Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

1989 • 2,140 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

The insulin signaling system.

1994 • 1,733 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

The Dbl family of oncogenes

1996 • 497 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho

1999 • 386 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

Membrane raft microdomains mediate front–rear polarity in migrating cells

1999 • 316 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition

2000 • 290 citations

Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.

1996 • 280 citations

Isolation and Characterization of Acid Phosphatase Mutants in Saccharomyces cerevisiae

1973 • 276 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

Dbl family proteins

1997 • 260 citations

Vav2 Is an Activator of Cdc42, Rac1, and RhoA

2000 • 250 citations

Regulation and function of the Rho subfamily of small GTPases

1994 • 233 citations

Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G₁₂ family to Rho

2000 • 224 citations

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia

2000 • 223 citations

Identification of AF-6 and Canoe as Putative Targets for Ras

1996 • 207 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.

1994 • 171 citations

TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of RhoG

2000 • 166 citations

Insulin-like Growth Factor-I-mediated Neurite Outgrowth in Vitro Requires Mitogen-activated Protein Kinase Activation

1997 • 157 citations

Tyrosine Phosphorylation of Paxillin and Focal Adhesion Kinase during Insulin-like Growth Factor-I-stimulated Lamellipodial Advance

1997 • 144 citations

Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. Clarification of the roles of type I insulin-like growth factor receptors and insulin receptors.

1986 • 136 citations

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.

1994 • 134 citations

Involvement of an SHP-2-Rho Small G Protein Pathway in Hepatocyte Growth Factor/Scatter Factor–induced Cell Scattering

2000 • 127 citations

Identification of the stef Gene That Encodes a Novel Guanine Nucleotide Exchange Factor Specific for Rac1

1999 • 106 citations

Insulin Receptor Substrate 2 And Shc Play Different Roles In Insulin-like Growth Factor I Signaling

1998 • 81 citations

GTPases and phosphatidylinositol 3-kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility.

2000 • 80 citations

GTPases and Phosphatidylinositol 3-Kinase Are Critical for Insulin-like Growth Factor-I-mediated Schwann Cell Motility

2000 • 72 citations

The DH Protein Family, Exchange Factors for Rho-Like GTPases

1999 • 53 citations

Rho‐specific binding and guanine nucleotide exchange catalysis by KIAA0380, a Dbl family member

1999 • 52 citations

Ras Partners

1994 • 51 citations

Functions of a Rho-specific Guanine Nucleotide Exchange Factor in Neurite Retraction

2000 • 45 citations

rac p21 Is Involved in Insulin-Induced Membrane Ruffling and rho p21 Is Involved in Hepatocyte Growth Factor- and 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-Induced Membrane Ruffling in KB Cells

1994 • 39 citations

Dbl and Vav Mediate Transformation via Mitogen-Activated Protein Kinase Pathways That are Distinct from Those Activated by Oncogenic Ras

1994 • 38 citations

Insulin-Like Growth Factor-Mediated Phosphorylation and Protooncogene Induction in Madin-Darby Canine Kidney Cells

1991 • 20 citations

Characterization of Insulin-Like Growth Factor I Receptors on Madin-Darby Canine Kidney (MDCK) Cell Line

1987 • 4 citations

Evidence for ras- and rho-dependent pathways in the regulation of glucose transport by growth factors

1997 • 1 citations