Control of Intramolecular Interactions between the Pleckstrin Homology and Dbl Homology Domains of Vav and Sos1 Regulates Rac Binding

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

A Cell's Sense of Direction

1999 • 884 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

1999 • 689 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

1998 • 426 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

1999 • 368 citations

Lck Regulates Vav Activation of Members of the Rho Family of GTPases

1997 • 305 citations

Phosphatidylinositol 3-Kinase-dependent Membrane Association of the Bruton's Tyrosine Kinase Pleckstrin Homology Domain Visualized in Single Living Cells

1999 • 291 citations

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

1998 • 249 citations

Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation

1997 • 230 citations

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

1998 • 220 citations

Cytoskeletal Reorganization by G Protein-Coupled Receptors Is Dependent on Phosphoinositide 3-Kinase γ, a Rac Guanosine Exchange Factor, and Rac

1998 • 181 citations

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

1997 • 178 citations

Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function

1998 • 173 citations

[52] Extraction and purification of polyphosphoinositides

1981 • 168 citations

Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors.

1994 • 147 citations

Structure and mutagenesis of the Dbl homology domain

1998 • 142 citations

The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C

1997 • 133 citations

Phosphorylation of CD19 Y484 and Y515, and Linked Activation of Phosphatidylinositol 3-Kinase, Are Required for B Cell Antigen Receptor-Mediated Activation of Bruton’s Tyrosine Kinase

1999 • 126 citations

Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain

1998 • 126 citations

Phospholipid-binding protein domains

1998 • 116 citations

Views on Vav

1997 • 103 citations

Fyn and ZAP-70 Are Required for Vav Phosphorylation in T Cells Stimulated by Antigen-presenting Cells

1998 • 101 citations

Lymphocyte signalling: A coordinating role for Vav?

1998 • 88 citations

The PH Domain and the Polybasic c Domain of Cytohesin-1 Cooperate specifically in Plasma Membrane Association and Cellular Function

1998 • 87 citations

Vav links antigen-receptor signaling to the actin cytoskeleton

1998 • 81 citations

Identification of the Ras GTPase-activating protein GAP1m as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo

1999 • 73 citations

Intracellular Mediators: Synthesis of L-.alpha.-Phosphatidyl-D-myo-inositol 3,4,5-Trisphosphate and Glyceryl Ether Analogs

1995 • 68 citations

The Solution Structure of the Pleckstrin Homology Domain of Human SOS1

1997 • 61 citations

Involvement of the Pleckstrin Homology Domain in the Insulin-stimulated Activation of Protein Kinase B

1998 • 59 citations

Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases

1997 • 34 citations

Growth factor stimulation of hematopoietic cells leads to membrane translocation of AKT1 protein kinase

1997 • 18 citations