Mechanisms of Alternative Pre-Messenger RNA Splicing

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

Listening to silence and understanding nonsense: exonic mutations that affect splicing

2002 • 2,143 citations

microRNAs

2001 • 1,653 citations

A genomic view of alternative splicing

2002 • 1,307 citations

Alternative splicing: increasing diversity in the proteomic world

2001 • 1,218 citations

RNA-Binding Proteins Tia-1 and Tiar Link the Phosphorylation of Eif-2α to the Assembly of Mammalian Stress Granules

1999 • 1,169 citations

An extensive network of coupling among gene expression machines

2002 • 1,137 citations

Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things

1998 • 1,121 citations

Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome

2001 • 1,113 citations

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

2002 • 1,081 citations

Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity

2000 • 1,067 citations

Exon Recognition in Vertebrate Splicing

1995 • 1,067 citations

Sorting out the complexity of SR protein functions

2000 • 1,064 citations

Integrating mRNA Processing with Transcription

2002 • 1,054 citations

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription

2000 • 1,049 citations

Predictive Identification of Exonic Splicing Enhancers in Human Genes

2002 • 1,035 citations

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

2000 • 923 citations

Large-Scale Proteomic Analysis of the Human Spliceosome

2002 • 911 citations

The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

1997 • 905 citations

Alternative pre-mRNA splicing: the logic of combinatorial control

2000 • 892 citations

Comprehensive proteomic analysis of the human spliceosome

2002 • 883 citations

AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs

2001 • 859 citations

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

2001 • 799 citations

hnRNP complexes: composition, structure, and function

1999 • 794 citations

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

2001 • 768 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Mechanism and regulation of mRNA polyadenylation

1997 • 762 citations

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

THE HIV-1 REV PROTEIN

1998 • 716 citations

Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1

2002 • 708 citations

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases

2000 • 689 citations

SR proteins and splicing control.

1996 • 668 citations

ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation

1998 • 644 citations

Alternative splicing: multiple control mechanisms and involvement in human disease

2002 • 643 citations

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

1994 • 622 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

Loss of the Muscle-Specific Chloride Channel in Type 1 Myotonic Dystrophy Due to Misregulated Alternative Splicing

2002 • 592 citations

RNA polymerase II and the integration of nuclear events

2000 • 561 citations

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

1996 • 559 citations

TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus

1998 • 557 citations

Protein Diversity from Alternative Splicing

2000 • 548 citations

Distinct Binding Specificities and Functions of Higher Eukaryotic Polypyrimidine Tract-Binding Proteins

1995 • 537 citations

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

1994 • 511 citations

Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins

1998 • 505 citations

Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene

1996 • 504 citations

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

1995 • 502 citations

Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex

1998 • 486 citations

RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing.

1994 • 481 citations

Sex in flies: the splice of life

1989 • 468 citations

Experimental annotation of the human genome using microarray technology

2001 • 446 citations

Identification of a (CUG)n Triplet Repeat RNA-Binding Protein and Its Expression in Myotonic Dystrophy

1996 • 444 citations

A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development

1999 • 441 citations

The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing

2001 • 420 citations

Nova-1 Regulates Neuron-Specific Alternative Splicing and Is Essential for Neuronal Viability

2000 • 415 citations

Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays

2002 • 406 citations

A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

2002 • 395 citations

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

1997 • 394 citations

Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly

2001 • 385 citations

Direct Coupling of Transcription and mRNA Processing through the Thermogenic Coactivator PGC-1

2000 • 383 citations

Exon Identity Established through Differential Antagonism between Exonic Splicing Silencer-Bound hnRNP A1 and Enhancer-Bound SR Proteins

2001 • 381 citations

Splicing is required for rapid and efficient mRNA export in metazoans

1999 • 375 citations

Polypyrimidine Tract Binding Protein Antagonizes Exon Definition

2001 • 373 citations

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein

1999 • 370 citations

Allosteric Cascade of Spliceosome Activation

2002 • 357 citations

The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.

