Calcineurin: From structure to function

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Neuronal Calcium Signaling

1998 • 2,126 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Control of Memory Formation Through Regulated Expression of a CaMKII Transgene

1996 • 1,525 citations

Synaptic plasticity: LTP and LTD

1994 • 1,301 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type

1998 • 998 citations

MAPKs: new JNK expands the group

1994 • 949 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

On target with a new mechanism for the regulation of protein phosphorylation

1993 • 901 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

1998 • 855 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

1994 • 818 citations

Early Animal Evolution: Emerging Views from Comparative Biology and Geology

1999 • 803 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

1995 • 749 citations

Beyond the Dopamine Receptor

1999 • 742 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.

1979 • 724 citations

THE STRUCTURE AND MECHANISM OF PROTEIN PHOSPHATASES: Insights into Catalysis and Regulation

1998 • 706 citations

Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity

1996 • 701 citations

An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression

1993 • 678 citations

Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation

1999 • 652 citations

Protein Phosphatases: Properties and Role in Cellular Regulation

1983 • 645 citations

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

1998 • 639 citations

Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein

1995 • 615 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Long-Term Depression in Hippocampus

1996 • 583 citations

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

1997 • 580 citations

The transcription factor NF-ATc is essential for cardiac valve formation

1998 • 580 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1992 • 561 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

1999 • 544 citations

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

1993 • 543 citations

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

1994 • 542 citations

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1996 • 535 citations

The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family

1989 • 535 citations

Protein Phosphorylation and Neuronal Function

1985 • 525 citations

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 • 525 citations

The CaM kinase II hypothesis for the storage of synaptic memory

1994 • 510 citations

Calcineurin is required for virulence of Cryptococcus neoformans

1997 • 504 citations

Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex

1999 • 497 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

1995 • 484 citations

Discovery of A Ca²⁺‐and calmodulin‐dependent protein phosphatase

1982 • 476 citations

DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission

1998 • 474 citations

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

1998 • 467 citations

Effects of mutant rat dynamin on endocytosis

1993 • 453 citations

Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate

1998 • 450 citations

Calcineurin acts through theCRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast

1997 • 438 citations

Calcineurin Inhibits VCX1-Dependent H⁺/Ca²+ Exchange and Induces Ca²+ ATPases in Saccharomyces cerevisiae

1996 • 431 citations

Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases

1994 • 430 citations

Crystal Structure of a Purple Acid Phosphatase Containing a Dinuclear Fe(III)-Zn(II) Active Site

1995 • 428 citations

Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals

1999 • 426 citations

Bidirectional Regulation of DARPP-32 Phosphorylation by Dopamine

1997 • 416 citations

Differential Expression and Function of Two Homologous Subunits of Yeast 1,3-β-D-Glucan Synthase

1995 • 407 citations

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

1997 • 403 citations

A Role for the Saccharomyces cerevisiae ATX1 Gene in Copper Trafficking and Iron Transport

1997 • 403 citations

Molecular aspects of cellular regulation

1980 • 394 citations

NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun

1999 • 373 citations

The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors

1996 • 370 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Restricted and Regulated Overexpression Reveals Calcineurin as a Key Component in the Transition from Short-Term to Long-Term Memory

1998 • 365 citations

The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

1994 • 362 citations

Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices

1990 • 356 citations

Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

1998 • 355 citations

Recruitment of a ROC1–CUL1 Ubiquitin Ligase by Skp1 and HOS to Catalyze the Ubiquitination of IκBα

1999 • 348 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Mitogen-Activated Protein Kinase Cascades as Regulators of Stress Responses

1998 • 331 citations

Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs

1990 • 330 citations

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

1998 • 329 citations

Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression inSaccharomyces cerevisiae

1997 • 328 citations

Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region

1995 • 326 citations

Roles of Phosphorylation Sites in Regulating Activity of the Transcription Factor Pho4

1999 • 324 citations

Specific Interaction of Type I Receptors of the TGF-β Family with the Immunophilin FKBP-12

1994 • 321 citations

Can calmodulin function without binding calcium?

1991 • 318 citations

Calcium as a cellular regulator

1999 • 315 citations

Identification of the NH₂‐terminal blocking group of calcineurin B as myristic acid

1982 • 312 citations

Role of Phosphorylation in Regulation of the Assembly of Endocytic Coat Complexes

1998 • 310 citations

Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1

1998 • 306 citations

Dual Calcium Ion Regulation of Calcineurin by Calmodulin and Calcineurin B

1994 • 303 citations

Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase.

