RHO GTPASES in neuronal morphogenesis

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION

1999 • 1,485 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1998 • 1,384 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

1998 • 1,263 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity

2000 • 1,067 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

1996 • 901 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

1997 • 819 citations

CENTRAL NERVOUS SYSTEM NEURONAL MIGRATION

1999 • 808 citations

Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

1997 • 727 citations

Small GTPases Rac and Rho in the Maintenance of Dendritic Spines and Branches in Hippocampal Pyramidal Neurons

2000 • 710 citations

Semaphorin 3A is a chemoattractant for cortical apical dendrites

2000 • 678 citations

Localized Rac Activation Dynamics Visualized in Living Cells

2000 • 667 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

2000 • 664 citations

Neuronal Polarity

1994 • 658 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 • 592 citations

Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

1990 • 560 citations

LIM-kinase1 Hemizygosity Implicated in Impaired Visuospatial Constructive Cognition

1996 • 554 citations

The Role of Local Actin Instability in Axon Formation

1999 • 526 citations

AXON GROWTH: ROLES OF MICROFILAMENTS AND MICROTUBULES

1970 • 522 citations

Directional guidance of neuronal migration in the olfactory system by the protein Slit

1999 • 517 citations

Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth

1999 • 516 citations

Structure, development, and plasticity of dendritic spines

1999 • 511 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop

2000 • 507 citations

Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42

1997 • 493 citations

Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation

1998 • 475 citations

PAK3 mutation in nonsyndromic X-linked mental retardation

1998 • 472 citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

1998 • 465 citations

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines

1996 • 454 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

GROWTH CONE GUIDANCE: First Steps Towards a Deeper Understanding

1999 • 431 citations

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1998 • 403 citations

Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase

2000 • 393 citations

IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.

1996 • 387 citations

Rac1 Mediates Collapsin-1-Induced Growth Cone Collapse

1997 • 384 citations

p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

1999 • 380 citations

Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment

1986 • 378 citations

Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation

2000 • 377 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

Growth of neurites without filopodial or lamellipodial activity in the presence of cytochalasin B.

1984 • 352 citations

Genes regulating dendritic outgrowth, branching, and routing in Drosophila

1999 • 332 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans

1998 • 319 citations

Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila

2000 • 315 citations

Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo

2000 • 294 citations

Essential Roles of Drosophila RhoA in the Regulation of Neuroblast Proliferation and Dendritic but Not Axonal Morphogenesis

2000 • 291 citations

Pak Functions Downstream of Dock to Regulate Photoreceptor Axon Guidance in Drosophila

1999 • 289 citations

A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons

2000 • 289 citations

Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Acts as a Cdc42 Effector in Promoting Cytoskeletal Reorganization

1998 • 269 citations

Role of a New Rho Family Member in Cell Migration and Axon Guidance in C. elegans

1997 • 251 citations

Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter Protein

1996 • 248 citations

Defective Neurogenesis in Citron Kinase Knockout Mice by Altered Cytokinesis and Massive Apoptosis

2000 • 246 citations

Rapid Dendritic Remodeling in the Developing Retina: Dependence on Neurotransmission and Reciprocal Regulation by Rac and Rho

2000 • 242 citations

Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis.

1996 • 216 citations

The Guanine Nucleotide Exchange Factor Trio Mediates Axonal Development in the Drosophila Embryo

2000 • 214 citations

Establishment of neuronal polarity: lessons from cultured hippocampal neurons

2000 • 213 citations

The Drosophila Trio Plays an Essential Role in Patterning of Axons by Regulating Their Directional Extension

2000 • 201 citations

Profilin and the Abl Tyrosine Kinase Are Required for Motor Axon Outgrowth in the Drosophila Embryo

1999 • 199 citations

The Neuronal Architecture ofXenopusRetinal Ganglion Cells Is Sculpted by Rho-Family GTPasesIn Vivo

1999 • 198 citations

Dosage-Sensitive, Reciprocal Genetic Interactions between the Abl Tyrosine Kinase and the Putative GEF trio Reveal trio 's Role in Axon Pathfinding

2000 • 188 citations

Increase in Neurite Outgrowth Mediated by Overexpression of Actin Depolymerizing Factor

2000 • 187 citations

Cytoskeletal reorganization underlying growth cone motility

1994 • 169 citations

The GTPase-Activating Protein n-Chimaerin Cooperates with Rac1 and Cdc42Hs To Induce the Formation of Lamellipodia and Filopodia

1996 • 152 citations

Agrin-Induced Acetylcholine Receptor Clustering Is Mediated by the Small Guanosine Triphosphatases Rac and Cdc42

2000 • 149 citations

Drosophila Rac1 controls motor axon guidance

1998 • 144 citations

Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II

2000 • 132 citations

Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17–32

1999 • 131 citations

Cdc42 stimulates neurite outgrowth and formation of growth cone filopodia and lamellipodia

2000 • 109 citations

Overexpression of a Neural-specific Rho Family GTPase, cRac1B, Selectively Induces Enhanced Neuritogenesis and Neurite Branching in Primary Neurons

1998 • 92 citations

Rac1-dependent actin filament organization in growth cones is necessary for ?1-integrin-mediated advance but not for growth on poly-D-lysine

1998 • 89 citations

The cyclin-dependent kinase Cdk5 controls multiple aspects of axon patterning in vivo

2000 • 84 citations

Rac is required for growth cone function but not neurite assembly

1997 • 75 citations

Breakthroughs in molecular andcellular mechanisms underlying X-linked mental retardation

1999 • 73 citations

Genghis Khan (Gek) as a putative effector forDrosophilaCdc42 and regulator of actin polymerization

1997 • 71 citations

Ras Family GTPases Control Growth of Astrocyte Processes

1999 • 68 citations

Small GTPases in axon outgrowth.

1996 • 44 citations

From Membrane to Cytoskeleton

1999 • 36 citations

Rho

2000 • 9 citations