1995 • 351 citations

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.

1989 • 349 citations

Stimulatory effect of splicing factors on transcriptional elongation

2001 • 346 citations

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

1991 • 338 citations

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctions

2000 • 337 citations

Structure, function and evolution of sex-determining systems in Dipteran insects

2000 • 337 citations

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

1998 • 334 citations

The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation

2000 • 333 citations

Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript

1990 • 333 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

Alternative RNA splicing in the nervous system

2001 • 331 citations

Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism.

1994 • 325 citations

A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.

1997 • 324 citations

RNA Polymerase II Targets Pre-mRNA Splicing Factors to Transcription Sites In Vivo

1999 • 322 citations

Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.

1994 • 321 citations

Expression of Msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila

1995 • 317 citations

Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA

1999 • 315 citations

A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.

1994 • 315 citations

Neuronal pp60 ^{c- src} Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

1987 • 313 citations

Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system

1993 • 313 citations

Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein

2000 • 312 citations

Coupling of Transcription with Alternative Splicing

1999 • 311 citations

The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA

1993 • 309 citations

SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells

1998 • 306 citations

A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.

1985 • 305 citations

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

1993 • 300 citations

RNA RECOGNITION BY RNP PROTEINS DURING RNA PROCESSING

1998 • 299 citations

hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs

1992 • 299 citations

Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG

1999 • 290 citations

Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage

1989 • 288 citations

The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.

1996 • 286 citations

Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?

1988 • 280 citations

Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase

1998 • 277 citations

The Apoptosis-Promoting Factor TIA-1 Is a Regulator of Alternative Pre-mRNA Splicing

2000 • 277 citations

The Regulation of Splice-Site Selection, and Its Role in Human Disease

1997 • 277 citations

Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP

2002 • 272 citations

Protein functions in pre-mRNA splicing

1997 • 272 citations

Sex lethal controls dosage compensation in Drosophila by a non-splicing mechanism

1997 • 265 citations

The mRNA assembly line: transcription and processing machines in the same factory

2002 • 260 citations

The Neuronal RNA Binding Protein Nova-1 Recognizes Specific RNA Targets In Vitro and In Vivo

1997 • 258 citations

Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA

1996 • 258 citations

Characterization of cDNAs encoding the polypyrimidine tract-binding protein.

1991 • 257 citations

hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing

1999 • 253 citations

hnRNP H Is a Component of a Splicing Enhancer Complex That Activates a c-srcAlternative Exon in Neuronal Cells

1999 • 247 citations

A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels

2001 • 245 citations

Crystal Structure of a Pumilio Homology Domain

2001 • 244 citations

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

1998 • 243 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

Phosphorylated RNA polymerase II stimulates pre-mRNA splicing

1999 • 239 citations

A Xenopus Protein Related to hnRNP I Has a Role in Cytoplasmic RNA Localization

1999 • 238 citations

Mutually exclusive splicing of α-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing

1989 • 238 citations

Identification of a New Class of Exonic Splicing Enhancers by In Vivo Selection

1997 • 237 citations

Alternatively Spliced Isoforms of Nerve- and Muscle-Derived Agrin

1999 • 236 citations

The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway

1997 • 236 citations

Capping, splicing, and 3′ processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD

2001 • 236 citations

Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo.

1997 • 233 citations

A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing

2000 • 231 citations

Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer.

1996 • 228 citations

Coupling RNA polymerase II transcription with pre-mRNA processing

1999 • 228 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

Oncoprotein TLS Interacts with Serine-Arginine Proteins Involved in RNA Splicing

1998 • 225 citations

Determinants of SR protein specificity

1999 • 224 citations

Splicing regulation as a potential genetic modifier

2002 • 224 citations

Selection of splice sites in pre-mRNAs with short internal exons.

