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Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

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Living with Water Stress: Evolution of Osmolyte Systems

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Two-Component Signal Transduction

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Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

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Signaling Through Scaffold, Anchoring, and Adaptor Proteins

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1991 • 1,937 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

The Transcriptional Program of Sporulation in Budding Yeast

1998 • 1,876 citations

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

Molecular evidence for an ancient duplication of the entire yeast genome

1997 • 1,786 citations

Genome-Wide Location and Function of DNA Binding Proteins

2000 • 1,720 citations

Structural determinants of water permeation through aquaporin-1

2000 • 1,710 citations

Dissecting the Regulatory Circuitry of a Eukaryotic Genome

1998 • 1,660 citations

The extended protein kinase C superfamily

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Preservation of Membranes in Anhydrobiotic Organisms: The Role of Trehalose

1984 • 1,457 citations

THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

1998 • 1,446 citations

Remodeling of Yeast Genome Expression in Response to Environmental Changes

2001 • 1,366 citations

Calcineurin: Form and Function

2000 • 1,336 citations

The AMP‐Activated Protein Kinase

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An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

Yeast Carbon Catabolite Repression

1998 • 1,245 citations

Anhydrobiosis

1992 • 1,184 citations

Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF

2001 • 1,101 citations

Tailoring wine yeast for the new millennium: novel approaches to the ancient art of winemaking

2000 • 1,092 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

Uptake and synthesis of compatible solutes as microbial stress responses to high-osmolality environments

1998 • 1,061 citations

The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE).

1996 • 1,050 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Structure of a Glycerol-Conducting Channel and the Basis for Its Selectivity

2000 • 980 citations

Two-component circuitry in Arabidopsis cytokinin signal transduction

2001 • 948 citations

MAP Kinase Pathways in the Yeast Saccharomyces cerevisiae

1998 • 939 citations

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

1999 • 918 citations

Signal Transduction Cascades Regulating Fungal Development and Virulence

2000 • 913 citations

Yeast HOG1 MAP Kinase Cascade Is Regulated by a Multistep Phosphorelay Mechanism in the SLN1–YPD1–SSK1 “Two-Component” Osmosensor

1996 • 876 citations

Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles

2000 • 867 citations

Cellular and Molecular Biology of the Aquaporin Water Channels

1999 • 823 citations

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

2000 • 796 citations

PROKARYOTIC OSMOREGULATION: Genetics and Physiology

1991 • 779 citations

Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity

1998 • 759 citations

Microbial water stress

1976 • 742 citations

Oxidative stress responses of the yeastSaccharomyces cerevisiae

1998 • 735 citations

The Complete Set of Genes Encoding Major Intrinsic Proteins in Arabidopsis Provides a Framework for a New Nomenclature for Major Intrinsic Proteins in Plants

2001 • 730 citations

TOR controls translation initiation and early G1 progression in yeast.

1996 • 728 citations

Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity

1999 • 701 citations

Structure and function of aquaporin water channels

2000 • 699 citations

Multiple Effects of Trehalose on Protein Folding In Vitro and In Vivo

1998 • 688 citations

Roles of the Glutathione- and Thioredoxin-Dependent Reduction Systems in the Escherichia Coli and Saccharomyces Cerevisiae Responses to Oxidative Stress

2000 • 681 citations

Novel sensing mechanisms and targets for the cAMP–protein kinase A pathway in the yeast Saccharomyces cerevisiae

1999 • 660 citations

Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis

1997 • 654 citations

Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor

1995 • 649 citations

GPD1, Which Encodes Glycerol-3-Phosphate Dehydrogenase, Is Essential for Growth under Osmotic Stress in Saccharomyces cerevisiae, and Its Expression Is Regulated by the High-Osmolarity Glycerol Response Pathway

1994 • 630 citations

Handbook of Food Preservation

2020 • 630 citations

Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth.

1994 • 616 citations

Aquaporins Constitute a Large and Highly Divergent Protein Family in Maize

2001 • 616 citations

The Ste20 group kinases as regulators of MAP kinase cascades

2001 • 606 citations

Osmosensing by Bacteria: Signals and Membrane-Based Sensors

1999 • 605 citations

Polarization of cell growth in yeast II. The role of the cortical actin cytoskeleton

2000 • 603 citations

Biochemistry, cell biology and molecular biology of lipids ofSaccharomyces cerevisiae

1998 • 601 citations

The target of rapamycin (TOR) proteins

2001 • 595 citations

The TOR signaling cascade regulates gene expression in response to nutrients

1999 • 593 citations

Yeast Stress Responses

2002 • 592 citations

Stress-controlled transcription factors, stress-induced genes and stress tolerance in budding yeast

2000 • 580 citations

Glucose repression in yeast

1999 • 573 citations

The GAF domain: an evolutionary link between diverse phototransducing proteins

1997 • 572 citations

Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK

1997 • 569 citations

Network dynamics and cell physiology

2001 • 564 citations

The H2O2 Stimulon in Saccharomyces cerevisiae

1998 • 564 citations

Review: Cell wall assembly in yeast

1994 • 551 citations

Yap1 and Skn7 Control Two Specialized Oxidative Stress Response Regulons in Yeast

1999 • 548 citations

Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity

1999 • 546 citations

Hsp104 is required for tolerance to many forms of stress.

1992 • 546 citations

The Transcriptional Response of Saccharomyces cerevisiae to Osmotic Shock

2000 • 546 citations

A Transmembrane Hybrid-Type Histidine Kinase in Arabidopsis Functions as an Osmosensor

1999 • 543 citations

Reserve carbohydrates metabolism in the yeastSaccharomyces cerevisiae

2001 • 541 citations

Large-scale analysis of the yeast genome by transposon tagging and gene disruption

1999 • 536 citations

Translational Regulation of Yeast GCN4

1997 • 533 citations

The two isoenzymes for yeast NAD⁺-dependent glycerol 3-phosphate dehydrogenase encoded byGPD1andGPD2have distinct roles in osmoadaptation and redox regulation

1997 • 528 citations

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

1999 • 526 citations

Latrunculin alters the actin-monomer subunit interface to prevent polymerization

2000 • 517 citations

Phenotypic analysis of temperature-sensitive yeast actin mutants

1985 • 512 citations

The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene.

1994 • 511 citations

H2O2 sensing through oxidation of the Yap1 transcription factor

2000 • 507 citations

The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.

1995 • 498 citations

Potassium transport in fungi and plants

2000 • 497 citations

Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.

1994 • 495 citations

Rapid gating and anion permeability of an intracellular aquaporin

1999 • 492 citations

Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins.

1990 • 488 citations

Thermotolerance in Saccharomyces cerevisiae: the Yin and Yang of trehalose

1998 • 481 citations

Regulation of trehalose mobilization in fungi

1984 • 480 citations

Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae.

1996 • 476 citations

Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast

1995 • 474 citations

YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides.

1994 • 472 citations

A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions.

1993 • 470 citations

Membrane Mechanisms and Intracellular Signalling in Cell Volume Regulation

1995 • 469 citations

Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

1997 • 460 citations

TOR signalling and control of cell growth

1997 • 458 citations

Integrating the MAP kinase signal into the G1 phase cell cycle machinery

2000 • 458 citations

Glucose repression in fungi

1995 • 451 citations

Highly Hydrophilic Proteins in Prokaryotes and Eukaryotes Are Common during Conditions of Water Deficit

2000 • 449 citations

Physiology of Osmotolerance in Fungi

1992 • 449 citations

Polarization of cell growth in yeast: I. Establishment and maintenance of polarity states

2000 • 441 citations

Identification of Yeast Rho1p GTPase as a Regulatory Subunit of 1,3-β-Glucan Synthase

1996 • 438 citations

Calcineurin acts through theCRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast

1997 • 438 citations

Regulation of yAP-1 nuclear localization in response to oxidative stress

1997 • 437 citations

MAP Kinases with Distinct Inhibitory Functions Impart Signaling Specificity during Yeast Differentiation

1997 • 434 citations

Trehalose synthase: guard to the gate of glycolysis in yeast?

1995 • 432 citations

A Yeast Protein Similar to Bacterial Two-Component Regulators

1993 • 431 citations

Calcineurin Inhibits VCX1-Dependent H⁺/Ca²+ Exchange and Induces Ca²+ ATPases in Saccharomyces cerevisiae

1996 • 431 citations

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.

1992 • 427 citations

Regulation of extracellular matrix gene expression by mechanical stress

1999 • 425 citations

A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle

1990 • 422 citations

Regulation of G Protein–Initiated Signal Transduction in Yeast: Paradigms and Principles

2001 • 421 citations

Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae

1998 • 421 citations

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

1996 • 419 citations

Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress.

