Mitogen-activated protein (MAP) kinase pathways in plants: Versatile signaling tools

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The MAPK signaling cascade

1995 • 3,300 citations

H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response

1994 • 2,757 citations

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Systemic Acquired Resistance.

1996 • 1,995 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases

1993 • 1,894 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Requirement of Salicylic Acid for the Induction of Systemic Acquired Resistance

1993 • 1,788 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

CARBOHYDRATE-MODULATED GENE EXPRESSION IN PLANTS

1996 • 1,760 citations

Resistance gene-dependent plant defense responses.

1996 • 1,660 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

The CLAVATA1Gene Encodes a Putative Receptor Kinase That Controls Shoot and Floral Meristem Size in Arabidopsis

1997 • 1,329 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

ABSCISIC ACID SIGNAL TRANSDUCTION

1998 • 1,214 citations

Ultrasensitivity in the mitogen-activated protein kinase cascade.

1996 • 1,200 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Transgenic plant aequorin reports the effects of touch and cold-shock and elicitors on cytoplasmic calcium

1991 • 1,140 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Gene Expression and Signal Transduction in Water-Stress Response

1997 • 1,102 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

Ethylene Responses Are Negatively Regulated by a Receptor Gene Family in Arabidopsis thaliana

1998 • 1,036 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

A Polypeptide from Tomato Leaves Induces Wound-Inducible Proteinase Inhibitor Proteins

1991 • 1,021 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Activation of the Ethylene Gas Response Pathway in Arabidopsis by the Nuclear Protein ETHYLENE-INSENSITIVE3 and Related Proteins

1997 • 1,003 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Calcium Regulation in Plant Cells and its Role in Signaling

1995 • 939 citations

MAP Kinase Pathways in the Yeast Saccharomyces cerevisiae

1998 • 939 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

Yeast HOG1 MAP Kinase Cascade Is Regulated by a Multistep Phosphorelay Mechanism in the SLN1–YPD1–SSK1 “Two-Component” Osmosensor

1996 • 876 citations

Death Don't Have No Mercy: Cell Death Programs in Plant-Microbe Interactions.

1996 • 866 citations

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

1998 • 819 citations

Regulation of protein kinase cascades by protein phosphatase 2A

1999 • 798 citations

The Arabidopsis ABSCISIC ACID-INSENSITIVE2 (ABI2) and ABI1 genes encode homologous protein phosphatases 2C involved in abscisic acid signal transduction.

1997 • 759 citations

Early Genes and Auxin Action

1996 • 754 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Rain-, wind-, and touch-induced expression of calmodulin and calmodulin-related genes in Arabidopsis

1990 • 719 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

1998 • 675 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Salicylic acid and disease resistance in plants

1997 • 659 citations

Signal perception and transduction in plant defense responses.

1997 • 648 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

The complexity of Raf-1 regulation

1997 • 633 citations

An Ethylene-Inducible Component of Signal Transduction Encoded by Never-ripe

1995 • 633 citations

CKI1, a Histidine Kinase Homolog Implicated in Cytokinin Signal Transduction

1996 • 616 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

1999 • 602 citations

Ethylene-Binding Sites Generated in Yeast Expressing the Arabidopsis ETR1 Gene

1995 • 593 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

High affinity binding of a fungal oligopeptide elicitor to parsley plasma membranes triggers multiple defense responses

1994 • 590 citations

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

1996 • 589 citations

Elicitor-stimulated ion fluxes and O ₂ ⁻ from the oxidative burst are essential components in triggering defense gene activation and phytoalexin synthesis in parsley

1997 • 582 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK

1997 • 569 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

The Five "Classical" Plant Hormones.

1997 • 548 citations

THE ETHYLENE GAS SIGNAL TRANSDUCTION PATHWAY: A Molecular Perspective

1998 • 548 citations

Tobacco MAP Kinase: A Possible Mediator in Wound Signal Transduction Pathways

1995 • 522 citations

Salicylic acid activates a 48-kD MAP kinase in tobacco.

1997 • 516 citations

Jasmonate-signalled plant gene expression

1997 • 516 citations

Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors

1998 • 510 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana.

1996 • 498 citations

The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.

1995 • 498 citations

Molecular responses to drought and cold stress

1996 • 476 citations

The protein kinases of budding yeast: six score and more

1997 • 473 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

Electrical signalling and systemic proteinase inhibitor induction in the wounded plant

1992 • 469 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

An octadecanoid pathway mutant (JL5) of tomato is compromised in signaling for defense against insect attack.

