Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

The Sequence of the Human Genome

2001 • 13,500 citations

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

2000 • 8,948 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

SMART, a simple modular architecture research tool: Identification of signaling domains

1998 • 3,523 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

From charcot to lou gehrig: deciphering selective motor neuron death in als

2001 • 1,373 citations

RHO–GTPases and cancer

2002 • 1,355 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ

2001 • 1,004 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

RHO GTPASES in neuronal morphogenesis

2000 • 982 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

1998 • 804 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

2001 • 722 citations

A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

1997 • 718 citations

Small GTPases Rac and Rho in the Maintenance of Dendritic Spines and Branches in Hippocampal Pyramidal Neurons

2000 • 710 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 692 citations

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

2001 • 660 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin

2001 • 537 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation

1998 • 475 citations

PAK3 mutation in nonsyndromic X-linked mental retardation

1998 • 472 citations

P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac

2002 • 460 citations

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines

1996 • 454 citations

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

2000 • 454 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons

1993 • 446 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

1998 • 426 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Human Ect2 Is an Exchange Factor for Rho Gtpases, Phosphorylated in G2/M Phases, and Involved in Cytokinesis

1999 • 418 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans

2000 • 410 citations

Atomic structure and chemistry of human serum albumin

1993 • 407 citations

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

1989 • 406 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase

2000 • 393 citations

The Rho GTPase and a Putative RhoGEF Mediate a Signaling Pathway for the Cell Shape Changes in Drosophila Gastrulation

1997 • 384 citations

Structural Basis for Relief of Autoinhibition of the Dbl Homology Domain of Proto-Oncogene Vav by Tyrosine Phosphorylation

2000 • 381 citations

Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation

2000 • 377 citations

The Neuronal Rho-GEF Kalirin-7 Interacts with PDZ Domain–Containing Proteins and Regulates Dendritic Morphogenesis

2001 • 375 citations

Rho GTPases in growth cone guidance

2001 • 364 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

2000 • 356 citations

Asef, a Link Between the Tumor Suppressor APC and G-Protein Signaling

2000 • 350 citations

Rac function and regulation during Drosophila development

2002 • 346 citations

GEFs: structural basis for their activation of small GTP-binding proteins

1999 • 334 citations

The Transmembrane Tyrosine Phosphatase DLAR Controls Motor Axon Guidance in Drosophila

1996 • 331 citations

EPS8 and E3B1 transduce signals from Ras to Rac

1999 • 329 citations

Function of Rho family proteins in actin dynamics during phagocytosis and engulfment

2000 • 326 citations

UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans

1998 • 319 citations

Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila

2000 • 315 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila

1998 • 309 citations

Lck Regulates Vav Activation of Members of the Rho Family of GTPases

1997 • 305 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

Regulation of Postsynaptic Structure and Protein Localization by the Rho-Type Guanine Nucleotide Exchange Factor dPix

2001 • 298 citations

Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative RhoRac guanine nucleotide exchange factor

1994 • 297 citations

Rac/Cdc42 and p65PAK Regulate the Microtubule-destabilizing Protein Stathmin through Phosphorylation at Serine 16

2001 • 293 citations

Essential Roles of Drosophila RhoA in the Regulation of Neuroblast Proliferation and Dendritic but Not Axonal Morphogenesis

2000 • 291 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

CD44 Interaction with Tiam1 Promotes Rac1 Signaling and Hyaluronic Acid-mediated Breast Tumor Cell Migration

2000 • 288 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Oncogene ect2 is related to regulators of small GTP-binding proteins

1993 • 281 citations

Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

2001 • 280 citations

Rho GTPases in transformation and metastasis

2002 • 274 citations

A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila

1999 • 274 citations

Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin

2000 • 273 citations

Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins

1999 • 268 citations

Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins

2001 • 241 citations

The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

2000 • 232 citations

Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation

1997 • 230 citations

The role of Rho GTPases in disease development

2002 • 227 citations

Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G₁₂ family to Rho

2000 • 224 citations

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia

2000 • 223 citations

A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins

1999 • 221 citations

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

2002 • 221 citations

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

1998 • 220 citations

SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling

2002 • 218 citations

The Guanine Nucleotide Exchange Factor Trio Mediates Axonal Development in the Drosophila Embryo

2000 • 214 citations

Vav proteins, adaptors and cell signaling

2001 • 212 citations

Isolation of a new human oncogene from a diffuse B-cell lymphoma

1985 • 210 citations

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

1996 • 209 citations

Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae.

