The Low Molecular Weight GTPase Rho Regulates Myofibril Formation and Organization in Neonatal Rat Ventricular Myocytes

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS

1997 • 876 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function

1993 • 689 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle

1996 • 586 citations

Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation

1997 • 576 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response.

1990 • 444 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic Mice

1995 • 314 citations

Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.

1996 • 280 citations

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

1994 • 245 citations

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

1993 • 228 citations

Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes

1996 • 220 citations

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

1994 • 189 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

Selective Requirement of Myosin Light Chain 2v in Embryonic Heart Function

1998 • 172 citations

Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.

1992 • 170 citations

Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene.

1996 • 157 citations

MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells

1997 • 152 citations

Inhibition of RhoA Translocation and Calcium Sensitization by In Vivo ADP-Ribosylation with the Chimeric Toxin DC3B

1997 • 151 citations

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor

1996 • 151 citations

Impairment of muscle function caused by mutations of phosphorylation sites in myosin regulatory light chain

1995 • 138 citations

Activation and Translocation of Rho (and ADP Ribosylation Factor) by Insulin in Rat Adipocytes

1997 • 90 citations

Contractile activity modulates actin synthesis and turnover in cultured neonatal rat heart cells.

1993 • 73 citations

[20] Purification and assay of recombinant C3 transferase

1995 • 62 citations

Activated Rho A Stimulates c- fos Gene Expression in Myocardial Cells

1997 • 48 citations

Studies on the function of Rho A protein in cardiac myofibrillogenesis

1997 • 43 citations

Myosin light-chain phosphorylation in diabetic cardiomyopathy in rats

1997 • 40 citations

Muscarinic receptor‐stimulated cytosol‐membrane translocation of RhoA

1997 • 36 citations

Down-regulation of G-protein-mediated Ca2+ sensitization in smooth muscle.

1997 • 33 citations

ADP‐ribosylation by Clostridium botulinum C3 exoenzyme increases steady‐state GTPase activities of recombinant rhoA and rhoB proteins

1992 • 29 citations

Regulation of rat ventricular myosin heavy chain expression by serum and contractile activity

1994 • 24 citations

Evidence for Myosin-Binding Phosphatase in Heart Myofibrils

1997 • 16 citations