1985 • 302 citations

Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity

1996 • 300 citations

Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT

1998 • 298 citations

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

1991 • 297 citations

Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats

1996 • 296 citations

PTG, a Protein Phosphatase 1-Binding Protein with a Role in Glycogen Metabolism

1997 • 293 citations

Ca2+-dependent regulation in neuronal gene expression

1997 • 290 citations

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

1995 • 288 citations

Homosynaptic long-term depression in the visual cortex

1994 • 285 citations

Activity-Dependent β-Adrenergic Modulation of Low Frequency Stimulation Induced LTP in the Hippocampal CA1 Region

1996 • 282 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.

1993 • 274 citations

Superoxide dismutase protects calcineurin from inactivation

1996 • 270 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

Identification of an autoinhibitory domain in calcineurin.

1990 • 268 citations

Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals

1998 • 268 citations

Molecular Glue: Kinase Anchoring and Scaffold Proteins

1996 • 264 citations

Transient cardiac expression of constitutively active Gα_qleads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

1998 • 262 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cells.

1993 • 250 citations

Intracellular Sequestration of Sodium by a Novel Na+/H+ Exchanger in Yeast Is Enhanced by Mutations in the Plasma Membrane H+-ATPase

1997 • 248 citations

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.

1992 • 244 citations

Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation

1999 • 242 citations

Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase

1995 • 241 citations

Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription

1997 • 239 citations

Cabin 1, A Negative Regulator for Calcineurin Signaling in T Lymphocytes

1998 • 235 citations

Cain, A Novel Physiologic Protein Inhibitor of Calcineurin

1998 • 232 citations

Essential role for induced Ca2+ influx followed by [Ca2+]i rise in maintaining viability of yeast cells late in the mating pheromone response pathway. A study of [Ca2+]i in single Saccharomyces cerevisiae cells with imaging of fura-2.

1990 • 227 citations

Recruitment of New Sites of Synaptic Transmission During the cAMP-Dependent Late Phase of LTP at CA3–CA1 Synapses in the Hippocampus

1997 • 225 citations

Two NFAT Transcription Factor Binding Sites Participate in the Regulation of CD95 (Fas) Ligand Expression in Activated Human T Cells

1997 • 222 citations

MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating.

1994 • 222 citations

Long-lasting forms of synaptic potentiation in the mammalian hippocampus.

1996 • 222 citations

Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells.

1995 • 220 citations

Stress signaling through Ca ²⁺ /calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants

1998 • 220 citations

Calcineurin

1999 • 217 citations

FKBP12 Binds the Inositol 1,4,5-Trisphosphate Receptor at Leucine-Proline (1400–1401) and Anchors Calcineurin to this FK506-like Domain

1997 • 216 citations

Calcineurin Inhibition of Dynamin I GTPase Activity Coupled to Nerve Terminal Depolarization

1994 • 215 citations

Two Classes of Plant cDNA Clones Differentially Complement Yeast Calcineurin Mutants and Increase Salt Tolerance of Wild-type Yeast

1996 • 207 citations

Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae

1993 • 206 citations

Temperature-Induced Expression of Yeast FKS2 Is under the Dual Control of Protein Kinase C and Calcineurin

1998 • 206 citations

Functional domain structure of calcineurin A: mapping by limited proteolysis

1989 • 201 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Immunophilins and nervous system

1995 • 195 citations

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast

1992 • 195 citations

Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum

1996 • 195 citations

Mammalian brain phosphoproteins as substrates for calcineurin.

1984 • 195 citations

Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450

1999 • 193 citations

Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells.

1992 • 191 citations

Calcineurin, the Ca²⁺/Calmodulin-Dependent Protein Phosphatase, Is Essential in Yeast Mutants with Cell Integrity Defects and in Mutants That Lack a Functional Vacuolar H⁺-Atpase

1995 • 189 citations

Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity.

1986 • 187 citations

Neurotransmitter-Induced Inhibition of Exocytosis in Insulin-Secreting β Cells by Activation of Calcineurin

1996 • 180 citations

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

1999 • 179 citations

TheSaccharomyces cerevisiae genes (CMP1 andCMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B

1991 • 179 citations

Expression of NFAT-Family Proteins in Normal Human T Cells

1997 • 176 citations

Nucleocytoplasmic Shuttling Factors Including Ran and CRM1 Mediate Nuclear Export of NFAT In Vitro

1998 • 175 citations

Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import.