1996 • 459 citations

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1999 • 456 citations

Rapid Avr9- and Cf-9–Dependent Activation of MAP Kinases in Tobacco Cell Cultures and Leaves: Convergence of Resistance Gene, Elicitor, Wound, and Salicylate Responses

1999 • 456 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

Stress signaling in yeast

1995 • 415 citations

Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1

1998 • 414 citations

The CLAVATA1 Receptor-like Kinase Requires CLAVATA3 for Its Assembly into a Signaling Complex That Includes KAPP and a Rho-Related Protein

1999 • 414 citations

Transcription factors and their genes in higher plants

1999 • 405 citations

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

1998 • 395 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1

1996 • 381 citations

Pathogen defence in plants — a paradigm of biological complexity

1998 • 378 citations

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1997 • 377 citations

Receptor-Mediated Activation of a MAP Kinase in Pathogen Defense of Plants

1997 • 372 citations

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.

1992 • 370 citations

Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins

1982 • 366 citations

Three protein kinase structures define a common motif

1994 • 364 citations

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

1995 • 363 citations

The Dual Specificity Mitogen-activated Protein Kinase Phosphatase-1 and -2 Are Induced by the p42/p44MAPK Cascade

1997 • 358 citations

Association of mitogen-activated protein kinase with the microtubule cytoskeleton.

1995 • 354 citations

Polypeptide signaling for plant defensive genes exhibits analogies to defense signaling in animals.

1996 • 349 citations

Mechanistic Studies of the Dual Phosphorylation of Mitogen-activated Protein Kinase

1997 • 347 citations

The coordinated action of protein tyrosine phosphatases and kinases in cell signaling

1994 • 342 citations

Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development

1995 • 330 citations

Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

1994 • 329 citations

MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases?

1997 • 318 citations

Histidine kinase activity of the ETR1 ethylene receptor from Arabidopsis

1998 • 317 citations

Gibberellins: perception, transduction and responses

1994 • 314 citations

Oligosaccharins, brassinolides, and jasmonates: nontraditional regulators of plant growth, development, and gene expression.

1997 • 303 citations

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae

1989 • 298 citations

Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.

1992 • 292 citations

Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways

1998 • 292 citations

Two-component signal transducers and MAPK cascades

1997 • 288 citations

Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation

1997 • 282 citations

Resistance gene N -mediated de novo synthesis and activation of a tobacco mitogen-activated protein kinase by tobacco mosaic virus infection

1998 • 276 citations

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

1991 • 274 citations

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

1997 • 272 citations

Cold-Induced Changes in Freezing Tolerance, Protein Phosphorylation, and Gene Expression (Evidence for a Role of Calcium)

1993 • 271 citations

Jasmonate-Based Wound Signal Transduction Requires Activation of WIPK, a Tobacco Mitogen-Activated Protein Kinase

1999 • 268 citations

Isolation of a wheat cDNA clone for an abscisic acid-inducible transcript with homology to protein kinases.

1992 • 267 citations

Regulation of the Saccharomyces cerevisiae HOG1 Mitogen-Activated Protein Kinase by the PTP2 and PTP3 Protein Tyrosine Phosphatases

1997 • 266 citations

Glucose and Stress Independently Regulate Source and Sink Metabolism and Defense Mechanisms via Signal Transduction Pathways Involving Protein Phosphorylation.

1997 • 265 citations

Activation of the Tobacco SIP Kinase by Both a Cell Wall–Derived Carbohydrate Elicitor and Purified Proteinaceous Elicitins from Phytophthora spp

1998 • 264 citations

The Two-Component System1

1998 • 263 citations

Suppression of auxin signal transduction by a MAPK cascade in higher plants

1998 • 256 citations

Crystal Structure of p38 Mitogen-activated Protein Kinase

1996 • 252 citations

Rapid changes of protein phosphorylation are involved in transduction of the elicitor signal in plant cells.

1991 • 249 citations

Two Distinct Raf Domains Mediate Interaction with Ras

1995 • 243 citations

MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae.

