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In yeast, RAS proteins are controlling elements of adenylate cyclase

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A Saccharomyces cerevisiae G‐protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose

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1990 • 305 citations

GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Gα subunit and functions in a Ras-independent pathway

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Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae.

1986 • 295 citations

SRV2, a gene required for RAS activation of adenylate cyclase in yeast

1990 • 263 citations

Sugar Sensing and Sugar-Mediated Signal Transduction in Plants

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IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae.

1989 • 251 citations

Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein

1990 • 249 citations

Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiae.

1986 • 232 citations

Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.

1987 • 221 citations

The Function of Ras Genes in Saccharomyces Cerevisiae

1990 • 218 citations

Cyclic 3′,5′-adenosine monophosphate stimulates trehalose degradation in baker's yeast

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Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions.

1988 • 206 citations

SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits.

1988 • 198 citations

ThePDE1-encoded Low-Affinity Phosphodiesterase in the YeastSaccharomyces cerevisiaeHas a Specific Function in Controlling Agonist-induced cAMP Signaling

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Studies on the mechanism of the glucose‐induced cAMP signal in glycolysis and glucose repression mutants of the yeast Saccharomyces cerevisiae

1988 • 128 citations

Requirement of One Functional RAS Gene and Inability of an Oncogenic ras Variant to Mediate the Glucose-Induced Cyclic AMP Signal in the Yeast Saccharomyces cerevisiae

1988 • 115 citations

The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway

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G-Protein Coupled Receptor from YeastSaccharomyces cerevisiae

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Requirement of one functional RAS gene and inability of an oncogenic ras variant to mediate the glucose-induced cyclic AMP signal in the yeast Saccharomyces cerevisiae.

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SDC25, a CDC25-like gene which contains a RAS-activating domain and is a dispensable gene of Saccharomyces cerevisiae.

1991 • 76 citations

Studies of RAS Function in the Yeast Saccharomyces cerevisiae

1988 • 76 citations

Involvement of the CDC25 gene product in the signal transmission pathway of the glucose-induced RAS-mediated cAMP signal in the yeast Saccharomyces cerevisiae

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The C‐terminal part of the CDC25 gene product plays a key role in signal transduction in the glucose‐induced modulation of cAMP level in Saccharomyces cerevisiae

1990 • 58 citations

A mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1^K1876M, specifically affects glucose‐ and acidification‐induced cAMP signalling and not the basal cAMP level

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Purification of intact and nicked forms of a zinc-containing, Mg2+-dependent, low Km cyclic AMP phosphodiesterase from bakers' yeast.

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RAS Genes in the Budding Yeast Saccharomyces cerevisiae

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Signal transduction: Prokaryotic and simple eukaryotic systems

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The lag phase rather than the exponential-growth phase on glucose is associated with a higher cAMP level in wild-type and cAPK-attenuated strains of the yeast Saccharomyces cerevisiae

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Partial Purification and Characterization of an Adenosine 3′: 5′-Cyclic Monophosphate Phosphodiesterase from Saccharomyces cerevisiae

1974 • 8 citations