1996 • 173 citations

Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons

1999 • 171 citations

A calcineurin-like gene ppb1 + in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning

1994 • 170 citations

NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum

1999 • 168 citations

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

1989 • 163 citations

A selective role of calcineurin Aα in synaptic depotentiation in hippocampus

1999 • 162 citations

The calmodulin-dependent activation and deactivation of the phosphoprotein phosphatase, calcineurin, and the effect of nucleotides, pyrophosphate, and divalent metal ions. Identification of calcineurin as a Zn and Fe metalloenzyme.

1984 • 160 citations

Alternative Polyadenylation Events Contribute to the Induction of NF-ATc in Effector T Cells

1999 • 160 citations

Amphiphysin I Is Associated with Coated Endocytic Intermediates and Undergoes Stimulation-dependent Dephosphorylation in Nerve Terminals

1997 • 160 citations

Calcineurin: Not Just a Simple Protein Phosphatase

1997 • 159 citations

Dephosphorylation of Neuromodulin by Calcineurin

1989 • 157 citations

Calcineurin, a Type 2B Protein Phosphatase, Modulates the Ca2+-Permeable Slow Vacuolar Ion Channel of Stomatal Guard Cells.

1995 • 149 citations

Point Mutations in v-Myb Disrupt a Cyclophilin-Catalyzed Negative Regulatory Mechanism

1998 • 148 citations

The Calcineurin-Dynamin 1 Complex as a Calcium Sensor for Synaptic Vesicle Endocytosis

1999 • 145 citations

Molecular Cloning and Characterization of Two Isoforms of Saccharomyces cerevisiae Acyl-CoA:Sterol Acyltransferase

1996 • 144 citations

The Product of HUM1, a Novel Yeast Gene, Is Required for Vacuolar Ca²⁺/H⁺ Exchange and Is Related to Mammalian Na⁺/Ca²⁺ Exchangers

1996 • 143 citations

Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member

1997 • 140 citations

Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.

1994 • 140 citations

The NGFI-B protein, an inducible member of the thyroid/steroid receptor family, is rapidly modified posttranslationally.

1990 • 139 citations

Suppression of GABAA receptor responses by NMDA application in hippocampal neurones acutely isolated from the adult guinea‐pig.

1995 • 138 citations

A Viral Mechanism for Inhibition of the Cellular Phosphatase Calcineurin

1998 • 136 citations

Direct Demonstration of NFATp Dephosphorylation and Nuclear Localization in Activated HT-2 Cells Using a Specific NFATp Polyclonal Antibody

1995 • 134 citations

Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220

1999 • 133 citations

The Calcium/Calmodulin-dependent Protein Phosphatase Calcineurin Is the Major Elk-1 Phosphatase

1997 • 132 citations

Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient

1997 • 130 citations

Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.

1990 • 130 citations

Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes.

1993 • 129 citations

T-Cell Receptor Stimulation Elicits an Early Phase of Activation and a Later Phase of Deactivation of the Transcription Factor NFAT1

1996 • 129 citations

Distinct Cellular Expression of Calcineurin Aα and Aβ in Rat Brain

1992 • 127 citations

Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast

1998 • 126 citations

Cyclosporin-a sensitive induction of NF-AT in murine B cells

1994 • 124 citations

Substrate specificity for the human rotamase FKBP: a view of FK506 and rapamycin as leucine-(twisted amide)-proline mimics

1990 • 123 citations

pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast

1998 • 121 citations

A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis

1998 • 119 citations

The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.

1994 • 117 citations

Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes

1994 • 116 citations

Activated Calcineurin Confers High Tolerance to Ion Stress and Alters the Budding Pattern and Cell Morphology of Yeast Cells

1996 • 116 citations

Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin.

1988 • 115 citations

Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.

1995 • 115 citations

The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B.

1993 • 115 citations

Role of Calcineurin and Protein Phosphatase‐2A in the Regulation of DARPP‐32 Dephosphorylation in Neostriatal Neurons

1999 • 114 citations

The balance between postsynaptic Ca(2+)-dependent protein kinase and phosphatase activities controlling synaptic strength.