1994 • 241 citations

Early events in the elicitation of plant defence

1998 • 240 citations

The tobacco wounding-activated mitogen-activated protein kinase is encoded by SIPK

1998 • 239 citations

Fungal elicitors induce a transient release of active oxygen species from cultured spruce cells that is dependent on Ca2+ and protein-kinase activity

1992 • 238 citations

Myelin basic protein kinase activity in tomato leaves is induced systemically by wounding and increases in response to systemin and oligosaccharide elicitors

1997 • 230 citations

Activation of the MKK/ERK Pathway during Somatic Cell Mitosis: Direct Interactions of Active ERK with Kinetochores and Regulation of the Mitotic 3F3/2 Phosphoantigen

1998 • 223 citations

Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms

1995 • 221 citations

Fungal elicitor triggers rapid, transient, and specific protein phosphorylation in parsley cell suspension cultures.

1990 • 220 citations

Receptor-mediated activation of a plant Ca ²⁺ -permeable ion channel involved in pathogen defense

1997 • 216 citations

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

1998 • 215 citations

Wounding Induces the Rapid and Transient Activation of a Specific MAP Kinase Pathway.

1997 • 214 citations

Abscisic Acid Induces Mitogen-Activated Protein Kinase Activation in Barley Aleurone Protoplasts.

1996 • 213 citations

An abscisic acid-induced protein kinase, PKABA1, mediates abscisic acid-suppressed gene expression in barley aleurone layers

1999 • 213 citations

SYSTEMIN: A Polypeptide Signal for Plant Defensive Genes

1998 • 209 citations

Transient Activation and Tyrosine Phosphorylation of a Protein Kinase in Tobacco Cells Treated with a Fungal Elicitor.

1995 • 209 citations

Characterization of two cDNAs that encode MAP kinase homologues in Arabidopsis thaliana and analysis of the possible role of auxin in activating such kinase activities in cultured cells

1994 • 205 citations

Environmental stress response in plants: the role of mitogen-activated protein kinases

1997 • 200 citations

Ethylene Signal Is Transduced via Protein Phosphorylation Events in Plants.

1993 • 199 citations

Phylogenetic and Functional Classification of Mitogen- and Stress-Activated Protein Kinases

1998 • 198 citations

Apoptosis in barley aleurone during germination and its inhibition by abscisic acid

1996 • 197 citations

Autoregulation of the Raf-1 serine/threonine kinase

1998 • 196 citations

A Proline-Rich Sequence Unique to MEK1 and MEK2 Is Required for Raf Binding and Regulates MEK Function

1995 • 196 citations

Early signal transduction pathways in plant–pathogen interactions

1998 • 195 citations

Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast.

1995 • 192 citations

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

1998 • 191 citations

Isolation of ATMEKK1 (a MAP Kinase Kinase Kinase)-Interacting Proteins and Analysis of a MAP Kinase Cascade inArabidopsis

1998 • 190 citations

Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase.

1992 • 188 citations

Mechanical signalling, calcium and plant form

1994 • 185 citations

Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlm1, Which Has Transcriptional Activity Regulated by the Mpk1 (Slt2) Mitogen-Activated Protein Kinase Pathway

1997 • 184 citations

A MAP Kinase Is Activated Late in Plant Mitosis and Becomes Localized to the Plane of Cell Division

1999 • 182 citations

Okadaic acid, a protein phosphatase inhibitor, blocks calcium changes, gene expression, and cell death induced by gibberellin in wheat aleurone cells.

1996 • 176 citations

Rapid stimulation of a soybean protein-serine kinase that phosphorylates a novel bZIP DNA-binding protein, G/HBF-1, during the induction of early transcription-dependent defenses

1997 • 175 citations

MP2C, a plant protein phosphatase 2C, functions as a negative regulator of mitogen-activated protein kinase pathways in yeast and plants

1998 • 173 citations

A higher plant seven-transmembrane receptor that influences sensitivity to cytokinins

1998 • 172 citations

An Abscisic Acid-Activated and Calcium-Independent Protein Kinase from Guard Cells of Fava Bean.

1996 • 169 citations

Inhibition of Pollen Tube Elongation by Microinjected Anti-Rop1Ps Antibodies Suggests a Crucial Role for Rho-Type GTPases in the Control of Tip Growth.

1997 • 169 citations

The MKK7 Gene Encodes a Group of c-Jun NH₂-Terminal Kinase Kinases

1999 • 169 citations

Systemic elevation of phosphatidic acid and lysophospholipid levels in wounded plants

1997 • 169 citations

Expression of the gene for a small GTP binding protein in transgenic tobacco elevates endogenous cytokinin levels, abnormally induces salicylic acid in response to wounding, and increases resistance to tobacco mosaic virus infection.

