Lck Regulates Vav Activation of Members of the Rho Family of GTPases

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Laboratory course manual for methods in yeast genetics

1986 • 1,310 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

1990 • 560 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

1989 • 406 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins

1985 • 365 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

1994 • 283 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

The actin cytoskeleton

1988 • 218 citations

Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity.

1991 • 204 citations

[40] Biological assays for Ras transformation

1995 • 199 citations

The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization

1992 • 170 citations

Loss of the Amino-Terminal Helix-Loop-Helix Domain of the vav Proto-Oncogene Activates Its Transforming Potential

1991 • 168 citations

Regulation of src family tyrosine kinases in lymphocytes

1993 • 144 citations

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.

1994 • 134 citations

Direct Stimulation of Vav Guanine Nucleotide Exchange Activity for Ras by Phorbol Esters and Diglycerides

1994 • 132 citations

Mechanism of activation of the vav protooncogene.

1991 • 122 citations

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.

1994 • 119 citations

Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24.

1992 • 106 citations

Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae.

1987 • 101 citations

The adenylyl cyclase gene from Schizosaccharomyces pombe.

1989 • 96 citations

Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor.

1994 • 90 citations

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.

1994 • 78 citations

Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly.

1995 • 76 citations

Identification of Residues of the H-Ras Protein Critical for Functional Interaction with Guanine Nucleotide Exchange Factors

1994 • 75 citations

Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and characterization of the CDC24 gene and adjacent regions of the chromosome.

1986 • 74 citations

Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia.

1994 • 64 citations

[35] Methods for analyzing c-Jun kinase

1995 • 52 citations

The products of the mcf-2 and vav proto-oncogenes and of the yeast gene cdc-24 share sequence similarities.

1992 • 32 citations

Amino Acid Residues in the CDC25 Guanine Nucleotide Exchange Factor Critical for Interaction with Ras

1994 • 25 citations