1996 • 208 citations

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes

1998 • 202 citations

The Drosophila Trio Plays an Essential Role in Patterning of Axons by Regulating Their Directional Extension

2000 • 201 citations

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1998 • 197 citations

Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating

2000 • 195 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

The Low Molecular Weight GTPase Rho Regulates Myofibril Formation and Organization in Neonatal Rat Ventricular Myocytes

1998 • 194 citations

Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1

2001 • 192 citations

Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins

2000 • 191 citations

Dosage-Sensitive, Reciprocal Genetic Interactions between the Abl Tyrosine Kinase and the Putative GEF trio Reveal trio 's Role in Axon Pathfinding

2000 • 188 citations

Evidence for the Involvement of Tiam1 in Axon Formation

2001 • 188 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

Control of Intramolecular Interactions between the Pleckstrin Homology and Dbl Homology Domains of Vav and Sos1 Regulates Rac Binding

2000 • 185 citations

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

2001 • 180 citations

Characterization of p190RhoGEF, A RhoA-specific Guanine Nucleotide Exchange Factor That Interacts with Microtubules

2001 • 172 citations

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

1998 • 171 citations

Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

2001 • 171 citations

Tyrosine Phosphorylation Mediates Both Activation and Downmodulation of the Biological Activity of Vav

2000 • 170 citations

Loss of the Amino-Terminal Helix-Loop-Helix Domain of the vav Proto-Oncogene Activates Its Transforming Potential

1991 • 168 citations

Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation

2000 • 168 citations

The Caenorhabditis elegans gene unc-89, required fpr muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.

1996 • 167 citations

Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos

2000 • 165 citations

Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase

1996 • 161 citations

The Faciogenital Dysplasia Gene Product FGD1 Functions as a Cdc42Hs-specific Guanine-Nucleotide Exchange Factor

1996 • 158 citations

The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton

1998 • 157 citations

The Dbl-related Protein, Lfc, Localizes to Microtubules and Mediates the Activation of Rac Signaling Pathways in Cells

1999 • 153 citations

TCR and CD28 Are Coupled Via ZAP-70 to the Activation of the Vav/Rac-1-/PAK-1/p38 MAPK Signaling Pathway

1999 • 148 citations

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

1994 • 148 citations

Targeting of Tiam1 to the Plasma Membrane Requires the Cooperative Function of the N-terminal Pleckstrin Homology Domain and an Adjacent Protein Interaction Domain

1997 • 145 citations

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.

1996 • 143 citations

Structure and mutagenesis of the Dbl homology domain

1998 • 142 citations

The Pleckstrin Homology Domain Mediates Transformation by Oncogenic Dbl through Specific Intracellular Targeting

1996 • 136 citations

Control of cell behaviour by signalling through Eph receptors and ephrins

2000 • 135 citations

The role of the PH domain in the signal-dependent membrane targeting of Sos

1997 • 131 citations

Ankyrin–Tiam1 Interaction Promotes Rac1 Signaling and Metastatic Breast Tumor Cell Invasion and Migration

2000 • 131 citations

The BCR gene and philadelphia chromosome-positive leukemogenesis.

2001 • 130 citations

A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.

1991 • 129 citations

Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein

1996 • 125 citations

Vav Regulates Activation of Rac but Not Cdc42 during FcγR-mediated Phagocytosis

2002 • 124 citations

Leukemia-associated Rho Guanine Nucleotide Exchange Factor, a Dbl Family Protein Found Mutated in Leukemia, Causes Transformation by Activation of RhoA

2001 • 124 citations

Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.

1995 • 124 citations

Mechanisms for Reversible Regulation between G13 and Rho Exchange Factors

2002 • 122 citations

Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13

1998 • 120 citations

Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.

1994 • 117 citations

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.

1991 • 116 citations

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

2000 • 116 citations

Nucleocytoplasmic Shuttling of the Cdc42p Exchange Factor Cdc24p

2000 • 115 citations

Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway

1997 • 113 citations

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

2001 • 110 citations

Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products.

1994 • 108 citations

Regulation of the Cool/Pix Proteins

2002 • 108 citations

Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

1999 • 108 citations

The N-Terminal Pleckstrin, Coiled-Coil, and IQ Domains of the Exchange Factor Ras-GRF Act Cooperatively To Facilitate Activation by Calcium

1996 • 104 citations

A Rho Exchange Factor Mediates Thrombin and Gα12-induced Cytoskeletal Responses

1999 • 103 citations

Hyperactivation of the folded gastrulation pathway induces specific cell shape changes

1998 • 102 citations

Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning.