1994 • 164 citations

Molecular Characterization of a Tyrosine-Specific Protein Phosphatase Encoded by a Stress-Responsive Gene in Arabidopsis

1998 • 159 citations

Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.

1992 • 153 citations

Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth

1999 • 152 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

The protein phosphatase inhibitor calyculin A mimics elicitor action in plant cells and induces rapid hyperphosphorylation of specific proteins as revealed by pulse labeling with [33P]phosphate.

1994 • 149 citations

The ‘second-codon rule’ and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes.

1992 • 147 citations

Genetic analysis of protein tyrosine phosphatases

1998 • 145 citations

Heterotrimeric G Proteins Are Implicated in Gibberellin Induction of α-Amylase Gene Expression in Wild Oat Aleurone

1998 • 142 citations

The pool of map kinase associated with microtubules is small but constitutively active.

1996 • 142 citations

Regulation of Plant Defense Response to Fungal Pathogens: Two Types of Protein Kinases in the Reversible Phosphorylation of the Host Plasma Membrane H+-ATPase.

1996 • 141 citations

Protein Phosphorylation Is Induced in Tobacco Cells by the Elicitor Cryptogein

1994 • 141 citations

ABA signal transduction

1998 • 138 citations

Activation of MAPK homologues by elicitors in tobacco cells

1998 • 136 citations

ATMPKs: a gene family of plant MAP kinases in Arabidopsis thaliana

1993 • 135 citations

Genetic analysis of ABA signal transduction pathways

1998 • 135 citations

Heat shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases

1999 • 134 citations

Identification of a dual‐specificity protein phosphatase that inactivates a MAP kinase fromArabidopsis

1998 • 134 citations

MsERK1: a mitogen-activated protein kinase from a flowering plant.

1993 • 132 citations

Cell cycle regulation during growth-dormancy cycles in pea axillary buds

1995 • 132 citations

Activation of Phospholipase A by Plant Defense Elicitors

1996 • 131 citations

Low temperature signal transduction during cold acclimation: protein phosphatase 2A as an early target for cold‐inactivation

1998 • 130 citations

NPK1, a tobacco gene that encodes a protein with a domain homologous to yeast BCK1, STE11, and Byr2 protein kinases.

1993 • 130 citations

Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

1996 • 127 citations

A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

1996 • 127 citations

A cell cycle regulated MAP kinase with a possible role in cytokinesis in tobacco cells

1998 • 125 citations

How regulated protein translocation can produce switch-like responses

1998 • 124 citations

Regulation by Cytokinins of Endogenous Levels of Jasmonic and Salicylic Acids in Mechanically Wounded Tobacco Plants

1996 • 123 citations

Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

1995 • 123 citations

In vitro phosphorylation of plant plasma membrane proteins in response to the proteinase inhibitor inducing factor

1989 • 122 citations

The Plant Wound Hormone Systemin Binds with the N-Terminal Part to Its Receptor but Needs the C-Terminal Part to Activate It

1998 • 120 citations

Receptor kinases in plant development

1998 • 113 citations

Protein phosphatases and signaling cascades in higher plants

1998 • 113 citations

MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases

1997 • 111 citations

Role of phosphorylation in elicitation of the oxidative burst in cultured soybean cells.

1995 • 109 citations

Identification of a possible MAP kinase cascade in Arabidopsis thaliana based on pairwise yeast two‐hybrid analysis and functional complementation tests of yeast mutants

1998 • 109 citations

The plant homologue of MAP kinase is expressed in a cell cycle‐dependent and organ‐specific manner

1993 • 106 citations

Growth factor‐stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

1994 • 104 citations

Protein phosphatase inhibitors activate anti‐fungal defence responses of soybean cotyledons and cell cultures

1994 • 104 citations

A functional homolog of mammalian protein kinase C participates in the elicitor-induced defense response in potato.

1997 • 103 citations

Systemic elevation of phosphatidic acid and lysophospholipid levels in wounded plants

1997 • 103 citations

Selective suppression of stress‐activated protein kinase pathway by protein phosphatase 2C in mammalian cells

1998 • 103 citations

A developmentally regulated MAP kinase activated by hydration in tobacco pollen.

