ras oncogenes in human cancer: a review.

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Mutational Activation of the K-rasOncogene

1987 • 542 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1985 • 458 citations

Human-tumor-derived cell lines contain common and different transforming genes

1981 • 455 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

1985 • 372 citations

A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.

1985 • 320 citations

Clonal analysis of myelodysplastic syndromes: evidence of multipotent stem cell origin

1989 • 312 citations

Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

1986 • 291 citations

Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa.

1986 • 277 citations

Analysis of RAS oncogene mutations in human lymphoid malignancies.

1988 • 226 citations

New human transforming genes detected by a tumorigenicity assay.

1984 • 217 citations

A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.

1984 • 207 citations

Three different mutations in codon 61 of the human N-rasgene detected by synthetic oligonucleotide hybridization

1984 • 167 citations

Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy.

1987 • 159 citations

Transforming genes in chronic myelogenous leukemia.

1988 • 155 citations

Definitive Treatment of “Malignant” Polyps of the Colon

1975 • 137 citations

Mutational activation of oncogenes in animal model systems of carcinogenesis (MTR 07217)

1987 • 115 citations

DNA repair, oncogenes and carcinogenesis

1988 • 80 citations

H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.

1988 • 75 citations

Relationship between an activated N-ras oncogene and chromosomal abnormality during leukemic progression from myelodysplastic syndrome

1988 • 69 citations

ras oncogene activation in human ovarian carcinoma.

1988 • 67 citations

Activated H-ras oncogenes in human kidney tumors.

1988 • 62 citations

Oncogenes in human primary hepatic cancer

1986 • 54 citations

Frequent overexpression, but not activation by point mutation, of ras genes in primary human gastric cancers

1987 • 47 citations

Metabolic aspects and actions unique to Estracyt.

1983 • 47 citations

ras gene activation in a minor proportion of the blast population in acute myeloid leukemia.

1987 • 47 citations

Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay.

1988 • 37 citations

Relapse cell population differs from acute onset clone as shown by absence of the initially activated N-ras oncogene in a patient with acute myelomonocytic leukemia

1988 • 35 citations

Isolation of activated ras transforming genes from two patients with Hodgkin's disease

1985 • 25 citations

Direct sequencing of amplified genomic fragments documents N-ras point mutations in myeloid leukemia.

1988 • 24 citations

Highly frequent detection of transforming genes in acute leukemias by transfection using in vivo selection assays

1987 • 8 citations