Heat shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases

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1995 • 4,589 citations

[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

1991 • 3,691 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine.

1990 • 859 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

1995 • 578 citations

Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast

1995 • 474 citations

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

1996 • 419 citations

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase.

1996 • 419 citations

Experiments with fission yeast : a laboratory course manual

1993 • 414 citations

The role of trehalose synthesis for the acquisition of thermotolerance in yeast

1994 • 379 citations

The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.

1996 • 365 citations

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

1995 • 363 citations

Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

1995 • 356 citations

Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle

1990 • 339 citations

The role of trehalose synthesis for the acquisition of thermotolerance in yeast

1994 • 320 citations

Activation and Regulation of the Spc1 Stress-Activated Protein Kinase in Schizosaccharomyces pombe

1996 • 300 citations

Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways

1998 • 292 citations

Experiments with fission yeast: A laboratory course manual

1994 • 290 citations

Role of Mitogen-activated Protein Kinase Phosphatase during the Cellular Response to Genotoxic Stress

1995 • 284 citations

Regulation of the Saccharomyces cerevisiae HOG1 Mitogen-Activated Protein Kinase by the PTP2 and PTP3 Protein Tyrosine Phosphatases

1997 • 266 citations

An emerging family of dual specificity MAP kinase phosphatases

1995 • 256 citations

Chapter 7 Physiological and Cytological Methods for Schizosaccharomyces pombe

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Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast.

1995 • 192 citations

The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.

1997 • 181 citations

Two Protein-tyrosine Phosphatases Inactivate the Osmotic Stress Response Pathway in Yeast by Targeting the Mitogen-activated Protein Kinase, Hog1

1997 • 173 citations

Signal transduction by MAP kinase cascades in budding yeast

1998 • 170 citations

Stress signal, mediated by a Hogl‐like MAP kinase, controls sexual development in fission yeast

1996 • 162 citations

Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast

1998 • 156 citations

Protein phosphatases and the regulation of MAP kinase activity

1998 • 151 citations

Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae.

1997 • 143 citations

The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.

1991 • 133 citations

Mitogen-activated Protein Kinase Phosphatases Inactivate Stress-activated Protein Kinase Pathways in Vivo

1997 • 132 citations

Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast

1997 • 131 citations

Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade.

1997 • 129 citations

Heat Stress Activates Fission Yeast Spc1/StyI MAPK by a MEKK-Independent Mechanism

1998 • 121 citations

Trehalose-6-P synthase is dispensable for growth on glucose but not for spore germination in Schizosaccharomyces pombe

1994 • 76 citations

Protein Phosphatase 2C Acts Independently of Stress-activated Kinase Cascade to Regulate the Stress Response in Fission Yeast

1997 • 72 citations

Stress-activated protein kinase pathway in cell cycle control of fission yeast

1997 • 71 citations

Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe.

1994 • 70 citations

The Fission Yeast Mitotic Regulatorwin1⁺Encodes an MAP Kinase Kinase Kinase That Phosphorylates and Activates Wis1 MAP Kinase Kinase in Response to High Osmolarity

1998 • 67 citations

Active Nucleocytoplasmic Shuttling Required for Function and Regulation of Stress-Activated Kinase Spc1/StyI in Fission Yeast

1999 • 58 citations

Signal Transduction: Switching off MAP kinases

1994 • 40 citations

Mcs4, a Two-Component System Response Regulator Homologue, Regulates the Schizosaccharomyces pombe Cell Cycle Control

1997 • 31 citations

Inactivation of Mitogen-Activated Protein Kinases by a Mammalian Tyrosine-Specific Phosphatase, PTPBR7

1999 • 26 citations

Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1/Spc1 MAP kinase in fission yeast

1998 • 26 citations

Protein Phosphatase 2C, Encoded byptc1⁺, Is Important in the Heat Shock Response ofSchizosaccharomyces pombe

1994 • 23 citations