Regulation of pre-mRNA splicing in metazoa

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

The superfamily of arginine/serine-rich splicing factors.

1995 • 671 citations

SR proteins and splicing control.

1996 • 668 citations

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

1994 • 622 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

1996 • 559 citations

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

1994 • 511 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

1997 • 394 citations

DYNAMIC RNA-RNA INTERACTIONS IN THE SPLICEOSOME

1994 • 356 citations

The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.

1995 • 351 citations

Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism.

1994 • 325 citations

A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.

1997 • 324 citations

Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I

1996 • 318 citations

The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.

1996 • 286 citations

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

1995 • 282 citations

Interaction of U2AF ⁶⁵ RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA

1996 • 279 citations

Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA

1996 • 258 citations

Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer.

1996 • 228 citations

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.

1996 • 200 citations

The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event.

1995 • 194 citations

Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer

1997 • 192 citations

Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.

1995 • 174 citations

SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.

1995 • 167 citations

Presence of Exon Splicing Silencers within Human Immunodeficiency Virus Type 1 tat Exon 2 and tat-rev Exon 3: Evidence for Inhibition Mediated by Cellular Factors

1995 • 165 citations

Identification of Positive and Negative Splicing Regulatory Elements within the Terminal tat-rev Exon of Human Immunodeficiency Virus Type 1

1995 • 162 citations

SR proteins can compensate for the loss of U1 snRNP functions in vitro.

1994 • 160 citations

Synergistic interactions between two distinct elements of a regulated splicing enhancer.

1995 • 156 citations

Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA.

1996 • 153 citations

Complementation by SR Proteins of Pre-mRNA Splicing Reactions Depleted of U1 snRNP

1994 • 152 citations

A splicing enhancer exhibits both constitutive and regulated activities.

1994 • 136 citations

Biochemistry and regulation of pre-mRNA splicing

1996 • 136 citations

Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI.

1994 • 124 citations

Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing.

1995 • 118 citations

The SR protein B52/SRp55 is essential for Drosophila development.

1994 • 112 citations

Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing

1993 • 104 citations

The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences.

1995 • 100 citations

Muscle-Specific Splicing Enhancers Regulate Inclusion of the Cardiac Troponin T Alternative Exon in Embryonic Skeletal Muscle

1996 • 98 citations

Characterization by cDNA Cloning of Two New Human Protein Kinases

1994 • 98 citations

Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors

1993 • 92 citations

Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps.

1995 • 86 citations

Polar zippers

1993 • 76 citations

Novel exploitation of a nuclear function by influenza virus: the cellular SF2/ASF splicing factor controls the amount of the essential viral M2 ion channel protein in infected cells.

1996 • 71 citations

The alternative splicing factor PSI regulates P-element third intron splicing in vivo.

1997 • 64 citations

SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element

1996 • 62 citations

A U6 snRNA:pre-mRNA interaction can be rate-limiting for U1-independent splicing.

1995 • 60 citations

Trans-acting factors regulate the expression of CD44 splice variants.

1996 • 53 citations

Cis-acting elements distinct from the 5' splice site promote U1-independent pre-mRNA splicing.

1996 • 50 citations

Selection of the bovine papillomavirus type 1 nucleotide 3225 3' splice site is regulated through an exonic splicing enhancer and its juxtaposed exonic splicing suppressor

1996 • 50 citations

Essential nucleotides direct neuron-specific splicing of gamma 2 pre-mRNA.

1996 • 46 citations

Genetic Enhancement of RNA-Processing Defects by a Dominant Mutation in B52, the Drosophila Gene for an SR Protein Splicing Factor

1995 • 42 citations

Titration of serine/arginine (SR) splicing factors during adenoviral infection modulates E1A pre-mRNA alternative splicing.

1995 • 41 citations

Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA.

1995 • 33 citations