1996 • 93 citations

Expression Cloning of lsc, a Novel Oncogene with Structural Similarities to the Dbl Family of Guanine Nucleotide Exchange Factors

1996 • 91 citations

Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation

1997 • 89 citations

Gα13 Requires Palmitoylation for Plasma Membrane Localization, Rho-dependent Signaling, and Promotion of p115-RhoGEF Membrane Binding

2000 • 88 citations

Ras-Specific Exchange Factor GRF: Oligomerization through Its Dbl Homology Domain and Calcium-Dependent Activation of Raf

1999 • 88 citations

Lymphocyte signalling: A coordinating role for Vav?

1998 • 88 citations

Activation of the Lbc Rho Exchange Factor Proto-Oncogene by Truncation of an Extended C Terminus That Regulates Transformation and Targeting

1999 • 84 citations

Tiam1 mutations in human renal-cell carcinomas

2000 • 84 citations

The Dbl Oncogene Product as a GDP/GTP Exchange Protein for the Rho Family: Its Properties in Comparison with Those of Smg GDS

1994 • 81 citations

The Rho Exchange Factor Net1 Is Regulated by Nuclear Sequestration

2002 • 81 citations

PKN Associates and Phosphorylates the Head-Rod Domain of Neurofilament Protein

1996 • 78 citations

Autoinhibition Mechanism of Proto-Dbl

2001 • 78 citations

Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor.

1995 • 77 citations

Identification of Potential Mechanisms for Regulation of p115 RhoGEF through Analysis of Endogenous and Mutant Forms of the Exchange Factor

2001 • 75 citations

Modulation of Oncogenic DBL Activity by Phosphoinositol Phosphate Binding to Pleckstrin Homology Domain

2001 • 75 citations

Skeletal-specific expression ofFgd1 during bone formation and skeletal defects in faciogenital dysplasia (FGDY; Aarskog syndrome)

2000 • 70 citations

Untying the Gordian Knot of Cytokinesis

2000 • 69 citations

Distinct roles for DH and PH domains in the Lbc oncogene

1997 • 66 citations

Activation of the Guanine Nucleotide Exchange Factor Dbl Following ACK1-Dependent Tyrosine Phosphorylation

2000 • 61 citations

Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins.

1994 • 56 citations

Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF

1999 • 55 citations

Rho proteins and the cellular mechanisms of mental retardation

2000 • 53 citations

Domain- and Site-Specific Phosphorylation of Bovine NF-L by Rho-Associated Kinase

1998 • 50 citations

Oligomerization of DH Domain Is Essential for Dbl-Induced Transformation

2001 • 47 citations

The N-terminal region of proto-dbl down regulates its transforming activity.

1989 • 46 citations

Studies on the function of Rho A protein in cardiac myofibrillogenesis

1997 • 43 citations

hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways

1999 • 42 citations

Activation of G1 Progression, JNK Mitogen-activated Protein Kinase, and Actin Filament Assembly by the Exchange Factor FGD1

1998 • 42 citations

Phospholipase C‐γ, protein kinase C and Ca²⁺/calmodulin‐dependent protein kinase II are involved in platelet‐derived growth factor‐induced phosphorylation of Tiam1

1998 • 42 citations

Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation

2000 • 40 citations

Association of the proto‐oncogene product Dbl with G protein βγ subunits

1999 • 39 citations

Ras Binding Triggers Ubiquitination of the Ras Exchange Factor Ras-GRF2

2001 • 37 citations

The Caenorhabditis elegans homolog of FGD1, the human Cdc42 GEF gene responsible for faciogenital dysplasia, is critical for excretory cell morphogenesis

2001 • 34 citations

The Ras-Specific Exchange Factors Mouse Sos1 (mSos1) and mSos2 Are Regulated Differently: mSos2 Contains Ubiquitination Signals Absent in mSos1

1997 • 30 citations

Molecular studies in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

2001 • 21 citations

Activation of Clg, a Novel Dbl Family Guanine Nucleotide Exchange Factor Gene, by Proviral Insertion atEvi24, a Common Integration Site in B Cell and Myeloid Leukemias

2002 • 19 citations

Activation of RhoA by Association of Gα13 with Dbl

2000 • 14 citations

Deleted Work

1955 • 0 citations