1996 • 113 citations

Postsynaptic Calcineurin Activity Downregulates Synaptic Transmission by Weakening Intracellular Ca²⁺Signaling Mechanisms in Hippocampal CA1 Neurons

1997 • 111 citations

Nur77 Is Differentially Modified in PC12 Cells upon Membrane Depolarization and Growth Factor Treatment

1991 • 108 citations

Purple acid phosphatase: a diiron enzyme that catalyzes a direct phospho group transfer to water

1993 • 106 citations

The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation

1994 • 105 citations

Identification of a Physical Interaction between Calcineurin and Nuclear Factor of Activated T Cells (NFATp)

1996 • 104 citations

Ca²⁺-Calmodulin Promotes Survival of Pheromone-Induced Growth Arrest by Activation of Calcineurin and Ca²⁺-Calmodulin-Dependent Protein Kinase

1996 • 104 citations

Two-site Interaction of Nuclear Factor of Activated T Cells with Activated Calcineurin

1998 • 101 citations

Regulation of granulocyte-macrophage colony-stimulating factor and E- selectin expression in endothelial cells by cyclosporin A and the T- cell transcription factor NFAT

1995 • 99 citations

Genetically engineered calmodulins differentially activate target enzymes.

1986 • 99 citations

Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77.

1995 • 99 citations

Overexpression and Purification of Human Calcineurin α fromEscherichia coliand Assessment of Catalytic Functions of Residues Surrounding the Binuclear Metal Center

1997 • 98 citations

Cytoskeletal Changes in the Brains of Mice Lacking Calcineurin Aα

1997 • 97 citations

Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells

1995 • 96 citations

Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression.

1995 • 96 citations

cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae

1991 • 95 citations

Impairment of gabaa receptor function byn-methyl-d-aspartate-mediated calcium influx in isolated ca1 pyramidal cells

1994 • 94 citations

Isotope-edited multidimensional NMR of calcineurin B in the presence of the non-deuterated detergent CHAPS

1993 • 94 citations

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

1998 • 93 citations

Multiple NF-ATc Isoforms with Individual Transcriptional Properties Are Synthesized in T Lymphocytes

1999 • 92 citations

Glutamate Induces a Calcineurin‐Mediated Dephosphorylation of Na⁺,K⁺‐ATPase that Results in Its Activation in Cerebellar Neurons in Culture

1996 • 90 citations

AKAP79 Inhibits Calcineurin through a Site Distinct from the Immunophilin-binding Region

1998 • 90 citations

Distinct tissue and cellular distribution of two major isoforms of calcineurin

1997 • 90 citations

Involvement of the Ca2+-dependent Phosphatase Calcineurin in Gene Transcription That Is Stimulated by cAMP through cAMP Response Elements

1995 • 89 citations

Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B)

1994 • 89 citations

Cooperation of Calcineurin and Vacuolar H+-ATPase in Intracellular Ca2+Homeostasis of Yeast Cells

1995 • 88 citations

Evidence for a second isoform of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)

1989 • 88 citations

The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth

1994 • 87 citations

Fiber-Type-Specific Transcription of the Troponin I Slow Gene Is Regulated by Multiple Elements

1999 • 86 citations

The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae.

1993 • 85 citations

Characterization of the phosphatase activity of a baculovirus-expressed calcineurin A isoform.

1992 • 85 citations

Suppression of Oxidative Damage by Saccharomyces cerevisiae ATX2, Which Encodes a Manganese-Trafficking Protein That Localizes to Golgi-Like Vesicles

1996 • 84 citations

Molecular cloning of a calmodulin-dependent phosphatase from murine testis: identification of a developmentally expressed nonneural isoenzyme.

1992 • 84 citations

Characterization of Dual Leucine Zipper-bearing Kinase, a Mixed Lineage Kinase Present in Synaptic Terminals Whose Phosphorylation State Is Regulated by Membrane Depolarization via Calcineurin

1996 • 83 citations

Intracellular Ca2+ Inhibits Smooth Muscle L-Type Ca2+ Channels by Activation of Protein Phosphatase Type 2B and by Direct Interaction with the Channel

1997 • 83 citations

Calcineurin Feedback Inhibition of Agonist-evoked cAMP Formation

1995 • 83 citations

Cognitive kinases.

1993 • 82 citations

Calmodulin binding by calcineurin. Ligand-induced renaturation of protein immobilized on nitrocellulose.

1987 • 81 citations

An essential role of the yeast pheromone-induced Ca2+ signal is to activate calcineurin.

