The Transcriptional Response of Saccharomyces cerevisiae to Osmotic Shock

Living with Water Stress: Evolution of Osmolyte Systems

1982 • 3,735 citations

Elevated recombination rates in transcriptionally active DNA

1989 • 1,666 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE).

1996 • 1,050 citations

MAP Kinase Pathways in the Yeast Saccharomyces cerevisiae

1998 • 939 citations

Yeast HOG1 MAP Kinase Cascade Is Regulated by a Multistep Phosphorelay Mechanism in the SLN1–YPD1–SSK1 “Two-Component” Osmosensor

1996 • 876 citations

Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity

1998 • 759 citations

The fungal vacuole: composition, function, and biogenesis

1990 • 758 citations

Regulation of Levels of Proline as an Osmolyte in Plants under Water Stress

1997 • 673 citations

Novel sensing mechanisms and targets for the cAMP–protein kinase A pathway in the yeast Saccharomyces cerevisiae

1999 • 660 citations

Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor

1995 • 649 citations

GPD1, Which Encodes Glycerol-3-Phosphate Dehydrogenase, Is Essential for Growth under Osmotic Stress in Saccharomyces cerevisiae, and Its Expression Is Regulated by the High-Osmolarity Glycerol Response Pathway

1994 • 630 citations

Yeast Stress Responses

2002 • 592 citations

Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK

1997 • 569 citations

The H2O2 Stimulon in Saccharomyces cerevisiae

1998 • 564 citations

Yap1 and Skn7 Control Two Specialized Oxidative Stress Response Regulons in Yeast

1999 • 548 citations

The two isoenzymes for yeast NAD⁺-dependent glycerol 3-phosphate dehydrogenase encoded byGPD1andGPD2have distinct roles in osmoadaptation and redox regulation

1997 • 528 citations

The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene.

1994 • 511 citations

Molecular responses to drought and cold stress

1996 • 476 citations

Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae.

1996 • 476 citations

A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions.

1993 • 470 citations

Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress.

1995 • 418 citations

Stress signaling in yeast

1995 • 415 citations

Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1

1998 • 414 citations

The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae

1998 • 386 citations

Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation

1999 • 382 citations

REGULATION OF GENE EXPRESSION BY HYPERTONICITY

1997 • 364 citations

Salt Tolerance in Plants and Microorganisms: Toxicity Targets and Defense Responses

1996 • 352 citations

Stress-induced transcriptional activation

1995 • 325 citations

The protein kinase C‐mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae

1999 • 325 citations

Effects of various types of stress on the metabolism of reserve carbohydrates in Saccharomyces cerevisiae: genetic evidence for a stress-induced recycling of glycogen and trehalose

1997 • 306 citations

Yap, a Novel Family of Eight bZIP Proteins in Saccharomyces cerevisiae with Distinct Biological Functions

1997 • 302 citations

Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator

1998 • 289 citations

Role of trehalose in survival of Saccharomyces cerevisiae under osmotic stress

1998 • 281 citations

A Second Osmosensing Signal Transduction Pathway in Yeast

1995 • 278 citations

Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p

1999 • 275 citations

Msn2p and Msn4p Control a Large Number of Genes Induced at the Diauxic Transition Which Are Repressed by Cyclic AMP in Saccharomyces cerevisiae

1998 • 269 citations

Purification and Characterization of Two Isoenzymes of DL-Glycerol-3-phosphatase from Saccharomyces cerevisiae

1996 • 233 citations

Two Homologous Zinc Finger Genes Identified by Multicopy Suppression in a SNF1 Protein Kinase Mutant of Saccharomyces cerevisiae

1993 • 218 citations

Kinase Activity-dependent Nuclear Export Opposes Stress-induced Nuclear Accumulation and Retention of Hog1 Mitogen-activated Protein Kinase in the Budding YeastSaccharomyces cerevisiae

1999 • 212 citations

The Saccharomyces cerevisiae HSP12 Gene Is Activated by the High-Osmolarity Glycerol Pathway and Negatively Regulated by Protein Kinase A

1995 • 207 citations

A search in the genome ofSaccharomyces cerevisiae for genes regulated via stress response elements

1998 • 204 citations

The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.

1995 • 189 citations

Metabolic and Regulatory Changes Associated with Growth of Saccharomyces cerevisiae in 1.4 M NaCl

1997 • 186 citations

A gene encoding sn‐glycerol 3‐phosphate dehydrogenase (NAD⁺) complements an osmosensitive mutant of Saccharomyces cerevisiae

1993 • 182 citations

Repressors and Upstream Repressing Sequences of the Stress-Regulated ENA1 Gene in Saccharomyces cerevisiae: bZIP Protein Sko1p Confers HOG-Dependent Osmotic Regulation

1999 • 181 citations

Signal transduction by MAP kinase cascades in budding yeast

1998 • 170 citations

Regulation of genes encoding subunits of the trehalose synthase complex inSaccharomyces cerevisiae: novel variations of STRE-mediated transcription control?

