Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

2000 • 913 citations

Identification of genes required for cytoplasmic localization in early C. elegans embryos

1988 • 841 citations

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

2000 • 740 citations

A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

1998 • 720 citations

Differential Localization of Rho Gtpases in Live Cells

2001 • 686 citations

Overexpression of the Dynamitin (p50) Subunit of the Dynactin Complex Disrupts Dynein-dependent Maintenance of Membrane Organelle Distribution

1997 • 652 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

1990 • 560 citations

A Role for Cdc42 in Macrophage Chemotaxis

1998 • 537 citations

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1994 • 525 citations

Rho GTPases and their effector proteins

2000 • 461 citations

Cytoplasmic dynein and dynactin in cell division and intracellular transport

1999 • 454 citations

Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures

2001 • 426 citations

DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

2000 • 405 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

The role of microtubule dynamics in growth cone motility and axonal growth.

1995 • 362 citations

Dynactin Is Required for Microtubule Anchoring at Centrosomes

1999 • 354 citations

Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1

2000 • 350 citations

Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells

1999 • 340 citations

Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish

2000 • 301 citations

PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos

1999 • 293 citations

Rac/Cdc42 and p65PAK Regulate the Microtubule-destabilizing Protein Stathmin through Phosphorylation at Serine 16

2001 • 293 citations

Integrin-mediated Adhesion Regulates Cell Polarity and Membrane Protrusion through the Rho Family of GTPases

2001 • 280 citations

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

2000 • 276 citations

Rho Guanosine Triphosphatase Mediates the Selective Stabilization of Microtubules Induced by Lysophosphatidic Acid

1998 • 257 citations

Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent Mechanism

1998 • 247 citations

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1994 • 231 citations

Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity.

1991 • 204 citations

Rac Mediates Cytoskeletal Rearrangements and Increased Cell Motility Induced by Urokinase-Type Plasminogen Activator Receptor Binding to Vitronectin

2001 • 186 citations

Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo

1996 • 149 citations

The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1

2000 • 145 citations

Dynein motor regulation stabilizes interphase microtubule arrays and determines centrosome position

1999 • 120 citations

RhoA and the Function of Platelet Integrin αIIbβ3

1998 • 116 citations

ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF-alpha secretion.

1999 • 75 citations

Nuclear migration: Cortical anchors for cytoplasmic dynein

2001 • 62 citations

ICAM-1-Coupled Signaling Pathways in Astrocytes Converge to Cyclic AMP Response Element-Binding Protein Phosphorylation and TNF-α Secretion

1999 • 61 citations

Cell polarity: the PARty expands

2001 • 37 citations