1997 • 81 citations

Cyclosporin A interferes with the inducible degradation of NF-xB inhibitors, but not with the processing of p105/NF-xB1 in T cells

1997 • 79 citations

Synaptic plasticity: Going through phases with LTP

1998 • 77 citations

Dynamin and Endocytosis*

1995 • 76 citations

Activation of nuclear factor-kappaB via T cell receptor requires a Raf kinase and Ca2+ influx. Functional synergy between Raf and calcineurin.

1996 • 76 citations

Dephosphorylation of Protein Kinase C Substrates, Neurogranin, Neuromodulin, and MARCKS, by Calcineurin and Protein Phosphatases 1 and 2A

1995 • 76 citations

Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment.

1991 • 75 citations

Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B)

1992 • 75 citations

Protein Phosphatase 2B of Saccharomyces Cerevisiae is Required for Tolerance to Manganese, in Blocking the Entry of ions into the Cells

1995 • 74 citations

Specific induction of Ca2+ transport activity in MATa cells of Saccharomyces cerevisiae by a mating pheromone, alpha factor.

1985 • 74 citations

Cyclophilin Residues That Affect Noncompetitive Inhibition of the Protein Serine Phosphatase Activity of Calcineurin by the Cyclophilin.cntdot.Cyclosporin A Complex

1994 • 74 citations

Bovine brain calmodulin-dependent protein phosphatase. Regulation of subunit A activity by calmodulin and subunit B.

1985 • 72 citations

Measurement of Calcineurin Phosphatase Activity in Cell Extracts

1996 • 72 citations

Phosphorylation of vimentin in mitotically selected cells. In vitro cyclic AMP-independent kinase and calcium-stimulated phosphatase activities.

1989 • 69 citations

The Saccharomyces cerevisiae SRK1 gene, a suppressor of bcy1 and ins1, may be involved in protein phosphatase function.

1991 • 68 citations

Calcineurin, a Type 2B Protein Phosphatase, Modulates the Ca 2+ -Permeable Slow Vacuolar Ion Channel of Stomatal Guard Cells

1995 • 68 citations

Differential distribution of the mRNA encoding two isoforms of the catalytic subunit of calcineurin in the rat brain

1991 • 68 citations

Adaptation to high-salt stress in Saccharomyces cerevisiae is regulated by Ca2+/calmodulin-dependent phosphoprotein phosphatase (calcineurin) and cAMP-dependent protein kinase

1995 • 68 citations

Mechanism Responsible for T-Cell Antigen Receptor- and CD28- or Interleukin 1 (IL-1) Receptor-Initiated Regulation of IL-2 Gene Expression by NF-κB

1998 • 67 citations

Characterization of the phosphotyrosyl protein phosphatase activity of calmodulin-dependent protein phosphatase.

1986 • 65 citations

vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.

1995 • 65 citations

Calmodulin-dependent protein phosphatase from Neurospora crassa. Molecular cloning and expression of recombinant catalytic subunit.

1991 • 65 citations

Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae

1993 • 65 citations

Heterosynaptic interactions between UP and LTD in CA1 hippocampal slices

1995 • 64 citations

Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)

1992 • 63 citations

Manganese effectively supports yeast cell-cycle progression in place of calcium.

1995 • 62 citations

Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin

1993 • 61 citations

Synaptic Plasticity: A molecular mechanism for metaplasticity

1995 • 60 citations

Kinetic and Spectroscopic Analyses of Mutants of a Conserved Histidine in the Metallophosphatases Calcineurin and λ Protein Phosphatase

1997 • 60 citations

Characterization of the calcium‐binding sites of calcineurin B

1995 • 58 citations

Primary Structure, Expression and Developmental Regulation of a Dictyostelium Calcineurin A Homologue

1996 • 58 citations

Identification in the Calcineurin A Subunit of the Domain That Binds the Regulatory B Subunit

1995 • 57 citations

Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus

1996 • 57 citations

Contributions of Myristoylation to Calcineurin Structure/Function

1996 • 56 citations

Calcineurin Inhibition and Cardiac Hypertrophy

1998 • 56 citations

Evidence That Calcineurin Accommodates an Active Site Binuclear Metal Center

1995 • 54 citations

Control of NFATx1 Nuclear Translocation by a Calcineurin-Regulated Inhibitory Domain

1997 • 54 citations

Calcineurin Regulates M Channel Modal Gating in Sympathetic Neurons

1996 • 53 citations

Interaction of FKBP12-FK506 with Calcineurin A at the B Subunit-binding Domain

1995 • 53 citations

An inhibitory role of calcineurin in endocytosis of synaptic vesicles at nerve terminals of Drosophila larvae

1997 • 53 citations

The role of calcium in activity-dependent neuronal gene regulation

1998 • 53 citations

Different mechanisms for suppression of apoptosis by cytokines and calcium mobilizing compounds

1998 • 52 citations

Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.