1991 • 224 citations

The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing

1999 • 223 citations

Modulation of DNA Binding Specificity by Alternative Splicing of the Wilms Tumor wt1 Gene Transcript

1992 • 221 citations

Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins

1998 • 220 citations

hnRNP A1 Recruited to an Exon In Vivo Can Function as an Exon Splicing Silencer

1999 • 219 citations

The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia

1998 • 214 citations

The Polypyrimidine Tract Binding Protein Binds Upstream of Neural Cell-Specific c-src Exon N1 To Repress the Splicing of the Intron Downstream

1997 • 214 citations

A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart.

1997 • 213 citations

A coactivator of pre-mRNA splicing

1998 • 212 citations

Profiling alternative splicing on fiber-optic arrays

2002 • 211 citations

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

1992 • 209 citations

Arginine/Serine-Rich Domains of SR Proteins Can Function as Activators of Pre-mRNA Splicing

1998 • 207 citations

Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin

2000 • 207 citations

The Regulation of the Drosophila Gene Reveals a Function for in Translational Control

1997 • 205 citations

Post-transcriptional regulation: The dawn of PTB

1997 • 202 citations

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.

1996 • 200 citations

The SR Protein SRp38 Represses Splicing in M Phase Cells

2002 • 200 citations

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2

1998 • 200 citations

Positive Control of Pre-mRNA Splicing in Vitro

1992 • 199 citations

Determination of the RNA Binding Specificity of the Heterogeneous Nuclear Ribonucleoprotein (hnRNP) H/H′/F/2H9 Family

2001 • 199 citations

Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors.

1994 • 199 citations

The Splicing Factor, Prp40, Binds the Phosphorylated Carboxyl-terminal Domain of RNA Polymerase II

2000 • 197 citations

Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization

1999 • 196 citations

Co-transcriptional commitment to alternative splice site selection

1998 • 195 citations

The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site

2000 • 195 citations

The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event.

1995 • 194 citations

Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome

2002 • 194 citations

Multisite RNA Binding and Release of Polypyrimidine Tract Binding Protein during the Regulation of c-src Neural-Specific Splicing

2000 • 193 citations

Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer

1997 • 192 citations

Functional Association of U2 snRNP with the ATP-Independent Spliceosomal Complex E

2000 • 192 citations

RNP particles at splice junction sequences on Drosophila chorion transcripts

1985 • 191 citations

Multiple Distinct Splicing Enhancers in the Protein-Coding Sequences of a Constitutively Spliced Pre-mRNA

1999 • 191 citations

Function of quaking in myelination: Regulation of alternative splicing

2002 • 190 citations

The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4

2001 • 189 citations

Functional domains of the human splicing factor ASF/SF2.

1993 • 188 citations

Finding splice sites within a wilderness of RNA.

1995 • 188 citations

Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila.

1993 • 186 citations

Dynamic Antagonism between ETR-3 and PTB Regulates Cell Type-Specific Alternative Splicing

2002 • 184 citations

Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis

1999 • 181 citations

A Subset of SR Proteins Activates Splicing of the Cardiac Troponin T Alternative Exon by Direct Interactions with an Exonic Enhancer

1995 • 180 citations

Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster.

1995 • 177 citations

Regulation of transcription factor localization: fine-tuning of gene expression

1996 • 177 citations

Pre-mRNA splicing in the absence of an SR protein RS domain

2000 • 177 citations

Regulation of Sex-Specific Selection of fruitless 5′ Splice Sites by transformerand transformer-2

1998 • 176 citations

Regulation of alternative pre-mRNA splicing by the ERK MAP-kinase pathway

2001 • 175 citations

The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export

1997 • 171 citations

Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro

1992 • 171 citations

Multiple RRMs Contribute to RNA Binding Specificity and Affinity for Polypyrimidine Tract Binding Protein

1997 • 168 citations

A predominantly nuclear protein affecting cytoplasmic localization of β-actin mRNA in fibroblasts and neurons

2002 • 167 citations

SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.