1995 • 418 citations

The Transcriptional Response of Yeast to Saline Stress

2000 • 417 citations

Compatible Solutes and Extreme Water Stress in Eukaryotic Micro-Organisms

1978 • 415 citations

Stress signaling in yeast

1995 • 415 citations

Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1

1998 • 414 citations

Genome‐wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway

1999 • 411 citations

Signaling to Rho GTPases

1999 • 411 citations

The molecular genetics of hexose transport in yeasts

1997 • 409 citations

Differential Expression and Function of Two Homologous Subunits of Yeast 1,3-β-D-Glucan Synthase

1995 • 407 citations

The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae

1998 • 400 citations

Water Relations of Sugar-tolerant Yeasts: the Role of Intracellular Polyols

1972 • 399 citations

A glimpse of the mechanisms of ion homeostasis during salt stress

1999 • 393 citations

Plant aquaporins: their molecular biology, biophysics and significance for plant water relations

1999 • 391 citations

The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae

1998 • 386 citations

Signal transduction in yeast

1994 • 385 citations

A Mechanosensitive Ion Channel in the Yeast Plasma Membrane

1988 • 382 citations

The heat shock and ethanol stress responses of yeast exhibit extensive similarity and functional overlap

1995 • 382 citations

Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation

1999 • 382 citations

A Proteome Analysis of the Cadmium Response in Saccharomyces cerevisiae

2001 • 381 citations

The Cell Surface Flocculin Flo11 Is Required for Pseudohyphae Formation and Invasion bySaccharomyces cerevisiae

1998 • 380 citations

The role of trehalose synthesis for the acquisition of thermotolerance in yeast

1994 • 379 citations

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

1994 • 378 citations

Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio

1996 • 375 citations

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect.

1992 • 371 citations

Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane.

1994 • 370 citations

Kinetic Characterization of Individual Hexose Transporters of Saccharomyces Cerevisiae and their Relation to the Triggering Mechanisms of Glucose Repression

1997 • 370 citations

Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

1991 • 369 citations

The role of aquaporins in cellular and whole plant water balance

2000 • 369 citations

The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.

1996 • 365 citations

A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae

1997 • 365 citations

Global gene expression during short‐term ethanol stress in Saccharomyces cerevisiae

2001 • 364 citations

A novel P‐type ATPase from yeast involved in sodium transport

1991 • 362 citations

The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

1994 • 362 citations

Large Scale Identification of Genes Involved in Cell Surface Biosynthesis and Architecture in Saccharomyces cerevisiae

1997 • 360 citations

Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

1995 • 357 citations

Trehalose metabolism in Escherichia coli: stress protection and stress regulation of gene expression

1993 • 356 citations

Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation

1998 • 356 citations

Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

1995 • 356 citations

Salt Tolerance in Plants and Microorganisms: Toxicity Targets and Defense Responses

1996 • 352 citations

Glucose depletion causes haploid invasive growth in yeast

2000 • 351 citations

The gating mechanism of the large mechanosensitive channel MscL

2001 • 350 citations

The TOR Kinases Link Nutrient Sensing to Cell Growth

2001 • 348 citations

A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

1995 • 342 citations

Regulatory Mechanisms for Modulation of Signaling through the Cell Integrity Slt2-mediated Pathway in Saccharomyces cerevisiae

2000 • 337 citations

Role of the Mitogen-Activated Protein Kinase Hog1p in Morphogenesis and Virulence of Candida albicans

1999 • 333 citations

Rho1p, a Yeast Protein at the Interface Between Cell Polarization and Morphogenesis

1996 • 329 citations

Turning genes off by Ssn6–Tup1: a conserved system of transcriptional repression in eukaryotes

2000 • 328 citations

Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression inSaccharomyces cerevisiae

1997 • 328 citations

The protein kinase C‐mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae

1999 • 325 citations

Stress-induced transcriptional activation

1995 • 325 citations

The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae

2001 • 325 citations

Dominant Mutations in a Gene Encoding a Putative Protein Kinase (BCKT) Bypass the Requirement for a Saccharomyces cerevisiae Protein Kinase C Homolog

1992 • 322 citations

Systematic mutational analysis of the yeast ACT1 gene.

1992 • 319 citations

Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae

1997 • 309 citations

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

2001 • 308 citations

Wsc1 and Mid2 Are Cell Surface Sensors for Cell Wall Integrity Signaling That Act through Rom2, a Guanine Nucleotide Exchange Factor for Rho1

2001 • 306 citations

Effects of various types of stress on the metabolism of reserve carbohydrates in Saccharomyces cerevisiae: genetic evidence for a stress-induced recycling of glycogen and trehalose

1997 • 306 citations

MKK1 and MKK2, Which Encode Saccharomyces cerevisiae Mitogen-Activated Protein Kinase-Kinase Homologs, Function in the Pathway Mediated by Protein Kinase C

1993 • 306 citations

Rapid changes of heat and desiccation tolerance correlated with changes of trehalose content in Saccharomyces cerevisiae cells subjected to temperature shifts

1987 • 305 citations

Physiology and Pathophysiology of Renal Aquaporinsa

1999 • 305 citations

The Yeast Phosphatidylinositol Kinase Homolog TOR2 Activates RHO1 and RHO2 via the Exchange Factor ROM2

1997 • 304 citations

Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1

1998 • 304 citations

Osmoregulation in Escherichia coli by accumulation of organic osmolytes: betaines, glutamic acid, and trehalose

1987 • 301 citations

Activation and Regulation of the Spc1 Stress-Activated Protein Kinase in Schizosaccharomyces pombe

1996 • 300 citations

Mother Cell–Specific HO Expression in Budding Yeast Depends on the Unconventional Myosin Myo4p and Other Cytoplasmic Proteins

1996 • 299 citations

Calcineurin: From structure to function

2001 • 298 citations

Signalling in the Yeasts: An Informational Cascade with Links to the Filamentous Fungi

1998 • 298 citations

Roles of glycerol and glycerol-3-phosphate dehydrogenase (NAD+) in acquired osmotolerance of Saccharomyces cerevisiae

1989 • 297 citations

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

1991 • 297 citations

Osmoregulation and glycerol metabolism in the yeastSaccharomyces cerevisiae

1997 • 295 citations

Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development.

1994 • 289 citations

Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator

1998 • 289 citations

MECHANOSENSITIVE CHANNELS OFESCHERICHIA COLI:The MscL Gene, Protein, and Activities

1997 • 287 citations

Activation of Yeast Protein Kinase C by Rho1 GTPase

1996 • 286 citations

TRK1 and TRK2 encode structurally related K+ transporters in Saccharomyces cerevisiae.

1991 • 285 citations

The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae

1997 • 284 citations

Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.

1996 • 284 citations

Cell Wall Stress Depolarizes Cell Growth via Hyperactivation of Rho1

1999 • 282 citations

Role of trehalose in survival of Saccharomyces cerevisiae under osmotic stress

1998 • 281 citations

Mechanical stress-initiated signal transductions in vascular smooth muscle cells

2000 • 281 citations

A Second Osmosensing Signal Transduction Pathway in Yeast

1995 • 278 citations

Aquaporins. A Molecular Entry into Plant Water Relations

2001 • 277 citations

Ion homeostasis during salt stress in plants

2001 • 277 citations

Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p

1999 • 275 citations

Pheromone response, mating and cell biology

2000 • 274 citations

Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.

1993 • 274 citations

Cell wall perturbation in yeast results in dual phosphorylation of the Slt2/Mpk1 MAP kinase and in an Slt2-mediated increase in FKS2–lacZ expression, glucanase resistance and thermotolerance

2000 • 273 citations

Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on qlycolytic flux

1995 • 269 citations

Regulation of the Saccharomyces cerevisiae HOG1 Mitogen-Activated Protein Kinase by the PTP2 and PTP3 Protein Tyrosine Phosphatases

1997 • 266 citations

Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity.

1996 • 266 citations

The Yeast Glycerol 3-Phosphatases Gpp1p and Gpp2p Are Required for Glycerol Biosynthesis and Differentially Involved in the Cellular Responses to Osmotic, Anaerobic, and Oxidative Stress

2001 • 264 citations

Subcellular localization of the Snf1 kinase is regulated by specific β subunits and a novel glucose signaling mechanism

2001 • 263 citations

Saccharomyces cerevisiae Mid2p Is a Potential Cell Wall Stress Sensor and Upstream Activator of the PKC1-MPK1 Cell Integrity Pathway

1999 • 262 citations

Histidine kinases: diversity of domain organization

1999 • 260 citations

A Lecithin Cholesterol Acyltransferase-like Gene Mediates Diacylglycerol Esterification in Yeast

2000 • 260 citations

Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.

1987 • 259 citations

Spoilage Yeasts

1992 • 258 citations

Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase.

1995 • 257 citations

Molecular dissection of gating in the ClC-2 chloride channel

1997 • 256 citations

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ

1998 • 256 citations

Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.

1993 • 256 citations

Cell Adhesion Molecules: Selectins and Integrins

1999 • 255 citations

Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway

2000 • 253 citations

Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor

1998 • 251 citations

Stress-Induced MAP Kinase Hog1 Is Part of Transcription Activation Complexes

2001 • 250 citations

Glycerol Metabolism in Yeasts

1968 • 249 citations

Intracellular Sequestration of Sodium by a Novel Na+/H+ Exchanger in Yeast Is Enhanced by Mutations in the Plasma Membrane H+-ATPase

1997 • 248 citations

Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast.

1996 • 248 citations

SBF Cell Cycle Regulator as a Target of the Yeast PKC-MAP Kinase Pathway

1997 • 247 citations

Cell Polarity in Yeast

1999 • 246 citations

Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast.

1996 • 245 citations

Osmotic stress and the yeast cytoskeleton: phenotype-specific suppression of an actin mutation.

1992 • 245 citations

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.