1997 • 103 citations

MAP Kinase Is Required for the Spindle Assembly Checkpoint but Is Dispensable for the Normal M Phase Entry and Exit in Xenopus Egg Cell Cycle Extracts

1997 • 102 citations

Rapid Avr9- and Cf-9-Dependent Activation of MAP Kinases in Tobacco Cell Cultures and Leaves: Convergence of Resistance Gene, Elicitor, Wound, and Salicylate Responses

1999 • 102 citations

Abscisic Acid Activates a 48-Kilodalton Protein Kinase in Guard Cell Protoplasts

1997 • 102 citations

Slow and Prolonged Activation of the p47 Protein Kinase during Hypersensitive Cell Death in a Culture of Tobacco Cells

1999 • 102 citations

Ras - a versatile cellular switch

1998 • 100 citations

Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation.

1994 • 97 citations

Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation.

1994 • 97 citations

Induction of Hypersensitive Cell Death by a Fungal Protein in Cultures of Tobacco Cells

1998 • 96 citations

Rapid and Transient Activation of a Myelin Basic Protein Kinase in Tobacco Leaves Treated with Harpin from Erwinia amylovora

1997 • 94 citations

GTP-binding proteins in plants

1999 • 92 citations

Ethylene gas: perception, signaling and response

1998 • 92 citations

ERK3 Is a Constitutively Nuclear Protein Kinase

1996 • 92 citations

K-252a inhibits the response of tomato cells to fungal elicitors in vivo and their microsomal protein kinase in vitro

1990 • 92 citations

Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate.

1991 • 92 citations

Cytoplasmic acidification as an early phosphorylation-dependent response of tobacco cells to elicitors

1996 • 92 citations

Kinetics of wound-induced hydraulic signals and variation potentials in wheat seedlings

1992 • 91 citations

Possible involvement of differential splicing in regulation of the activity of Arabidopsis ANP1 that is related to mitogen‐activated protein kinase kinase kinases (MAPKKKs)

1997 • 91 citations

Hypersensitive Response ElicitedbyErwinia amylovoraHarpin RequiresActive Plant Metabolism

1994 • 91 citations

Protein dephosphorylation mediates salicylic acid‐induced expression of PR‐1 genes in tobacco

1997 • 89 citations

Immunological characterization of avian MAP kinases: evidence for nuclear localization.

1992 • 89 citations

Molecular cloning and expression of a MAP kinase homologue from pea

1993 • 86 citations

Jasmonic acid in wound signal transduction pathways

1997 • 85 citations

An insulin-stimulated ribosomal protein S6 kinase from rabbit liver

1989 • 84 citations

Structure-Function Studies of p38 Mitogen-activated Protein Kinase

1997 • 83 citations

Isolation and characterization of a tobacco cDNA clone encoding a putative MAP kinase

1993 • 83 citations

A Potential Signaling Role for Profilin in Pollen of Papaver rhoeas

1998 • 83 citations

Insulin Stimulation of a MEK-Dependent but ERK-Independent SOS Protein Kinase

1996 • 82 citations

Challenges in understanding RLK function

1998 • 82 citations

PRK1, a receptor‐like kinase of Petunia inflata, is essential for postmeiotic development of pollen

1996 • 81 citations

Gibberellin-regulated expression in oat aleurone cells of two kinases that show homology to MAP kinase and a ribosomal protein kinase

1995 • 79 citations

PK12, a plant dual-specificity protein kinase of the LAMMER family, is regulated by the hormone ethylene.

1996 • 77 citations

Molecular genetics of auxin and cytokinin

1994 • 74 citations

Molecular Cloning, Functional Expression in Escherichia coli, and Characterization of Multiple Mitogen‐Activated‐Protein Kinases from Tobacco

1995 • 73 citations

An Arabidopsis thaliana root‐specific kinase homolog is induced by dehydration, ABA, and NaCl

1995 • 73 citations

Contributions of the Mitogen-activated Protein (MAP) Kinase Backbone and Phosphorylation Loop to MEK Specificity

1996 • 73 citations

Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain

1997 • 71 citations

Regulation of Plant Defense Response to Fungal Pathogens: Two Types of Protein Kinases in the Reversible Phosphorylation of the Host Plasma Membrane H + -ATPase

1996 • 70 citations

2,4-Dichlorophenoxyacetic Acid-enhanced Phosphorylation of Soybean Nuclear Proteins

1978 • 70 citations

Cloning and characterisation of MEK1, an Arabidopsis gene encoding a homologue of MAP kinase kinase.