1995 • 167 citations

The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element

2001 • 166 citations

Functional characterization of SR and SR-related genes in Caenorhabditis elegans

2000 • 166 citations

CD44 Acts Both as a Growth‐ and Invasiveness‐Promoting Molecule and as a Tumor‐Suppressing Cofactor

2000 • 166 citations

Regulation of Nuclear Localization during Signaling

2001 • 165 citations

Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6middle dotU5] tri-snRNP

1999 • 165 citations

The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation

1999 • 164 citations

ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform

1996 • 163 citations

The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal

1995 • 163 citations

Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator

1998 • 162 citations

Splicing Regulation at the Second Catalytic Step by Sex-lethal Involves 3′ Splice Site Recognition by SPF45

2002 • 162 citations

A CTD function linking transcription to splicing

1997 • 160 citations

A Structured Retroviral RNA Element That Mediates Nucleocytoplasmic Export of Intron-Containing RNA

1997 • 160 citations

Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA.

1992 • 157 citations

Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold

2000 • 156 citations

Tissue-Specific Splicing in Vivo of the β-Tropomyosin Gene: Dependence on an RNA Secondary Structure

1991 • 156 citations

Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor

1999 • 156 citations

Molecular Genetic Dissection of the Sex-Specific and Vital Functions of the Drosophila melanogaster Sex Determination Gene fruitless

2001 • 155 citations

The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding.

1992 • 154 citations

An Intronic Splicing Silencer Causes Skipping of the IIIb Exon of Fibroblast Growth Factor Receptor 2 through Involvement of Polypyrimidine Tract Binding Protein

2000 • 153 citations

Common themes in the function of transcription and splicing enhancers

1997 • 151 citations

Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing

2002 • 151 citations

Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element.

1994 • 150 citations

Conserved Sr Protein Kinase Functions in Nuclear Import and Its Action Is Counteracted by Arginine Methylation inSaccharomyces cerevisiae

2000 • 149 citations

SC35 Plays a Role in T Cell Development and Alternative Splicing of CD45

2001 • 147 citations

Substrate Specificities of SR Proteins in Constitutive Splicing Are Determined by Their RNA Recognition Motifs and Composite Pre-mRNA Exonic Elements

1999 • 146 citations

Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?

1991 • 146 citations

Phosphorylation Regulates In Vivo Interaction and Molecular Targeting of Serine/Arginine-rich Pre-mRNA Splicing Factors

1999 • 146 citations

RNAi-Mediated PTB Depletion Leads to Enhanced Exon Definition

2002 • 143 citations

Alternative splicing: combinatorial output from the genome

2002 • 143 citations

Control of retroviral RNA splicing through maintenance of suboptimal processing signals.

1990 • 141 citations

A Model System for Activation-Induced Alternative Splicing of CD45 Pre-mRNA in T Cells Implicates Protein Kinase C and Ras

2000 • 141 citations

Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing

2001 • 141 citations

Polypyrimidine Tract Binding Protein Functions as a Repressor To Regulate Alternative Splicing of α-Actinin Mutally Exclusive Exons

1999 • 139 citations

A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation

2002 • 139 citations

The role of U2AF35 and U2AF65 in enhancer-dependent splicing

2001 • 139 citations

Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells

1996 • 138 citations

ASESORÍAS INNOVADORAS EN RECURSOS HUMANOS PARA LAS PYMES MEDIANTE EL USO DE LA RED DE INTERNET

1969 • 136 citations

A splicing enhancer exhibits both constitutive and regulated activities.

1994 • 136 citations

RNA processing and human disease

2000 • 135 citations

Alternative Splicing and Programmed Cell Death

1999 • 133 citations

A Complex Intronic Splicing Enhancer from the c-src Pre-mRNA Activates Inclusion of a Heterologous Exon

1997 • 133 citations

The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.

1987 • 133 citations

Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity.

