Cellular and Molecular Biology of the Aquaporin Water Channels

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein

1992 • 1,979 citations

Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain

1997 • 1,396 citations

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.

1995 • 1,017 citations

Cloning and expression of apical membrane water channel of rat kidney collecting tubule

1993 • 1,002 citations

Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-dependent Concentration of Urine

1994 • 870 citations

Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.

1991 • 795 citations

Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.

1993 • 761 citations

Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney.

1993 • 709 citations

Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.

1994 • 701 citations

Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules.

1988 • 669 citations

Molecular structure of the water channel through aquaporin CHIP. The hourglass model.

1994 • 632 citations

Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord

1998 • 593 citations

Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein

1992 • 588 citations

The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.

1993 • 580 citations

Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells.

1994 • 575 citations

AQUAPORINS AND WATER PERMEABILITY OF PLANT MEMBRANES

1997 • 563 citations

Severely Impaired Urinary Concentrating Ability in Transgenic Mice Lacking Aquaporin-1 Water Channels

1998 • 553 citations

CHIP28 water channels are localized in constitutively water-permeable segments of the nephron.

1993 • 543 citations

The major intrinsic protein (MIP) of the bovine lens fiber membrane: Characterization and structure based on cDNA cloning

1984 • 525 citations

The vacuolar membrane protein gamma-TIP creates water specific channels in Xenopus oocytes.

1993 • 506 citations

Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.

1994 • 502 citations

Pathophysiology of the Aquaporin Water Channels

1996 • 492 citations

Molecular Characterization of a Broad Selectivity Neutral Solute Channel

1998 • 465 citations

The Aquaporins, Blueprints for Cellular Plumbing Systems

1998 • 457 citations

The three-dimensional structure of aquaporin-1

1997 • 451 citations

Water movement through lipid bilayers, pores, and plasma membranes : theory and reality

1987 • 441 citations

Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla.

1995 • 437 citations

Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice

1998 • 437 citations

Aquaporin-4 Water Channel Protein in the Rat Retina and Optic Nerve: Polarized Expression in Müller Cells and Fibrous Astrocytes

1998 • 423 citations

Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress.

1995 • 418 citations

Molecular Cloning and Characterization of an Aquaporin cDNA from Salivary, Lacrimal, and Respiratory Tissues

1995 • 414 citations

Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat

1997 • 409 citations

Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat.

1994 • 395 citations

Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues

1995 • 392 citations

Water and Glycerol Permeabilities of Aquaporins 1–5 and MIP Determined Quantitatively by Expression of Epitope-tagged Constructs inXenopus Oocytes

1997 • 391 citations

Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation

1999 • 382 citations

Cloning and Functional Expression of a New Water Channel Abundantly Expressed in the Testis Permeable to Water, Glycerol, and Urea

1997 • 379 citations

Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins.

1991 • 378 citations

Effect of expressing the water channel aquaporin-1 on the CO₂ permeability ofXenopus oocytes

1998 • 375 citations

Turgor-responsive gene transcription and RNA levels increase rapidly when pea shoots are wilted. Sequence and expression of three inducible genes

1990 • 372 citations

Transport of water and urea in red blood cells

1984 • 354 citations

Localization and quantification of endoplasmic reticulum Ca(2+)-ATPase isoform transcripts

1995 • 341 citations

Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones.

1998 • 325 citations

Substrate specificity and transport properties of the glycerol facilitator of Escherichia coli

1980 • 321 citations

Phylogenetic Characterization of the MIP Family of Transmembrane Channel Proteins

1996 • 314 citations

Mutations in aquaporin-1 in Phenotypically Normal Humans Without Functional CHIP Water Channels

1994 • 312 citations

Aquaporins: water channel proteins of plant and animal cells

1994 • 304 citations

Aquaporins in complex tissues: distribution of aquaporins 1–5 in human and rat eye

1998 • 300 citations

Cloning and characterization of the vasopressin-regulated urea transporter

1993 • 299 citations

Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex.

1996 • 295 citations

ADH ACTION: EVIDENCE FOR A MEMBRANE SHUTTLE MECHANISM*

1981 • 291 citations

Upregulation of aquaporin-2 water channel expression in chronic heart failure rat.

1997 • 289 citations

Localization of the CHIP28 water channel in rat kidney

1992 • 284 citations

Significance of plasmalemma aquaporins for water‐transport in Arabidopsis thaliana

1998 • 279 citations

Three-dimensional organization of a human water channel

1997 • 278 citations

Cloning and Functional Expression of a New Aquaporin (AQP9) Abundantly Expressed in the Peripheral Leukocytes Permeable to Water and Urea, but Not to Glycerol

1998 • 277 citations

Mutations in the founder of the MIP gene family underlie cataract development in the mouse

1996 • 266 citations

Characterization of Biological Membranes by Equivalent Pores

1968 • 264 citations

Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney.

1994 • 264 citations

An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex.