1997 • 69 citations

The MEK1 Proline-rich Insert Is Required for Efficient Activation of the Mitogen-activated Protein Kinases ERK1 and ERK2 in Mammalian Cells

1998 • 69 citations

Functional Mapping of the N-terminal Regulatory Domain in the Human Raf-1 Protein Kinase

1995 • 68 citations

Insulin and Epidermal Growth Factor Receptors Regulate Distinct Pools of Grb2-SOS in the Control of Ras Activation

1996 • 68 citations

MMK2, a novel alfalfa MAP kinase, specifically complements the yeast MPK1 function

1995 • 66 citations

Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases

1999 • 66 citations

Studies on Elicitor-Signal Transduction Leading to Differential Expression of Defense Genes in Cultured Tobacco Cells

1995 • 66 citations

The Pisum sativum MAP kinase homologue (PsMAPK) rescues the Saccharomyces cerevisiae hog1 deletion mutant under conditions of high osmotic stress

1996 • 66 citations

Cytosolic acidification but not auxin at physiological concentration is an activator of MAP kinases in tobacco cells

1998 • 65 citations

The Electronic Plant Gene Register

1998 • 63 citations

An increase in cytosolic calcium ion concentration precedes hypoosmotic shock‐induced activation of protein kinases in tobacco suspension culture cells

1997 • 62 citations

The Expression Pattern of the Gene for NPK1 Protein Kinase Related to Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK) in a Tobacco Plant: Correlation with Cell Proliferation

1998 • 61 citations

Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.

1994 • 60 citations

Protein kinases

1994 • 60 citations

Evidence suggesting protein tyrosine phosphorylation in plants depends on the developmental conditions

1999 • 60 citations

Inhibition by kinase inhibitors of the development and the disappearance of the preprophase band of microtubules in tobacco BY-2 cells

1992 • 59 citations

Abscisic acid signal transduction in epidermal cells of Pisum sativum L. Argenteum : both dehydrin mRNA accumulation and stomatal responses require protein phosphorylation and dephosphorylation

1997 • 58 citations

A homologue of the MAP/ERK family of protein kinase genes is expressed in vegetative and in female reproductive organs of Petunia hybrida

1995 • 58 citations

MAP Kinase Cascades in Arabidopsis: Their Roles in Stress and Hormone Responses

2000 • 55 citations

Regulation of p42 Mitogen‐Activated‐Protein Kinase Activity by Protein Phosphatase 2A Under Conditions of Growth Inhibition by Epidermal Growth Factor in A431 Cells

1996 • 54 citations

De novo transcription of specific mRNAs during the induction of tobacco pollen embryogenesis

1993 • 53 citations

Distinct Steps in Yeast Spore Morphogenesis Require Distinct SMK1 MAP Kinase Thresholds

1999 • 52 citations

Elicitation of Plant Hypersensitive Response by Bacteria

1996 • 51 citations

A tobacco protein kinase, NPK2, has a domain homologous to a domain found in activators of mitogen-activated protein kinases (MAPKKs)

1995 • 50 citations

Molecular genetics of auxin and cytokinin

1994 • 49 citations

An endogenous factor from soybean (Glycine max L.) cell cultures activates phosphorylation of a protein which is dephosphorylated in vivo in elicitor-challenged cells

1989 • 49 citations

Phosphorylation of nuclear proteins directs binding to salicylic acid‐responsive elements

1997 • 48 citations

Plant MAP kinase kinase kinases structure, classification and evolution

1999 • 45 citations

Ethylene perception: from two-component signal transducers to gene induction

1998 • 45 citations

An unusual protein kinase displaying characteristics of both the serine/threonine and tyrosine families is encoded by the Arabidopsis thaliana gene ATN1

1996 • 43 citations

Serine/Threonine Protein Phosphatase Is Required for Tobacco Mosaic Virus-Mediated Programmed Cell Death

1995 • 43 citations

Higher plant tyrosine-specific protein phosphatases (PTPs) contain novel amino-terminal domains: expression during embryogenesis.

