Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

E-cadherin mediated adhesion system in cancer cells

1996 • 281 citations

Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation

1997 • 230 citations

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift.

1995 • 216 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

The biology of hepatocyte growth factor/scatter factor

1992 • 32 citations

C-Met signalling in an HGF/SF-insensitive variant MDCK cell line with constitutive motile/invasive behaviour

1996 • 18 citations

Deleted Work

1955 • 0 citations