Vav proteins, adaptors and cell signaling

LAT

1998 • 1,251 citations

LAT Palmitoylation

1998 • 837 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Structural Basis for Relief of Autoinhibition of the Dbl Homology Domain of Proto-Oncogene Vav by Tyrosine Phosphorylation

2000 • 381 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

Lck Regulates Vav Activation of Members of the Rho Family of GTPases

1997 • 305 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins

1999 • 268 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways

1999 • 239 citations

Activation of Vav by Nef Induces Cytoskeletal Rearrangements and Downstream Effector Functions

1999 • 234 citations

Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

1997 • 224 citations

The role of NF-AT transcription factors in T cell activation and differentiation11We dedicate this review to Prof. Dr. Rigomar Rieger (Gatersleben), a great scientist and man, on the occasion of his 70th birthday. One of us (E.S.) had the pleasure of working in his department.

2000 • 203 citations

Mechanism for down-regulation of CD28 by Nef

2001 • 202 citations

SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1

1997 • 201 citations

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

1996 • 194 citations

CD19 as a Membrane-Anchored Adaptor Protein of B Lymphocytes: Costimulation of Lipid and Protein Kinases by Recruitment of Vav

1998 • 179 citations

A Functional T-Cell Receptor Signaling Pathway Is Required for p95^vav Activity

1995 • 173 citations

Tyrosine Phosphorylation Mediates Both Activation and Downmodulation of the Biological Activity of Vav

2000 • 170 citations

Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors.

1994 • 147 citations

Vav3 Mediates Receptor Protein Tyrosine Kinase Signaling, Regulates GTPase Activity, Modulates Cell Morphology, and Induces Cell Transformation

2000 • 146 citations

Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling

1998 • 127 citations

CD19 Amplifies B Lymphocyte Signal Transduction by Regulating Src-Family Protein Tyrosine Kinase Activation

1999 • 120 citations

The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters.

2000 • 114 citations

Synergistic Activation of NFAT by HIV-1 Nef and the Ras/MAPK Pathway

2000 • 112 citations

Binding of Vav to Grb2 through dimerization of Src homology 3 domains.

1994 • 112 citations

A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT

2001 • 105 citations

p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by Nef

2000 • 104 citations

A Guanine Nucleotide Exchange Factor-independent Function of Vav1 in Transcriptional Activation

2000 • 103 citations

Apoptosis in AIDS.

2001 • 102 citations

Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase

1996 • 95 citations

Regulation of inositol lipid kinases by Rho and Rac

1998 • 90 citations

Three domains of SLP-76 are required for its optimal function in a T cell line.

1997 • 87 citations

Vav-2 controls NFAT-dependent transcription inB- but not T-lymphocytes

2000 • 78 citations

The Src Homology 2 Domain of Vav Is Required for Its Compartmentation to the Plasma Membrane and Activation of C-Jun Nh2-Terminal Kinase 1

2000 • 73 citations

SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity

1999 • 70 citations

Specific Subdomains of Vav Differentially Affect T Cell and NK Cell Activation

2000 • 56 citations

Nucleocytoplasmic shuttling and the control of NF-AT signaling

2000 • 55 citations

Role of CD19 tyrosine 391 in synergistic activation of B lymphocytes by coligation of CD19 and membrane Ig.

1997 • 49 citations

Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors

2000 • 42 citations

HIV and SIV Nef Modulate Signal Transduction and Protein Sorting in T Cells

1999 • 26 citations

Expression of a novel isoform of Vav, Vav-T, containing a single Src homology 3 domain in murine testicular germ cells

1997 • 20 citations

Interactions of HIV-1 NEF with cellular signal transducing proteins

2000 • 2 citations