The FKBP12-Rapamycin-binding Domain Is Required for FKBP12-Rapamycin-associated Protein Kinase Activity and G1 Progression

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1991 • 1,937 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP

1996 • 881 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

TOR controls translation initiation and early G1 progression in yeast.

1996 • 728 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes

1997 • 685 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

1995 • 547 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints

1995 • 509 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

1994 • 475 citations

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

1994 • 378 citations

A Signaling Pathway to Translational Control

1996 • 370 citations

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

1994 • 358 citations

Mechanism of TGFβ receptor inhibition by FKBP12

1997 • 342 citations

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1995 • 315 citations

The Yeast Phosphatidylinositol Kinase Homolog TOR2 Activates RHO1 and RHO2 via the Exchange Factor ROM2

1997 • 304 citations

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

1995 • 298 citations

ATM-related genes: What do they tell us about functions of the human gene?

1995 • 276 citations

Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

1993 • 271 citations

TOR2 is required for organization of the actin cytoskeleton in yeast

1996 • 261 citations

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1995 • 243 citations

Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

1995 • 239 citations

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.

1995 • 225 citations

Rapamycin Sensitivity in Saccharomyces cerevisiae Is Mediated by a Peptidyl-Prolyl cis-trans Isomerase Related to Human FK506-Binding Protein

1991 • 213 citations

A template for the protein kinase family

1993 • 196 citations

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

1995 • 165 citations

The Mammalian Target of Rapamycin Phosphorylates Sites Having a (Ser/Thr)-Pro Motif and Is Activated by Antibodies to a Region near Its COOH Terminus

1997 • 165 citations

FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.

1993 • 149 citations

S6 Phosphorylation and the p70^s6k/p85^s6k

1994 • 148 citations

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

1994 • 138 citations

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.

1995 • 80 citations

Translational Control

2008 • 55 citations

Cancer Predisposition: Ataxia–telangiectasia at the crossroads

1995 • 48 citations

Rapamycin Dissociates p70 Activation from DNA Synthesis Stimulated by Bombesin and Insulin in Swiss 3T3 Cells

1997 • 42 citations