1995 • 133 citations

Eukaryotic mRNA Processing

1997 • 133 citations

Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB)

2001 • 133 citations

Functional Recognition of the 5′ Splice Site by U4/U6.U5 tri-snRNP Defines a Novel ATP-Dependent Step in Early Spliceosome Assembly

2000 • 132 citations

A Family of Human RNA-binding Proteins Related to theDrosophila Bruno Translational Regulator

2000 • 132 citations

A Second Exon Splicing Silencer within Human Immunodeficiency Virus Type 1 tat Exon 2 Represses Splicing of Tat mRNA and Binds Protein hnRNP H

2001 • 128 citations

The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute

1998 • 128 citations

SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D

2002 • 125 citations

Conservation in budding yeast of a kinase specific for SR splicing factors

1999 • 125 citations

Regulation of Alternative Splicing by the ATP-Dependent DEAD-Box RNA Helicase p72

2002 • 125 citations

Generation of Alternative Ultrabithorax Isoforms and Stepwise Removal of a Large Intron by Resplicing at Exon–Exon Junctions

1998 • 124 citations

Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI.

1994 • 124 citations

The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta -tropomyosin alternative exon 6A

1997 • 124 citations

Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection

1999 • 123 citations

Retroviruses as Model Systems for the Study of Nuclear RNA Export Pathways

1998 • 123 citations

Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation

2002 • 122 citations

Alternatively spliced forms of cyclin D1 modulate entry into the cell cycle in an inverse manner

1998 • 121 citations

Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing.

1995 • 118 citations

Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB

1999 • 116 citations

Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing

2001 • 116 citations

Protein Phosphorylation Plays an Essential Role in the Regulation of Alternative Splicing and Sex Determination in Drosophila

1998 • 115 citations

The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA.

1991 • 112 citations

Avian retroviral RNA element promotes unspliced RNA accumulation in the cytoplasm

1996 • 112 citations

Two Closely Related Human Nuclear Export Factors Utilize Entirely Distinct Export Pathways

2001 • 112 citations

The SR protein B52/SRp55 is essential for Drosophila development.

1994 • 112 citations

Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus

1999 • 111 citations

Conserved Intron Elements Repress Splicing of a Neuron-Specific c-src Exon In Vitro

1997 • 111 citations

X-chromosome-counting mechanisms that determine nematode sex

1997 • 110 citations

Regulation of pre-mRNA splicing in metazoa

1997 • 110 citations

Regulation of Drosophila P element transposition

1991 • 105 citations

Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs

1997 • 105 citations

Alternative Splicing of the Fibronectin EIIIB Exon Depends on Specific TGCATG Repeats

1998 • 105 citations

RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins

1997 • 105 citations

A Human Papillomavirus E2 Transcriptional Activator

1999 • 103 citations

Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon.

1994 • 101 citations

Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing

1998 • 100 citations

Control ofDrosophila Sex-lethalpre-mRNA splicing by its own female-specific product

1992 • 100 citations

Muscle-Specific Splicing Enhancers Regulate Inclusion of the Cardiac Troponin T Alternative Exon in Embryonic Skeletal Muscle

1996 • 98 citations

Heterogeneous Ribonucleoprotein A1 Is Part of an Exon-specific Splice-silencing Complex Controlled by Oncogenic Signaling Pathways

2000 • 98 citations

The neuron-specific RNA-binding protein ELAV regulates neuroglian alternative splicing in neurons and binds directly to its pre-mRNA

2001 • 98 citations

The STAR/GSG Family Protein rSLM-2 Regulates the Selection of Alternative Splice Sites

2001 • 97 citations

Dopamine and Glutamate Induce Distinct Striatal Splice Forms of Ania-6, an RNA Polymerase II-Associated Cyclin

2001 • 94 citations

Activity‐dependent regulation of alternative splicing patterns in the rat brain

1999 • 94 citations

Region-specific alternative splicing in the nervous system: Implications for regulation by the RNA-binding protein NAPOR

2002 • 94 citations

The SRm160/300 splicing coactivator is required for exon-enhancer function

1999 • 93 citations

Serine-Arginine (SR) Protein-like Factors That Antagonize Authentic SR Proteins and Regulate Alternative Splicing

2001 • 92 citations

The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA.