1992 • 244 citations

The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast.

1996 • 243 citations

Spa2p Interacts with Cell Polarity Proteins and Signaling Components Involved in Yeast Cell Morphogenesis

1998 • 242 citations

Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae.

1994 • 242 citations

MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae.

1994 • 241 citations

Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins

2000 • 236 citations

A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.

1992 • 235 citations

Dissection of Filamentous Growth by Transposon Mutagenesis in Saccharomyces cerevisiae

1997 • 234 citations

Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ.

1999 • 234 citations

Purification and Characterization of Two Isoenzymes of DL-Glycerol-3-phosphatase from Saccharomyces cerevisiae

1996 • 233 citations

The osmotic integrity of the yeast cell requires a functional PKC1 gene product.

1992 • 229 citations

Transcriptional regulation by cyclic AMP-responsive factors

2000 • 228 citations

Calcofluor White Alters the Assembly of Chitin Fibrils in Saccharomyces cerevisiae and Candida albicans Cells

1983 • 228 citations

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.

1996 • 228 citations

The Nhal antiporter of Saccharomyces cerevisiae mediates sodium and potassium eft: lux

1998 • 228 citations

A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator

1997 • 227 citations

Genetic Analysis of the Bipolar Pattern of Bud Site Selection in the Yeast Saccharomyces cerevisiae

1996 • 227 citations

Transcript Expression in Saccharomyces cerevisiae at High Salinity

2001 • 224 citations

Cell wall dynamics in yeast

1999 • 224 citations

Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase.

1996 • 224 citations

The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

1998 • 222 citations

MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating.

1994 • 222 citations

Two Homologous Zinc Finger Genes Identified by Multicopy Suppression in a SNF1 Protein Kinase Mutant of Saccharomyces cerevisiae

1993 • 218 citations

The actin cytoskeleton

1988 • 218 citations

His-Asp Phosphotransfer Signal Transduction

1998 • 215 citations

Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress

2001 • 214 citations

A Homolog of Voltage-Gated Ca²⁺Channels Stimulated by Depletion of Secretory Ca²⁺ in Yeast

2000 • 213 citations

Novel Localization of a Na+/H+ Exchanger in a Late Endosomal Compartment of Yeast

1998 • 212 citations

Kinase Activity-dependent Nuclear Export Opposes Stress-induced Nuclear Accumulation and Retention of Hog1 Mitogen-activated Protein Kinase in the Budding YeastSaccharomyces cerevisiae

1999 • 212 citations

Molecular Identification of a Eukaryotic, Stretch-Activated Nonselective Cation Channel

1999 • 211 citations

Trehalose is required for the acquisition of tolerance to a variety of stresses in the filamentous fungus Aspergillus nidulans The GenBank accession number for the sequence reported in this paper is AF043230.

2001 • 211 citations

Roles of Sugar Alcohols in Osmotic Stress Adaptation. Replacement of Glycerol by Mannitol and Sorbitol in Yeast

1999 • 210 citations

Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1

2000 • 209 citations

Composition and Functional Analysis of the Saccharomyces cerevisiae Trehalose Synthase Complex

1998 • 209 citations

Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae.

1996 • 208 citations

Analysis of RhoA-binding Proteins Reveals an Interaction Domain Conserved in Heterotrimeric G Protein β Subunits and the Yeast Response Regulator Protein Skn7

1998 • 208 citations

Two-component systems in plant signal transduction

2000 • 207 citations

Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase

1997 • 207 citations

Temperature-Induced Expression of Yeast FKS2 Is under the Dual Control of Protein Kinase C and Calcineurin

1998 • 206 citations

The SPA2 protein of yeast localizes to sites of cell growth.

1989 • 204 citations

A search in the genome ofSaccharomyces cerevisiae for genes regulated via stress response elements

1998 • 204 citations

Transport of Water and Glycerol in Aquaporin 3 Is Gated by H+

1999 • 203 citations

12 Pheromone Response and Signal Transduction during the Mating Process of Saccharomyces cerevisiae

1992 • 200 citations

Genomic Exploration of the Hemiascomycetous Yeasts: 1. A set of yeast species for molecular evolution studies¹

2000 • 200 citations

The role of the YAP1 and YAP2 genes in the regulation of the adaptive oxidative stress responses of Saccharomyces cerevisiae

1995 • 200 citations

Ptc1, a Type 2C Ser/Thr Phosphatase, Inactivates the HOG Pathway by Dephosphorylating the Mitogen-Activated Protein Kinase Hog1

2001 • 199 citations

Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast.

1994 • 199 citations

Remembrance of things PAS: regulation of development by bHLH–PAS proteins

1999 • 198 citations

A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants

1991 • 197 citations

The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae.

1993 • 197 citations

Ethanol-induced water stress in yeast

1998 • 197 citations

Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae.

1993 • 195 citations

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast

1992 • 195 citations

Mid2 Is a Putative Sensor for Cell Integrity Signaling in Saccharomyces cerevisiae

1999 • 194 citations

A Homolog of Mammalian, Voltage-Gated Calcium Channels Mediates Yeast Pheromone-Stimulated Ca²⁺ Uptake and Exacerbates the cdc1(Ts) Growth Defect

1997 • 194 citations

Yeast RLM1 Encodes a Serum Response Factor-Like Protein That May Function Downstream of the Mpk1 (Slt2) Mitogen-Activated Protein Kinase Pathway

1995 • 194 citations

Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast.

1995 • 192 citations

Sensors of extracellular nutrients in Saccharomyces cerevisiae

2001 • 192 citations

Activity of 1,3-β-D-Glucan Synthase Requires the GTP-binding Protein Rho1

1996 • 192 citations

Global and Specific Translational Regulation in the Genomic Response of Saccharomyces cerevisiae to a Rapid Transfer from a Fermentable to a Nonfermentable Carbon Source

2001 • 192 citations

Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae.

1987 • 192 citations

A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae.

1994 • 191 citations

The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure.

1994 • 190 citations

The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.

1995 • 189 citations

ROLE OF SMALL G PROTEINS IN YEAST CELL POLARIZATION AND WALL BIOSYNTHESIS

1998 • 189 citations

Calcineurin, the Ca²⁺/Calmodulin-Dependent Protein Phosphatase, Is Essential in Yeast Mutants with Cell Integrity Defects and in Mutants That Lack a Functional Vacuolar H⁺-Atpase

1995 • 189 citations

Cell wall integrity modulates RHO1 activity via the exchange factor ROM2

1998 • 189 citations

Trehalose lowers membrane phase transitions in dry yeast cells

1994 • 189 citations

Evolution of Osmotic Stress Signaling Via Map Kinase Cascades

1998 • 188 citations

Differential importance of trehalose in stress resistance in fermenting and nonfermenting Saccharomyces cerevisiae cells

1995 • 188 citations

The importance of the glycerol 3-phosphate shuttle during aerobic growth ofSaccharomyces cerevisiae

1998 • 187 citations

Microbial Water Stress Physiology: Principles and Perspectives

1990 • 187 citations

The Saccharomyces cerevisiae MADS-Box Transcription Factor Rlm1 Is a Target for the Mpk1 Mitogen-Activated Protein Kinase Pathway

1997 • 187 citations

Metabolic and Regulatory Changes Associated with Growth of Saccharomyces cerevisiae in 1.4 M NaCl

1997 • 186 citations

Metabolic surprises inSaccharomyces cerevisiaeduring adaptation to saline conditions: questions, some answers and a model

2000 • 186 citations

Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlm1, Which Has Transcriptional Activity Regulated by the Mpk1 (Slt2) Mitogen-Activated Protein Kinase Pathway

1997 • 184 citations

Molecular Biology of Trehalose and the Trehalases in the Yeast Saccharomyces cerevisiae

1997 • 183 citations

The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p

1998 • 183 citations

The yeast A kinases differentially regulate iron uptake and respiratory function

2000 • 182 citations

A gene encoding sn‐glycerol 3‐phosphate dehydrogenase (NAD⁺) complements an osmosensitive mutant of Saccharomyces cerevisiae

1993 • 182 citations

The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.

1997 • 181 citations

Low external pH induces HOG1‐dependent changes in the organization of the Saccharomyces cerevisiae cell wall

2001 • 181 citations

Repressors and Upstream Repressing Sequences of the Stress-Regulated ENA1 Gene in Saccharomyces cerevisiae: bZIP Protein Sko1p Confers HOG-Dependent Osmotic Regulation

1999 • 181 citations

Identification of cis and trans Components of a Novel Heat Shock Stress Regulatory Pathway in Saccharomyces cerevisiae

1993 • 180 citations

The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans

1996 • 179 citations

TheSaccharomyces cerevisiae genes (CMP1 andCMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B

1991 • 179 citations

Yeast Respond to Hypotonic Shock with a Calcium Pulse

1996 • 179 citations

Trehalose and Trehalase in Arabidopsis

2001 • 179 citations

A New Antioxidant with Alkyl Hydroperoxide Defense Properties in Yeast

1999 • 178 citations

Identification of a developmentally regulated septin and involvement of the septins in spore formation in Saccharomyces cerevisiae.

