Translational Regulation of Yeast GCN4

Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology

1987 • 4,385 citations

Escherichia coli and Salmonella typhimurium: Cellular and molecular biology

1988 • 3,957 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

Multiple upstream AUG codons mediate translational control of GCN4

1986 • 654 citations

Class II Aminoacyl Transfer Rna Synthetases: Crystal Structure of Yeast Aspartyl-trna Synthetase Complexed with tRNA ^Asp

1991 • 635 citations

Translational control

1991 • 464 citations

The Histidyl-tRNA Synthetase-Related Sequence in the eIF-2α Protein Kinase GCN2 Interacts with tRNA and Is Required for Activation in Response to Starvation for Different Amino Acids

1995 • 455 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

Mutations at a Zn(II) finger motif in the yeast elF-2β gene alter ribosomal start-site selection during the scanning process

1988 • 283 citations

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability.

1989 • 278 citations

Integration of amino acid biosynthesis into the cell cycle of Saccharomyces cerevisiae

1975 • 252 citations

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control.

1991 • 243 citations

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

1993 • 227 citations

Evidence that GCN1 and GCN20, Translational Regulators of GCN4, Function on Elongating Ribosomes in Activation of eIF2α Kinase GCN2

1997 • 209 citations

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

1989 • 201 citations

tRNA _i ^met Functions in Directing the Scanning Ribosome to the Start Site of Translation

1988 • 199 citations

Tryptophan biosynthesis in Saccharomyces cerevisiae: control of the flux through the pathway

1978 • 189 citations

Translational control of GCN4: an in vivo barometer of initiation-factor activity

1994 • 183 citations

GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.

1995 • 175 citations

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae.

1991 • 164 citations

The Elongation Factor 3 Unique in Higher Fungi and Essential for Protein Biosynthesis Is an E Site Factor

1995 • 161 citations

Homologous Segments in Three Subunits of the Guanine Nucleotide Exchange Factor eIF2B Mediate Translational Regulation by Phosphorylation of eIF2

1997 • 136 citations

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

1993 • 128 citations

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

1992 • 127 citations

Modulation of tRNA(_i^Met), eIF-2, and eIF-2B Expression Shows that GCN4 Translation Is Inversely Coupled to the Level of eIF-2·GTP·Met-tRNA(_i^Met) Ternary Complexes

1995 • 124 citations

Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control.

1989 • 121 citations

Complex formation by positive and negative translational regulators of GCN4.

1991 • 119 citations

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.

1990 • 115 citations

Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control

1994 • 115 citations

Histidyl-tRNA Synthetase-related Sequences in GCN2 Protein Kinase Regulate in Vitro Phosphorylation of eIF-2

1996 • 112 citations

Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron.

1994 • 105 citations

Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA.

1989 • 102 citations

Purified yeast translational initiation factor eIF-3 is an RNA-binding protein complex that contains the PRT1 protein.

1994 • 102 citations

Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae.

1986 • 100 citations

The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae.

1990 • 99 citations

Identification of a Regulatory Subcomplex in the Guanine Nucleotide Exchange Factor eIF2B That Mediates Inhibition by Phosphorylated eIF2

1996 • 95 citations

A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript.

1987 • 89 citations

Evidence that GCD6 and GCD7, Translational Regulators of GCN4, Are Subunits of the Guanine Nucleotide Exchange Factor for eIF-2 in Saccharomyces cerevisiae

1993 • 88 citations

GCD11, a Negative Regulator of GCN4 Expression, Encodes the γ Subunit of eIF-2 in Saccharomyces cerevisiae

1993 • 84 citations

A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast.

1993 • 81 citations

Cloning and Characterization of a cDNA Encoding a Protein Synthesis Initiation Factor-2α (eIF-2α) Kinase fromDrosophila melanogaster

1997 • 76 citations

Genetic characterization of the Saccharomyces cerevisiae translational initiation suppressors sui1, sui2 and SUI3 and their effects on HIS4 expression.

1990 • 74 citations

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.

1995 • 73 citations

Subunit Assembly and Guanine Nucleotide Exchange Activity of Eukaryotic Initiation Factor-2B Expressed in Sf9 Cells

1997 • 70 citations

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.

1995 • 68 citations

Autoregulation of the yeast lysyl-tRNA synthetase gene GCD5/KRS1 by translational and transcriptional control mechanisms

1992 • 66 citations

Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation.

1994 • 63 citations

Role of Transfer Ribonucleic Acids in the Regulation of Several Biosyntheses in Saccharomyces cerevisiae

1976 • 54 citations

Multicopy tRNA Genes Functionally Suppress Mutations in Yeast eIF-2α Kinase GCN2: Evidence for Separate Pathways Coupling GCN4 Expression to Uncharged tRNA

1994 • 54 citations

Sequences 5′ of the first upstream open reading frame inGCN4mRNA are required for efficient translational reinitiation

1995 • 47 citations

Identification and characterization of four new GCD genes in Saccharomyces cerevisiae

1986 • 45 citations

Molecular characterization ofGCD1, a yeast gene required for general control of amino acid biosynthesis and cell-cycle initiation

1988 • 40 citations

Evidence that the GCN2 protein kinase regulates reinitiation by yeast ribosomes.

1988 • 40 citations

Amino acid sequence similarity between GCN3 and GCD2, positive and negative translational regulators of GCN4: evidence for antagonism by competition.

1989 • 39 citations

The positive regulatory function of the 5'-proximal open reading frames in GCN4 mRNA can be mimicked by heterologous, short coding sequences.

1988 • 38 citations

The first and fourth upstream open reading frames in GCN4 mRNA have similar initiation efficiencies but respond differently in translational control to change in length and sequence.

1988 • 36 citations

gcd12 mutations are gcn3-dependent alleles of GCD2, a negative regulator of GCN4 in the general amino acid control of Saccharomyces cerevisiae.

1989 • 26 citations

Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization

1994 • 20 citations

Negative regulatory gene for general control of amino acid biosynthesis in Saccharomyces cerevisiae.

1986 • 7 citations

Genetic evidence for functional specificity of the yeast GCN2 kinase

1996 • 5 citations