1998 • 257 citations

Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia

1999 • 249 citations

The Major Intrinsic Protein Family of Arabidopsis Has 23 Members That Form Three Distinct Groups with Functional Aquaporins in Each Group

1997 • 249 citations

Water Channel Properties of Major Intrinsic Protein of Lens

1995 • 248 citations

Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study.

1993 • 238 citations

Manic-Depressive Illness and Creativity

1995 • 233 citations

The AQP2 water channel: Effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats

1995 • 231 citations

Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat.

1997 • 228 citations

Transcriptional regulation of aquaporin-2 water channel gene by cAMP.

1997 • 228 citations

Antimonite is accumulated by the glycerol facilitator GlpF in Escherichia coli

1997 • 227 citations

Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung

1998 • 224 citations

Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4

1997 • 222 citations

Molecular Cloning and Characterization of AqpZ, a Water Channel from Escherichia coli

1995 • 218 citations

Biologically active two-dimensional crystals of aquaporin CHIP.

1994 • 211 citations

Ultrastructure, Pharmacologic Inhibition, and Transport Selectivity of Aquaporin CHIP in Proteoliposomes

1994 • 206 citations

Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat.

1996 • 205 citations

Patients with autosomal nephrogenic diabetes insipidus homozygous for mutations in the aquaporin 2 water-channel gene.

1994 • 204 citations

Functional reconstitution of the isolated erythrocyte water channel CHIP28.

1992 • 202 citations

Root-Knot Nematode—Directed Expression of a Plant Root—Specific Gene

1994 • 200 citations

Cloning of a Novel Water and Urea-Permeable Aquaporin from Mouse Expressed Strongly in Colon, Placenta, Liver, and Heart

1997 • 199 citations

Glucose transporters serve as water channels.

1990 • 197 citations

Keratinocyte Growth Factor Modulates Alveolar Epithelial Cell Phenotype In Vitro: Expression of Aquaporin 5

1998 • 196 citations

Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct

1997 • 193 citations

The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.

1996 • 193 citations

Evolution of the MIP family of integral membrane transport proteins

1991 • 192 citations

Cloning and Functional Expression of a Second New Aquaporin Abundantly Expressed in Testis

1997 • 191 citations

Comparison of the Water Transporting Properties of MIP and AQP1

1997 • 190 citations

Functional Analysis of Nodulin 26, an Aquaporin in Soybean Root Nodule Symbiosomes

1997 • 189 citations

Extrarenal tissue distribution of CHIP28 water channels by in situ hybridization and antibody staining

1994 • 188 citations

Secretin Promotes Osmotic Water Transport in Rat Cholangiocytes by Increasing Aquaporin-1 Water Channels in Plasma Membrane

1997 • 187 citations

The human Na⁺–glucose cotransporter is a molecular water pump

1998 • 187 citations

Functional characterization of the Escherichia coli glycerol facilitator, GlpF, in Xenopus oocytes.

1994 • 185 citations

Developmental gene expression and tissue distribution of the CHIP28 water-channel protein.

1993 • 185 citations

Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle.

1998 • 183 citations

Cloning of a water channel homolog expressed in brain meningeal cells and kidney collecting duct that functions as a stilbene-sensitive glycerol transporter.

1994 • 182 citations

Molecular Cloning and Expression of a Novel Human Aquaporin from Adipose Tissue with Glycerol Permeability

1997 • 178 citations

Molecular Cloning of a New Aquaporin from Rat Pancreas and Liver

1997 • 178 citations

Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat

1997 • 171 citations

Forskolin Stimulation of Water and Cation Permeability in Aquaporin1 Water Channels

1996 • 169 citations

Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice

1998 • 168 citations

Bidirectional Water Fluxes and Specificity for Small Hydrophilic Molecules in Aquaporins 0–5

1998 • 167 citations

Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.

1994 • 163 citations

Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen.

1987 • 160 citations

cAMP motifs regulating transcription in the aquaporin 2 gene

1996 • 160 citations

Regulation of aquaporin-2 water channel trafficking by vasopressin

1997 • 160 citations

Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins

1990 • 154 citations

Glycerol facilitator of Escherichia coli: cloning of glpF and identification of the glpF product

1990 • 152 citations

Expression of mRNA coding for kidney and red cell water channels in Xenopus oocytes.

1990 • 147 citations

Regulation of Aquaporin-4 Water Channels by Phorbol Ester-dependent Protein Phosphorylation

1998 • 147 citations

Two TIP‐like genes encoding aquaporins are expressed in sunflower guard cells

1997 • 143 citations

Renal aquaporins

1996 • 142 citations

Aquaporin-1 water channel expression in human kidney.

1997 • 142 citations

Evidence for the Presence of Aquaporin-3 in Human Red Blood Cells

1998 • 140 citations

An Aquaporin-Like Gene Required for the Brassica Self-Incompatibility Response

1997 • 133 citations

Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens.

