GEFs: structural basis for their activation of small GTP-binding proteins

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

The structural basis of the activation of Ras by Sos

1998 • 765 citations

Structural Basis for Activation of ARF GTPase

1998 • 534 citations

The Dbl family of oncogenes

1996 • 497 citations

Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex

1999 • 441 citations

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1990 • 410 citations

Brefeldin A

1999 • 385 citations

N-Terminal Hydrophobic Residues of the G-Protein ADP-Ribosylation Factor-1 Insert into Membrane Phospholipids upon GDP to GTP Exchange

1997 • 351 citations

The 1.7 Å crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller

1998 • 298 citations

The structure of the Escherichia coli EF-Tu· EF-Ts complex at 2.5 Å resolution

1996 • 289 citations

Structure of the human ADP-ribosylation factor 1 complexed with GDP

1994 • 284 citations

The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

1995 • 224 citations

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

1998 • 220 citations

Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

1995 • 217 citations

Helix unwinding in the effector region of elongation factor EF-Tu–GDP

1996 • 216 citations

G-protein diseases furnish a model for the turn-on switch

1998 • 192 citations

Structure of the Guanine Nucleotide Exchange Factor Sec7 Domain of Human Arno and Analysis of the Interaction with ARF GTPase

1998 • 184 citations

Structure of the Sec7 domain of the Arf exchange factor ARNO

1998 • 183 citations

A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta -phosphate to destabilize GDP on ARF1

1998 • 180 citations

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

1998 • 171 citations

Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins.

1993 • 147 citations

Structure and mutagenesis of the Dbl homology domain

1998 • 142 citations

Crystal structure of the EF-Tu˙EF-Ts complex from Thermus thermophilus

1997 • 122 citations

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N)

1997 • 106 citations

Invasion of the Nucleotide Snatchers

1998 • 74 citations

Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgamma S

1997 • 70 citations

Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface

1995 • 56 citations

Mss4 does not function as an exchange factor for Rab in endoplasmic reticulum to Golgi transport.

1997 • 55 citations

Solution structure of the cytohesin-1 (B2–1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1

1998 • 39 citations

Conserved Histidine Residues of RCC1 Are Essential for Nucleotide Exchange on Ran

1996 • 33 citations