Regulation of extracellular matrix gene expression by mechanical stress

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Das Gesetz der Transformation der Knochen

1893 • 1,947 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Cell Biology of Extracellular Matrix

1988 • 1,498 citations

Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages

1997 • 1,218 citations

Regulation of development and differentiation by the extracellular matrix

1993 • 1,216 citations

Fibroblasts, myofibroblasts, and wound contraction

1994 • 1,150 citations

Cell biology of extracellular matrix

1992 • 1,042 citations

The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen

1997 • 956 citations

THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS

1997 • 876 citations

Replication of smooth muscle cells in vascular disease.

1986 • 770 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

Fibrocartilage in tendons and ligaments — an adaptation to compressive load

1998 • 736 citations

Cyclic Stretching Stimulates Synthesis of Matrix Components by Arterial Smooth Muscle Cells in Vitro

1976 • 701 citations

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.

1993 • 638 citations

Mammalian Skeletal Muscle Fiber Type Transitions

1997 • 629 citations

Connective tissue morphogenesis by fibroblast traction

1982 • 586 citations

Multiple signals converging on NF-κB

1999 • 483 citations

Integrin signaling: specificity and control of cell survival and cell cycle progression

1997 • 474 citations

Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study

1992 • 456 citations

Changes in musculoskeletal structure and function with prolonged bed rest

1997 • 439 citations

Absence of integrin α7 causes a novel form of muscular dystrophy

1997 • 435 citations

Chick myotendinous antigen. I. A monoclonal antibody as a marker for tendon and muscle morphogenesis.

1984 • 435 citations

Cellular Tensegrity: Exploring How Mechanical Changes in the Cytoskeleton Regulate Cell Growth, Migration, and Tissue Pattern during Morphogenesis

1994 • 428 citations

Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins.

1995 • 399 citations

Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.

1995 • 343 citations

Role of integrins in cellular responses to mechanical stress and adhesion

1997 • 335 citations

Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts.

1998 • 330 citations

SPATIAL RELATIONSHIPS IN EARLY SIGNALING EVENTS OF FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION

1997 • 319 citations

Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains

1992 • 307 citations

Forces on adhesive contacts affect cell function

1998 • 271 citations

Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis

1991 • 217 citations

Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase.

1996 • 217 citations

Mechanical Stressing of Integrin Receptors Induces Enhanced Tyrosine Phosphorylation of Cytoskeletally Anchored Proteins

1998 • 216 citations

A Conserved LIM Protein That Affects Muscular Adherens Junction Integrity and Mechanosensory Function in Caenorhabditis elegans

1999 • 208 citations

Various hypertrophic stimuli induce distinct phenotypes in cardiomyocytes

1997 • 206 citations

Pretranslational regulation of extracellular matrix macromolecules and collagenase expression in fibroblasts by mechanical forces.

1992 • 204 citations

Regulation of extracellular matrix synthesis by mechanical stress

1996 • 189 citations

Chondrocyte biosynthesis correlates with local tissue strain in statically compressed adult articular cartilage

1997 • 180 citations

Cell shape: Determinants, regulation, and regulatory role

1990 • 180 citations

Tenascin-C expression by fibroblasts is elevated in stressed collagen gels.

1994 • 176 citations

Tissue-specific expression of the fibril-associated collagens XII and XIV

1994 • 158 citations

Cell Shape: Determinants, Regulation, and Regulatory Role

1989 • 149 citations

Interaction Between a Putative Mechanosensory Membrane Channel and a Collagen

1996 • 145 citations

Expression of tenascin by vascular smooth muscle cells. Alterations in hypertensive rats and stimulation by angiotensin II.

1992 • 129 citations

Integrins and Modulation of Transmitter Release from Motor Nerve Terminals by Stretch

1995 • 128 citations

Collagenase gene expression in fibroblasts is regulated by a three‐dimensional contact with collagen

1989 • 118 citations

Large and small splice variants of collagen XII: differential expression and ligand binding.

1995 • 113 citations

A Three-dimensional Collagen Lattice Activates NF-κB in Human Fibroblasts: Role in Integrin α2 Gene Expression and Tissue Remodeling

1998 • 108 citations

Downregulation of collagen synthesis in fibroblasts within three‐dimensional collagen lattices involves transcriptional and posttranscriptional mechanisms

1993 • 102 citations

Regulation of Collagen VI Expression in Fibroblasts

1989 • 100 citations

The Fibrinogen-like Globe of Tenascin-C Mediates Its Interactions with Neurocan and Phosphacan/Protein-tyrosine Phosphatase-ζ/β

1997 • 98 citations

Rapid and Reversible Regulation of Collagen XII Expression by Changes in Tensile Stress

1999 • 89 citations

Temporal and Spatial Expressions of Type XII Collagen in the Remodeling Periodontal Ligament during Experimental Tooth Movement

1995 • 72 citations

Expression of Tenascin-C in Bones Responding to Mechanical Load

1997 • 59 citations

Ion Channels as Mechanical Transducers

1989 • 50 citations

The bearable lightness of being: Bones, muscles, and spaceflight

1998 • 43 citations

The chick and human collagen α1(XII) gene promoter

1998 • 40 citations

Regulation of collagen production and collagen mRNA amounts in fibroblasts in response to culture conditions

1986 • 17 citations

A Unifying Hypethesis for the Immunopathogenesis of Oral Lichen-Planus

1994 • 11 citations