1992 • 52 citations

Protein Phosphatase 2B of Saccharomyces Cerevisiae is Required for Tolerance to Manganese, in Blocking the Entry of ions into the Cells

1995 • 52 citations

Isolation and Sequence of a cDNA Clone for Human Calcineurin B, the Ca²⁺-Binding Subunit of the Ca²⁺/Calmodulin-Stimulated Protein Phosphatase

1989 • 51 citations

Spectroscopic and Enzymatic Characterization of the Active Site Dinuclear Metal Center of Calcineurin: Implications for a Mechanistic Role

1997 • 50 citations

Nonradioactive Assay for Protein Phosphatase 2B (Calcineurin) Activity Using a Partial Sequence of the Subunit of cAMP-Dependent Protein Kinase as Substrate

1994 • 49 citations

Molecular cloning and characterization of the genes encoding the two subunits of Drosophila melanogaster calcineurin.

1992 • 49 citations

Mapping of the immunophilin-immunosuppressant site of interaction on calcineurin.

1994 • 48 citations

Isotope effects on the mechanism of calcineurin catalysis: kinetic solvent isotope and isotope exchange studies

1994 • 48 citations

Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation

1994 • 48 citations

Differential subcellular localization of neural isoforms of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin) in central nervous system neurons: immunohistochemistry on formalin-fixed paraffin sections employing antigen retrieval by microwave irradiation.

1996 • 47 citations

cDNA cloning of a novel testis-specific calcineurin B-like protein

1991 • 46 citations

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively

1996 • 46 citations

Proton, carbon-13, nitrogen-15 nuclear magnetic resonance backbone assignments and secondary structure of human calcineurin B

1994 • 45 citations

Stoichiometry and dynamic interaction of metal ion activators with calcineurin phosphatase.

1986 • 45 citations

Yeast Cls2p/Csg2p localized on the endoplasmic reticulum membrane regulates a non‐exchangeable intracellular Ca²⁺ pool cooperatively with calcineurin

1996 • 44 citations

Cyclosporin A sensitivity of the NF-χB site of the IL2Rα promoter in untransformed murine T cells

1994 • 44 citations

Myristoylation of Calcineurin B Is Not Required for Function or Interaction with Immunophilin-Immunosuppressant Complexes in the Yeast Saccharomyces cerevisiae

1995 • 43 citations

CAPP‐calmodulin: A potent competitive inhibitor of calmodulin actions

1984 • 43 citations

Two Independent Calcineurin-Binding Regions in the N-Terminal Domain of Murine NF-ATx1 Recruit Calcineurin to Murine NF-ATx1

1999 • 41 citations

A calcineurin inhibitor, FK506, blocks voltage-gated calcium channel-dependent LTP in the hippocampus

1998 • 41 citations

8 Calcium control of adenylyl cyclase: The calcineurin connection

1997 • 40 citations

Distribution of calcineurin A isoenzyme mRNAs in rat thymus and kidney

1995 • 38 citations

The immunophilins

1994 • 38 citations

Factors responsible for the Ca²⁺‐dependent inactivation of calcineurin in brain

1995 • 37 citations

Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2Bβ

1991 • 37 citations

Role of Ca++/Calmodulin binding proteins in Aspergillus nidulans cell cycle regulation

1996 • 36 citations

Yeast as model T cells

1994 • 35 citations

Calcineurin Subunit Interactions: Mapping the Calcineurin B Binding Domain on Calcineurin A

1995 • 35 citations

A role for calcineurin in Dictyostelium discoideum development

1996 • 35 citations

Phosphorylation of the carboxyl-terminal region of dystrophin

1996 • 34 citations

cDNA cloning of an alternatively spliced isoform of the regulatory subunit of Ca2+/calmodulin-dependent protein phosphatase (calcineurin Bα2)