1996 • 178 citations

Yeast genome evolution in the post-genome era

1999 • 178 citations

The heat shock response in yeast: differential regulations and contributions of the Msn2p/Msn4p and Hsf1p regulons

1999 • 177 citations

Discrete Roles of the Spc1 Kinase and the Atf1 Transcription Factor in the UV Response of Schizosaccharomyces pombe

1997 • 176 citations

Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast.

1995 • 174 citations

β‐1,6‐Glucan synthesis in Saccharomyces cerevisiae

2000 • 173 citations

The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway‐dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage

2001 • 173 citations

TOR2 Is Part of Two Related Signaling Pathways Coordinating Cell Growth in Saccharomyces cerevisiae

1998 • 173 citations

Two Protein-tyrosine Phosphatases Inactivate the Osmotic Stress Response Pathway in Yeast by Targeting the Mitogen-activated Protein Kinase, Hog1

1997 • 173 citations

Signal transduction by MAP kinase cascades in budding yeast

1998 • 170 citations

Peroxide Sensors for the Fission Yeast Stress-activated Mitogen-activated Protein Kinase Pathway

2001 • 168 citations

Deletion of SNF1 affects the nutrient response of yeast and resembles mutations which activate the adenylate cyclase pathway.

1991 • 168 citations

Rho1p-Bni1p-Spa2p Interactions: Implication in Localization of Bni1p at the Bud Site and Regulation of the Actin Cytoskeleton inSaccharomyces cerevisiae

1998 • 168 citations

Cloning and characterization of GPD2, a second gene encoding sn‐glycerol 3‐phosphate dehydrogenase (NAD⁺) in Saccharomyces cerevisiae, and its comparison with GPD1

1995 • 166 citations

Multiple roles for Cdc42 in cell regulation

2001 • 165 citations

Multistep Phosphorelay Proteins Transmit Oxidative Stress Signals to the Fission Yeast Stress-activated Protein Kinase

2000 • 165 citations

Regulators of Pseudohyphal Differentiation in Saccharomyces cerevisiae Identified Through Multicopy Suppressor Analysis in Ammonium Permease Mutant Strains

1998 • 165 citations

Cloning and genetic mapping of SNF1, a gene required for expression of glucose-repressible genes in Saccharomyces cerevisiae.

1984 • 165 citations

Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae.

1993 • 165 citations

Roles of Three Histidine Kinase Genes in Hyphal Development and Virulence of the Pathogenic Fungus Candida albicans

1999 • 164 citations

The Skn7 Response Regulator ofSaccharomyces cerevisiaeInteracts with Hsf1 In Vivo and Is Required for the Induction of Heat Shock Genes by Oxidative Stress

2000 • 164 citations

Stress signal, mediated by a Hogl‐like MAP kinase, controls sexual development in fission yeast

1996 • 162 citations

Induction of heat, freezing and salt tolerance by heat and salt shock in Saccharomyces cerevisiae

1995 • 159 citations

beta-subunits of Snf1 kinase are required for kinase function and substrate definition

2000 • 159 citations

SKN7, a yeast multicopy suppressor of a mutation affecting cell wall beta-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors

1993 • 159 citations

The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signaling components

1999 • 159 citations

Possible His to Asp phosphorelay signaling in an Arabidopsis two‐component system

2000 • 158 citations

The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton

1998 • 157 citations

Cloning of two related genes encoding the 56-kDa and 123-kDa subunits of trehalose synthase from the yeast Saccharomyces cerevisiae

1993 • 156 citations

Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast

2001 • 156 citations

Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast

1998 • 156 citations

Yeast Skn7p functions in a eukaryotic two-component regulatory pathway.

1994 • 155 citations

The growth and signalling defects of the ggs1 (fdp1/byp1) deletion mutant on glucose are suppressed by a deletion of the gene encoding hexokinase PII

1993 • 154 citations

Dynamic Localization and Function of Bni1p at the Sites of Directed Growth in Saccharomyces cerevisiae

2001 • 153 citations

Heat shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase T of Saccharomyces cerevisiae

1991 • 153 citations

Regulation of genes encoding subunits of the trehalose synthase complex inSaccharomyces cerevisiae: novel variations of STRE-mediated transcription control?

1996 • 153 citations

Expression of the yeast plasma membrane [H+]ATPase in secretory vesicles. A new strategy for directed mutagenesis.

1991 • 152 citations

The SPA2 gene of Saccharomyces cerevisiae is important for pheromone-induced morphogenesis and efficient mating.

1990 • 152 citations

The response regulator-like protein Pos9/Skn7 ofSaccharomyces cerevisiae is involved in oxidative stress resistance

1996 • 151 citations

Rck2 Kinase Is a Substrate for the Osmotic Stress-Activated Mitogen-Activated Protein Kinase Hog1

2000 • 150 citations

A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint

2001 • 149 citations

Activity of the yeast MAP kinase homologue Slt2 is critically required for cell integrity at 37° C

1993 • 149 citations

Cell volume regulated transporters of compatible osmolytes

1995 • 149 citations

Structural clues in the sequences of the aquaporins

2000 • 148 citations

The FKBP12-Rapamycin-binding Domain Is Required for FKBP12-Rapamycin-associated Protein Kinase Activity and G1 Progression

1999 • 147 citations

Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42

2000 • 147 citations

Three genes whose expression is induced by stress inSaccharomyces cerevisiae

1999 • 146 citations

The PPZ Protein Phosphatases Are Important Determinants of Salt Tolerance in Yeast Cells

1995 • 145 citations

Active glycerol uptake is a mechanism underlying halotolerance in yeasts: a study of 42 species

1999 • 145 citations

Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae.

1997 • 143 citations

Hsf1p and Msn2/4p cooperate in the expression of Saccharomyces cerevisiae genes HSP26 and HSP104 in a gene‐ and stress type‐dependent manner

2001 • 143 citations

Glycerol Export and Glycerol-3-phosphate Dehydrogenase, but Not Glycerol Phosphatase, Are Rate Limiting for Glycerol Production in Saccharomyces cerevisiae

2001 • 143 citations

A yeast homologue of the bovine lens fibre MIP gene family complements the growth defect of a Saccharomyces cerevisiae mutant on fermentable sugars but not its defect in glucose-induced RAS-mediated cAMP signalling.

1991 • 143 citations

Isolation and characterization of Saccharomyces cerevisiae mutants defective in glycerol catabolism

1977 • 142 citations

Hyperphosphorylation of Msn2p and Msn4p in response to heat shock and the diauxic shift is inhibited by cAMP in Saccharomyces cerevisiae

2000 • 142 citations

A Novel Nuclear Export Signal Sensitive to Oxidative Stress in the Fission Yeast Transcription Factor Pap1

1999 • 141 citations

The hybrid histidine kinase DokA is part of the osmotic response system of Dictyostelium.

1996 • 141 citations

Characterization of the yeast (1-->6)-beta-glucan biosynthetic components, Kre6p and Skn1p, and genetic interactions between the PKC1 pathway and extracellular matrix assembly.

1994 • 141 citations

Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus Candida albicans

1998 • 141 citations

Defective Hyphal Development and Avirulence Caused by a Deletion of the SSK1 Response Regulator Gene in Candida albicans

2000 • 140 citations

Requirement of STE50 for Osmostress-Induced Activation of the STE11 Mitogen-Activated Protein Kinase Kinase Kinase in the High-Osmolarity Glycerol Response Pathway

1998 • 140 citations

Coordination of the Mating and Cell Integrity Mitogen-Activated Protein Kinase Pathways in Saccharomyces cerevisiae

1997 • 140 citations

Physiological response to anaerobicity of glycerol-3-phosphate dehydrogenase mutants of Saccharomyces cerevisiae

1997 • 139 citations

Function of Trehalose and Glycogen in Cell Cycle Progression and Cell Viability in Saccharomyces cerevisiae

1999 • 138 citations

Managing hypoosmotic stress: Aquaporins and medianosensitive channels in Escherichia coli

1999 • 138 citations

Nutrient-induced signal transduction through the protein kinase A pathway and its role in the control of metabolism, stress resistance, and growth in yeast

2000 • 137 citations

Dynamics and organization of MAP kinase signal pathways

1995 • 136 citations

Anatomy of a transcription factor important for the Start of the cell cycle in Saccharomyces cerevisiae

1992 • 136 citations

Heat shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases

1999 • 134 citations

Mutagenic study of the structure, function and biogenesis of the yeast plasma membrane H+-ATPase

2000 • 134 citations

A refined structure of human aquaporin‐1

2001 • 134 citations

Multiple transduction pathways regulate the sodium‐extrusion gene PMR2/ENA1 during salt stress in yeast

1996 • 134 citations

The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.

1991 • 133 citations

Yap1p, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response.

1994 • 132 citations

Osmotic Balance Regulates Cell Fusion during Mating in Saccharomyces cerevisiae

1997 • 131 citations

Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast

1997 • 131 citations

GUT2, a gene for mitochondrial glycerol 3‐phosphate dehydrogenase of Saccharomyces cerevisiae

1993 • 130 citations

Schizosaccharomyces pombe gad7⁺ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation

1996 • 130 citations

NHP6A and NHP6B, which encode HMG1-like proteins, are candidates for downstream components of the yeast SLT2 mitogen-activated protein kinase pathway.