1998 • 91 citations

Regulation of Alternative Splicing of Protein Kinase Cβ by Insulin

1995 • 90 citations

Determination of functional domains in polypyrimidine-tract-binding protein

1998 • 90 citations

The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts

1996 • 87 citations

Roles for SR Proteins and hnRNP A1 in the Regulation of c-src Exon N1

2003 • 87 citations

Selection of Novel Exon Recognition Elements from a Pool of Random Sequences

1995 • 86 citations

Ischemia Induces a Translocation of the Splicing Factor tra2-β1 and Changes Alternative Splicing Patterns in the Brain

2002 • 86 citations

Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein.

1990 • 86 citations

Heterogeneous Nuclear Ribonucleoprotein A1 and UP1 Protect Mammalian Telomeric Repeats and Modulate Telomere Replication in Vitro

2000 • 85 citations

half pint Regulates Alternative Splice Site Selection in Drosophila

2002 • 85 citations

Heterogeneous Nuclear Ribonucleoprotein (hnRNP) K Is a Component of an Intronic Splicing Enhancer Complex That Activates the Splicing of the Alternative Exon 6A from Chicken β-Tropomyosin Pre-mRNA

2002 • 84 citations

Conserved Intron Elements Repress Splicing of a Neuron-Specific c-src Exon In Vitro

1995 • 81 citations

The Function of Multisite Splicing Enhancers

1998 • 81 citations

The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila

1995 • 80 citations

Conserved stem-loop structures in the HIV-1 RNA region containing the A3 3' splice site and its cis-regulatory element: possible involvement in RNA splicing

2001 • 79 citations

Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing.

1993 • 78 citations

Identification of a Bidirectional Splicing Enhancer: Differential Involvement of SR Proteins in 5′ or 3′ Splice Site Activation

1999 • 78 citations

Splicing in the Inner Ear: a Familiar Tune, but What Are the Instruments?

1998 • 77 citations

The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation.

1994 • 77 citations

The Neuron-Enriched Splicing Pattern of Drosophila erect wing Is Dependent on the Presence of ELAV Protein

2000 • 76 citations

A Yeast Intronic Splicing Enhancer and Nam8p Are Required for Mer1p-Activated Splicing

2000 • 76 citations

Modulation of P-Element Pre-mRNA Splicing by a Direct Interaction between PSI and U1 snRNP 70K Protein

2001 • 75 citations

Participation of the C-Terminal Domain of RNA Polymerase II in Exon Definition during Pre-mRNA Splicing

2000 • 75 citations

A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA

2001 • 74 citations

The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element.

1993 • 74 citations

SRp30c Is a Repressor of 3′ Splice Site Utilization

2002 • 72 citations

Combinatorial control of a neuron-specific exon

1999 • 71 citations

Intronic sequences and 3' splice sites control Rous sarcoma virus RNA splicing

1992 • 71 citations

U2AF35 is encoded by an essential gene clustered in an operon with RRM/cyclophilin in Caenorhabditis elegans

1999 • 70 citations

The intranuclear site of excision of each intron in Balbiani ring 3 pre-mRNA is influenced by the time remaining to transcription termination and different excision efficiencies for the various introns.

1996 • 70 citations

The alternative splicing factor PSI regulates P-element third intron splicing in vivo.

1997 • 64 citations

Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor

1991 • 63 citations

Single stranded RNA binding proteins

2000 • 62 citations

Change in plasma membrane Ca2+-ATPase splice-variant expression in response to a rise in intracellular Ca2+

1996 • 62 citations

The genetic analysis of snf: a Drosophila sex determination gene required for activation of Sex-lethal in both the germline and the soma.

