EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Predicting Subcellular Localization of Proteins Based on their N-terminal Amino Acid Sequence

2000 • 4,297 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT

1998 • 1,082 citations

Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture

1995 • 847 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Multiple roles of eph receptors and ephrins in neural development

2001 • 611 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Rho GTPases: Signaling, Migration, and Invasion

2000 • 584 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

Signal sequences: more than just greasy peptides

1998 • 544 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase

2000 • 393 citations

PAK to the future

1999 • 391 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

Tyrosine Kinase Receptors Concentrated in Caveolae-like Domains from Neuronal Plasma Membrane

1997 • 248 citations

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

1996 • 209 citations

TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of RhoG

2000 • 166 citations

RhoG GTPase Controls a Pathway That Independently Activates Rac1 and Cdc42Hs

1998 • 162 citations

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

1994 • 151 citations

Ephrins and their Eph receptors: multitalented directors of embryonic development

1999 • 148 citations

Multiple Determinants Direct the Orientation of Signal–Anchor Proteins: The Topogenic Role of the Hydrophobic Signal Domain

1997 • 145 citations

A versatile microporation technique for the transfection of cultured CNS neurons

1999 • 139 citations

αPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

1999 • 105 citations

Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins.

1994 • 56 citations

Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse

1995 • 52 citations

Characterization of Ngef, a Novel Member of the Dbl Family of Genes Expressed Predominantly in the Caudate Nucleus

2000 • 30 citations

Characterisation of the Sek‐1 receptor tyrosine kinase

1995 • 17 citations

Modulation of erbB kinase activity and oncogenic potential by single point mutations in the glycine loop of the catalytic domain.

1994 • 16 citations

[20] Analysis of ion channel associated proteins

1999 • 12 citations

Modulation of erbB Kinase Activity and Oncogenic Potential by Single Point Mutations in the Glycine Loop of the Catalytic Domain

1994 • 9 citations

DNA cloning 2. Expression systems

1996 • 9 citations