1994 • 130 citations

COS1 , a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicans

1998 • 129 citations

The importance of aquaporin water channel protein structures

2000 • 129 citations

Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade.

1997 • 129 citations

Engineering baker’s yeast: room for improvement

1999 • 128 citations

Characterization of the Wsc1 Protein, a Putative Receptor in the Stress Response of Saccharomyces cerevisiae

1999 • 128 citations

Dimorphism in fungal pathogens: Candida albicans and Ustilago maydis—similar inputs, different outputs

2001 • 128 citations

The freeze-thaw stress response of the yeast Saccharomyces cerevisiae is growth phase specific and is controlled by nutritional state via the RAS-cyclic AMP signal transduction pathway

1997 • 128 citations

A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway.

1993 • 127 citations

Regulation of a yeast HSP70 gene by a cAMP responsive transcriptional control element.

1990 • 127 citations

Characterization of the osmotic-stress response inSaccharomyces cerevisiae: osmotic stress and glucose repression regulate glycerol-3-phosphate dehydrogenase independently

1994 • 126 citations

Different signalling pathways contribute to the control of GPD1 gene expression by osmotic stress in Saccharomyces cerevisiae

1999 • 126 citations

A Yeast Mitogen-Activated Protein Kinase Homolog (Mpk1p) Mediates Signalling by Protein Kinase C

1993 • 126 citations

Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast

2000 • 125 citations

Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases

1998 • 125 citations

The osmoreactive betaine carrier BetP from Corynebacterium glutamicum is a sensor for cytoplasmic K+

2001 • 124 citations

Expression of a cytoplasmic transhydrogenase inSaccharomyces cerevisiae results in formation of 2-oxoglutarate due to depletion of the NADPH pool

2000 • 124 citations

Synergy Between Trehalose and Hsp104 for Thermotolerance in Saccharomyces cerevisiae

1996 • 124 citations

Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae

1995 • 123 citations

Yeasts in Natural and Artificial Habitats

1997 • 123 citations

Defects in Protein Glycosylation Cause SHO1-Dependent Activation of a STE12 Signaling Pathway in Yeast

2000 • 122 citations

Response of Saccharomyces cerevisiae to severe osmotic stress: evidence for a novel activation mechanism of the HOG MAP kinase pathway

2000 • 122 citations

Heat Stress Activates Fission Yeast Spc1/StyI MAPK by a MEKK-Independent Mechanism

1998 • 121 citations

Fission yeast Tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature

2001 • 121 citations

Microbial MIP channels

2000 • 121 citations

Analysis of the otsBA operon for osmoregulatory trehalose synthesis in Escherichia coli and homology of the OtsA and OtsB proteins to the yeast trehalose-6-phosphate synthase/phosphatase complex

1994 • 119 citations

Trehalases and trehalose hydrolysis in fungi

2006 • 119 citations

Mitogen-activated protein (MAP) kinase pathways in plants: Versatile signaling tools

2001 • 117 citations

Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1.

1992 • 116 citations

Osmostress‐induced changes in yeast gene expression

1992 • 115 citations

Thioredoxin Peroxidase Is Required for the Transcriptional Response to Oxidative Stress in Budding Yeast

2000 • 115 citations

The Saccharomyces cerevisiae sln1p-ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion

2000 • 114 citations

Actin cytoskeleton: Are FH proteins local organizers?

1997 • 114 citations

Disruption of the yeast ATH1 gene confers better survival after dehydration, freezing, and ethanol shock: potential commercial applications

1996 • 113 citations

YeastSKO1gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription

1992 • 113 citations

Induction of neutral trehalase Nth1 by heat and osmotic stress is controlled by STRE elements and Msn2/Msn4 transcription factors: variations of PKA effect during stress and growth

2000 • 112 citations

The General Control of Amino Acid Biosynthetic Genes in the Yeast Saccharomyces Cerevisia

1986 • 112 citations

Functional study of the Saccharomyces cerevisiae Nha1p C‐terminus

2001 • 112 citations

Osmostress response of the yeast Saccharomyces

1993 • 111 citations

Regulation of Cell Cycle Progression by Swe1p and Hog1p Following Hypertonic Stress

2001 • 111 citations

Glucose repression affects ion homeostasis in yeast through the regulation of the stress‐activated ENA1 gene

1997 • 111 citations

Evolution of Cyclin-Dependent Kinases (CDKs) and CDK-Activating Kinases (CAKs): Differential Conservation of CAKs in Yeast and Metazoa

2000 • 110 citations

Cla4p, a Saccharomyces cerevisiae Cdc42p-Activated Kinase Involved in Cytokinesis, Is Activated at Mitosis†

1997 • 110 citations

Transcriptional Factor Mutations Reveal Regulatory Complexities of Heat Shock and Newly Identified Stress Genes in Saccharomyces cerevisiae

1998 • 110 citations

The Escherichia coli aquaporin‐Z water channel

2000 • 109 citations

New genes involved in carbon catabolite repression and derepression in the yeast Saccharomyces cerevisiae

1982 • 108 citations

Negative regulation of transcription of the Saccharomyces cerevisiae catalase T (CTT1) gene by cAMP is mediated by a positive control element.

1991 • 108 citations

On the mechanism by which a heat shock induces trehalose accumulation in Saccharomyces cerevisiae

1992 • 107 citations

The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock

1999 • 107 citations

Nutritional Control of Nucleocytoplasmic Localization of cAMP-dependent Protein Kinase Catalytic and Regulatory Subunits in Saccharomyces cerevisiae

2000 • 107 citations

Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases.

1987 • 106 citations

Mutants of Saccharomyces cerevisiae sensitive to oxidative and osmotic stress

1995 • 106 citations

Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases

1989 • 106 citations

Nucleocytoplasmic Distribution of Budding Yeast Protein Kinase A Regulatory Subunit Bcy1 Requires Zds1 and Is Regulated by Yak1-Dependent Phosphorylation of Its Targeting Domain

2001 • 106 citations

Differential Regulation of the Cell Wall Integrity Mitogen-Activated Protein Kinase Pathway in Budding Yeast by the Protein Tyrosine Phosphatases Ptp2 and Ptp3

1999 • 105 citations

A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzyme

2000 • 105 citations

A screen for upstream components of the yeast protein kinase C signal transduction pathway identifies the product of the SLG1 gene

1998 • 105 citations

The control of intracellular glycerol in Saccharomyces cerevisiae influences osmotic stress response and resistance to increased temperature

2000 • 104 citations

Expression and Function of the Trehalase Genes NTH1 and YBR0106 in Saccharomyces cerevisiae

1995 • 104 citations

Ca²⁺-Calmodulin Promotes Survival of Pheromone-Induced Growth Arrest by Activation of Calcineurin and Ca²⁺-Calmodulin-Dependent Protein Kinase

1996 • 104 citations

cdc2 and the regulation of mitosis: six interacting mcs genes.

1989 • 103 citations

Phenotypic features of trehalase mutants in Saccharomyces cerevisiae

1995 • 102 citations

Aquaporins in Saccharomyces

1998 • 102 citations

The glycerol kinase (GUT1) gene of Saccharomyces cerevisiae: cloning and characterization

1993 • 101 citations

Structural analysis of the subunits of the trehalose‐6‐phosphate synthase/phosphatase complex in Saccharomyces cerevisiae and their function during heat shock

1997 • 101 citations

Positioning of cell growth and division after osmotic stress requires a map kinase pathway

1994 • 100 citations

Expression of bacterial mtlD in Saccharomyces cerevisiae results in mannitol synthesis and protects a glycerol-defective mutant from high-salt and oxidative stress

1997 • 100 citations

GUP1 and its close homologue GUP2, encoding multimembrane‐spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae

2000 • 100 citations

The Osmoregulatory Pathway Represses Mating Pathway Activity in Saccharomyces cerevisiae: Isolation of a FUS3 Mutant That Is Insensitive to the Repression Mechanism

1996 • 99 citations

Global Regulation of Mitochondrial Biogenesis in Saccharomyces cerevisiae

1993 • 98 citations

Stimulation of the yeast high osmolarity glycerol (HOG) pathway: evidence for a signal generated by a change in turgor rather than by water stress

2000 • 98 citations

A yeast transcription factor bypassing the requirement for SBF and DSC1/MBF in budding yeast has homology to bacterial signal transduction proteins.

1995 • 97 citations

Purification, Reconstitution, and Characterization of KdpD, the Turgor Sensor of Escherichia coli

1997 • 97 citations

Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae.