1992 • 62 citations

Elements regulating an alternatively spliced exon of the rat fibronectin gene.

1993 • 62 citations

Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain

2001 • 61 citations

Developmental regulation of SR protein phosphorylation and activity

1999 • 61 citations

RNA Processing: Splicing and the Cytoplasmic Localisation of mRNA

2002 • 61 citations

SF2/ASF binds to a splicing enhancer in the third HIV-1 tat exon and stimulates U2AF binding independently of the RS domain

2001 • 60 citations

Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1.

1994 • 59 citations

Coupled in vitro synthesis and splicing of RNA polymerase II transcripts

2000 • 59 citations

Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal

1999 • 59 citations

Alternative splicing, muscle contraction and intraspecific variation: associations between troponin T transcripts, Ca2+ sensitivity and the force and power output of dragonfly flight muscles during oscillatory contraction

2001 • 59 citations

A Cellular Protein, hnRNP H, Binds to the Negative Regulator of Splicing Element from Rous Sarcoma Virus

2000 • 58 citations

Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development

1999 • 57 citations

Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro.

1992 • 56 citations

RNA structural patterns and splicing: molecular basis for an RNA-based enhancer.

1995 • 55 citations

Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein

2002 • 55 citations

Molecular genetic analysis of the heterodimeric splicing factor U2AF: the RS domain on either the large or small Drosophila subunit is dispensable in vivo

1998 • 54 citations

Control of alternative pre-mRNA splicing by distributed pentameric repeats

1997 • 53 citations

Growth factor-inducible alternative splicing of nontransmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA.

1993 • 53 citations

Mammalian pre-mRNA splicing factors

1997 • 53 citations

Muscle-Specific Splicing of a Heterologous Exon Mediated by a Single Muscle-Specific Splicing Enhancer from the Cardiac Troponin T Gene

1998 • 51 citations

Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle

1999 • 50 citations

A Human RNA Polymerase II-containing Complex Associated with Factors Necessary for Spliceosome Assembly

2002 • 50 citations

An RNA Splicing Enhancer-Like Sequence Is a Component of a Splicing Inhibitor Element from Rous Sarcoma Virus

1998 • 49 citations

Regulation of transcription factor localization: fine-tuning of gene expression

1996 • 47 citations

Mechanisms of Transcriptional Timing in Drosophila

1992 • 46 citations

Sex-lethal autoregulation requires multiple cis-acting elements upstream and downstream of the male exon and appears to depend largely on controlling the use of the male exon 5' splice site.

1993 • 46 citations

U1 Small Nuclear Ribonucleoprotein and Splicing Inhibition by the Rous Sarcoma Virus Negative Regulator of Splicing Element

1999 • 45 citations

Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein

1999 • 44 citations

Distinct Factor Requirements for Exonic Splicing Enhancer Function and Binding of U2AF to the Polypyrimidine Tract

1999 • 44 citations

Novel Exonic Elements That Modulate Splicing of the Human Fibronectin EDA Exon

1997 • 42 citations

Structural and functional analysis of the avian leukemia virus constitutive transport element

1999 • 40 citations

Exonic splicing enhancers contribute to the use of both 3′ and 5′ splice site usage of rat β-tropomyosin pre-mRNA

1999 • 40 citations

Cooperation of pre-mRNA sequence elements in splice site selection.