1999 • 42 citations

Mastoparan induces an increase in cytosolic calcium ion concentration and subsequent activation of protein kinases in tobacco suspension culture cells

1998 • 42 citations

Gibberellin signaling

1998 • 41 citations

Cytokinin signaling

1998 • 40 citations

Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors

1998 • 37 citations

MAPKKK-Related protein kinase NPK1: Regulation of the M phase of plant cell cycle

1998 • 37 citations

Ultrastructural distribution of a MAP kinase and transcripts in quiescent and cycling plant cells and pollen grains

1999 • 36 citations

Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues.

1993 • 36 citations

MEK1 mediates a positive feedback on Raf-1 activity independently of Ras and Src

1997 • 35 citations

Regulation of the Phosphorylation of Chromatin-associated Proteins in Lemna and Hordeum

1975 • 33 citations

Evidence for the activation of a MAP kinase upon phosphate‐induced cell cycle re‐entry in tobacco cells

1998 • 32 citations

Activation of 40-kDa Protein Kinases in Response to Hypo- and Hyperosmotic Shock in the Halotolerant Green Alga Dunaliella tertiolecta

1996 • 32 citations

Molecular cloning and characterization of maize ZmMEK1, a protein kinase with a catalytic domain homologous to mitogen- and stress-activated protein kinase kinases

1998 • 32 citations

Characterisation of novel plant genes encoding MEKK/STE11 and RAF-related protein kinases

1999 • 30 citations

Isolation and Preliminary Characterization of a Casein Kinase from Cauliflower Nuclei

1978 • 29 citations

Molecular Cloning and Characterization of Three cDNAs Encoding Putative Mitogen-activated Protein Kinase Kinases (MAPKKs) in Arabidopsis thaliana

1998 • 28 citations

Osjab (Accession No. AF072849): a rice homolog of the human AB1transcriptional coactivator (PGR98-149).

1998 • 27 citations

Cloning and characterization of a novel member of protein kinase family from soybean

1993 • 27 citations

Phosphorylation of tobacco eukaryotic translation initiation factor 4A upon pollen tube germination

1998 • 26 citations

Local and systemic signals in the wound response

1993 • 26 citations

Tyrosine phosphatase signalling in a lower plant: cell‐cycle and oxidative stress‐regulated expression of the Chlamydomonas eugametos VH‐PTP13 gene

1995 • 26 citations

Phosphorylation of Plant Proteins and the Identification of Protein‐Tyrosine Kinase Activity in Maize Seedlings

1996 • 23 citations

Molecular characterisation of plant cDNAs BnMAP4Kα1 and BnMAP4Kα2 belonging to the GCK/SPS1 subfamily of MAP kinase kinase kinase kinase

1999 • 22 citations

Abscisic acid-induced gene-expression requires the activity of protein(s) sensitive to the protein-tyrosine phosphatase inhibitor phenylarsine oxide

1996 • 22 citations

MAP Kinases in Plant Signal Transduction

2000 • 21 citations

Synthesis and phosphorylation of pollen proteins during the pollen-stigma interaction in self-compatible Brassica napus L. and self-incompatible Brassica oleracea L.

1995 • 20 citations

Auxin-regulated changes in protein phosphorylation in pea epicotyls

1987 • 19 citations

Abscisic acid-induced gene-expression requires the activity of protein(s) sensitive to the protein-tyrosine phosphatase inhibitor phenylarsine oxide

1996 • 17 citations

The timing of protein kinase activation events in the cascade that regulates mitotic progression in Tradescantia stamen hair cells.

1995 • 17 citations

Molecular characterisation and expression of an Arabidopsis thaliana L. MAP kinase kinase cDNA, AtMAP2Kα

1999 • 17 citations

Ultraviolet Radiation-stimulated Efflux of 86-Rubidium from Cultured Tobacco Cells

1978 • 17 citations

The SAM kinase pathway: An integrated circuit for stress signaling in plants

1998 • 17 citations

ATMRK1, an Arabidopsis protein kinase related to mammal mixed-lineage kinases and Raf protein kinases

1997 • 14 citations

Arabidopsis thaliana cDNA isolated by functional complementation shows homology to serine/threonine protein kinases

1996 • 14 citations

Auxin‐induced delay of abscission: The involvement of calcium ions and protein phosphorylation in bean explants

1988 • 8 citations

A Heat‐Stress Pulse Inactivates a 50 kDa Myelin Basic Protein Kinase in Tomato

1998 • 6 citations

Metabolic labeling of mitogenactivated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues

1993 • 1 citations

Deleted Work

1955 • 0 citations