1994 • 97 citations

Induction of Pseudohyphal Growth by Overexpression of PHD1, a Saccharomyces cerevisiae Gene Related to Transcriptional Regulators of Fungal Development

1994 • 96 citations

The Rho-GEF Rom2p Localizes to Sites of Polarized Cell Growth and Participates in Cytoskeletal Functions inSaccharomyces cerevisiae

1997 • 95 citations

The Saccharomyces cerevisiae aldose reductase is implied in the metabolism of methylglyoxal in response to stress conditions

2001 • 95 citations

cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae

1991 • 95 citations

Glycolytic Gene Expression in Saccharomyces cerevisiae: Nucleotide Sequence of GCR1, Null Mutants, and Evidence for Expression

1986 • 94 citations

The Eukaryotic Two-Component Histidine Kinase Sln1p RegulatesOCH1via the Transcription Factor, Skn7p

2002 • 93 citations

Genetic interactions among genes involved in the STT4-PKC1 pathway of Saccharomyces cerevisiae

1994 • 92 citations

Redirection of the Respiro-Fermentative Flux Distribution in Saccharomyces cerevisiae by Overexpression of the Transcription Factor Hap4p

2000 • 92 citations

Expression of the Glyoxalase I Gene of Saccharomyces cerevisiae Is Regulated by High Osmolarity Glycerol Mitogen-activated Protein Kinase Pathway in Osmotic Stress Response

1998 • 92 citations

The two-component hybrid kinase regulator CaNIKl of Candida albicans

1998 • 92 citations

Calcofluor Antifungal Action Depends on Chitin and a Functional High-Osmolarity Glycerol Response (HOG) Pathway: Evidence for a Physiological Role of the Saccharomyces cerevisiae HOG Pathway under Noninducing Conditions

2000 • 91 citations

The GATA Transcription Factors GLN3 and GAT1 Link TOR to Salt Stress in Saccharomyces cerevisiae

2001 • 91 citations

Characteristics of Fps1-dependent and -independent glycerol transport in Saccharomyces cerevisiae

1997 • 91 citations

Microbial Water Relations: Features of the Intracellular Composition of Sugar-Tolerant Yeasts

1974 • 91 citations

Histidine Phosphorylation and Two-Component Signaling in Eukaryotic Cells

2001 • 90 citations

PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiae

1992 • 89 citations

The level of cAMP-dependent protein kinase A activity strongly affects osmotolerance andosmo-instigated gene expression changes inSaccharomyces cerevisiae

2000 • 89 citations

Protein kinase C in yeast. Characteristics of the Saccharomyces cerevisiae PKC1 gene product

1994 • 89 citations

The control of trehalose biosynthesis in Saccharomyces cerevisiae: Evidence for a catabolite inactivation and repression of trehalose‐6‐phosphate synthase and trehalose‐6‐phosphate phosphatase

1991 • 88 citations

A role for the yeast actin cytoskeleton in pheromone receptor clustering and signalling

1998 • 88 citations

Regulation of the Escherichia coli water channel gene aqpZ

1998 • 88 citations

Control of Saccharomyces cerevisiae Catalase T Gene (CTT1) Expression by Nutrient Supply via the RAS-Cyclic AMP Pathway

1989 • 87 citations

Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects

2001 • 87 citations

Deletion of the ATH1 gene in Saccharomyces cerevisiae prevents growth on trehalose

1996 • 87 citations

Cell wall maintenance in fungi

2000 • 87 citations

Coordinate expression of ribosomal protein genes in yeast as a function of cellular growth rate

1991 • 87 citations

The Yeast KRE9 Gene Encodes an O Glycoprotein involved in cell surface β-Glucan Assembly

1993 • 86 citations

Mild temperature shock affects transcription of yeast ribosomal protein genes as well as the stability of their mRNAs

1988 • 85 citations

A Dual Role for Intracellular Trehalose in the Resistance of Yeast Cells to Water Stress

1999 • 85 citations

Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1

1992 • 84 citations

Intracellular Glycerol Levels Modulate the Activity of Sln1p, aSaccharomyces cerevisiae Two-component Regulator

1999 • 84 citations

Neutral trehalase Nth1p of Saccharomyces cerevisiae encoded by the NTH1 gene is a multiple stress responsive protein

1997 • 83 citations

The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells

1993 • 83 citations

Yeast Skn7p activity is modulated by the Sln1p-Ypd1p osmosensor and contributes to regulation of the HOG pathway

1998 • 83 citations

Screening and identification of yeast sequences that cause growth inhibition when overexpressed

1997 • 82 citations

ACR1, a yeast ATF/CREB repressor.

1992 • 82 citations

Regulatory Subunit (CNB1 Gene Product) of Yeast Ca²⁺/Calmodulin-Dependent Phosphoprotein Phosphatases Is Required for Adaptation to Pheromone

1992 • 82 citations

Microaerobic glycerol formation inSaccharomyces cerevisiae

2000 • 81 citations

Mechanisms of Salt Tolerance Conferred by Overexpression of the HAL1 Gene in Saccharomyces cerevisiae

1997 • 81 citations

Activation of the Saccharomyces cerevisiae Filamentation/Invasion Pathway by Osmotic Stress in High-Osmolarity Glycogen Pathway Mutants

1999 • 80 citations

Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae

1999 • 80 citations

Energy flux and osmoregulation of Saccharomyces cerevisiae grown in chemostats under NaCl stress

1993 • 80 citations

Glucose-triggered signalling in Saccharomyces cerevisiae: different requirements for sugar phosphorylation between cells grown on glucose and those grown on non-fermentable carbon sources

1996 • 79 citations

Trehalose-6-phosphate synthase/phosphatase complex from bakers’ yeast: purification of a proteolytically activated form

1991 • 79 citations

Isolation of Hyperactive Mutants of the MAPK p38/Hog1 That Are Independent of MAPK Kinase Activation

2001 • 78 citations

Opposite roles of trehalase activity in heat-shock recovery and heat-shock survival in Saccharomyces cerevisiae

1999 • 78 citations

MID1, a Novel Saccharomyces cerevisiae Gene Encoding a Plasma Membrane Protein, Is Required for Ca²⁺ Influx and Mating

1994 • 78 citations

The mitochondrial cytochrome c peroxidase Ccp1 of Saccharomyces cerevisiae is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7)

1999 • 77 citations

Protein Kinase A and Mitogen-Activated Protein Kinase Pathways Antagonistically Regulate Fission Yeast fbp1 Transcription by Employing Different Modes of Action at Two Upstream Activation Sites

2000 • 77 citations

Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae

2001 • 76 citations

Roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress.

1999 • 76 citations

Nuclear Import of the Yeast AP-1-like Transcription Factor Yap1p Is Mediated by Transport Receptor Pse1p, and This Import Step Is Not Affected by Oxidative Stress

2001 • 76 citations

TRK1 and TRK2 Encode Structurally Related K⁺ Transporters in Saccharomyces cerevisiae

1991 • 75 citations

A pathway in the yeast cell division cycle linking protein kinase C (Pkc1) to activation of Cdc28 at START.

1996 • 75 citations

A Synthetic Lethal Screen Identifies SLK1, a Novel Protein Kinase Homolog Implicated in Yeast Cell Morphogenesis and Cell Growth

1992 • 74 citations

Novel alleles of yeast hexokinase PII with distinct effects on catalytic activity and catabolite repression of SUC2

1999 • 74 citations

Dynamic, Rho1p-dependent localization of Pkc1p to sites of polarized growth

2000 • 74 citations

Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae

1992 • 73 citations

Multiple Levels of Control Regulate the Yeast cAMP-response Element-binding Protein Repressor Sko1p in Response to Stress

2001 • 73 citations

Protein Phosphatase 2C Acts Independently of Stress-activated Kinase Cascade to Regulate the Stress Response in Fission Yeast

1997 • 72 citations

The oxidative stress response mediated via Pos9/Skn7 is negatively regulated by the Ras/PKA pathway in Saccharomyces cerevisiae

1999 • 72 citations

K+ and Ionic Strength Directly Influence the Autophosphorylation Activity of the Putative Turgor Sensor KdpD ofEscherichia coli

2000 • 72 citations

Growth-related expression of ribosomal protein genes in Saccharomyces cerevisiae

1993 • 72 citations

Aca1 and Aca2, ATF/CREB Activators in Saccharomyces cerevisiae, Are Important for Carbon Source Utilization but Not the Response to Stress

2000 • 71 citations

A Fission Yeast Gene (prrl+) That Encodes a Response Regulator Implicated in Oxidative Stress Response

1999 • 71 citations

A novel `two-component' protein containing histidine kinase and response regulator domains required for sporulation in Aspergillus nidulans

2000 • 70 citations

Molecular mechanism of the multiple regulation of theSaccharomyces cerevisiae ATF1 gene encoding alcohol acetyltransferase

1999 • 70 citations

Purification of trehalose synthase from baker's yeast

1993 • 70 citations

Functional Analysis of the Stress Response Element and Its Role in the Multistress Response ofSaccharomyces cerevisiae

1998 • 70 citations

The Ssn6-Tup1 repressor complex of Saccharomyces cerevisiae is involved in the osmotic induction of HOG-dependent and -independent genes

1998 • 69 citations

Identification of a putative histidine kinase two‐component phosphorelay gene ( CaHK1 ) in Candida albicans

1998 • 69 citations

Evidence for a heat shock transcription factor-independent mechanism for heat shock induction of transcription in Saccharomyces cerevisiae.

1990 • 68 citations

Visualization of AqpZ-Mediated Water Permeability in Escherichia coli by Cryoelectron Microscopy

1999 • 68 citations

Contribution to the physiological characterization of glycerol active uptake in Saccharomycescerevisiae

1997 • 67 citations

General stress response: In search of a common denominator.

1997 • 67 citations

Aquaporins in Saccharomyces : Characterization of a second functional water channel protein

2001 • 67 citations

BRO1, a Novel Gene That Interacts with Components of the Pkc1p–Mitogen-Activated Protein Kinase Pathway in Saccharomyces cerevisiae

1996 • 67 citations

The Fission Yeast Mitotic Regulatorwin1⁺Encodes an MAP Kinase Kinase Kinase That Phosphorylates and Activates Wis1 MAP Kinase Kinase in Response to High Osmolarity

1998 • 67 citations

Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast.