1994 • 131 citations

Selectivity of the Renal Collecting Duct Water Channel Aquaporin-3

1996 • 131 citations

A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k

1993 • 127 citations

Expression of Aquaporins in the Rat Ocular Tissue

1997 • 122 citations

The three-dimensional structure of human erythrocyte aquaporin CHIP.

1994 • 120 citations

Functional unit of 30 kDa for proximal tubule water channels as revealed by radiation inactivation.

1991 • 120 citations

Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism.

1994 • 118 citations

Alterations in membrane-associated particle distribution during antidiuretic challenge in frog urinary bladder epithelium

1976 • 110 citations

Localization of aquaporin CHIP in the human eye: implications in the pathogenesis of glaucoma and other disorders of ocular fluid balance.

1994 • 109 citations

Upregulation of aquaporin 2 water channel expression in pregnant rats.

1998 • 109 citations

Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers.

1994 • 106 citations

Tandem sequence repeats in transmembrane channel proteins

1991 • 106 citations

Aqp1expression in erythroleukemia cells: genetic regulation of glucocorticoid and chemical induction

1997 • 104 citations

Vasopressin stimulates formation of coated pits in rat kidney collecting ducts

1983 • 103 citations

Aquaporins in Saccharomyces

1998 • 102 citations

Mercury-Sensitive Residues and Pore Site in AQP3 Water Channel

1997 • 100 citations

Structure of the Osmo-regulated H2O-channel, AQP-CHIP, in Projection at 3.5 Å Resolution

1995 • 97 citations

Progress on the Structure and Function of Aquaporin 1

1998 • 95 citations

MOLECULAR BIOLOGY OF DIABETES INSIPIDUS

1995 • 94 citations

Quantification of Aquaporin-CHIP water channel protein in microdissected renal tubules by fluorescence-based ELISA.

1995 • 91 citations

Surface Topographies at Subnanometer-resolution Reveal Asymmetry and Sidedness of Aquaporin-1

1996 • 91 citations

Regulation of the Escherichia coli water channel gene aqpZ

1998 • 88 citations

Ion, water and neutral solute transport in Xenopus oocytes expressing frog lens MIP

1995 • 85 citations

Concurrent expression of erythroid and renal aquaporin CHIP and appearance of water channel activity in perinatal rats.

1993 • 82 citations

Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum.

1994 • 77 citations

Regulation of the Arabidopsis thaliana aquaporin gene AthH2 (PIP1b)

1996 • 73 citations

Structural Analysis of a MIP Family Protein from the Digestive Tract of Cicadella viridis

1995 • 72 citations

A Heterotrimeric G Protein of the Gi Family Is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial Cells

1998 • 71 citations

Secondary structure analysis of purified functional CHIP28 water channels by CD and FTIR spectroscopy

1993 • 68 citations

Adenovirus-mediated Expression of Aquaporin-5 in Epithelial Cells

1996 • 67 citations

Function and regulation of seed aquaporins

1997 • 65 citations

Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung.

1997 • 59 citations

Cloning of a Novel Rat Kidney cDNA Homologous to CHIP28 and WCH-CD Water Channels

1993 • 57 citations

Secondary structures comparison of aquaporin-1 and bacteriorhodopsin: a Fourier transform infrared spectroscopy study of two-dimensional membrane crystals

1997 • 56 citations

Localization and expression of a collecting duct water channel, aquaporin, in hydrated and dehydrated rats.

1995 • 55 citations

Distinct biogenesis mechanisms for the water channels MIWC and CHIP28 at the endoplasmic reticulum

1995 • 52 citations

Molecular physiology of water transport: Aquaporin nomenclature workshop. Mammalian aquaporins

1997 • 49 citations

Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels

1995 • 47 citations

[29] Functional analyses of aquaporin water channel proteins

1999 • 43 citations

Membrane Dynamics of the Water Transport Protein Aquaporin-1 in Intact Human Red Cells

1999 • 41 citations

Myosin isoform expression and force generation in cultured resistance arteries

1997 • 31 citations

The wacA gene of Dictyostelium discoideum is a developmentally regulated member of the MIP family

1997 • 27 citations

cDNA cloning of a functional water channel from toad urinary bladder epithelium

1996 • 26 citations

Glycerol uptake in Escherichia coli is sensitive to membrane lipid composition

1993 • 22 citations

Do aquaporins have a role in nocturnal enuresis?

1997 • 16 citations

Focus on “Effect of expressing the water channel aquaporin-1 on the CO₂ permeability ofXenopus oocytes”

1998 • 16 citations

Predictive evidence for a porin-type β-barrel fold in CHIP28 and other members of the MIP family. A restricted-pore model common to water channels and facilitators

1995 • 15 citations

Localization of the FA-CHIP water channel in frog urinary bladder

1998 • 15 citations

Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder

1996 • 13 citations

Stopped-Flow Spectrophotometric Assay of Glycerol Permeation in Escherichia coli: Applicability and Limitations

1978 • 7 citations

Molecular physiology of water transport: Aquaporin nomenclature workshop. Mammalian aquaporins

1997 • 4 citations