Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.

1998 • 834 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

1998 • 720 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 • 615 citations

Integrin signalling and tyrosine phosphorylation: just the FAKs?

1998 • 502 citations

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

1993 • 447 citations

Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

1997 • 433 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events

1998 • 400 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1998 • 283 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

1996 • 275 citations

Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin αIIbβ3

1998 • 239 citations

The Platelet Cytoskeleton

1993 • 235 citations

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.

1994 • 233 citations

Integrin-mediated Tyrosine Phosphorylation and Cytokine Message Induction in Monocytic Cells

1995 • 228 citations

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3.

1994 • 227 citations

Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.

1993 • 219 citations

Focal adhesion assembly

1997 • 212 citations

p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase

1996 • 170 citations

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIbbeta 3

1997 • 170 citations

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1995 • 163 citations

Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2

1998 • 145 citations

Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen.

1997 • 136 citations

D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-Acetate

1996 • 135 citations

Coordinated Regulation of the Tyrosine Phosphorylation of Cbl by Fyn and Syk Tyrosine Kinases

1998 • 120 citations

Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.

1997 • 107 citations

Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willebrand Factor-stimulated Platelets

1997 • 103 citations

Cbl

1998 • 89 citations

Biphasic Activation of PKBα/Akt In Platelets

1998 • 82 citations

Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav.

1996 • 81 citations

Thrombin Receptor Activation and Integrin Engagement Stimulate Tyrosine Phosphorylation of the Proto-oncogene Product, p95vav, in Platelets

1996 • 74 citations

NH2-terminal modification of the phosphatase 2A catalytic subunit allows functional expression in mammalian cells.

1992 • 67 citations

The VAV Family of Signal Transduction Molecules

1996 • 66 citations

Regulation of β1-integrin-mediated cell adhesion by the CbI adaptor protein

1998 • 57 citations

Association of a p95 Vav-containing Signaling Complex with the FcϵRI γ Chain in the RBL-2H3 Mast Cell Line

1996 • 56 citations

Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation.

1994 • 49 citations

Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells.

1997 • 48 citations

Reconstitution of T Cell Antigen Receptor‐Induced Erk2 Kinase Activation in Lck‐Negative JCaM1 Cells by Syk

1997 • 47 citations

Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation.

1997 • 29 citations

Oncogenic forms of Cbl abrogate the anchorage requirement but not the growth factor requirement for proliferation

1998 • 21 citations