1992 • 66 citations

Increased dosage of theMSN1gene restores invertase expression in yeast mutants defective in the SNF1 protein kinase

1990 • 66 citations

Global changes in protein synthesis during adaptation of the yeast Saccharomyces cerevisiae to 0.7 M NaCl

1995 • 65 citations

Conservation and release of osmolytes by yeasts during hypo-osmotic stress

2001 • 65 citations

Mechanisms of Salt Tolerance Conferred by Overexpression of theHAL1 Gene inSaccharomyces cerevisiae

1997 • 65 citations

Protein chaperones and the heat shock response in Saccharomyces cerevisiae

1998 • 65 citations

Association of the Cell Cycle Transcription Factor Mbp1 with the Skn7 Response Regulator in Budding Yeast

1999 • 64 citations

The Isolation of FOS-1, a Gene Encoding a Putative Two-Component Histidine Kinase from Aspergillus fumigatus

2000 • 64 citations

The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.

1995 • 63 citations

Transcriptional Regulators of the Schizosaccharomyces pombe fbp1 Gene Include Two Redundant Tup1p-like Corepressors and the CCAAT Binding Factor Activation Complex

2001 • 63 citations

Effects of different carbon fluxes on G1 phase duration, cyclin expression, and reserve carbohydrate metabolism in Saccharomyces cerevisiae

1997 • 63 citations

The hypo-osmolarity-sensitive phenotype of the Saccharomyces cerevisiae hpo2 mutant is due to a mutation in PKC1, which regulates expression of β-glucanase

1994 • 63 citations

Understanding the Growth Phenotype of the Yeast gcr1 Mutant in Terms of Global Genomic Expression Patterns

2000 • 62 citations

Regulation of Meiosis in Fission Yeast.

1996 • 61 citations

The high diversity of aquaporins reveals novel facets of plant membrane functions

2000 • 60 citations

Polymorphism ofSaccharomyces cerevisiae aquaporins

2000 • 60 citations

Characterization of SKM1, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK‐like protein kinase

1997 • 58 citations

Stress factors acting at the level of the plasma membrane induce transcription via the stress response element (STRE) of the yeast Saccharomyces cerevisiae

1999 • 58 citations

Differential Stabilities of Phosphorylated Response Regulator Domains Reflect Functional Roles of the Yeast Osmoregulatory SLN1 and SSK1 Proteins

1999 • 58 citations

Active Nucleocytoplasmic Shuttling Required for Function and Regulation of Stress-Activated Kinase Spc1/StyI in Fission Yeast

1999 • 58 citations

Mutations in the SAM domain of STE50 differentially influence the MAPK-mediated pathways for mating, filamentous growth and osmotolerance in Saccharomyces cerevisiae

2000 • 57 citations

The MID2 gene encodes a putative integral membrane protein with a Ca2+-binding domain and shows mating pheromone-stimulated expression in Saccharomyces cerevisiae

1994 • 57 citations

Novel Role for an HPt Domain in Stabilizing the Phosphorylated State of a Response Regulator Domain

2000 • 57 citations

A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase

1999 • 57 citations

Physiological overlap between osmotolerance and thermotolerance inSaccharomyces cerevisiae

1988 • 57 citations

Identification of a putative histidine kinase two-component phosphorelay gene (CaHK1) inCandida albicans

1998 • 57 citations

Nephrogenic diabetes insipidus

2000 • 55 citations

The Sko1p Repressor and Gcn4p Activator Antagonistically Modulate Stress-Regulated Transcription in Saccharomyces cerevisiae

2001 • 55 citations

Identification and Characterization of the CLK1 Gene Product, a Novel CaM Kinase-like Protein Kinase from the Yeast Saccharomyces cerevisiae

1996 • 55 citations

Both isoforms of protein phosphatase Z are essential for the maintenance of cell size and integrity in Saccharomyces cerevisiae in response to osmotic stress

1993 • 54 citations

The Win1 Mitotic Regulator Is a Component of the Fission Yeast Stress-activated Sty1 MAPK Pathway

1998 • 54 citations

Transmembrane Signal Transduction and Osmoregulation in Escherichia coli: Functional Importance of the Transmembrane Regions of Membrane-Located Protein Kinase, EnvZ1

1992 • 54 citations

Transmembrane Signal Transduction and Osmoregulation in Escherichia coli: II. The Osmotic Sensor, EnvZ, Located in the Isolated Cytoplasmic Membrane Displays Its Phosphorylation and Dephosphorylation Abilities as to the Activator Protein, OmpR1

1990 • 53 citations

A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant.

1992 • 53 citations

Transcription activation of yeast ribosomal protein genes requires additional elements apart from binding sites for Abf1p or Rap1p

1995 • 53 citations

Osmoresponsive proteins and functional assessment strategies in Saccharomyces cerevisiae

1997 • 53 citations

Yeast - a panacea for the structure-function analysis of membrane proteins?

2001 • 53 citations

Molecular Analysis of SSN6, a Gene Functionally Related to the SNF1 Protein Kinase of Saccharomyces cerevisiae

1987 • 53 citations

Molecular and functional characterization of a mutant allele of the mitogen-activated protein-kinase geneSLT2(MPK1) rescued from yeast autolytic mutants

1996 • 53 citations

Isolation and sequence of theHOG1 homologue fromDebaryomyces hansenii by complementation of thehog1? strain ofSaccharomyces cerevisiae

2000 • 52 citations

Global regulators of ribosome biosynthesis in yeast

1995 • 52 citations

Identification ofYPD1, a gene ofCandida albicans which encodes a two-component phosphohistidine intermediate protein

2000 • 52 citations

Prenylation of Rho1p Is Required for Activation of Yeast 1,3-β-Glucan Synthase

1999 • 51 citations

The Extracellular Domain of the Saccharomyces cerevisiae Sln1p Membrane Osmolarity Sensor Is Necessary for Kinase Activity

1999 • 51 citations

The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.

1992 • 50 citations

Conditional lethality of a yeast strain expressing human RHOA in place of RHO1.

1994 • 50 citations

Spy1, a Histidine-Containing Phosphotransfer Signaling Protein, Regulates the Fission Yeast Cell Cycle through the Mcs4 Response Regulator

2000 • 50 citations

The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p

2001 • 49 citations

The Zygosaccharomyces rouxii strain CBS732 contains only one copy of the HOG1 and the SOD2 genes

2001 • 49 citations

Genetic and Biochemical Characterization of a Phosphatidylinositol-Specific Phospholipase C in Saccharomyces cerevisiae

1993 • 49 citations

Identification of a putative response regulator two-component phosphorelay gene (CaSSK1) fromCandida albicans

1999 • 49 citations

SLK1, a yeast homolog of MAP kinase activators, has a RAS/cAMP-independent role in nutrient sensing

1994 • 48 citations

The essential protein Fap7 is involved in the oxidative stress response of Saccharomyces cerevisiae

2000 • 47 citations

The osmo‐inducible gpdl⁺ gene is a target of the signaling pathway involving Wis1 MAP‐kinase kinase in fission yeast

1995 • 47 citations

Divergent Regulation of the Evolutionarily Closely Related Promoters of the Saccharomyces cerevisiae STA2 and MUC1 Genes

1999 • 46 citations

Role of Atfl and Papl in the Induction of the Catalase Gene of Fission Yeast Schizosaccharomyces pombe

2000 • 46 citations

Activated Alleles of Yeast SLN1 Increase Mcm1-dependent Reporter Gene Expression and Diminish Signaling through the Hog1 Osmosensing Pathway

1997 • 46 citations

Implications ofFPS1deletion and membrane ergosterol content for glycerol efflux fromSaccharomyces cerevisiae

2001 • 46 citations

Nucleocytoplasmic traffic of MAP kinases.

1999 • 45 citations

Glycerol production in relation to the ATP pool and heat production rate of the yeasts Debaryomyces hansenii and Saccharomyces cerevisiae during salt stress

1987 • 45 citations

Existence of a tightly regulated water channel inSaccharomyces cerevisiae

2001 • 45 citations

Functional roles of conserved amino acid residues surrounding the phosphorylatable histidine of the yeast phosphorelay protein YPD1

2000 • 45 citations

Ssa1p chaperone interacts with the guanine nucleotide exchange factor of ras Cdc25p and controls the cAMP pathway in Saccharomyces cerevisiae

1998 • 45 citations

Modular complexes that regulate actin assembly in budding yeast

2001 • 44 citations

Transmembrane signal transduction and osmoregulation in Escherichia coli. Functional importance of the periplasmic domain of the membrane-located protein kinase, EnvZ.

