Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

Socs1 binds to multiple signalling proteins and suppresses Steel factor-dependent proliferation

1999 • 205 citations

Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIα

1999 • 205 citations

The Rho Small G Protein Family-Rho GDI System as a Temporal and Spatial Determinant for Cytoskeletal Control

1998 • 200 citations

Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes.

1993 • 192 citations

The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein

1992 • 175 citations

A Functional T-Cell Receptor Signaling Pathway Is Required for p95^vav Activity

1995 • 173 citations

The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization

1992 • 170 citations

C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases

1997 • 169 citations

Loss of the Amino-Terminal Helix-Loop-Helix Domain of the vav Proto-Oncogene Activates Its Transforming Potential

1991 • 168 citations

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

1996 • 152 citations

Does Vav bind to F‐actin through a CH domain?

1995 • 145 citations

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.

1996 • 143 citations

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav.

1994 • 140 citations

Interaction of Vav with ENX-1, a Putative Transcriptional Regulator of Homeobox Gene Expression

1996 • 129 citations

GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein.

1993 • 125 citations

Mechanism of activation of the vav protooncogene.

1991 • 122 citations

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm

1997 • 118 citations

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.

1991 • 116 citations

Expression level, subcellular distribution and Rho-GDI binding affinity of merlin in comparison with ezrin/radixin/moesin proteins

1999 • 86 citations

Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity

1998 • 65 citations

Involvement of NH2-terminal Sequences in the Negative Regulation of Vav Signaling and Transforming Activity

1999 • 54 citations

RhoGAPs and RhoGDIs, (His)stories of Two Families

1999 • 47 citations

Single point mutations in the SH2 domain impair the transforming potential of vav and fail to activate proto-vav.

1993 • 42 citations

Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases

1997 • 42 citations

Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation

1996 • 34 citations

Mutagenic analysis of Vav reveals that an intact SH3 domain is required for transformation

1998 • 32 citations

The products of the mcf-2 and vav proto-oncogenes and of the yeast gene cdc-24 share sequence similarities.

1992 • 32 citations

Vav: Captain Hook for signal transduction?

1995 • 19 citations