1994 • 33 citations

Calcineurin—the missing link in cardiac hypertrophy

1998 • 32 citations

Identification and molecular characterization of the calmodulin‐binding subunit gene (CMP1) of protein phosphatase 2B from Saccharomyces cerevisiae

1992 • 32 citations

Nuclear Factor of Activated T Cells (NFAT) as a New Component of the Signal Transduction Pathway in Glioma Cells

1998 • 31 citations

Isotope Effect Studies on the Calcineurin Phosphoryl-Transfer Reaction: Transition State Structure and Effect of Calmodulin and Mn²⁺

1997 • 31 citations

Regulation of Calcineurin Gene Expression in Schizosaccharomyces pombe

1995 • 30 citations

Mechanism of Ca 2+ -dependent Inactivation of L-type Ca 2+ Channels in GH 3 Cells: Direct Evidence Against Dephosphorylation by Calcineurin

1997 • 29 citations

Detection of the FK506-FKBP-Calcineurin Complex by a Simple Binding Assay

1993 • 27 citations

Activation of Calcineurin A Subunit Phosphatase Activity by Its Calcium-Binding B Subunit

1996 • 26 citations

Binding of Active Cyclosporins to Cyclophilin A and B, Complex Formation with Calcineurin A

1993 • 25 citations

Modulation by calcineurin of 5‐HT₃receptor function in NG108‐15 neuroblastoma x glioma cells

1996 • 24 citations

Chromosomal mapping of the human genes for the calmodulindependent protein phosphatase (calcineurin) catalytic subunit

1991 • 23 citations

Role of Calcineurin in Ca²⁺‐Induced Release of Catecholamines and Neuropeptides

1998 • 22 citations

Ca²⁺/calmodulin‐activated protein phosphatase

1992 • 22 citations

Protein Phosphatase 2B-dependent Pathway of Insulin Action on Single Cl − Channel Conductance in Renal Epithelium

1998 • 22 citations

Identification of a cDNA encoding a Drosophila calcium/calmodulin regulated protein phosphatase, which has its most abundant expression in the early embryo

1994 • 21 citations

Immunocytochemical localization of calcineurin in the adult and developing primary visual cortex of cats

1993 • 21 citations

Molecular and Phylogenetic Analysis of Calmodulin-Dependent Protein Phosphatase (Calcineurin) Catalytic Subunit Genes

1992 • 21 citations

Depolarization of Rat Brain Synaptosomes Increases Phosphorylation of Voltage-sensitive Sodium Channels

1997 • 19 citations

Domain II of calmodulin is involved in activation of calcineurin

1988 • 17 citations

Activation of the protein phosphatase calcineurin during carbachol exposure decreases the extent of recovery from end-plate desensitization

1996 • 16 citations

Identification of testis specific calcineurin β subunit isoform by a monoclonal antibody and detection of a specific six amino acid sequence

1992 • 15 citations

Additions and Corrections to The Caenorhabditis elegans small GTP-binding protein RhoA is enriched in the nerve ring and sensory neurons during larval development.

1995 • 15 citations

Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae

1999 • 14 citations

Dynamic equilibrium between calcineurin and kinase activities regulates the phosphorylation state and localization of the nuclear factor of activated T-cells

1997 • 11 citations

NMR identification of calcineurin B residues affected by binding of a calcineurin A peptide

1995 • 11 citations

Molecular cloning and characterization of the promoter region of the calcineurin Aα gene

1992 • 11 citations

Isolation and sequence of rat testis cdna for a calcium binding polypeptide similar to the regulatory subunit of calcineurin

1991 • 10 citations

Characterization of calcineurin from Hymenolepis microstoma and H. diminuta and its interaction with cyclosporin A

1997 • 9 citations

Drosophila melanogaster contains both X-linked and autosomal homologues of the gene encoding calcineurin B

1996 • 8 citations

Calcineurin-catalyzed reaction with phosphite and phosphate esters of tyrosine

1991 • 8 citations

Reconstitution of Active Human Calcineurin from Recombinant Subunits Expressed in Bacteria

1995 • 4 citations

Chromosomal assignments of the genes for the calcineurin Aα (<i>Calna</i><i>1</i>) and Aβ subunits (<i>Calna2</i>) in the rat

1994 • 3 citations

Calcineurin B- and calmodulin-binding preferences identified with phage-displayed peptide libraries

1999 • 2 citations

Yeast has homologs ( CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase

1992 • 1 citations