1991 • 44 citations

The Prr1 response regulator is essential for transcription of ste11 + and for sexual development in fission yeast

2000 • 44 citations

The High Osmolarity Glycerol Response (HOG) MAP Kinase Pathway Controls Localization of a Yeast Golgi Glycosyltransferase

1998 • 44 citations

Protein expression during exponential growth in 0.7 M NaCl medium ofSaccharomyces cerevisiae

1996 • 42 citations

Two putative MAP kinase genes, ZrHOG1 and ZrHOG2, cloned from the salt-tolerant yeast Zygosaccharomyces rouxii are functionally homologous to the Saccharomyces cerevisiae HOG1 gene

1999 • 42 citations

How water molecules pass through aquaporins

2001 • 41 citations

Mutations in a Protein Tyrosine Phosphatase Gene (PTP2) and a Protein Serine/Threonine Phosphatase Gene (PTC1) Cause a Synthetic Growth Defect in Saccharomyces cerevisiae

1993 • 41 citations

Characterization of domains in the yeast MAP kinase Slt2 (Mpk1) required for functional activity and in vivo interaction with protein kinases Mkk1 and Mkk2

1995 • 41 citations

Amino acid uptake is strongly affected during exponential growth ofSaccharomyces cerevisiaein 0.7 M NaCl medium

1998 • 41 citations

Transposon mutagenesis reveals novel loci affecting tolerance to salt stress and growth at low temperature

2001 • 40 citations

Transmembrane signal transduction by the Escherichia coli osmotic sensor, EnvZ: intermolecular complementation of transmembrane signalling

1994 • 39 citations

The Saccharomyces cerevisiae RanGTP-Binding Protein Msn5p Is Involved in Different Signal Transduction Pathways

1999 • 38 citations

The Essential Transcription Factor, Mcm1, Is a Downstream Target of Sln1, a Yeast "Two-component" Regulator

1995 • 38 citations

Chapter 7 Aquaporins of plants: Structure, function, regulation, and role in plant water relations

2001 • 38 citations

Nutritional upshift response of ribosomal protein gene transcription inSaccharomyces cerevisiae

1994 • 38 citations

A mutation in the Rho1-GAP-encoding gene BEM2 of Saccharomyces cerevisiae affects morphogenesis and cell wall functionality

1998 • 37 citations

The RCK1 and RCK2 protein kinase genes from Saccharomyces cerevisiae suppress cell cycle checkpoint mutations in Schizosaccharomyces pombe

1995 • 36 citations

NHP6A and NHP6B, Which Encode HMG1-Like Proteins, Are Candidates for Downstream Components of the Yeast SLT2 Mitogen-Activated Protein Kinase Pathway

1994 • 36 citations

Cloning and Genetic Mapping of SNF1, a Gene Required for Expression of Glucose-Repressible Genes in Saccharomyces cerevisiae

1984 • 36 citations

AGT1 , Encoding an α-Glucoside Transporter Involved in Uptake and Intracellular Accumulation of Trehalose in Saccharomyces cerevisiae

1999 • 36 citations

Tor Controls Translation Initiation and Early G1 Progression

1996 • 35 citations

Analysis of the Pore of the Unusual Major Intrinsic Protein Channel, Yeast Fps1p

2001 • 34 citations

Isolation and characterization of osmosensitive vacuolar mutants of Saccharomyces cerevisiae

1991 • 34 citations

Effect of xylitol and trehalose on dry resistance of yeasts

1997 • 33 citations

Changes in activities of several enzymes involved in carbohydrate metabolism during the cell cycle of Saccharomyces cerevisiae

1988 • 33 citations

STRE- and cAMP-independent transcriptional induction ofSaccharomyces cerevisiaeGSY2 encoding glycogen synthase during diauxic growth on glucose

1999 • 32 citations

Antifungal Properties and Target Evaluation of Three Putative Bacterial Histidine Kinase Inhibitors

1999 • 32 citations

Fission Yeast pap1-Dependent Transcription Is Negatively Regulated by an Essential Nuclear Protein, crml

1992 • 32 citations

Protein-protein interactions in the yeastPKC1 pathway: Pkc1p interacts with a component of the MAP kinase cascade

1996 • 31 citations

From feast to famine: Adaptation to nutrient depletion in yeast

1997 • 31 citations

Mutants affected in the putative diacylglycerol binding site of yeast protein kinase C

1997 • 31 citations

Mcs4, a Two-Component System Response Regulator Homologue, Regulates the Schizosaccharomyces pombe Cell Cycle Control

1997 • 31 citations

Cooperative Regulation of DOG2 , Encoding 2-Deoxyglucose-6-Phosphate Phosphatase, by Snf1 Kinase and the High-Osmolarity Glycerol–Mitogen-Activated Protein Kinase Cascade in Stress Responses of Saccharomyces cerevisiae

2000 • 31 citations

Perturbation of the Nucleus: A Novel Hog1p-independent, Pkc1p-dependent Consequence of Hypertonic Shock in Yeast

2001 • 31 citations

4. Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts

1999 • 31 citations

Evidence for a Dual Osmoregulatory Mechanism in the Yeast Saccharomyces cerevisiae

1993 • 30 citations

Nuclear protein import, but not mRNA export, is defective in all Saccharomyces cerevisiae mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p

1998 • 29 citations

Unigenic evolution: a novel genetic method localizes a putative leucine zipper that mediates dimerization of the Saccharomyces cerevisiae regulator Gcr1p.

1995 • 29 citations

Mutations in GCR1, a transcriptional activator of Saccharomyces cerevisiae glycolytic genes, function as suppressors of gcr2 mutations.

1995 • 27 citations

Osmoregulation in the model organismEscherichia coli: genes governing the synthesis of glycine betaine and trehalose and their use in metabolic engineering of stress tolerance

1998 • 27 citations

Mutations in SPC110, encoding the yeast spindle pole body calmodulin-binding protein, cause defects in cell integrity as well as spindle formation

2000 • 26 citations

Negatively charged phospholipids influence the activity of the sensor kinase KdpD of Escherichia coli

1999 • 26 citations

A multicopy suppressor gene, MSS10, restores STA2 expression in Saccharomyces cerevisiae strains containing the STA10 repressor gene

1996 • 25 citations

Functional analysis of theNeurospora crassa PZL-1 protein phosphatase by expression in budding and fission yeast

2001 • 24 citations

Rap1p-binding Sites in the Saccharomyces cerevisiae GPD1 Promoter Are Involved in Its Response to NaCl

2000 • 24 citations

ACR1, a Yeast ATF/CREB Repressor

1992 • 24 citations

Two-component signal-transduction systems in budding yeast MAP a different pathway?

1995 • 23 citations

Differential role of Hsps and trehalose in stress tolerance

1998 • 23 citations

Water Transport across Yeast Vacuolar and Plasma Membrane-Targeted Secretory Vesicles Occurs by Passive Diffusion

1999 • 22 citations

SGD1 encodes an essential nuclear protein of Saccharomyces cerevisiae that affects expression of the GPD1 gene for glycerol 3‐phosphate dehydrogenase

2000 • 22 citations

Vacuole Fusion Regulated by Protein Phosphatase 2C in Fission Yeast

1999 • 22 citations

Identification of ASK10 as a multicopy activator of Skn7p-dependent transcription of a HIS3 reporter gene.

1996 • 19 citations

The protein kinases Rck1 and Rck2 inhibit meiosis in budding yeast

2000 • 19 citations

Regulation of Mitochondrial Biogenesis in Saccharomyces cerevisiae

1995 • 18 citations

The Osmotic Integrity of the Yeast Cell Requires a Functional PKC1 Gene Product

1992 • 18 citations

Identification of ASK10 as a multicopy activator of Skn7p-dependent transcription of a HIS3 reporter gene

1996 • 17 citations

The Fission Yeast Genes pyp1⁺ and pyp2⁺ Encode Protein Tyrosine Phosphatases That Negatively Regulate Mitosis

1992 • 17 citations

Elevated Growth of Saccharomyces cerevisiae ATH1 Null Mutants on Glucose Is an Artifact of Nonmatching Auxotrophies of Mutant and Reference Strains

1999 • 17 citations

Channel gating: Twist to open

2001 • 17 citations

Five novel elements involved in the regulation of mitosis in fission yeast

1992 • 15 citations

A genetic screen reveals a role for the late G1-specific transcription factor Swi4p in diverse cellular functions including cytokinesis

1997 • 14 citations

Regulation of Trehalase Activity during the Cell Cycle of Saccharomyces cerevisiae

1988 • 14 citations

Cellular function of protein phosphatase 2C in yeast.

1994 • 13 citations

Multiple effects of protein phosphatase 2A on nutrient‐induced signalling in the yeast Saccharomyces cerevisiae^‡

2001 • 11 citations

Candidate osmosensors from Candida utilis and Kluyveromyces lactis: structural and functional homology to the Sho1p putative osmosensor from Saccharomyces cerevisiae

2000 • 11 citations

New Elements in the Mitotic Control of the Fission Yeast Schizosaccharomyces pombe

1991 • 10 citations

SLG1 plays a role during G1 in the decision to enter or exit the cell cycle

2000 • 9 citations

Identification of the catalase gene promoter region involved in superinduction inSchizosaccharomyces pombecaused by cycloheximide and hydrogen peroxide

1999 • 8 citations

Physiological and genetic characterisation of osmosensitive mutants of Saccharomyes cerevisiae

1998 • 6 citations

The aquaporin superfamily: structure and function

2002 • 5 citations

Multi-domainial Structure of the Yeast Transcription Factor, Gcrl, and its Possible Mode of DNA-binding.

1995 • 4 citations