Tiam1 mutations in human renal-cell carcinomas

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors

1998 • 745 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1995 • 597 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

Role of Rac1 and Oxygen Radicals in Collagenase-1 Expression Induced by Cell Shape Change

1998 • 392 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

Oncogene ect2 is related to regulators of small GTP-binding proteins

1993 • 281 citations

Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation

1997 • 230 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.

1994 • 134 citations

Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.

1995 • 124 citations

Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products.

1994 • 108 citations

Basal Phosphorylation of the PEST Domain in IκBβ Regulates Its Functional Interaction with the c-rel Proto-Oncogene Product

1996 • 91 citations

Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton.

1996 • 86 citations

Adherens junction proteins in tumour progression.

1995 • 83 citations

Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin.

1995 • 79 citations

Molecular Cloning of Rat RAC Protein Kinase α and β and Their Association with Protein Kinase Cζ

1994 • 71 citations

Structural Basis for Pleckstrin Homology Domain Mutations in X-Linked Agammaglobulinemia

1995 • 61 citations

Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression

2000 • 57 citations

Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins.

1994 • 56 citations

Phospholipase C‐γ, protein kinase C and Ca²⁺/calmodulin‐dependent protein kinase II are involved in platelet‐derived growth factor‐induced phosphorylation of Tiam1

1998 • 42 citations

Cytomorphological, cytogenetic, and molecular biological characterization of four new human renal carcinoma cell lines of the clear cell type

1994 • 21 citations

Signaling pathways regulated by Rho-like proteins

1996 • 17 citations

In vitro invasiveness of human epithelioid-sarcoma cell lines: Association with cell motility and inverse correlation with the expression of tissue inhibitor of metalloproteinases

1999 • 17 citations