

1997 • 71 citations

Interaction of Actin Filaments with Microtubules Is Mediated by Microtubule‐Associated Proteins and Regulated by Phosphorylationa

1986 • 63 citations

Reorganization of microtubules during mitosis in Dictyostelium: Dissociation from MTOC and selective assembly/disassembly in situ

1987 • 63 citations

Centripetal transport of microtubules in motile cells

1995 • 63 citations

Cytoarchitecture of size-excluding compartments in living cells

1993 • 62 citations

A novel homo-oligomeric protein responsible for an MPF-dependent microtubule-severing activity.

1992 • 51 citations

Detection of single fluorescent microtubules and methods for determining their dynamics in living cells

1988 • 51 citations

Dual action of 2,3-butanedione monoxime (BDM) on K+ current in human T lymphocytes.

1992 • 35 citations

Microtubule detachment from the microtubule-organizing center as a key event in the complete turnover of microtubules in cells.

1990 • 34 citations

High Resolution Multimode Digital Imaging System for Mitosis Studies In Vivo and In Vitro

1994 • 31 citations

2,3-Butanedione 2-Monoxime (BDM) Induces Calcium Release from Canine Cardiac Sarcoplasmic Reticulum

1996 • 28 citations

A High Resolution Multimode Digital Imaging System for Fluorescence Studies of Mitosis

1996 • 5 citations

Inhibition by 2,3-butanedione-monoxime of mitochondrial ADP-dependent respiration and muscle contraction.

1993 • 5 citations