1992 • 40 citations

Modulation of msl-2 5′ splice site recognition by Sex-lethal

2001 • 38 citations

The gene fl(2)d is needed for the sex-specific splicing of transformer pre-mRNA but not for double-sex pre-mRNA in Drosophila melanogaster

1996 • 37 citations

The role of overlapping U1 and U11 5′ splice site sequences in a negative regulator of splicing

1999 • 37 citations

The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing

2002 • 37 citations

Selective Regulation of Agrin mRNA Induction and Alternative Splicing in PC12 Cells by Ras-dependent Actions of Nerve Growth Factor

1997 • 36 citations

Positive and Negative Modulation of Human Immunodeficiency Virus Type 1 Rev Function by cis and trans Regulators of Viral RNA Splicing

2002 • 35 citations

Distinct mechanisms of splicing regulation in vivo by the Drosophila protein Sex-lethal

1997 • 34 citations

Both Loss-of-Function and Gain-of-Function Mutations in snf Define a Role for snRNP Proteins in Regulating Sex-lethal Pre-mRNA Splicing in Drosophila Development

1996 • 34 citations

Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements.

1996 • 34 citations

Regulation of alternative pre-mRNA splicing

2002 • 33 citations

Alternative Splicing and the Control of Flowering Time

2002 • 32 citations

A novel isoform ratio switch of the polypyrimidine tract binding protein

1999 • 32 citations

Retroviral RNA elements integrate components of post-transcriptional gene expression

2001 • 32 citations

Strong RNA Splicing Enhancers Identified by a Modified Method of Cycled Selection Interact with SR Protein

2001 • 30 citations

Sex, AGility, and the Regulation of Alternative Splicing

2002 • 30 citations

An Intronic Downstream Enhancer Promotes 3′ Splice Site Usage of a Neural Cell-specific Exon

2000 • 29 citations

Regulation of SR protein localization during development

2001 • 29 citations

Analysis of the functional specificity of RS domains invivo

1998 • 28 citations

A novel isoform ratio switch of the polypyrimidine tract binding protein

1999 • 28 citations

Alternative Splicing of a Neural-Specific Src mRNA (Src+) Is a Rapid and Protein Synthesis-Independent Response to Neural Induction in Xenopus laevis

1993 • 28 citations

Switch in 3′ Splice Site Recognition between Exon Definition and Splicing Catalysis Is Important for Sex-lethalAutoregulation

2001 • 26 citations

Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins

2002 • 26 citations

Induction of Long‐Term Potentiation In Vivo Regulates Alternate Splicing to Alter Syntaxin 3 Isoform Expression in Rat Dentate Gyrus

1998 • 26 citations

Analysis of autoregulation at the level of pre-mRNA splicing of the suppressor-of-white-apricot gene in Drosophila.

1994 • 25 citations

An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection

1999 • 25 citations

Localization of Serine Kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), Specific for the SR Family of Splicing Factors in Mouse and Human Chromosomes

1999 • 25 citations

Ca2+ and pH modulate alternative splicing of exon 5 in NMDA receptor subunit 1

1999 • 23 citations

Pararetro- and retrovirus RNA: splicing and the control of nuclear export

1996 • 20 citations

Splicing of the drosophila Sex-lethal early transcripts involves exon skipping that is independent of Sex-lethal protein.

1996 • 19 citations

In vitro selection of exonic splicing enhancer sequences: identification of novel CD44 enhancers

2001 • 17 citations

Chapter 9 Alternative mRNA splicing in the nervous system

1992 • 17 citations

RNA splicing: More clues from spinal muscular atrophy

1999 • 16 citations

Role of the Constitutive Splicing Factors U2AF65 and SAP49 in Suboptimal RNA Splicing of Novel Retroviral Mutants

1998 • 16 citations

The Sex-lethal Early Splicing Pattern Uses a Default Mechanism Dependent on the Alternative 5′ Splice Sites

1997 • 14 citations

Novel functions for `nuclear factors' in the cytoplasm: theSex-lethalparadigm

1997 • 14 citations

Doublesex in the Middle

2002 • 13 citations

Presence of Exon Splicing Silencers within Human Immunodeficiency Virus Type 1 tat Exon 2 and tat-rev Exon 3: Evidence for Inhibition Mediated by Cellular Factors

1995 • 7 citations

Two domains and one RNA: a molecular threesome.

1999 • 5 citations