1996 • 153 citations

Dynamic responses of reserve carbohydrate metabolism under carbon and nitrogen limitations inSaccharomyces cerevisiae

1999 • 151 citations

Three genes whose expression is induced by stress inSaccharomyces cerevisiae

1999 • 146 citations

The PPZ Protein Phosphatases Are Important Determinants of Salt Tolerance in Yeast Cells

1995 • 145 citations

A proposal for nomenclature of aldehyde dehydrogenases inSaccharomyces cerevisiae and characterization of the stress-inducibleALD2 andALD3 genes

1999 • 142 citations

Requirement of STE50 for Osmostress-Induced Activation of the STE11 Mitogen-Activated Protein Kinase Kinase Kinase in the High-Osmolarity Glycerol Response Pathway

1998 • 140 citations

Multiple transduction pathways regulate the sodium‐extrusion gene PMR2/ENA1 during salt stress in yeast

1996 • 134 citations

Characterization of the osmotic-stress response inSaccharomyces cerevisiae: osmotic stress and glucose repression regulate glycerol-3-phosphate dehydrogenase independently

1994 • 126 citations

Differential Requirement of the Yeast Sugar Kinases for Sugar Sensing in Establishing the Catabolite‐Repressed State

1996 • 126 citations

Different signalling pathways contribute to the control of GPD1 gene expression by osmotic stress in Saccharomyces cerevisiae

1999 • 126 citations

Proline transport in Saccharomyces cerevisiae

1981 • 125 citations

Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae

1995 • 123 citations

Microbial MIP channels

2000 • 121 citations

Transcriptional Elements Involved in the Repression of Ribosomal Protein Synthesis

1999 • 117 citations

Expression and Function of the Trehalase Genes NTH1 and YBR0106 in Saccharomyces cerevisiae

1995 • 104 citations

Positioning of cell growth and division after osmotic stress requires a map kinase pathway

1994 • 100 citations

The Osmoregulatory Pathway Represses Mating Pathway Activity in Saccharomyces cerevisiae: Isolation of a FUS3 Mutant That Is Insensitive to the Repression Mechanism

1996 • 99 citations

Expression of the Glyoxalase I Gene of Saccharomyces cerevisiae Is Regulated by High Osmolarity Glycerol Mitogen-activated Protein Kinase Pathway in Osmotic Stress Response

1998 • 92 citations

Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins.

1993 • 85 citations

Osmotic Response Element Enhancer Activity

1999 • 85 citations

Neutral trehalase Nth1p of Saccharomyces cerevisiae encoded by the NTH1 gene is a multiple stress responsive protein

1997 • 83 citations

Effect of salt stress on lipid composition and membrane fluidity of the salttolerant yeast Zygosaccharomyces rouxii

1992 • 76 citations

Growth-related expression of ribosomal protein genes in Saccharomyces cerevisiae

1993 • 72 citations

Functional Analysis of the Stress Response Element and Its Role in the Multistress Response ofSaccharomyces cerevisiae

1998 • 70 citations

The Ssn6-Tup1 repressor complex of Saccharomyces cerevisiae is involved in the osmotic induction of HOG-dependent and -independent genes

1998 • 69 citations

A genomic locus in Saccharomyces cerevisiae with four genes up‐regulated by osmotic stress

1995 • 69 citations

Global changes in protein synthesis during adaptation of the yeast Saccharomyces cerevisiae to 0.7 M NaCl

1995 • 65 citations

Genome-wide transcriptional analysis inS. cerevisiae by mini-array membrane hybridization

1999 • 62 citations

Stress factors acting at the level of the plasma membrane induce transcription via the stress response element (STRE) of the yeast Saccharomyces cerevisiae

1999 • 58 citations

Osmoregulation and protein expression in a pbs2Δ mutant of Saccharomyces cerevisiae during adaptation to hypersaline stress

1997 • 56 citations

Osmoresponsive proteins and functional assessment strategies in Saccharomyces cerevisiae

1997 • 53 citations

High-osmolarity signalling in Saccharomyces cerevisiae is modulated in a carbon-source-dependent fashion

1997 • 52 citations

Multiple independent regulatory pathways control UBI4 expression after heat shock in Saccharomyces cerevisiae

1999 • 46 citations

Nucleocytoplasmic traffic of MAP kinases.

1999 • 45 citations

Protein expression during exponential growth in 0.7 M NaCl medium ofSaccharomyces cerevisiae

1996 • 42 citations

The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein

1994 • 33 citations

Gene linkage of two‐dimensional polyacrylamide gel electrophoresis resolved proteins from isogene families in Saccharomyces cerevisiae by microsequencing of in‐gel trypsin generated peptides

1995 • 31 citations

Isolation and Characterization of Membrane Vesicles ofSaccharomyces cerevisiaeHarboring the High-Affinity Phosphate Transporter

1996 • 26 citations

Effect of altered sterol composition on the salt tolerance of Zygosaccharomyces rouxii

1991 • 10 citations