Activation of Clg, a Novel Dbl Family Guanine Nucleotide Exchange Factor Gene, by Proviral Insertion atEvi24, a Common Integration Site in B Cell and Myeloid Leukemias

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Small GTP-Binding Proteins

2001 • 2,449 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

A Pathogenetic Role for TNFα in the Syndrome of Cachexia, Arthritis, and Autoimmunity Resulting from Tristetraprolin (TTP) Deficiency

1996 • 742 citations

Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

1999 • 725 citations

A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

1997 • 718 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach.

1991 • 665 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

A role for Rho in Ras transformation.

1995 • 538 citations

The Dbl family of oncogenes

1996 • 497 citations

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

2001 • 454 citations

Phosphoinositide 3-kinase signalling pathways

2006 • 443 citations

Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability

2000 • 438 citations

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

1998 • 356 citations

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

1998 • 352 citations

Predicting internal exons by oligonucleotide composition and discriminant analysis of spliceable open reading frames

1994 • 348 citations

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

1996 • 312 citations

Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative RhoRac guanine nucleotide exchange factor

1994 • 297 citations

Vav2 Is an Activator of Cdc42, Rac1, and RhoA

2000 • 250 citations

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

2000 • 238 citations

Leukaemia disease genes: large-scale cloning and pathway predictions

1999 • 238 citations

Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G₁₂ family to Rho

2000 • 224 citations

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia

2000 • 223 citations

The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation

2000 • 211 citations

The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis

2001 • 200 citations

Retroviral insertional mutagenesis as a strategy to identify cancer genes

1996 • 198 citations

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

2001 • 180 citations

Mice Defective in Two Apoptosis Pathways in the Myeloid Lineage Develop Acute Myeloblastic Leukemia

1998 • 173 citations

Activated PAK4 Regulates Cell Adhesion and Anchorage-Independent Growth

2001 • 166 citations

Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos

2000 • 165 citations

Multiple roles for Cdc42 in cell regulation

2001 • 165 citations

Hyperactivation of P21ras and the Hematopoietic-Specific Rho Gtpase, Rac2, Cooperate to Alter the Proliferation of Neurofibromin-Deficient Mast Cells in Vivo and in Vitro

2001 • 139 citations

Ankyrin–Tiam1 Interaction Promotes Rac1 Signaling and Metastatic Breast Tumor Cell Invasion and Migration

2000 • 131 citations

The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q

2000 • 125 citations

Leukemia-associated Rho Guanine Nucleotide Exchange Factor, a Dbl Family Protein Found Mutated in Leukemia, Causes Transformation by Activation of RhoA

2001 • 124 citations

Identification and Characterization of hPEM-2, a Guanine Nucleotide Exchange Factor Specific for Cdc42

1999 • 123 citations

The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells

1997 • 107 citations

Regulation of Cell Function by Rho Family GTPases

2000 • 100 citations

Evi-2, a common integration site involved in murine myeloid leukemogenesis.

1990 • 98 citations

The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes

1991 • 91 citations

Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice

1982 • 85 citations

[9] Guanine nucleotide exchange catalyzed by dbl oncogene product

1995 • 76 citations

Spontaneous and induced leukemias of myeloid origin in recombinant inbred BXH mice

1984 • 74 citations

Guanine nucleotide exchange factors: Activators of Ras superfamily proteins

1995 • 73 citations

Cdc42 Is a Substrate for Caspases and Influences Fas-induced Apoptosis

2001 • 72 citations

Activation of the Rap1 Guanine Nucleotide Exchange Gene,CalDAG-GEF I, in BXH-2 Murine Myeloid Leukemia

2001 • 68 citations

Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels

1995 • 64 citations

Molecular Biology of Chronic Myeloid Leukemia

2001 • 59 citations

Genetic Profile of Insertion Mutations in Mouse Leukemias and Lymphomas

2000 • 55 citations

Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?

1996 • 42 citations

Loss of Fas (CD95/APO-1) Regulatory Function Is an Important Step in Early MALT-Type Lymphoma Development

2001 • 41 citations

Genetic heterogeneity in acute myeloid leukemia: maximizing information flow from MuLV mutagenesis studies

2000 • 34 citations

Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation

1998 • 30 citations

Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas

1995 • 30 citations

Ectopic expression of constitutively activated Ral GTPase inhibits cell shape changes during Drosophila eye development

1999 • 21 citations