Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

A role for Rho in Ras transformation.

1995 • 538 citations

The Dbl family of oncogenes

1996 • 497 citations

Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue

1997 • 487 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.

1990 • 277 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

1998 • 249 citations

Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases

1998 • 233 citations

Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation

1997 • 230 citations

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

1998 • 220 citations

Cytoskeletal Reorganization by G Protein-Coupled Receptors Is Dependent on Phosphoinositide 3-Kinase γ, a Rac Guanosine Exchange Factor, and Rac

1998 • 181 citations

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

1998 • 171 citations

Ca2+/Calmodulin-dependent Protein Kinase II Regulates Tiam1 by Reversible Protein Phosphorylation

1999 • 169 citations

A GDP Dissociation Inhibitor That Serves as a GTPase Inhibitor for the Ras-Like Protein CDC42Hs

1992 • 164 citations

The Dbl-related Protein, Lfc, Localizes to Microtubules and Mediates the Activation of Rac Signaling Pathways in Cells

1999 • 153 citations

Targeting of Tiam1 to the Plasma Membrane Requires the Cooperative Function of the N-terminal Pleckstrin Homology Domain and an Adjacent Protein Interaction Domain

1997 • 145 citations

A Phosphatidylinositol 4-Kinase Pleckstrin Homology Domain That Binds Phosphatidylinositol 4-Monophosphate

1998 • 140 citations

Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells.

1993 • 123 citations

Regulation of binding of rhoB p20 to membranes by its specific regulatory protein, GDP dissociation inhibitor.

1991 • 113 citations

Translocation of the Rac1 Guanine Nucleotide Exchange Factor Tiam1 Induced by Platelet-derived Growth Factor and Lysophosphatidic Acid

2000 • 90 citations

Lysophosphatidic Acid Induces Threonine Phosphorylation of Tiam1 in Swiss 3T3 Fibroblasts via Activation of Protein Kinase C

1997 • 86 citations

Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch

1999 • 67 citations

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

1999 • 52 citations

Phospholipase C‐γ, protein kinase C and Ca²⁺/calmodulin‐dependent protein kinase II are involved in platelet‐derived growth factor‐induced phosphorylation of Tiam1

1998 • 42 citations

Association of the proto‐oncogene product Dbl with G protein βγ subunits

1999 • 39 citations

Membrane Binding and Enzymatic Activation of a Dbl Homology Domain Require the Neighboring Pleckstrin Homology Domain

1997 • 15 citations