Gα13 Requires Palmitoylation for Plasma Membrane Localization, Rho-dependent Signaling, and Promotion of p115-RhoGEF Membrane Binding

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Signaling—2000 and Beyond

2000 • 2,544 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho

1999 • 386 citations

A Cytoplasmic Acyl-Protein Thioesterase That Removes Palmitate from G Protein α Subunits and p21RAS

1998 • 382 citations

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

1998 • 352 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

Lipid modifications of G proteins: alpha subunits are palmitoylated.

1993 • 336 citations

Signalling functions of protein palmitoylation

1998 • 328 citations

Activation of RhoA by Lysophosphatidic Acid and Gα_12/13Subunits in Neuronal Cells: Induction of Neurite Retraction

1999 • 303 citations

Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

1993 • 293 citations

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.

1990 • 277 citations

Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.

1987 • 276 citations

The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho

1998 • 265 citations

Emerging roles for RGS proteins in cell signalling

1999 • 255 citations

Molecular cloning and expression of palmitoyl-protein thioesterase.

1994 • 229 citations

Receptor regulation of G-protein palmitoylation.

1994 • 229 citations

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

1990 • 225 citations

RGS proteins: more than just GAPs for heterotrimeric G proteins

1999 • 200 citations

Autoacylation of G Protein α Subunits

1996 • 197 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.

1993 • 180 citations

G alpha 13 stimulates Na-H exchange.

1994 • 175 citations

G-protein Palmitoyltransferase Activity Is Enriched in Plasma Membranes

1996 • 170 citations

Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors

1998 • 167 citations

Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase

1996 • 161 citations

Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association.

1997 • 160 citations

A novel N-terminal motif for palmitoylation of G-protein α subunits

1993 • 156 citations

Regulation of cell proliferation by G proteins

1998 • 151 citations

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor

1996 • 151 citations

Inhibition of Brain G _z GAP and Other RGS Proteins by Palmitoylation of G Protein α Subunits

1997 • 147 citations

Functional Importance of the Amino Terminus of Gqα

1996 • 143 citations

Interaction with Gβγ Is Required for Membrane Targeting and Palmitoylation of Gαs and Gαq

2000 • 116 citations

RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Gα₁₁

1999 • 107 citations

A Rho Exchange Factor Mediates Thrombin and Gα12-induced Cytoskeletal Responses

1999 • 103 citations

The G protein .alpha.s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification

1993 • 97 citations

Purification of a Protein Palmitoyltransferase that Acts on H-Ras Protein and on a C-terminal N-Ras Peptide

1996 • 96 citations

Plasma Membrane Localization of Gα_zRequires Two Signals

1998 • 94 citations

Fatty Acylation of α2

1995 • 90 citations

Regulation of Gq/11α by the Gonadotropin-Releasing Hormone Receptor

1997 • 88 citations

Activation of the Lbc Rho Exchange Factor Proto-Oncogene by Truncation of an Extended C Terminus That Regulates Transformation and Targeting

1999 • 84 citations

Expression of GTPase-deficient Giα2 Results in Translocation of Cytoplasmic RGS4 to the Plasma Membrane

1998 • 78 citations

Lipid Modifications and Membrane Targeting of G<sub>α</sub>

1998 • 73 citations

Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cells.

1996 • 71 citations

The α‐subunits of G‐proteins G₁₂ and G₁₃ are palmitoylated, but not amidically myristoylated

1994 • 63 citations

Purification and Biochemical Characterization of a Protein-palmitoyl Acyltransferase from Human Erythrocytes

1997 • 62 citations

Partial Constitutive Activation of Pheromone Responses by a Palmitoylation-Site Mutant of a G Protein α Subunit in Yeast

1996 • 60 citations

Failure to myristoylate the alpha subunit of Gz is correlated with an inhibition of palmitoylation and membrane attachment, but has no affect on phosphorylation by protein kinase C.

1994 • 56 citations

N-terminal fatty acylation of the α-subunit of the G-protein Gi1: only the myristoylated protein is a substrate for palmitoylation

1994 • 49 citations

Regulation of Gq/11 by the Gonadotropin-Releasing Hormone Receptor

1997 • 44 citations

Gα₁₂ Requires Acylation for Its Transforming Activity

1998 • 39 citations

Serotonin-mediated palmitoylation and depalmitoylation of G alpha proteins in rat brain cortical membranes.

1998 • 23 citations

Interaction of the G‐protein G₁₁α with receptors and phosphoinositidase C:

1997 • 20 citations